[Contribution of omega-3 fatty acids for memory and cognitive function].

Abstract:

INTRODUCTION:A decline in memory and cognitive function is considered to be a normal consequence of aging. Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements with the ability to reduce the risk of cognitive decline, including Alzheimer's disease (AD). AIM:To study the effect of omega-3 on cognitive decline through the review of recent observational, interventional, and experimental studies. METHODS:We conducted a Pubmed, Medline, Cochrane and Embase search for epidemiological and clinical studies in the international literature using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3 fatty acids", "EPA and DHA". CONCLUSIONS:Studies have shown the protective role of omega-3 fatty acids in mild cognitive impairment, dementia, and the risk and progression of Alzheimer's disease in the elderly. Further studies are needed to understand the mechanism of action of omega-3 fatty acids on cognition. Doses, composition of EPA and DHA capsules and time of supplementation should be explored. Introduccion:Una disminución de la función cognitiva y de la memoria se considera que es una consecuencia normal del envejecimiento. Los ácidos grasos omega-3 poliinsaturados son cada vez más propuestos como suplementos dietéticos con la capacidad de reducir el riesgo de deterioro cognitivo, incluyendo la enfermedad de Alzheimer (EA). Objetivo:Estudiar el efecto de los omega-3 en el deterioro cognitivo a través de la revisión de estudios recientes de observación, intervención y experimentales. Métodos:Se realizó una búsqueda en PubMed, Medline, Cochrane y Embase para los estudios epidemiológicos y clínicos en la literatura internacional que utilizan combinaciones de las siguientes palabras clave: “la enfermedad de Alzheimer”, “deterioro cognitivo leve”, “función cognitiva”, “factores dietéticos”, “ácidos grasos omega-3”, “EPA y DHA”. Conclusiones:Los estudios han demostrado el papel protector de los ácidos grasos omega-3 en el deterioro cognitivo leve, demencia y en el riesgo y la progresión de la enfermedad de Alzheimer en los adultos mayores. Se necesitan más estudios para comprender el mecanismo de acción de los ácidos grasos omega-3 sobre la cognición. Las dosis, la composición de cápsulas de EPA y DHA y el tiempo de suplementación deben ser explorados.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Waitzberg DL,Garla P

doi

10.3305/nh.2014.30.3.7632

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

467-77

issue

3

eissn

0212-1611

issn

1699-5198

journal_volume

30

pub_type

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