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Transplantation of adipose tissue protects BB/OK rats from type 1 diabetes development.

Abstract：

:B(io) B(reedding)/O(ttawa) K(alsburg) rats spontaneously develop insulin-dependent type 1 diabetes. Days before BB/OK rats become diabetic, their body seems to be flabby which may be attributed to loss of subcutaneous fat. However, the rats are normoglycemic and manifest 3-4 days later. This observation prompted us to search for possibilities to avoid the loss of adipose tissue. BB/OK rats were subcutaneously grafted with visceral adipose tissue. In total, 34 (71%) out of 48 male and 23 (49%) out of 47 female BB/OK rats grafted with adipose tissue developed type 1 diabetes so that significantly more females than males were protected from diabetes development (p=0.03). In the control group, 17 (85%) out of 20 male and 20 (95%) out of 21 female BB/OK rats were diabetic. Adipose tissue transplantation can protect BB/OK rats from type 1 diabetes development in a sex specific manner. One could conclude that the manipulations have influenced fat accumulation and/or fat metabolism which prevent type 1 diabetes development in about 50% of BB/OK rats. This idea is supported by the finding that a mutation in the leptin receptor of NOD mice suppresses type 1 diabetes progression.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Bahr J,Klöting N,Klöting I,Follak N

doi

10.1016/j.trim.2011.01.003

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

238-40

issue

4

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(11)00005-0

journal_volume

24

pub_type

杂志文章

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