Neural mass models as a tool to investigate neural dynamics during seizures.

abstract：:When two-frame apparent motion stimuli are presented with an appropriate inter-stimulus interval (ISI), motion is perceived in the direction opposite to the actual image shift. Herein, we measured a simple eye movement, ocular following responses (OFRs), in macaque monkeys to examine the ISI reversal effect on oculomo...

journal_title：Journal of computational neuroscience

authors： Takemura A,Matsumoto J,Hashimoto R,Kawano K,Miura K

更新日期：2020-07-17 00:00:00

abstract：:Linear additivity of synaptic input is a pervasive assumption in computational neuroscience, and previously Bernander et al. (Journal of Neurophysiology 72:2743-2753, 1994) point out that the sublinear additivity of a passive neuronal model can be linearized with voltage-dependent currents. Here we re-examine this per...

journal_title：Journal of computational neuroscience

authors： Morel D,Levy W

更新日期：2009-10-01 00:00:00

abstract：:Computational modeling of dendritic morphology is a powerful tool for quantitatively describing complex geometrical relationships, uncovering principles of dendritic development, and synthesizing virtual neurons to systematically investigate cellular biophysics and network dynamics. A feature common to many morphologi...

journal_title：Journal of computational neuroscience

authors： Donohue DE,Ascoli GA

更新日期：2005-10-01 00:00:00

abstract：:Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Here a model of calmodulin binding and trapping by CaMKII in a dendritic spine was used to estimate levels and durations of CaMKII activation followin...

journal_title：Journal of computational neuroscience

authors： Holmes WR

更新日期：2000-01-01 00:00:00

abstract：:We introduce a method for computing probabilities for spontaneous activity and propagation failure of the action potential in spatially extended, conductance-based neuronal models subject to noise, based on statistical properties of the membrane potential. We compare different estimators with respect to the quality of...

journal_title：Journal of computational neuroscience

authors： Sauer M,Stannat W

更新日期：2016-02-01 00:00:00

abstract：:In this paper, we investigate the dynamics of a neuron-glia cell system and the underlying mechanism for the occurrence of seizures. For our mathematical and numerical investigation of the cell model we will use bifurcation analysis and some computational methods. It turns out that an increase of the potassium concent...

journal_title：Journal of computational neuroscience

authors： Erhardt AH,Mardal KA,Schreiner JE

更新日期：2020-05-01 00:00:00

abstract：:We study the dynamics and bifurcations of noise-free neurons coupled by gap junctions and inhibitory synapses, using both delayed delta functions and alpha functions to model the latter. We focus on the case of two cells, as in the studies of Chow and Kopell (2000) and Lewis and Rinzel (2003), but also show that stabl...

journal_title：Journal of computational neuroscience

authors： Gao J,Holmes P

更新日期：2007-02-01 00:00:00

abstract：:Many neuronal systems exhibit slow random alternations and sudden switches in activity states. Models with noisy relaxation dynamics (oscillatory, excitable or bistable) account for these temporal, slow wave, patterns and the fluctuations within states. The noise-induced transitions in a relaxation dynamics are analog...

journal_title：Journal of computational neuroscience

authors： Lim S,Rinzel J

更新日期：2010-02-01 00:00:00

abstract：:Lyapunov exponents are a basic and powerful tool to characterise the long-term behaviour of dynamical systems. The computation of Lyapunov exponents for continuous time dynamical systems is straightforward whenever they are ruled by vector fields that are sufficiently smooth to admit a variational model. Hybrid neuron...

journal_title：Journal of computational neuroscience

authors： Bizzarri F,Brambilla A,Gajani GS

更新日期：2013-10-01 00:00:00

abstract：:By varying the noise intensity, we study stochastic spiking coherence (i.e., collective coherence between noise-induced neural spikings) in an inhibitory population of subthreshold neurons (which cannot fire spontaneously without noise). This stochastic spiking coherence may be well visualized in the raster plot of ne...

journal_title：Journal of computational neuroscience

authors： Lim W,Kim SY

更新日期：2011-11-01 00:00:00

abstract：:Within the theory that describes the hippocampus as a device for the on-line storage of complex memories, the crucial autoassociative operations are ascribed mainly to the recurrent CA3 network. The CA3-to-CA1 connections may still be important, both in completing information retrieval and in re-expanding, with minima...

journal_title：Journal of computational neuroscience

authors： Treves A

更新日期：1995-09-01 00:00:00

abstract：:Sensory neurons code information about stimuli in their sequence of action potentials (spikes). Intuitively, the spikes should represent stimuli with high fidelity. However, generating and propagating spikes is a metabolically expensive process. It is therefore likely that neural codes have been selected to balance en...

journal_title：Journal of computational neuroscience

authors： Johnson EC,Jones DL,Ratnam R

更新日期：2016-04-01 00:00:00

abstract：:We use a modeling approach to examine ideas derived from physiological network analyses, pertaining to the switch of a motor control network between two opposite control modes. We studied the femur-tibia joint control system of the insect leg, and its switch between resistance reflex in posture control and "active rea...

journal_title：Journal of computational neuroscience

authors： Stein W,Straub O,Ausborn J,Mader W,Wolf H

更新日期：2008-12-01 00:00:00

abstract：:Much evidence indicates that recognition memory involves two separable processes, recollection and familiarity discrimination, with familiarity discrimination being dependent on the perirhinal cortex of the temporal lobe. Here, we describe a new neural network model designed to mimic the response patterns of perirhina...

journal_title：Journal of computational neuroscience

authors： Bogacz R,Brown MW,Giraud-Carrier C

更新日期：2001-01-01 00:00:00

abstract：:The influence of unreliable synapses on the dynamic properties of a neural network is investigated for a homogeneous integrate-and-fire network with delayed inhibitory synapses. Numerical and analytical calculations show that the network relaxes to a state with dynamic clusters of identical size which permanently exch...

journal_title：Journal of computational neuroscience

authors： Friedrich J,Kinzel W

更新日期：2009-08-01 00:00:00

abstract：:Transcranial Direct brain stimulation (tDCS) is commonly used in order to modulate cortical networks activity during physiological processes through the application of weak electrical fields with scalp electrodes. Cathodal stimulation has been shown to decrease brain excitability in the context of epilepsy, with varia...

journal_title：Journal of computational neuroscience

authors： Denoyer Y,Merlet I,Wendling F,Benquet P

更新日期：2020-05-01 00:00:00

abstract：:We develop a new computationally efficient approach for the analysis of complex large-scale neurobiological networks. Its key element is the use of a new phenomenological model of a neuron capable of replicating important spike pattern characteristics and designed in the form of a system of difference equations (a map...

journal_title：Journal of computational neuroscience

authors： Rulkov NF,Timofeev I,Bazhenov M

更新日期：2004-09-01 00:00:00

abstract：:We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 s...

journal_title：Journal of computational neuroscience

authors： Selvaraj P,Sleigh JW,Freeman WJ,Kirsch HE,Szeri AJ

更新日期：2014-06-01 00:00:00

abstract：:Avian brain area HVC is known to be important for the production of birdsong. In zebra finches, each RA-projecting neuron in HVC emits a single burst of spikes during a song motif. The population of neurons is activated in a precisely timed, stereotyped sequence. We propose a model of these burst sequences that relies...

journal_title：Journal of computational neuroscience

authors： Jin DZ,Ramazanoğlu FM,Seung HS

更新日期：2007-12-01 00:00:00

abstract：:Replicability and reproducibility of computational models has been somewhat understudied by "the replication movement." In this paper, we draw on methodological studies into the replicability of psychological experiments and on the mechanistic account of explanation to analyze the functions of model replications and m...

journal_title：Journal of computational neuroscience

authors： Miłkowski M,Hensel WM,Hohol M

更新日期：2018-12-01 00:00:00

abstract：:Can one develop an abstract description of the dynamics of pattern generators that provides quantitative insight into their operation? We explored this question by examining the dynamics of a model central pattern generator that was created using an evolutionary algorithm. We propose an abstract description based on t...

journal_title：Journal of computational neuroscience

authors： Chiel HJ,Beer RD,Gallagher JC

更新日期：1999-09-01 00:00:00

abstract：:Characterizing how different cortical rhythms interact and how their interaction changes with sensory stimulation is important to gather insights into how these rhythms are generated and what sensory function they may play. Concepts from information theory, such as Transfer Entropy (TE), offer principled ways to quant...

journal_title：Journal of computational neuroscience

authors： Besserve M,Schölkopf B,Logothetis NK,Panzeri S

更新日期：2010-12-01 00:00:00

abstract：:A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30-80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchron...

journal_title：Journal of computational neuroscience

authors： Börgers C,Krupa M,Gielen S

更新日期：2010-06-01 00:00:00

abstract：:Confirming that synaptic loss is directly related to cognitive deficit in Alzheimer's disease (AD) has been the focus of many studies. Compensation mechanisms counteract synaptic loss and prevent the catastrophic amnesia induced by synaptic loss via maintaining the activity levels of neural circuits. Here we investiga...

journal_title：Journal of computational neuroscience

authors： Abuhassan K,Coyle D,Belatreche A,Maguire L

更新日期：2014-02-01 00:00:00

abstract：:We consider whole-cell voltage-clamp data of isolated currents characterized by the Hodgkin-Huxley paradigm. We examine the errors associated with the typical parameter estimation method for these data and show them to be unsatisfactorally large especially if the time constants of activation and inactivation are not s...

journal_title：Journal of computational neuroscience

authors： Willms AR,Baro DJ,Harris-Warrick RM,Guckenheimer J

更新日期：1999-03-01 00:00:00

abstract：:The primary sensory feature represented within the rodent barrel cortex is the velocity with which a whisker has been deflected. Whisker deflection velocity is encoded within the thalamus via population synchrony (higher deflection velocities entail greater synchrony among the corresponding thalamic population). Thala...

journal_title：Journal of computational neuroscience

authors： Liu R,Patel M,Joshi B

更新日期：2014-12-01 00:00:00

abstract：:We developed a multicompartmental Hodgkin-Huxley model of the Hermissenda type-B photoreceptor and used it to address the relative contributions of reductions of two K+ currents, IA and IC, to changes in cellular excitability and synaptic strength that occur in these cells after associative learning. We found that red...

journal_title：Journal of computational neuroscience

authors： Fost JW,Clark GA

更新日期：1996-06-01 00:00:00

abstract：:The effect of a non-symmetric waveform on nerve conduction block induced by high-frequency biphasic stimulation is investigated using a lumped circuit model of the unmyelinated axon based on Hodgkin-Huxley equations. The simulation results reveal that the block threshold monotonically increases with the stimulation fr...

journal_title：Journal of computational neuroscience

authors： Zhao S,Yang G,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2014-10-01 00:00:00

abstract：:Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs) at low stimulus levels, and that of...

journal_title：Journal of computational neuroscience

authors： Lai YC,Winslow RL,Sachs MB

更新日期：1994-08-01 00:00:00

abstract：:The pathophysiology of auditory hallucination, a common symptom of schizophrenia, has yet been understood, but during auditory hallucination, primary auditory cortex (A1) shows paradoxical responses. When auditory stimuli are absent, A1 becomes hyperactive, while A1 responses to auditory stimuli are reduced. Such acti...

journal_title：Journal of computational neuroscience

authors： Lee JH

更新日期：2017-12-01 00:00:00