Abstract:
:The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, Ih, in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the Ih in these neurons is needed to reduce neuronal excitability selectively for distal unsynchronized, but not for synchronized, inputs.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Migliore M,Messineo L,Ferrante Mdoi
10.1023/b:jcns.0000004837.81595.b0subject
Has Abstractpub_date
2004-01-01 00:00:00pages
5-13issue
1eissn
0929-5313issn
1573-6873pii
5256109journal_volume
16pub_type
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