Abstract:
:We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Selvaraj P,Sleigh JW,Freeman WJ,Kirsch HE,Szeri AJdoi
10.1007/s10827-013-0484-2subject
Has Abstractpub_date
2014-06-01 00:00:00pages
515-25issue
3eissn
0929-5313issn
1573-6873journal_volume
36pub_type
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