Abstract：
BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific tolerance for subsequently transplanted organs [1]. METHODS:Mice received an allogeneic HSC and third party MP transplantation simultaneous with placement of a MP-matched skin graft. Variants tested include time of graft placement, MP genotype and source of cells. RESULTS:Using B10;B6-Rag2(-/-)Il2rg(-/-) mice, we demonstrate that specific tolerance can be induced by MP given simultaneous with the skin graft in the complete absence of MP-donor-matched lymphoid cells. Ex vivo expanded MP function as well as sorted cells in inducing tolerance. In addition we demonstrate that tolerance can be induced by MP in the context of autologous HSC transplantation. CONCLUSIONS:Our results demonstrate that the previously observed expansion of organ donor matched Treg is not essential for tolerance, and that MP tolerance protocols can be envisioned in most clinical settings, including those involving deceased donor organs.
journal_name
Transpl Immunoljournal_title
Transplant immunologyauthors
Domen J,Li Y,Sun L,Simpson P,Gandy Kdoi
10.1016/j.trim.2014.04.001subject
Has Abstractpub_date
2014-08-01 00:00:00pages
112-8issue
2eissn
0966-3274issn
1878-5492pii
S0966-3274(14)00024-0journal_volume
31pub_type
杂志文章abstract：:Previous work on the facilitation of xenogeneic and allogeneic bone marrow engraftment in irradiated mice and dogs with transferrins allowed the development of a model for induction of an apparently durable state of immunological unresponsiveness or 'tolerance' in chemically immunosuppressed mice. The system is based ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(96)80051-7
更新日期：1996-12-01 00:00:00
abstract：:Although natural killer cells lyse targets without pre-sensitization, and in an MHC-unrestricted manner, they can also respond to healthy allogeneic cells of different MHC type. Such alloreactivity is a consequence of NK cells using clonally distributed, inhibitory MHC class I receptors to achieve tolerance to healthy...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2006.09.022
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Graft-versus-host disease is one of the major complications after allogeneic bone marrow transplantation, but it is not easy to anticipate the onset. Cytokines released by type 1 T helper cells are thought to play a pivotal role in acute graft-versus-host disease aGVHD. The ability to predict the likely occu...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2005.10.002
更新日期：2006-01-01 00:00:00
abstract：:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.06.003
更新日期：2012-08-01 00:00:00
abstract：:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/0966-3274(94)90063-9
更新日期：1994-09-01 00:00:00
abstract：:FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...
journal_title：Transplant immunology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.trim.2006.02.002
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Pigs are frequently used as animal models for experiments in the surgical field, including allo- and xeno-transplantation. Regeneration studies, including studies dealing with human- and monkey-induced pluripotent stem cells (iPSC), have gradually progressed, with pigs sometimes being used as the scaffold. H...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.12.002
更新日期：2017-02-01 00:00:00
abstract：:The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.01.011
更新日期：2007-06-01 00:00:00
abstract：AIMS:Chronic renal allograft loss is still an unsolved problem in kidney transplantation. We evaluated the impact of FTY720, a S1P receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes and Peyer's patches, on blood lymphocytes and graft infiltrating cells in a ra...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.01.003
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the neuroimmune system, thereby, increasing the risk of neurodegeneration. Here, we measured the impact...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2019.101248
更新日期：2020-02-01 00:00:00
abstract：:Persistent rejection in the face of treatment and multiple episodes of rejection are associated with the development of chronic rejection and graft loss in solid organ transplantation. The factors that create an environment for rejection that persists in the face of treatment are as yet not understood. The objective o...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2004.11.001
更新日期：2005-03-01 00:00:00
abstract：:RNA interference (RNAi) has recently emerged as an efficient method to silence gene expression in mammalian cells by transfection of small interfering RNAs (siRNAs). The Janus kinase 3 (JAK3) is also pertinent to the development of a new immuno-suppressant. This study aimed to inhibit JAK3 expression using RNAi to det...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.02.004
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2017.04.003
更新日期：2017-06-01 00:00:00
abstract：:Graft rejection and graft-versus-host disease are leading causes of transplant related mortality despite advancements in immunosuppressive therapy. Mesenchymal stem cells (MSCs) offer a promising addition to immunosuppressive drugs (ISD), while NK-cells are increasingly used as effector cells in graft-versus-leukemia....
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：:Mycophenolate mofetil (MMF) a potent immunosuppressive agent, has recently been approved for clinical use (CellCept) in renal transplant patients in combination with cyclosporine (CsA). With the expanded use of tacrolimus (Prograf) as well in renal transplant patients, there is a lack of pharmacokinetic studies clarif...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/s0966-3274(97)80042-1
更新日期：1997-09-01 00:00:00
abstract：:The containment of direct and indirect recognition of donor alloantigens by enhancement of the number and activity of regulatory T cells (Tregs) has been one of the promising approaches to achieve transplant tolerance. Two major methods, dendritic cell (DC) and anti-CD3/CD28 antibodies (Abs) have been introduced for e...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.07.004
更新日期：2009-12-01 00:00:00
abstract：:Diphtheria toxin (DT)-based anti-CD3 immunotoxins have clinical relevance in numerous applications including autoimmune disease therapies and organ transplantation tolerance protocols. Pre-existing anti-DT antibodies acquired either by vaccination against diphtheria toxin or infections with C. diphtheriae may interfer...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.05.003
更新日期：2012-08-01 00:00:00
abstract：:Complex polygenic and multifactorial diseases remain a challenge for human geneticists. Here we aim to remind basic definitions of multifactorial diseases and the genetic related concepts underlying classical methods. Knowledge on pathophysiological process and the genetic information available conditions the design o...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2005.03.015
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) can be used for immunomodulation therapy after solid organ transplantation. Here, we focus on the immunoregulatory potential of combination therapies of MSCs and classic pharmacotherapy to mediate acceptance of solid organ grafts. METHODS:To determine which drugs influence the ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2011.06.002
更新日期：2011-09-01 00:00:00
abstract：:Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2006.03.001
更新日期：2006-06-01 00:00:00
abstract：INTRODUCTION:Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.06.002
更新日期：2007-11-01 00:00:00
abstract：:CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...
journal_title：Transplant immunology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.trim.2008.01.005
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Transforming growth factor beta-1(TGFB1) is involved in the acute rejection (AR) episodes of solid organ transplant recipients. However, results from published studies on the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk are conflicting and inconclusive. METHODS:PUBMED, EMBASE, ...
journal_title：Transplant immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.trim.2014.01.001
更新日期：2014-03-01 00:00:00
abstract：:Application of mesenchymal stromal cells (MSCs) has been proposed for solid organ transplantation based on their potent immuno-modulatory effects in vitro and in vivo. We investigated the potential of MSCs to improve acceptance of kidney transplants in an MHC-incompatible rat model including isogeneic kidney transplan...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2013.08.004
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:Destruction of transplanted kidneys through chronic allograft nephropathy [CAN], also known as chronic rejection, is the greatest obstacle in successful kidney transplantation. Causes behind CAN are many, from pre-transplant causes to infections. Viral infections, especially CMV, are a risk factor for chro...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.07.004
更新日期：2008-01-01 00:00:00
abstract：:Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2003.12.011
更新日期：2004-04-01 00:00:00
abstract：:Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique ...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2007.05.003
更新日期：2007-11-01 00:00:00
abstract：:Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from im...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/s0966-3274(02)00009-6
更新日期：2002-05-01 00:00:00
abstract：:Over the last 25 years the importance of the humoral presensitization status of transplant recipients has increasingly been recognized. With greater understanding of the precise specificity of the pretransplant antibody status of recipients it is clear that the graft survival figures will improve. The development of n...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/0966-3274(94)90045-0
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.10.004
更新日期：2012-12-01 00:00:00
