Abstract:
:A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30-80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchronization by an inhibitory input pulse often fails for populations of classical Hodgkin-Huxley neurons. Our reasoning suggests that in general, synchronization by inhibitory input pulses can fail when the transition of the target neurons from rest to spiking involves a Hopf bifurcation, especially when inhibition is shunting, not hyperpolarizing. Surprisingly, synchronization is more likely to fail when the inhibitory pulse is stronger or longer-lasting. These findings have potential implications for the question which neurons participate in brain rhythms, in particular in gamma oscillations.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Börgers C,Krupa M,Gielen Sdoi
10.1007/s10827-010-0233-8subject
Has Abstractpub_date
2010-06-01 00:00:00pages
509-26issue
3eissn
0929-5313issn
1573-6873journal_volume
28pub_type
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