Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer.

abstract：:Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were ma...

journal_title：Journal of biomedical optics

authors： Hu L,Lu Z,Wang B,Cao J,Ma X,Tian Z,Gao Z,Qin L,Wu X,Liu Y,Wang L

更新日期：2011-03-01 00:00:00

abstract：:Fluorescence image-guided surgery (FIGS) is an emerging technique in oncology, neurology, and cardiology. To adapt intraoperative imaging for various surgical applications, increasingly flexible and compact FIGS instruments are necessary. We present a compact, portable FIGS system and demonstrate its use in cardiovasc...

journal_title：Journal of biomedical optics

authors： Wang X,Bhaumik S,Li Q,Staudinger VP,Yazdanfar S

更新日期：2010-03-01 00:00:00

abstract：:We describe a systematic approach to image, track, and quantify the movements of HIV viruses embedded in human cervical mucus. The underlying motivation for this study is that, in HIV-infected adults, women account for more than half of all new cases and most of these women acquire the infection through heterosexual c...

journal_title：Journal of biomedical optics

authors： Boukari F,Makrogiannis S,Nossal R,Boukari H

更新日期：2016-09-01 00:00:00

abstract：:Waveguide evanescent field fluorescence (WEFF) microscopy is a new development that allows the imaging of contact regions between biological cells and their substratum, as well as imaging of ultrathin films such as monomolecular Langmuir-Blodgett (LB) films. Mixed-lipid monolayer systems mimicking lung surfactant were...

journal_title：Journal of biomedical optics

authors： Hassanzadeh A,Mittler S

更新日期：2011-04-01 00:00:00

abstract：:Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate t...

journal_title：Journal of biomedical optics

authors： Ortega-Martinez A,Touchette G,Zhu H,Kochevar IE,Franco W

更新日期：2017-09-01 00:00:00

abstract：:Pelvic organ prolapse (POP) occurs when changes to the pelvic organ support structures cause descent or herniation of the pelvic organs into the vagina. Clinical evaluation of POP is a series of manual measurements known as the pelvic organ prolapse quantification (POP-Q) score. However, it fails to identify the mecha...

journal_title：Journal of biomedical optics

authors： Parkinson LA,Gargett CE,Young N,Rosamilia A,Vashi AV,Werkmeister JA,Papageorgiou AW,Arkwright JW

更新日期：2016-12-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:Frequency-domain diffuse optical spectroscopy (FD-DOS) utilizes intensity-modulated light to characterize optical scattering and absorption in thick tissue. Previous FD-DOS systems have been limited by large device footprints, complex electronics, high costs, and limited acquisition speeds, all of which complicate acc...

journal_title：Journal of biomedical optics

authors： Torjesen A,Istfan R,Roblyer D

更新日期：2017-03-01 00:00:00

abstract：:Optical quantification of large lesions imaged with diffuse optical tomography in reflection geometry is depth dependence due to the exponential decay of photon density waves. We introduce a depth-correction method that incorporates the target depth information provided by coregistered ultrasound. It is based on balan...

journal_title：Journal of biomedical optics

authors： Tavakoli B,Zhu Q

更新日期：2011-05-01 00:00:00

abstract：:We investigate the statistical polarization parameters of biological tissue histological section images with different morphological structure. First we outline the results of polarization coordinate mapping and analysis of the statistics of the first to fourth orders of biological tissue image polarization azimuth an...

journal_title：Journal of biomedical optics

authors： Angelsky OV,Ushenko AG,Ushenko YA,Ushenko YG,Tomka YY,Pishak VP

更新日期：2005-11-01 00:00:00

abstract：:Optical resolution photoacoustic microscopy (ORPAM) is important for various biomedical applications, such as the study of cellular structures, microcirculation systems, and tumor angiogenesis. However, the lateral resolution of a conventional ORPAM is limited by optical diffraction. In this work, we report a simulati...

journal_title：Journal of biomedical optics

authors： Upputuri PK,Wen ZB,Wu Z,Pramanik M

更新日期：2014-01-01 00:00:00

abstract：:We measure the tumor vascular response to varying irradiance rates during photodynamic therapy (PDT) in a Dunning rat prostate model with interstitial Doppler optical coherence tomography (IS-DOCT). Rats are given a photosensitizer drug, Photofrin, and the tumors are exposed to light (635 nm) with irradiance rates ran...

journal_title：Journal of biomedical optics

authors： Standish BA,Jin X,Smolen J,Mariampillai A,Munce NR,Wilson BC,Vitkin IA,Yang VX

更新日期：2007-05-01 00:00:00

abstract：:Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex ...

journal_title：Journal of biomedical optics

authors： Zimmerley M,Lin CY,Oertel DC,Marsh JM,Ward JL,Potma EO

更新日期：2009-07-01 00:00:00

abstract：:Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OC...

journal_title：Journal of biomedical optics

authors： Aguirre AD,Chen Y,Bryan B,Mashimo H,Huang Q,Connolly JL,Fujimoto JG

更新日期：2010-01-01 00:00:00

abstract：:An integrated miniature multi-modal microscope (4M device) for microendoscopy was built and tested. Imaging performance is evaluated and imaging results are presented for both fluorescence and reflectance samples. Images of biological samples show successful imaging of both thin layers of fixed cells prepared on a sli...

journal_title：Journal of biomedical optics

authors： Rogers JD,Landau S,Tkaczyk TS,Descour MR,Rahman MS,Richards-Kortum R,Kärkäinen AH,Christenson T

更新日期：2008-09-01 00:00:00

abstract：:We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during corona...

journal_title：Journal of biomedical optics

authors： Häggblad E,Lindbergh T,Karlsson MG,Casimir-Ahn H,Salerud EG,Strömberg T

更新日期：2008-09-01 00:00:00

abstract：:Traditional white-light and fluorescent imaging techniques provide powerful methods to extract high-resolution information from two-dimensional (2-D) sections, but to retrieve information from a three-dimensional (3-D) volume they require relatively slow scanning methods that result in increased acquisition time. Usin...

journal_title：Journal of biomedical optics

authors： Duocastella M,Sun B,Arnold CB

更新日期：2012-05-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spect...

journal_title：Journal of biomedical optics

authors： Ishikawa W,Sato M,Fukuda Y,Matsumoto T,Takemura N,Sakatani K

更新日期：2014-02-01 00:00:00

abstract：:We have combined a confocal laser scanning head modified for TPE (two-photon excitation) microscopy with some spectroscopic modules to study single molecules and molecular aggregates. The behavior of the TPE microscope unit has been characterized by means of point spread function measurements and of the demonstration ...

journal_title：Journal of biomedical optics

authors： Diaspro A,Chirico G,Federici F,Cannone F,Beretta S,Robello M

更新日期：2001-07-01 00:00:00

abstract：:Application of a fiber optic biosensor (FOB) to the real-time investigation of the interaction kinetics between FITC-conjugated monoclonal sheep anti-human C-reactive protein (CRP) antibody and CRP isoforms on the surface of optical fiber is described. Recently, both the native pentameric CRP (pCRP), an acute phase pr...

journal_title：Journal of biomedical optics

authors： Chou C,Hsu HY,Wu HT,Tseng KY,Chiou A,Yu CJ,Lee ZY,Chan TS

更新日期：2007-03-01 00:00:00

abstract：:Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

journal_title：Journal of biomedical optics

authors： Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

更新日期：2012-01-01 00:00:00

abstract：:Penetration profiles of topically applied drugs and cosmetic products provide important information on their efficacy. The application of tape stripping in combination with UV/VIS spectroscopy is checked to determine the local position of topically applied substances inside the stratum corneum, the penetration profile...

journal_title：Journal of biomedical optics

authors： Weigmann HJ,Jacobi U,Antoniou C,Tsikrikas GN,Wendel V,Rapp C,Gers-Barlag H,Sterry W,Lademann J

更新日期：2005-01-01 00:00:00

abstract：:In order to understand the relationship between accommodation and vision quality, a custom-built ultra-long scan depth spectral domain optical coherence tomography (UL-SDOCT) and a Shack-Hartmann wavefront sensor (HSWFS) were combined. The resolution and scan depth of UL-SDOCT are 6 μm and 15.6 mm, respectively, which...

journal_title：Journal of biomedical optics

authors： Shi G,Wang Y,Yuan Y,Wei L,Lv F,Zhang Y

更新日期：2012-12-01 00:00:00

abstract：:Abdominal surgeries carry considerable risk of gastrointestinal and intra-abdominal hemorrhage, which could possibly cause patient death. Photoacoustic imaging is one solution to overcome this challenge by providing visualization of major blood vessels during surgery. We investigate the feasibility of in vivo blood ve...

journal_title：Journal of biomedical optics

authors： Kempski KM,Wiacek A,Graham M,González E,Goodson B,Allman D,Palmer J,Hou H,Beck S,He J,Bell MAL

更新日期：2019-08-01 00:00:00

abstract：:Laser speckle contrast imaging is a technique used for imaging blood flow without scanning. Though several studies have attempted to combine spatial and temporal statistics of laser speckle images for reducing image noise as well as preserving acceptable spatiotemporal resolution, the statistical accuracy of these spa...

journal_title：Journal of biomedical optics

authors： Qiu J,Li P,Luo W,Wang J,Zhang H,Luo Q

更新日期：2010-01-01 00:00:00

abstract：:A transgenic mouse model with a Clim [co-factor of LIM (a combination of first letters of Lin-11 (C. elegans), ISL1 (rat), and Mec-3 (C. elegans) gene names) domain proteins] gene partially blocked in the epithelial compartment of its tissues is used to establish the sensitivity of intrinsic reflectance nonlinear opti...

journal_title：Journal of biomedical optics

authors： Lyubovitsky JG,Spencer JA,Krasieva TB,Andersen B,Tromberg BJ

更新日期：2006-01-01 00:00:00

abstract：:The earliest steps of breast cancer begin with aberrations in mammary ductal structure. Techniques that enable an investigator to image in situ and then analyze the same tissue using biochemical tools facilitates identification of genetic networks and signaling pathways active in the imaged structure. Cellular confoca...

journal_title：Journal of biomedical optics

authors： Parrish A,Halama E,Tilli MT,Freedman M,Furth PA

更新日期：2005-09-01 00:00:00

abstract：:A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths (685 to 830 nm) to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a peri...

journal_title：Journal of biomedical optics

authors： Papazoglou ES,Neidrauer M,Zubkov L,Weingarten MS,Pourrezaei K

更新日期：2009-11-01 00:00:00

abstract：:Animal models are widely used to investigate the pathological mechanisms of spinal cord injury (SCI), most commonly in rats. It is well known that compromised blood flow caused by mechanical disruption of the vasculature can produce irreversible damage and cell death in hypoperfused tissue regions and spinal cord tiss...

journal_title：Journal of biomedical optics

authors： Phillips JP,Cibert-Goton V,Langford RM,Shortland PJ

更新日期：2013-03-01 00:00:00