Abstract：
:Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from immunoreceptors have emerged. After immunoreceptor engagement a core signaling complex is assembled comprising cytoplasmic immunoreceptor chains, kinases of the Src and ZAP70 families and various cytoplasmic and transmembrane adaptor molecules. Further effectors nucleate onto this complex evoking the characteristic responses of lymphocyte activation. Successful maturation of T cells into effector cells relies on the presence of a persistent stimulus presented in an appropriate extracellular environment. Encounter of MHC presented antigenic peptides and their cognate T cell receptors (TCRs) results in the formation of a nanometer intercellular gap between T cells and antigen presenting cells, which is now commonly referred to as the immunological synapse. The synapse is believed to sustain persistent TCR engagement. Its formation requires massive changes in T cell cytoskeletal architecture which essentially relies on signals provided by costimulatory molecules. The well orchestrated interplay between TCR and costimulatory signals decides about successful immune response and tolerance induction or immune failure and autoimmunity.
journal_name
Transpl Immunoljournal_title
Transplant immunologyauthors
Kiefer F,Vogel WF,Arnold Rdoi
10.1016/s0966-3274(02)00009-6subject
Has Abstractpub_date
2002-05-01 00:00:00pages
69-82issue
2-4eissn
0966-3274issn
1878-5492pii
S0966-3274(02)00009-6journal_volume
9pub_type
杂志文章,评审abstract：:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.06.003
更新日期：2012-08-01 00:00:00
abstract：:The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1mg/kg/day, day 0-5) and TAK-779 (10mg/kg/day, day 0-10). Graft surviv...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2011.04.003
更新日期：2011-07-01 00:00:00
abstract：:MicroRNAs are small, noncoding RNAs that control expression of target genes through inhibiting protein translation or inducing degradation of mRNA transcripts of target genes. According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of mult...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.trim.2017.06.002
更新日期：2017-08-01 00:00:00
abstract：:The interaction of antibodies with cell surface antigens may induce redistribution of immune complexes, followed by antigen depletion, with increased resistance to injurious effect of antibody and complement (antigenic modulation). Human natural antibodies to Gal alpha 1,3Gal beta 1,4GlcNAc-R (alpha Gal) epitopes expr...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(99)80026-4
更新日期：1999-06-01 00:00:00
abstract：:The myeloid-related proteins 8 and 14 exist as a dimeric complex (MRP 8/14) and serve as early and highly specific markers for inflammatory processes, such as allograft rejection and non-viral (bacterial or fungal) infections. An elevated procalcitonin (PCT) concentration in serum also serves as a diagnostic indicator...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.10.004
更新日期：2008-02-01 00:00:00
abstract：:Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/s0966-3274(02)00042-4
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:We recently reported that autoreactive antibody (Ab) against nuclear histone H1 had been identified as an immunosuppressive factor in a rat tolerogenic orthotopic liver transplantation (OLT) model. The present study aimed to determine whether the up-regulation of antihistone H1 Ab by histone H1 vaccination l...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.01.003
更新日期：2007-04-01 00:00:00
abstract：:The neomacrolide antibiotic azithromycin is known to have an anti-inflammatory effect and is increasingly being used in the treatment of chronic inflammatory pulmonary diseases. We investigated whether azithromycin influenced matrix remodeling. Matrix metalloproteinase (MMP)-9 protein levels were measured by ELISA in ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Tim-3 was recently described as a Th1-specific molecule, participating in the regulation of immune responses and in the induction of allograft tolerance. Here, we studied Tim-3 mRNA expression together with molecular markers of T-cell activation and cytotoxicity, in rejected human kidney grafts. METHODS:Twe...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2006.11.003
更新日期：2007-04-01 00:00:00
abstract：:New immunosuppressive strategies have improved short- and long-term graft survival. The current aim is to decrease the intensity of the immunosuppressive regimen, in an attempt to limit side effects and the direct toxicity of calcineurin inhibitor (CNI) for kidney function. We describe here current experience in liver...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2006.11.007
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:The immunomodulator, FTY720, lowers the peripheral lymphocyte count (PLC) by inducing migration of circulating lymphocytes to secondary lymphoid organs. We investigated the efficacy of mono- vs. combined-FTY720/CsA therapy on graft survival (GS) and on lowering the PLC in a solid organ and a skin graft model,...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(01)00031-4
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Peripheral blood CD4+ T cell adenosine triphosphate (ATP) release has been reported to be an adjunct tool to evaluate global cellular immune response in solid-organ transplant recipients. However, the correlation between the ATP level and rejection was controversial. The aim of this prospective clinical stud...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2013.10.008
更新日期：2014-01-01 00:00:00
abstract：:Mycophenolate mofetil (MMF) a potent immunosuppressive agent, has recently been approved for clinical use (CellCept) in renal transplant patients in combination with cyclosporine (CsA). With the expanded use of tacrolimus (Prograf) as well in renal transplant patients, there is a lack of pharmacokinetic studies clarif...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/s0966-3274(97)80042-1
更新日期：1997-09-01 00:00:00
abstract：:The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...
journal_title：Transplant immunology
pub_type： 社论
doi：10.1016/j.trim.2020.101304
更新日期：2020-08-01 00:00:00
abstract：:The ImmuKnow assay measures cell-mediated immunity, quantifying ATP production from peripheral blood CD4+T-cells in solid-organ transplant patients who undergo immunosuppressive therapy. We aimed to measure functional immunity in lung transplant recipients and correlate Immuknow values with immunosuppression levels, p...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.04.001
更新日期：2016-07-01 00:00:00
abstract：:Although the clinical significance of anti-HLA antibodies in heart and lung transplantation is less well studied than in renal transplantation, several studies have shown that heart and lung recipients transplanted in the presence of donor-specific antibodies are at increased risk for early acute rejection and have a ...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2004.01.005
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Antibody-mediated rejection (ABMR) is the leading cause of kidney graft loss worldwide. Criteria for acute humoral rejection (currently labeled active humoral rejection) established by the 2007 Banff classification are highly specific but lack sensitivity. Modifications to the Banff classification were intro...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2018.08.008
更新日期：2018-12-01 00:00:00
abstract：:Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.03.002
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.08.002
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Since the Fas/Fas Ligand (FasL) interaction has been recognized as an apoptotic pathway, it eliminates the activated T cells and promotes the survival of grafts. In this study, the effect of FasL transfection of pig chondrocytes on allogeneic transplantation was examined in vitro and in vivo. ME...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2008.02.001
更新日期：2008-05-01 00:00:00
abstract：:Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2005.02.003
更新日期：2005-06-01 00:00:00
abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.03.002
更新日期：2014-05-01 00:00:00
abstract：:Diphtheria toxin (DT)-based anti-CD3 immunotoxins have clinical relevance in numerous applications including autoimmune disease therapies and organ transplantation tolerance protocols. Pre-existing anti-DT antibodies acquired either by vaccination against diphtheria toxin or infections with C. diphtheriae may interfer...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.05.003
更新日期：2012-08-01 00:00:00
abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/0966-3274(93)90005-s
更新日期：1993-01-01 00:00:00
abstract：:The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2007.01.011
更新日期：2007-06-01 00:00:00
abstract：:Epigenetics and transplantation seem an odd couple. The influence of epigenetic changes on the immune response of the host following an organ graft is not one of the more obvious connections. However, modifying host immunity to a graft via epigenetic changes of immune related genes could have unexpected ramifications ...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2010.05.001
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.trim.2011.05.006
更新日期：2011-07-01 00:00:00
abstract：:Treatment with autologous bone marrow transplantation (ABMT) can change the natural history of diabetes in patients with new-onset Type 1 diabetes (T1D). Effects of syngeneic bone marrow transplantation (syn-BMT) on diabetic nephropathy were studied in streptozotocin-induced diabetic mice. Diabetic mice received sibli...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.12.003
更新日期：2010-02-01 00:00:00
abstract：:The gene expression of the cytotoxic T-cell molecules perforin, granzyme B and Fas ligand are associated with acute rejection in renal allograft recipients. Several immune mechanisms are linked to severe systemic inflammation in brain-dead organ donors. We examined the mRNA expression of these T-cell activation biomar...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2008.12.002
更新日期：2009-03-01 00:00:00
abstract：:We present management strategies utilised for the first case of an urgent live-donor ABO incompatible B blood group renal transplant, in a patient with a prior A blood group lung transplant for cystic fibrosis. Three years on, renal function is excellent and stable, whilst lung function has improved. ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.09.002
更新日期：2016-11-01 00:00:00
