Dissecting cooperative calmodulin binding to CaM kinase II: a detailed stochastic model.

abstract：:The temporal durations between events often exert a strong influence over behavior. The details of this influence have been extensively characterized in behavioral experiments in different animal species. A remarkable feature of the data collected in these experiments is that they are often time-scale invariant. This ...

journal_title：Journal of computational neuroscience

authors： Almeida R,Ledberg A

更新日期：2010-02-01 00:00:00

abstract：:The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal ...

journal_title：Journal of computational neuroscience

authors： Migliore M,Messineo L,Ferrante M

更新日期：2004-01-01 00:00:00

abstract：:It is widely believed that the theta rhythm in the hippocampus is caused by the rhythmic input from the medial septum-diagonal band of Broca (MSDB). The main MSDB output is formed by GABAergic projection neurons which are divided into two subpopulations and fire at different phases of the hippocampal theta rhythm. The...

journal_title：Journal of computational neuroscience

authors： Mysin IE,Kitchigina VF,Kazanovich Y

更新日期：2015-08-01 00:00:00

abstract：:Much evidence indicates that recognition memory involves two separable processes, recollection and familiarity discrimination, with familiarity discrimination being dependent on the perirhinal cortex of the temporal lobe. Here, we describe a new neural network model designed to mimic the response patterns of perirhina...

journal_title：Journal of computational neuroscience

authors： Bogacz R,Brown MW,Giraud-Carrier C

更新日期：2001-01-01 00:00:00

abstract：:Neural mass models are successful in modeling brain rhythms as observed in macroscopic measurements such as the electroencephalogram (EEG). While the synaptic current is explicitly modeled in current models, the single cell electrophysiology is not taken into account. To allow for investigations of the effects of chan...

journal_title：Journal of computational neuroscience

authors： Zandt BJ,Visser S,van Putten MJ,Ten Haken B

更新日期：2014-12-01 00:00:00

abstract：:Information transfer may not be limited only to synapses. Therefore, the processes and dynamics of biological neuron-astrocyte coupling and intercellular interaction within this domain are worth investigating. Existing models of tripartite synapse consider an astrocyte as a point process. Here, we extended the tripart...

journal_title：Journal of computational neuroscience

authors： Lorenzo J,Vuillaume R,Binczak S,Jacquir S

更新日期：2020-02-01 00:00:00

abstract：:We have previously formulated an abstract dynamical system for networks of spiking neurons and derived a formal result that identifies the criterion for its dynamics, without inputs, to be "sensitive to initial conditions". Since formal results are applicable only to the extent to which their assumptions are valid, we...

journal_title：Journal of computational neuroscience

authors： Banerjee A

更新日期：2006-06-01 00:00:00

abstract：:The kinematics of the hand and fingers were studied during various keystrokes in typing. These movements were defined by 17 degrees of freedom of motion, and methods were developed to identify simplifying strategies in the execution of the task. Most of the analysis was restricted to the 11 degrees of freedom of the f...

journal_title：Journal of computational neuroscience

authors： Soechting JF,Flanders M

更新日期：1997-01-01 00:00:00

abstract：:The firing rate of neurons in parietal area 7a of the behaving Rhesus monkey with its head fixed incorporates both visual and eye position information. This neural tuning is not in an ego-centered coordinate space. This physiological result was unexpected as behavioral deficits following parietal damage in human and m...

journal_title：Journal of computational neuroscience

authors： Siegel RM

更新日期：1998-12-01 00:00:00

abstract：:Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve large, distributed networks of brain areas, principled examinations of multi-n...

journal_title：Journal of computational neuroscience

authors： Sizemore AE,Giusti C,Kahn A,Vettel JM,Betzel RF,Bassett DS

更新日期：2018-02-01 00:00:00

abstract：:Voltage-sensitive dye imaging (VSDi) has revealed fundamental properties of neocortical processing at macroscopic scales. Since for each pixel VSDi signals report the average membrane potential over hundreds of neurons, it seems natural to use a mean-field formalism to model such signals. Here, we present a mean-field...

journal_title：Journal of computational neuroscience

authors： Zerlaut Y,Chemla S,Chavane F,Destexhe A

更新日期：2018-02-01 00:00:00

abstract：:In the compensatory optomotor response of the fly the interesting phenomenon of gain control has been observed by Reichardt and colleagues (Reichardt et al., 1983): The amplitude of the response tends to saturate with increasing stimulus size, but different saturation plateaus are assumed with different velocities at ...

journal_title：Journal of computational neuroscience

authors： Borst A,Egelhaaf M,Haag J

更新日期：1995-03-01 00:00:00

abstract：:Phase precession is one of the most well known examples within the temporal coding hypothesis. Here we present a biophysical spiking model for phase precession in hippocampal CA1 which focuses on the interaction between place cells and local inhibitory interneurons. The model's functional block is composed of a place ...

journal_title：Journal of computational neuroscience

authors： Castro L,Aguiar P

更新日期：2012-08-01 00:00:00

abstract：:Several neuron types have been shown to exhibit (subthreshold) membrane potential resonance (MPR), defined as the occurrence of a peak in their voltage amplitude response to oscillatory input currents at a preferred (resonant) frequency. MPR has been investigated both experimentally and theoretically. However, whether...

journal_title：Journal of computational neuroscience

authors： Bel A,Rotstein HG

更新日期：2019-04-01 00:00:00

abstract：:Networks of hippocampal interneurons, with pyramidal neurons pharmacologically disconnected, can generate gamma-frequency (20 Hz and above) oscillations. Experiments and models have shown how the network frequency depends on excitation of the interneurons, and on the parameters of GABAA-mediated IPSCs between the inte...

journal_title：Journal of computational neuroscience

authors： Traub RD,Jefferys JG,Whittington MA

更新日期：1997-04-01 00:00:00

abstract：:With the advancement in computer technology, it has become possible to fit complex models to neuronal data. In this work, we test how two methods can estimate parameters of simple neuron models (passive soma) to more complex ones (neuron with one dendritic cylinder and two active conductances). The first method uses c...

journal_title：Journal of computational neuroscience

authors： Tabak J,Murphey CR,Moore LE

更新日期：2000-11-01 00:00:00

abstract：:Wider dissemination and testing of computational models are crucial to the field of computational neuroscience. Databases are being developed to meet this need. ModelDB is a web-accessible database for convenient entry, retrieval, and running of published models on different platforms. This article provides a guide to...

journal_title：Journal of computational neuroscience

authors： Hines ML,Morse T,Migliore M,Carnevale NT,Shepherd GM

更新日期：2004-07-01 00:00:00

abstract：:Motoneuron responses were elicited by global visual motion and stepwise displacements of an illuminated stripe. Stimulus protocols were identical to those used in previous behavioral studies of compensatory eyestalk reflexes. The firing rates and directional selectivity of the motoneuron responses were measured with r...

journal_title：Journal of computational neuroscience

authors： Miller CS,Johnson DH,Schroeter JP,Myint L,Glantz RM

更新日期：2003-09-01 00:00:00

abstract：:We introduce a method for computing probabilities for spontaneous activity and propagation failure of the action potential in spatially extended, conductance-based neuronal models subject to noise, based on statistical properties of the membrane potential. We compare different estimators with respect to the quality of...

journal_title：Journal of computational neuroscience

authors： Sauer M,Stannat W

更新日期：2016-02-01 00:00:00

abstract：:The effect of a non-symmetric waveform on nerve conduction block induced by high-frequency biphasic stimulation is investigated using a lumped circuit model of the unmyelinated axon based on Hodgkin-Huxley equations. The simulation results reveal that the block threshold monotonically increases with the stimulation fr...

journal_title：Journal of computational neuroscience

authors： Zhao S,Yang G,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2014-10-01 00:00:00

abstract：:During slow-wave sleep, brain electrical activity is dominated by the slow (< 1 Hz) electroencephalogram (EEG) oscillations characterized by the periodic transitions between active (or Up) and silent (or Down) states in the membrane voltage of the cortical and thalamic neurons. Sleep slow oscillation is believed to pl...

journal_title：Journal of computational neuroscience

authors： Komarov M,Krishnan G,Chauvette S,Rulkov N,Timofeev I,Bazhenov M

更新日期：2018-02-01 00:00:00

abstract：:Confirming that synaptic loss is directly related to cognitive deficit in Alzheimer's disease (AD) has been the focus of many studies. Compensation mechanisms counteract synaptic loss and prevent the catastrophic amnesia induced by synaptic loss via maintaining the activity levels of neural circuits. Here we investiga...

journal_title：Journal of computational neuroscience

authors： Abuhassan K,Coyle D,Belatreche A,Maguire L

更新日期：2014-02-01 00:00:00

abstract：:A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30-80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchron...

journal_title：Journal of computational neuroscience

authors： Börgers C,Krupa M,Gielen S

更新日期：2010-06-01 00:00:00

abstract：:The goal of this paper is to design experiments that confirm the evidence of cognitive responses in functional near infrared spectroscopy and to establish relevant spectral subbands. Hemodynamic responses of brain during single-event trials in an odd-ball experiment are measured by functional near infrared spectroscop...

journal_title：Journal of computational neuroscience

authors： Akgül CB,Sankur B,Akin A

更新日期：2005-01-01 00:00:00

abstract：:Retinal ganglion cells (RGCs) display differences in their morphology and intrinsic electrophysiology. The goal of this study is to characterize the ionic currents that explain the behavior of ON and OFF RGCs and to explore if all morphological types of RGCs exhibit the phenomena described in electrophysiological data...

journal_title：Journal of computational neuroscience

authors： Maturana MI,Kameneva T,Burkitt AN,Meffin H,Grayden DB

更新日期：2014-04-01 00:00:00

abstract：:This work presents a probabilistic method for inferring the parameter ranges in a biologically relevant mathematical model of the cortex most likely to be producing seizures observed in an electrocorticogram (ECoG) signal from a human subject. Additionally, this method produces a probabilistic pathway of the temporal ...

journal_title：Journal of computational neuroscience

authors： Dadok VM,Kirsch HE,Sleigh JW,Lopour BA,Szeri AJ

更新日期：2015-06-01 00:00:00

abstract：:Motivated by experimental observations of the head direction system, we study a three population network model that operates as a continuous attractor network. This network is able to store in a short-term memory an angular variable (the head direction) as a spatial profile of activity across neurons in the absence of...

journal_title：Journal of computational neuroscience

authors： Boucheny C,Brunel N,Arleo A

更新日期：2005-03-01 00:00:00

abstract：:The existence of electrical communication among pyramidal cells (PCs) in the adult cortex has been debated by neuroscientists for several decades. Gap junctions (GJs) among cortical interneurons have been well documented experimentally and their functional roles have been proposed by both computational neuroscientists...

journal_title：Journal of computational neuroscience

authors： Crodelle J,Zhou D,Kovačič G,Cai D

更新日期：2020-11-01 00:00:00

abstract：:The implications for motor learning of the model developed in the previous article are analyzed using idealized Pavlovian eyelid conditioning trials, a simple example of cerebellar motor learning. Results suggest that changes in gr-->Pkj synapses produced by a training trial disrupt equilibrium and lead to subsequent ...

journal_title：Journal of computational neuroscience

authors： Kenyon GT,Medina JF,Mauk MD

更新日期：1998-03-01 00:00:00

abstract：:Inhibitory networks are now recognized as being the controllers of several brain rhythms. However, experimental work with inhibitory cells is technically difficult not only because of their smaller percentage of the neuronal population, but also because of their diverse properties. As such, inhibitory network models w...

journal_title：Journal of computational neuroscience

authors： Skinner FK,Bazzazi H,Campbell SA

更新日期：2005-06-01 00:00:00