Abstract:
:The existence of electrical communication among pyramidal cells (PCs) in the adult cortex has been debated by neuroscientists for several decades. Gap junctions (GJs) among cortical interneurons have been well documented experimentally and their functional roles have been proposed by both computational neuroscientists and experimentalists alike. Experimental evidence for similar junctions among pyramidal cells in the cortex, however, has remained elusive due to the apparent rarity of these couplings among neurons. In this work, we develop a neuronal network model that includes observed probabilities and strengths of electrotonic coupling between PCs and gap-junction coupling among interneurons, in addition to realistic synaptic connectivity among both populations. We use this network model to investigate the effect of electrotonic coupling between PCs on network behavior with the goal of theoretically addressing this controversy of existence and purpose of electrotonically coupled PCs in the cortex.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Crodelle J,Zhou D,Kovačič G,Cai Ddoi
10.1007/s10827-020-00762-5subject
Has Abstractpub_date
2020-11-01 00:00:00pages
387-407issue
4eissn
0929-5313issn
1573-6873pii
10.1007/s10827-020-00762-5journal_volume
48pub_type
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