Abstract:
:We consider whole-cell voltage-clamp data of isolated currents characterized by the Hodgkin-Huxley paradigm. We examine the errors associated with the typical parameter estimation method for these data and show them to be unsatisfactorally large especially if the time constants of activation and inactivation are not sufficiently separated. The size of these errors is due to the fact that the steady-state and kinetic properties of the current are estimated disjointly. We present an improved parameter estimation method that utilizes all of the information in the voltage-clamp conductance data to estimate steady-state and kinetic properties simultaneously and illustrate its success compared to the standard method using simulated data and data from P. interruptus shal channels expressed in oocytes.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Willms AR,Baro DJ,Harris-Warrick RM,Guckenheimer Jdoi
10.1023/a:1008880518515subject
Has Abstractpub_date
1999-03-01 00:00:00pages
145-68issue
2eissn
0929-5313issn
1573-6873journal_volume
6pub_type
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