New aspect of immunosuppressive treatment in liver transplantation. How could you induce tolerance in liver transplantation?

abstract：:TIRC7 delivers essential signals during immune activation as antibodies targeting TIRC7 inhibit lymphocyte proliferation and Th1 cytokine expression in vitro and prolonged kidney and heart allograft survival in vivo. Immunohistochemical analysis of biopsy specimens from human renal allografts undergoing rejection desp...

journal_title：Transplant immunology

authors： Kumamoto Y,Tamura A,Volk HD,Reinke P,Löhler J,Tullius SG,Utku N

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Our laboratory has demonstrated that xenogeneic porcine thymus tissue grafted in thymectomized (ATX) and T cell-depleted mice induces donor-specific tolerance. Recipient thymectomy is essential for the success of tolerance induction. In contrast, studies in pigs grafted with non-vascularized allogeneic class...

journal_title：Transplant immunology

authors： Rodríguez-Barbosa JI,Haller GW,Zhao G,Sachs DH,Sykes M

更新日期：2005-10-01 00:00:00

abstract：:The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...

journal_title：Transplant immunology

authors： Ihara Y,Miyagawa S,Hasegawa T,Kimura T,Xu H,Fukuzawa M

更新日期：2007-06-01 00:00:00

abstract：AIMS:Chronic renal allograft loss is still an unsolved problem in kidney transplantation. We evaluated the impact of FTY720, a S1P receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes and Peyer's patches, on blood lymphocytes and graft infiltrating cells in a ra...

journal_title：Transplant immunology

authors： Koch M,Poehnert D,Nashan B

更新日期：2016-03-01 00:00:00

abstract：:There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...

journal_title：Transplant immunology

authors： Iida Y,Iwata H,Mori Y,Takagi H,Nitta T,Kanetake K,Umeda Y,Hirose H

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Peripheral blood CD4+ T cell adenosine triphosphate (ATP) release has been reported to be an adjunct tool to evaluate global cellular immune response in solid-organ transplant recipients. However, the correlation between the ATP level and rejection was controversial. The aim of this prospective clinical stud...

journal_title：Transplant immunology

authors： Wang XZ,Jin ZK,Tian XH,Xue WJ,Tian PX,Ding XM,Zheng J,Li Y,Jing X,Luo ZZ

更新日期：2014-01-01 00:00:00

abstract：:The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1...

journal_title：Transplant immunology

authors： Salek Farrokhi A,Zarnani AH,Moazzeni SM

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

journal_title：Transplant immunology

authors： Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

更新日期：2020-10-01 00:00:00

abstract：:Complex polygenic and multifactorial diseases remain a challenge for human geneticists. Here we aim to remind basic definitions of multifactorial diseases and the genetic related concepts underlying classical methods. Knowledge on pathophysiological process and the genetic information available conditions the design o...

journal_title：Transplant immunology

authors： Barnetche T,Gourraud PA,Cambon-Thomsen A

更新日期：2005-08-01 00:00:00

abstract：:Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

journal_title：Transplant immunology

authors： Borg AJ,Kumagai-Braesch M,Möller E

更新日期：1996-06-01 00:00:00

abstract：:The immune system is an adaptive defense system capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. This highly specific response is provided by T and B lymphocytes. The enormous diversity of the antigen-specific receptors on these cells is generated by random rearr...

journal_title：Transplant immunology

authors： Arnold B

更新日期：2002-08-01 00:00:00

abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

journal_title：Transplant immunology

authors： Mach F

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Every transplanted organ relies on a reliable and sound vascular system. Therefore, our study focused on the investigation if platelet inhibition alone or combined with mTOR-inhibition has a beneficial effect on the microvascular integrity in allogeneic murine skin grafts. METHODS:Skin transplantation was p...

journal_title：Transplant immunology

authors： Motsch B,Heim C,Koch N,Ramsperger-Gleixner M,Weyand M,Ensminger SM

更新日期：2015-11-01 00:00:00

abstract：:FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...

journal_title：Transplant immunology

authors： Vaessen LM,van Besouw NM,Mol WM,Ijzermans JN,Weimar W

更新日期：2006-04-01 00:00:00

abstract：:Chronic allograft dysfunction is one of the most important reasons for late graft loss after renal transplantation. Its etiology is multifactorial and combines immunological as well as non-immunological mechanisms. It is known from large registry data that MHC mismatches are inversely correlated to long term allograft...

journal_title：Transplant immunology

authors： Poehnert D,Broecker V,Mengel M,Nashan B,Koch M

更新日期：2010-02-01 00:00:00

abstract：:Keratinocytes are activated to express MHC class II and ICAM-1 molecules during cutaneous inflammatory reactions. It is controversial how the interaction between these 'nonprofessional' antigen presenting cells (APC) and infiltrating T cells affects the local inflammatory response. To address this issue we analyzed wh...

journal_title：Transplant immunology

authors： de Bueger M,Bakker A,Goulmy E

更新日期：1993-01-01 00:00:00

abstract：:CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...

journal_title：Transplant immunology

authors： Wang Z,Xiao L,Shi BY,Qian YY,Bai HW,Chang JY,Cai M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Antibody-mediated rejection (ABMR) is the leading cause of kidney graft loss worldwide. Criteria for acute humoral rejection (currently labeled active humoral rejection) established by the 2007 Banff classification are highly specific but lack sensitivity. Modifications to the Banff classification were intro...

journal_title：Transplant immunology

authors： Solar-Cafaggi D,Marino L,Uribe-Uribe N,Morales-Buenrostro LE

更新日期：2018-12-01 00:00:00

abstract：:Despite improvements in the prevention and treatment of graft-versus-host disease (GvHD) this allogeneic immune response is still one of major complications following allogeneic stem cell transplantation (SCT). Identification of patients at risk for the development of acute and chronic GvHD would facilitate early inte...

journal_title：Transplant immunology

authors： Ukena SN,Geffers R,Buchholz S,Stadler M,Franzke A

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Since the Fas/Fas Ligand (FasL) interaction has been recognized as an apoptotic pathway, it eliminates the activated T cells and promotes the survival of grafts. In this study, the effect of FasL transfection of pig chondrocytes on allogeneic transplantation was examined in vitro and in vivo. ME...

journal_title：Transplant immunology

authors： Xie GH,Wang SJ,Wang Y,Zhang Y,Zhang HZ,Jin S,Wang QF,Liu ZC,Ge HL

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

journal_title：Transplant immunology

authors： Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

更新日期：2019-04-01 00:00:00

abstract：:Introduction of MHC class I Kb cDNA via recombinant retrovirus into B10.AKM (Kk) bone marrow cells (BMC) has been shown to confer specific hyporesponsiveness to B10.MBR (Kb) allogeneic skin grafts in lethally irradiated B10.AKM recipients of the transduced syngeneic BMC. We have recently developed a nonmyeloablative c...

journal_title：Transplant immunology

authors： Hayashi H,LeGuern C,Sachs DH,Sykes M

更新日期：1996-03-01 00:00:00

abstract：:The myeloid-related proteins 8 and 14 exist as a dimeric complex (MRP 8/14) and serve as early and highly specific markers for inflammatory processes, such as allograft rejection and non-viral (bacterial or fungal) infections. An elevated procalcitonin (PCT) concentration in serum also serves as a diagnostic indicator...

journal_title：Transplant immunology

authors： Jung DY,Park JB,Lee EN,Lee HA,Joh JW,Kwon CH,Ki CS,Lee SY,Kim SJ

更新日期：2008-02-01 00:00:00

abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

journal_title：Transplant immunology

authors： Gjertsen HA,Lundin KE,Hansen T,Thorsby E

更新日期：1993-01-01 00:00:00

abstract：:This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

journal_title：Transplant immunology

authors： Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

更新日期：2020-10-01 00:00:00

abstract：:The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1mg/kg/day, day 0-5) and TAK-779 (10mg/kg/day, day 0-10). Graft surviv...

journal_title：Transplant immunology

authors： Takama Y,Miyagawa S,Yamamoto A,Firdawes S,Ueno T,Ihara Y,Kondo A,Matsunami K,Otsuka H,Fukuzawa M

更新日期：2011-07-01 00:00:00

abstract：:B(io) B(reedding)/O(ttawa) K(alsburg) rats spontaneously develop insulin-dependent type 1 diabetes. Days before BB/OK rats become diabetic, their body seems to be flabby which may be attributed to loss of subcutaneous fat. However, the rats are normoglycemic and manifest 3-4 days later. This observation prompted us to...

journal_title：Transplant immunology

authors： Bahr J,Klöting N,Klöting I,Follak N

更新日期：2011-05-01 00:00:00

abstract：:Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...

journal_title：Transplant immunology

authors： Lobashevsky AL,Manwaring JE,Travis MM,Nord BL,Higgins NG,Serov YA,Arnoff TS,Hommel-Berrey GA,Goggins WC,Taber TE,Carter CB Sr,Smith DS,Wozniak TC,O'Donnell JA,Turrentine MW

更新日期：2009-07-01 00:00:00

abstract：:Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n=5) no BD, 2h ventilation...

journal_title：Transplant immunology

authors： Cicora F,Stringa P,Guerrieri D,Vásquez D,Toniolo F,Roberti J,Raimondi C

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the neuroimmune system, thereby, increasing the risk of neurodegeneration. Here, we measured the impact...

journal_title：Transplant immunology

authors： Dirks M,Pflugrad H,Tryc AB,Schrader AK,Ding X,Lanfermann H,Jäckel E,Schrem H,Beneke J,Barg-Hock H,Klempnauer J,Falk CS,Weissenborn K

更新日期：2020-02-01 00:00:00