Loss of viral gene expression and retention of tumorigenicity by Abelson lymphoma cells.

abstract：:Caprine arthritis encephalitis virus (CAEV) is a lentivirus closely related to visna virus and more distantly to other lentiviruses, such as human immunodeficiency virus. The genomes of visna virus and CAEV contain a tat gene encoding a protein able to weakly transactivate its own long terminal repeat, suggesting that...

journal_title：Journal of virology

authors： Harmache A,Vitu C,Russo P,Bouyac M,Hieblot C,Peveri P,Vigne R,Suzan M

更新日期：1995-09-01 00:00:00

abstract：:The high rate of HIV-1 evolution contributes to immune escape, enables the virus to escape drug therapy, and may underlie the difficulty of producing an effective vaccine. Identifying constraints on HIV evolution is therefore of prime importance. To investigate this problem, we examined the relationships between seque...

journal_title：Journal of virology

authors： Woo J,Robertson DL,Lovell SC

更新日期：2010-12-01 00:00:00

abstract：:Interallelic complementation between certain temperature-sensitive mutants of gene 42 of bacteriophage T4 was demonstrated by measuring the incorporation of labeled thymine into DNA. ...

journal_title：Journal of virology

authors： Chiu CS,Greenberg GR

更新日期：1973-08-01 00:00:00

abstract：:Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Although IBDV-induced host cell apoptosis has been established, the underlying molecular mechanism is still unclear. We report here that IBDV viral protein 5 (VP5) is a major apoptosis induce...

journal_title：Journal of virology

authors： Li Z,Wang Y,Xue Y,Li X,Cao H,Zheng SJ

更新日期：2012-02-01 00:00:00

abstract：:African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs that has significant economic consequences for the swine industry. The control of African swine fever (ASF) has been hampered by the unavailability of vaccines. Successful experimental vaccines hav...

journal_title：Journal of virology

authors： O'Donnell V,Risatti GR,Holinka LG,Krug PW,Carlson J,Velazquez-Salinas L,Azzinaro PA,Gladue DP,Borca MV

更新日期：2016-12-16 00:00:00

abstract：UNLABELLED:Based on an explant reactivation model, it has been proposed that CD8(+) T cells maintain latency in trigeminal ganglia (TG) of mice latently infected with herpes simplex virus 1 (HSV-1) [T. Liu, K. M. Khanna, X. Chen, D. J. Fink, and R. L. Hendricks, J Exp Med 191:1459-1466, 2000, doi:10.1084/jem.191.9.1459...

journal_title：Journal of virology

authors： Mott KR,Gate D,Matundan HH,Ghiasi YN,Town T,Ghiasi H

更新日期：2016-04-29 00:00:00

abstract：:The amino-terminal region of the Vif molecule in human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) contains a conserved SLV/Ix4Yx9Y motif that was first described in 1992, but the importance of this motif for Vif function has not yet been examined. Our characterization of the ...

journal_title：Journal of virology

authors： Chen G,He Z,Wang T,Xu R,Yu XF

更新日期：2009-09-01 00:00:00

abstract：:The glycoprotein E(rns) of pestiviruses is a virion-associated and -secreted RNase that is involved in virulence. The requirements at the cleavage site in heteropolymeric RNA substrates were studied for E(rns). Limited digestion of heteropolymeric RNA substrates indicated a cleavage 5' of uridine residues irrespective...

journal_title：Journal of virology

authors： Hausmann Y,Roman-Sosa G,Thiel HJ,Rümenapf T

更新日期：2004-05-01 00:00:00

abstract：:cpts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (RSV). It was derived by subjecting a cold-passaged (cp) strain of RSV to a single round of chemical mutagenesis. cpts530 is a temperature-sensitive (ts) mutant that is attenuated in mice and chimpanzees, and its ts p...

journal_title：Journal of virology

authors： Juhasz K,Whitehead SS,Bui PT,Biggs JM,Crowe JE,Boulanger CA,Collins PL,Murphy BR

更新日期：1997-08-01 00:00:00

abstract：:Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in ...

journal_title：Journal of virology

authors： Maness NJ,Sacha JB,Piaskowski SM,Weisgrau KL,Rakasz EG,May GE,Buechler MB,Walsh AD,Wilson NA,Watkins DI

更新日期：2009-10-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that dramatically reorganizes host gene expression to immortalize primary B cells. In this study, we analyzed EBV-regulated host gene expression changes following primary B-cell infection, both during initial proliferation and through transformation into lymph...

journal_title：Journal of virology

authors： Price AM,Tourigny JP,Forte E,Salinas RE,Dave SS,Luftig MA

更新日期：2012-10-01 00:00:00

abstract：:Rubella virus contains three structural proteins, capsid, E2, and E1. E2 and E1 are type I membrane glycoproteins that form a heterodimer in the endoplasmic reticulum (ER) before they are transported to and retained in the Golgi complex, where virus assembly occurs. The bulk of unassembled E2 and E1 subunits are not t...

journal_title：Journal of virology

authors： Hobman TC,Lemon HF,Jewell K

更新日期：1997-10-01 00:00:00

abstract：:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proxim...

journal_title：Journal of virology

authors： Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM

更新日期：2004-08-01 00:00:00

abstract：:The family Bunyaviridae is the most diversified family of RNA viruses. We describe a novel prototypic bunyavirus, tentatively named Gouléako virus, isolated from various mosquito species trapped in Côte d'Ivoire. The S segment comprised 1,087 nucleotides (nt), the M segment 3,188 nt, and the L segment 6,358 nt, consti...

journal_title：Journal of virology

authors： Marklewitz M,Handrick S,Grasse W,Kurth A,Lukashev A,Drosten C,Ellerbrok H,Leendertz FH,Pauli G,Junglen S

更新日期：2011-09-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is a key sensor for recognizing nucleic acids derived from RNA viruses and triggers beta interferon (IFN-β) production. Because of its important role in antiviral innate immunity, the activity of RIG-I must be tightly controlled. Here, we used yeast two-hybrid screening to identi...

journal_title：Journal of virology

authors： Li MT,Di W,Xu H,Yang YK,Chen HW,Zhang FX,Zhai ZH,Chen DY

更新日期：2013-09-01 00:00:00

abstract：:Several independent cell lines transformed by simian virus 40 carry a species of viral RNA of 900,000 to 1,000,000 daltons. A viral RNA species of similar size is found early in the lytic cycle. Late in the viral lytic cycle, two prominent viral RNA species of about 600,000 and 900,000 daltons are seen. The larger lat...

journal_title：Journal of virology

authors： Weinberg RA,Ben-Ishai Z,Newbold JE

更新日期：1974-06-01 00:00:00

abstract：:Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce...

journal_title：Journal of virology

authors： Cladel NM,Budgeon LR,Cooper TK,Balogh KK,Hu J,Christensen ND

更新日期：2013-08-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00

abstract：:We have examined the transcriptional utilization of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) under differentiating conditions by using the embryonal carcinoma cell line NTERA-2. NTERA-2 cells undergo two distinct pathways of terminal differentiation, to a neuronal phenotype in respons...

journal_title：Journal of virology

authors： Zeichner SL,Hirka G,Andrews PW,Alwine JC

更新日期：1992-04-01 00:00:00

abstract：:Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in both strands. Upon infectious entry into a host cell, this genome is converted into a covalently closed superhelical form (CCC-DNA), which later serves as the template for transcription. Here we examined whether the viral polymerase ...

journal_title：Journal of virology

authors： Köck J,Schlicht HJ

更新日期：1993-08-01 00:00:00

abstract：:Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypep...

journal_title：Journal of virology

authors： Hiller G,Eibl H,Weber K

更新日期：1981-09-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) gag polyprotein is processed by the viral protease to yield the structural proteins of the virus. One of these structural proteins, p15, and its protease cleavage products, p7 and p6, are believed to be responsible for the viral RNA binding which is prerequisite for assembly of i...

journal_title：Journal of virology

authors： Sheng N,Erickson-Viitanen S

更新日期：1994-10-01 00:00:00

abstract：UNLABELLED:Rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses that cause severe gastroenteritis in children. In addition to an error-prone genome replication mechanism, RVs can increase their genetic diversity by reassorting genes during host coinfection. Such exchanges allow RVs to acquire advantageous ge...

journal_title：Journal of virology

authors： Zhang S,McDonald PW,Thompson TA,Dennis AF,Akopov A,Kirkness EF,Patton JT,McDonald SM

更新日期：2014-09-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms of action of the tat-responsive sequence, mutational analysis of the tat-responsive sequence was carried out. The most critical region comprised nucleotides +18 to +44 and included the 3-nucleotide bulge at positions +23 to +25, the loop sequence, and an intact stem. In a...

journal_title：Journal of virology

authors： Roy S,Parkin NT,Rosen C,Itovitch J,Sonenberg N

更新日期：1990-03-01 00:00:00

abstract：:Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 40...

journal_title：Journal of virology

authors： Burns CC,Shaw J,Jorba J,Bukbuk D,Adu F,Gumede N,Pate MA,Abanida EA,Gasasira A,Iber J,Chen Q,Vincent A,Chenoweth P,Henderson E,Wannemuehler K,Naeem A,Umami RN,Nishimura Y,Shimizu H,Baba M,Adeniji A,Williams AJ,

更新日期：2013-05-01 00:00:00

abstract：:PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox potyvirus (PPV). In addition to the well-known highly immunogenic N- and C-terminal domains of CP, regions within the core domain of the protein have also shown high immunogenicity. Moreover, the N ...

journal_title：Journal of virology

authors： Fernández-Fernández MR,Martínez-Torrecuadrada JL,Roncal F,Domínguez E,García JA

更新日期：2002-12-01 00:00:00

abstract：:Vaccinia virus has a wide host range and infects mammalian cells of many different species. This suggests that the cell surface receptors for vaccinia virus are ubiquitously expressed and highly conserved. Alternatively, different receptors are used for vaccinia virus infection of different cell types. Here we report ...

journal_title：Journal of virology

authors： Chung CS,Hsiao JC,Chang YS,Chang W

更新日期：1998-02-01 00:00:00

abstract：:The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. I...

journal_title：Journal of virology

authors： Zhang X,Alekseev K,Jung K,Vlasova A,Hadya N,Saif LJ

更新日期：2008-05-01 00:00:00

abstract：:While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the infectious cell culture HCV model (HCVcc), we demonstrate that the b...

journal_title：Journal of virology

authors： Diao J,Pantua H,Ngu H,Komuves L,Diehl L,Schaefer G,Kapadia SB

更新日期：2012-10-01 00:00:00