Model of familiarity discrimination in the perirhinal cortex.

abstract：:The resistive or non-resistive nature of the extracellular space in the brain is still debated, and is an important issue for correctly modeling extracellular potentials. Here, we first show theoretically that if the medium is resistive, the frequency scaling should be the same for electroencephalogram (EEG) and magne...

journal_title：Journal of computational neuroscience

authors： Dehghani N,Bédard C,Cash SS,Halgren E,Destexhe A

更新日期：2010-12-01 00:00:00

abstract：:In this paper, we systematically investigate both the synfire propagation and firing rate propagation in feedforward neuronal network coupled in an all-to-all fashion. In contrast to most earlier work, where only reliable synaptic connections are considered, we mainly examine the effects of unreliable synapses on both...

journal_title：Journal of computational neuroscience

authors： Guo D,Li C

更新日期：2011-06-01 00:00:00

abstract：:Avian brain area HVC is known to be important for the production of birdsong. In zebra finches, each RA-projecting neuron in HVC emits a single burst of spikes during a song motif. The population of neurons is activated in a precisely timed, stereotyped sequence. We propose a model of these burst sequences that relies...

journal_title：Journal of computational neuroscience

authors： Jin DZ,Ramazanoğlu FM,Seung HS

更新日期：2007-12-01 00:00:00

abstract：:The original version of this article unfortunately has some typographical errors in equations (5), (6), (7), (8), and (12). ...

journal_title：Journal of computational neuroscience

authors： Devecioğlu İ,Güçlü B

更新日期：2020-08-01 00:00:00

abstract：:The ability to image calcium movement within individual neurons inspires questions of functionality including whether calcium entry into the nucleus is related to genetic regulation for phenomena such as long term potentiation. Calcium waves have been initiated in hippocampal pyramidal cells with glutmatergic signals ...

journal_title：Journal of computational neuroscience

authors： Peercy BE

更新日期：2008-10-01 00:00:00

abstract：:Linear additivity of synaptic input is a pervasive assumption in computational neuroscience, and previously Bernander et al. (Journal of Neurophysiology 72:2743-2753, 1994) point out that the sublinear additivity of a passive neuronal model can be linearized with voltage-dependent currents. Here we re-examine this per...

journal_title：Journal of computational neuroscience

authors： Morel D,Levy W

更新日期：2009-10-01 00:00:00

abstract：:Transcranial Direct brain stimulation (tDCS) is commonly used in order to modulate cortical networks activity during physiological processes through the application of weak electrical fields with scalp electrodes. Cathodal stimulation has been shown to decrease brain excitability in the context of epilepsy, with varia...

journal_title：Journal of computational neuroscience

authors： Denoyer Y,Merlet I,Wendling F,Benquet P

更新日期：2020-05-01 00:00:00

abstract：:We address how spatial frequency selectivity arises in Macaque primary visual cortex (V1) by simulating V1 with a large-scale network model consisting of O(10(4)) excitatory and inhibitory integrate-and-fire neurons with realistic synaptic conductances. The new model introduces variability of the widths of subregions ...

journal_title：Journal of computational neuroscience

authors： Zhu W,Shelley M,Shapley R

更新日期：2009-04-01 00:00:00

abstract：:Networks of spiking neurons can have persistently firing stable bump attractors to represent continuous spaces (like temperature). This can be done with a topology with local excitatory synapses and local surround inhibitory synapses. Activating large ranges in the attractor can lead to multiple bumps, that show repel...

journal_title：Journal of computational neuroscience

authors： Huyck CR,Vergani AA

更新日期：2020-08-01 00:00:00

abstract：:A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30-80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchron...

journal_title：Journal of computational neuroscience

authors： Börgers C,Krupa M,Gielen S

更新日期：2010-06-01 00:00:00

abstract：:The classical view of cortical information processing is that of a bottom-up process in a feedforward hierarchy. However, psychophysical, anatomical, and physiological evidence suggests that top-down effects play a crucial role in the processing of input stimuli. Not much is known about the neural mechanisms underlyin...

journal_title：Journal of computational neuroscience

authors： Siegel M,Körding KP,König P

更新日期：2000-03-01 00:00:00

abstract：:Confirming that synaptic loss is directly related to cognitive deficit in Alzheimer's disease (AD) has been the focus of many studies. Compensation mechanisms counteract synaptic loss and prevent the catastrophic amnesia induced by synaptic loss via maintaining the activity levels of neural circuits. Here we investiga...

journal_title：Journal of computational neuroscience

authors： Abuhassan K,Coyle D,Belatreche A,Maguire L

更新日期：2014-02-01 00:00:00

abstract：:We explore the effects of stochastic sodium (Na) channel activation on the variability and dynamics of spiking and bursting in a model neuron. The complete model segregates Hodgin-Huxley-type currents into two compartments, and undergoes applied current-dependent bifurcations between regimes of periodic bursting, chao...

journal_title：Journal of computational neuroscience

authors： Rowat PF,Elson RC

更新日期：2004-03-01 00:00:00

abstract：:The lack of a deeper understanding of how olfactory sensory neurons (OSNs) encode odors has hindered the progress in understanding the olfactory signal processing in higher brain centers. Here we employ methods of system identification to investigate the encoding of time-varying odor stimuli and their representation f...

journal_title：Journal of computational neuroscience

authors： Kim AJ,Lazar AA,Slutskiy YB

更新日期：2011-02-01 00:00:00

abstract：:We have presented a new generation mechanism of slow spiking or repetitive discharges with extraordinarily long inter-spike intervals using the modified Hodgkin-Huxley equations (Doi and Kumagai, 2001). This generation process of slow firing is completely different from that of the well-known potassium A-current in th...

journal_title：Journal of computational neuroscience

authors： Doi S,Kumagai S

更新日期：2005-12-01 00:00:00

abstract：:The response of leaky integrate-and-fire neurons is analyzed for periodic inputs whose phases vary with their spatial location. The model gives the relationship between the spatial summation distance and the degree of phase locking of the output spikes (i.e., locking to the periodic stochastic inputs, measured by the ...

journal_title：Journal of computational neuroscience

authors： Kuhlmann L,Burkitt AN,Paolini A,Clark GM

更新日期：2002-01-01 00:00:00

abstract：:This work presents a probabilistic method for inferring the parameter ranges in a biologically relevant mathematical model of the cortex most likely to be producing seizures observed in an electrocorticogram (ECoG) signal from a human subject. Additionally, this method produces a probabilistic pathway of the temporal ...

journal_title：Journal of computational neuroscience

authors： Dadok VM,Kirsch HE,Sleigh JW,Lopour BA,Szeri AJ

更新日期：2015-06-01 00:00:00

abstract：:The calcium calmodulin dependent kinase (CaMKII) is important for long-term potentiation at dendritic spines. Photo-activatable GFP (PaGFP) - CaMKII fusions were used to map CaMKII movements between and within spines in dissociated hippocampal neurons. Photo-activated PaGFP (GFP*) generated in the shaft spread uniform...

journal_title：Journal of computational neuroscience

authors： Khan S,Reese TS,Rajpoot N,Shabbir A

更新日期：2012-08-01 00:00:00

abstract：:Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Here a model of calmodulin binding and trapping by CaMKII in a dendritic spine was used to estimate levels and durations of CaMKII activation followin...

journal_title：Journal of computational neuroscience

authors： Holmes WR

更新日期：2000-01-01 00:00:00

abstract：:Models of electrical activity in excitable cells involve nonlinear interactions between many ionic currents. Changing parameters in these models can produce a variety of activity patterns with sometimes unexpected effects. Further more, introducing new currents will have different effects depending on the initial para...

journal_title：Journal of computational neuroscience

authors： Fletcher P,Bertram R,Tabak J

更新日期：2016-06-01 00:00:00

abstract：:Information transfer may not be limited only to synapses. Therefore, the processes and dynamics of biological neuron-astrocyte coupling and intercellular interaction within this domain are worth investigating. Existing models of tripartite synapse consider an astrocyte as a point process. Here, we extended the tripart...

journal_title：Journal of computational neuroscience

authors： Lorenzo J,Vuillaume R,Binczak S,Jacquir S

更新日期：2020-02-01 00:00:00

abstract：:The timing of transmitter release from nerve endings is considered nowadays as one of the factors determining the plasticity and efficacy of synaptic transmission. In the neuromuscular junction, the moments of release of individual acetylcholine quanta are related to the synaptic delays of uniquantal endplate currents...

journal_title：Journal of computational neuroscience

authors： Saveliev A,Khuzakhmetova V,Samigullin D,Skorinkin A,Kovyazina I,Nikolsky E,Bukharaeva E

更新日期：2015-10-01 00:00:00

abstract：:Wider dissemination and testing of computational models are crucial to the field of computational neuroscience. Databases are being developed to meet this need. ModelDB is a web-accessible database for convenient entry, retrieval, and running of published models on different platforms. This article provides a guide to...

journal_title：Journal of computational neuroscience

authors： Hines ML,Morse T,Migliore M,Carnevale NT,Shepherd GM

更新日期：2004-07-01 00:00:00

abstract：:We use a modeling approach to examine ideas derived from physiological network analyses, pertaining to the switch of a motor control network between two opposite control modes. We studied the femur-tibia joint control system of the insect leg, and its switch between resistance reflex in posture control and "active rea...

journal_title：Journal of computational neuroscience

authors： Stein W,Straub O,Ausborn J,Mader W,Wolf H

更新日期：2008-12-01 00:00:00

abstract：:This paper presents a synergistic parametric and non-parametric modeling study of short-term plasticity (STP) in the Schaffer collateral to hippocampal CA1 pyramidal neuron (SC) synapse. Parametric models in the form of sets of differential and algebraic equations have been proposed on the basis of the current underst...

journal_title：Journal of computational neuroscience

authors： Song D,Wang Z,Marmarelis VZ,Berger TW

更新日期：2009-02-01 00:00:00

abstract：:Information theoretical approaches to sensory processing in electric fish have focused on the encoding of amplitude modulations in a single sensory pathway in the South American gymnotiforms. To assess the generality of these studies, we investigated the encoding of amplitude and phase modulations in the distantly rel...

journal_title：Journal of computational neuroscience

authors： Carlson BA,Kawasaki M

更新日期：2008-08-01 00:00:00

abstract：:Synchronization of excitable cells coupled by reciprocal inhibition is a topic of significant interest due to the important role that inhibitory synaptic interaction plays in the generation and regulation of coherent rhythmic activity in a variety of neural systems. While recent work revealed the synchronizing influen...

journal_title：Journal of computational neuroscience

authors： Oh M,Matveev V

更新日期：2009-04-01 00:00:00

abstract：:Most neurons in the primary visual cortex initially respond vigorously when a preferred stimulus is presented, but adapt as stimulation continues. The functional consequences of adaptation are unclear. Typically a reduction of firing rate would reduce single neuron accuracy as less spikes are available for decoding, b...

journal_title：Journal of computational neuroscience

authors： Cortes JM,Marinazzo D,Series P,Oram MW,Sejnowski TJ,van Rossum MC

更新日期：2012-06-01 00:00:00

abstract：:Calmodulin (CaM) is a major Ca(2+) binding protein involved in two opposing processes of synaptic plasticity of CA1 pyramidal neurons: long-term potentiation (LTP) and depression (LTD). The N- and C-terminal lobes of CaM bind to its target separately but cooperatively and introduce complex dynamics that cannot be well...

journal_title：Journal of computational neuroscience

authors： Byrne MJ,Putkey JA,Waxham MN,Kubota Y

更新日期：2009-12-01 00:00:00

abstract：:Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve large, distributed networks of brain areas, principled examinations of multi-n...

journal_title：Journal of computational neuroscience

authors： Sizemore AE,Giusti C,Kahn A,Vettel JM,Betzel RF,Bassett DS

更新日期：2018-02-01 00:00:00