Abstract：
:The primary sensory feature represented within the rodent barrel cortex is the velocity with which a whisker has been deflected. Whisker deflection velocity is encoded within the thalamus via population synchrony (higher deflection velocities entail greater synchrony among the corresponding thalamic population). Thalamic (TC) cells project to regular spiking (RS) cells within the barrel cortex, as well as to inhibitory cortical fast-spiking (FS) neurons, which in turn project to RS cells. Thus, TC spikes result in EPSPs followed, with a small time lag, by IPSPs within an RS cell, and hence the RS cell decodes TC population synchrony by employing a phase-delayed inhibition synchrony detection scheme. As whisker deflection velocity is increased, the probability that an RS cell spikes rises, while jitter in the timing of RS cell spikes remains constant. Furthermore, repeated whisker deflections with fixed velocity lead to system adaptation--TC →RS, TC →FS, and FS →RS synapses all weaken substantially, leading to a smaller probability of spiking of the RS cell and increased jitter in the timing of RS cell spikes. Interestingly, RS cell activity is better able to distinguish among different whisker deflection velocities after adaptation. In this work, we construct a biophysical model of a basic 'building block' of barrel cortex - the feedforward circuit consisting of TC cells, FS cells, and a single RS cell - and we examine the ability of the purely feedforward circuit to explain the experimental data on RS cell spiking probability, jitter, adaptation, and deflection velocity discrimination. Moreover, we study the contribution of the phase-delayed inhibition network structure to the ability of an RS cell to decode whisker deflection velocity encoded via TC population synchrony.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Liu R,Patel M,Joshi Bdoi
10.1007/s10827-014-0535-3subject
Has Abstractpub_date
2014-12-01 00:00:00pages
387-401issue
3eissn
0929-5313issn
1573-6873journal_volume
37pub_type
杂志文章abstract：:A Web-based simulation system of the spinal cord circuitry responsible for muscle control is described. The simulator employs two-compartment motoneuron models for S, FR and FF types, with synaptic inputs acting through conductance variations. Four motoneuron pools with their associated interneurons are represented in...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-008-0092-8
更新日期：2008-12-01 00:00:00
abstract：:Many neuronal systems exhibit slow random alternations and sudden switches in activity states. Models with noisy relaxation dynamics (oscillatory, excitable or bistable) account for these temporal, slow wave, patterns and the fluctuations within states. The noise-induced transitions in a relaxation dynamics are analog...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-009-0178-y
更新日期：2010-02-01 00:00:00
abstract：:During neural development sensory stimulation induces long-term changes in the receptive field of the neurons that encode the stimuli. The Bienenstock-Cooper-Munro (BCM) model was introduced to model and analyze this process computationally, and it remains one of the major models of unsupervised plasticity to this day...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-019-00715-7
更新日期：2019-04-01 00:00:00
abstract：:The phase relationship between the activity of hippocampal place cells and the hippocampal theta rhythm systematically processes as the animal runs through the region in an environment called the place field of the cell. We present a minimal biophysical model of the phase precession of place cells in region CA3 of the...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1008976210366
更新日期：2000-07-01 00:00:00
abstract：:Much evidence indicates that recognition memory involves two separable processes, recollection and familiarity discrimination, with familiarity discrimination being dependent on the perirhinal cortex of the temporal lobe. Here, we describe a new neural network model designed to mimic the response patterns of perirhina...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1008925909305
更新日期：2001-01-01 00:00:00
abstract：:We develop a new computationally efficient approach for the analysis of complex large-scale neurobiological networks. Its key element is the use of a new phenomenological model of a neuron capable of replicating important spike pattern characteristics and designed in the form of a system of difference equations (a map...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/B:JCNS.0000037683.55688.7e
更新日期：2004-09-01 00:00:00
abstract：:In this paper, we investigate the dynamics of a neuron-glia cell system and the underlying mechanism for the occurrence of seizures. For our mathematical and numerical investigation of the cell model we will use bifurcation analysis and some computational methods. It turns out that an increase of the potassium concent...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-020-00746-5
更新日期：2020-05-01 00:00:00
abstract：:The influence of unreliable synapses on the dynamic properties of a neural network is investigated for a homogeneous integrate-and-fire network with delayed inhibitory synapses. Numerical and analytical calculations show that the network relaxes to a state with dynamic clusters of identical size which permanently exch...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-008-0127-1
更新日期：2009-08-01 00:00:00
abstract：:An analytical model is proposed that can predict the shape of the poststimulus time histogram (PSTH) response to a current pulse of a neuron subjected to uncorrelated background input. The model is based on an explicit description of noise in the form of an escape rate and corresponding hazard function. Two forms of t...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1012841516004
更新日期：2001-09-01 00:00:00
abstract：:Epilepsy is one of the most common neurological disorders and is characterized by recurrent seizures. We use theoretical neuroscience tools to study brain dynamics during seizures. We derive and simulate a computational model of a network of hippocampal neuronal populations. Each population within the network is based...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-017-0636-x
更新日期：2017-04-01 00:00:00
abstract：:Information transfer may not be limited only to synapses. Therefore, the processes and dynamics of biological neuron-astrocyte coupling and intercellular interaction within this domain are worth investigating. Existing models of tripartite synapse consider an astrocyte as a point process. Here, we extended the tripart...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-019-00734-4
更新日期：2020-02-01 00:00:00
abstract：:Phase precession is one of the most well known examples within the temporal coding hypothesis. Here we present a biophysical spiking model for phase precession in hippocampal CA1 which focuses on the interaction between place cells and local inhibitory interneurons. The model's functional block is composed of a place ...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-011-0378-0
更新日期：2012-08-01 00:00:00
abstract：:A number of tests exist to check for statistical significance of phase synchronisation within the Electroencephalogram (EEG); however, the majority suffer from a lack of generality and applicability. They may also fail to account for temporal dynamics in the phase synchronisation, regarding synchronisation as a consta...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-012-0428-2
更新日期：2013-06-01 00:00:00
abstract：:The precise mapping of how complex patterns of synaptic inputs are integrated into specific patterns of spiking output is an essential step in the characterization of the cellular basis of network dynamics and function. Relative to other principal neurons of the hippocampus, the electrophysiology of CA1 pyramidal cell...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-006-8797-z
更新日期：2006-10-01 00:00:00
abstract：:We investigate the use of extracellular action potential (EAP) recordings for biophysically faithful compartmental models. We ask whether constraining a model to fit the EAP is superior to matching the intracellular action potential (IAP). In agreement with previous studies, we find that the IAP method under-constrain...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-006-0018-2
更新日期：2007-08-01 00:00:00
abstract：:Networks of hippocampal interneurons, with pyramidal neurons pharmacologically disconnected, can generate gamma-frequency (20 Hz and above) oscillations. Experiments and models have shown how the network frequency depends on excitation of the interneurons, and on the parameters of GABAA-mediated IPSCs between the inte...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1008839312043
更新日期：1997-04-01 00:00:00
abstract：:Motivated by experimental observations of the head direction system, we study a three population network model that operates as a continuous attractor network. This network is able to store in a short-term memory an angular variable (the head direction) as a spatial profile of activity across neurons in the absence of...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-005-6559-y
更新日期：2005-03-01 00:00:00
abstract：:We address how spatial frequency selectivity arises in Macaque primary visual cortex (V1) by simulating V1 with a large-scale network model consisting of O(10(4)) excitatory and inhibitory integrate-and-fire neurons with realistic synaptic conductances. The new model introduces variability of the widths of subregions ...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-008-0110-x
更新日期：2009-04-01 00:00:00
abstract：:We consider whole-cell voltage-clamp data of isolated currents characterized by the Hodgkin-Huxley paradigm. We examine the errors associated with the typical parameter estimation method for these data and show them to be unsatisfactorally large especially if the time constants of activation and inactivation are not s...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1008880518515
更新日期：1999-03-01 00:00:00
abstract：:The response of neurons to external stimuli greatly depends on the intrinsic dynamics of the network. Here, the intrinsic dynamics are modeled as coupling and the external input is modeled as shared and unshared noise. We assume the neurons are repetitively firing action potentials (i.e., neural oscillators), are weak...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-008-0120-8
更新日期：2009-06-01 00:00:00
abstract：:This modeling study examines the possible functional roles of two hyperpolarization-activated conductances in lateral superior olive (LSO) principal neurons. Inputs of these LSO neurons are transformed into an output, which provides a firing-rate code for a certain interaural sound intensity difference (IID) range. Re...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-005-5637-5
更新日期：2006-04-01 00:00:00
abstract：:Avian brain area HVC is known to be important for the production of birdsong. In zebra finches, each RA-projecting neuron in HVC emits a single burst of spikes during a song motif. The population of neurons is activated in a precisely timed, stereotyped sequence. We propose a model of these burst sequences that relies...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-007-0032-z
更新日期：2007-12-01 00:00:00
abstract：:We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 s...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-013-0484-2
更新日期：2014-06-01 00:00:00
abstract：:We explore the effects of stochastic sodium (Na) channel activation on the variability and dynamics of spiking and bursting in a model neuron. The complete model segregates Hodgin-Huxley-type currents into two compartments, and undergoes applied current-dependent bifurcations between regimes of periodic bursting, chao...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/B:JCNS.0000014104.08299.8b
更新日期：2004-03-01 00:00:00
abstract：:The paper presents a hierarchical series of computational models for myelinated axonal compartments. Three classes of models are considered, either with distributed parameters (2.5D EQS-ElectroQuasi Static, 1D TL-Transmission Lines) or with lumped parameters (0D). They are systematically analyzed with both analytical ...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-019-00726-4
更新日期：2019-12-01 00:00:00
abstract：:Motoneuron responses were elicited by global visual motion and stepwise displacements of an illuminated stripe. Stimulus protocols were identical to those used in previous behavioral studies of compensatory eyestalk reflexes. The firing rates and directional selectivity of the motoneuron responses were measured with r...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1025873027017
更新日期：2003-09-01 00:00:00
abstract：:Nonlinear biophysical properties of individual neurons are known to play a major role in the nervous system, especially those active at subthreshold membrane potentials that integrate synaptic inputs during action potential initiation. Previous electrophysiological studies have made use of a piecewise linear character...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-011-0325-0
更新日期：2011-11-01 00:00:00
abstract：:Information from the vestibular, sensorimotor, or visual systems can affect the firing of grid cells recorded in entorhinal cortex of rats. Optic flow provides information about the rat's linear and rotational velocity and, thus, could influence the firing pattern of grid cells. To investigate this possible link, we m...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-012-0396-6
更新日期：2012-12-01 00:00:00
abstract：:Calmodulin (CaM) is a major Ca(2+) binding protein involved in two opposing processes of synaptic plasticity of CA1 pyramidal neurons: long-term potentiation (LTP) and depression (LTD). The N- and C-terminal lobes of CaM bind to its target separately but cooperatively and introduce complex dynamics that cannot be well...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1007/s10827-009-0173-3
更新日期：2009-12-01 00:00:00
abstract：:The response of leaky integrate-and-fire neurons is analyzed for periodic inputs whose phases vary with their spatial location. The model gives the relationship between the spatial summation distance and the degree of phase locking of the output spikes (i.e., locking to the periodic stochastic inputs, measured by the ...
journal_title：Journal of computational neuroscience
pub_type： 杂志文章
doi：10.1023/a:1014994113776
更新日期：2002-01-01 00:00:00
