Human herpesvirus-8 infection and Kaposi's sarcoma after liver and kidney transplantation in different geographical areas of Spain.


:Since data on human herpesvirus 8 (HHV-8) infection in Spain is not available, our purpose was to determine the prevalence of HHV-8 infection and the risk of developing Kaposi's sarcoma (KS) among organ transplant recipients in different geographical areas of Spain. The study population consisted of 1019 liver and kidney transplant recipients recruited in four transplant units in Spain. Only post-transplant serum samples were available for all participants. IgG anti-HHV-8 latent and lytic antigens were detected by using an indirect immunofluorescence assay as well as enzyme-linked immunosorbant assays. In available samples, HHV-8 DNA genome was detected by using a nested polymerase chain reaction in sera, blood mononuclear cells and KS tissues. The prevalence of HHV-8 infection after transplantation was calculated. To determine risk factors for infection, odds ratios (OR) and 95% confidence intervals (CI) were also calculated. Of the 788 kidney transplants, 5 (0.6%) were HHV-8-positive shortly after transplantation. Of the 231 liver transplant individuals, 8 (3.4%) developed IgG anti-HHV-8 antibodies after transplantation. Thus, incidence of HHV-8 infection is significantly higher among liver transplant recipients in comparison with that in the control population (OR=6, 95% CI=1.2-28.5, p<0.05). In this series, HHV-8 prevalence in liver transplant recipients was higher in the northern (6.6-6.9%) than in the central (2.9%) or the southeastern (1.4%) areas of Spain. Four renal transplant recipients (0.5%) and five of the liver transplant recipients (2.16%) developed KS after transplantation. Time of KS diagnosis after transplant is significantly higher in kidney transplant patients (33.7 months) than in liver transplant recipients (10.4 months), indicating that the latter have a higher risk of developing KS.


Transpl Immunol


Transplant immunology


García-Astudillo LA,Leyva-Cobián F




Has Abstract


2006-12-01 00:00:00














  • Targeted gene disruption of the heat shock protein 72 gene (hsp70.1) in the donor tissue is associated with a prolonged rejection-free survival in the murine skin allograft model.

    abstract::It is known that the expression level of the heat shock protein (HSP) is elevated in allograft tissues, but the specific role of the HSP in the acute rejection has not been elucidated. This study aims to determine how and when the HSP72 molecule works immunologically in the process of acute allograft rejection from a ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Oh KH,Kim JY,Kim D,Lee EM,Oh HY,Seo JS,Han JS,Kim S,Lee JS,Ahn C

    更新日期:2004-12-01 00:00:00

  • Effects of desferrioxamine on human cytomegalovirus replication and expression of HLA antigens and adhesion molecules in human vascular endothelial cells.

    abstract::Desferrioxamine (DFO), commonly used in therapy as a chelator of ferric ion in disorders of iron overload, is a potent inhibitor of human cytomegalovirus (HCMV) replication in cultured fibroblast cells. Moreover, DFO has immunomodulatory activity both in vitro and in vivo. We studied DFO effects on HCMV replication in...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cinatl J,Scholz M,Weber B,Cinatl J,Rabenau H,Markus BH,Encke A,Doerr HW

    更新日期:1995-12-01 00:00:00

  • Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes.

    abstract::Clinical ophthalmologists are highly successful in grafting allogeneic corneas onto healthy eye graft beds--only a small percentage are rejected. By contrast, a high percentage of allografts are rejected when grafted into vascularized or '"high-risk' recipient eyes. The following experiments test the hypothesis that d...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ksander BR,Sano Y,Streilein JW

    更新日期:1996-03-01 00:00:00

  • Donor-specific tolerance in a murine model: the result of extra-thymic T cell deletion?

    abstract::Previously, we established a murine model, that involves the engraftment of fully allogeneic T cell depleted donor bone marrow cells in sublethally irradiated and single dose anti-CD3 treated recipient mice. These mice developed permanent stable multilineage mixed chimerism and donor-specific tolerance without graft-v...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: van Pel M,van Breugel DW,van Wijk M,Luypen S,Vingerhoed J,Roholl PJ,Boog CJ

    更新日期:2003-07-01 00:00:00

  • The detection and relevance of pretransplant antibodies.

    abstract::Over the last 25 years the importance of the humoral presensitization status of transplant recipients has increasingly been recognized. With greater understanding of the precise specificity of the pretransplant antibody status of recipients it is clear that the graft survival figures will improve. The development of n...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Shenton BK

    更新日期:1994-06-01 00:00:00

  • Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.

    abstract::Introduction of MHC class I Kb cDNA via recombinant retrovirus into B10.AKM (Kk) bone marrow cells (BMC) has been shown to confer specific hyporesponsiveness to B10.MBR (Kb) allogeneic skin grafts in lethally irradiated B10.AKM recipients of the transduced syngeneic BMC. We have recently developed a nonmyeloablative c...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Hayashi H,LeGuern C,Sachs DH,Sykes M

    更新日期:1996-03-01 00:00:00

  • Hypodermin C improves the survival of kidney allografts.

    abstract::Although immunosuppressive therapies have made organ transplantation a common medical procedure worldwide, chronic toxicity is a major issue of long-term treatment. One method to improve such therapies is the application of immunomodulatory agents from parasites, such as Hypoderma lineatum (Diptera: Oestridae). Hypode...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Hu A,Wang Y,Yuan H,Wu L,Zheng K

    更新日期:2018-12-01 00:00:00

  • Preventive effects of syngeneic bone marrow transplantation on diabetic nephropathy in mice.

    abstract::Treatment with autologous bone marrow transplantation (ABMT) can change the natural history of diabetes in patients with new-onset Type 1 diabetes (T1D). Effects of syngeneic bone marrow transplantation (syn-BMT) on diabetic nephropathy were studied in streptozotocin-induced diabetic mice. Diabetic mice received sibli...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ouyang J,Hu G,Wen Y,Zhang X

    更新日期:2010-02-01 00:00:00

  • Signal transduction and co-stimulatory pathways.

    abstract::Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from im...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Kiefer F,Vogel WF,Arnold R

    更新日期:2002-05-01 00:00:00

  • Microvascular integrity plays an important role for graft survival after experimental skin transplantation.

    abstract:BACKGROUND:Every transplanted organ relies on a reliable and sound vascular system. Therefore, our study focused on the investigation if platelet inhibition alone or combined with mTOR-inhibition has a beneficial effect on the microvascular integrity in allogeneic murine skin grafts. METHODS:Skin transplantation was p...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Motsch B,Heim C,Koch N,Ramsperger-Gleixner M,Weyand M,Ensminger SM

    更新日期:2015-11-01 00:00:00

  • Unresponsiveness to human leukocytes in immunosuppressed mice by combined donor-derived human transferrin and antigens.

    abstract::Previous work on the facilitation of xenogeneic and allogeneic bone marrow engraftment in irradiated mice and dogs with transferrins allowed the development of a model for induction of an apparently durable state of immunological unresponsiveness or 'tolerance' in chemically immunosuppressed mice. The system is based ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Pierpaoli W,Lesnikov VA,Lesnikova MP,Arrighi S,Bardotti A

    更新日期:1996-12-01 00:00:00

  • Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model.

    abstract:BACKGROUND:Mesenchymal stem cells (MSCs) can be used for immunomodulation therapy after solid organ transplantation. Here, we focus on the immunoregulatory potential of combination therapies of MSCs and classic pharmacotherapy to mediate acceptance of solid organ grafts. METHODS:To determine which drugs influence the ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Eggenhofer E,Renner P,Soeder Y,Popp FC,Hoogduijn MJ,Geissler EK,Schlitt HJ,Dahlke MH

    更新日期:2011-09-01 00:00:00

  • 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes.

    abstract::Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Borg AJ,Kumagai-Braesch M,Möller E

    更新日期:1996-06-01 00:00:00

  • MiR-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase.

    abstract:OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

    更新日期:2020-10-01 00:00:00

  • Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients.

    abstract::Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Gibbs PJ,Tan LC,Sadek SA,Howell WM

    更新日期:2005-06-01 00:00:00

  • Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population.

    abstract::Recently, the signal transducer and activator of transcription 4 (STAT4) gene have been associated with multiple autoimmune diseases. Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 po...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Yang H,Zhou Q,Chen ZM,Chen WQ,Wang MM,Chen JH

    更新日期:2011-05-01 00:00:00

  • Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

    abstract::Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Brogan IJ,Pravica V,Hutchinson IV

    更新日期:2000-06-01 00:00:00

  • Antibody response to HBV vaccination on dialysis does not correlate with the development of deNovo anti-HLA antibodies after renal transplantation.

    abstract:BACKGROUND:Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Kauke T,Link M,Rentsch M,Stangl M,Guba M,Andrassy J,Werner J,Meiser B,Fischereder M,Habicht A

    更新日期:2017-06-01 00:00:00

  • A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor.

    abstract::Immunisation against Human Leucocyte Antigens (HLA) can be caused by pregnancy, blood transfusion, or organ transplants. The HLA antibody status of a given patient significantly influences their access and waiting time to transplant. For some highly sensitised patients (HSP) there is hardly any suitable donor availabl...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: Mumford L,Fuggle SV,Martorell J,Slavcev A,Iniotaki A,Haasnoot GW,Heidt S,Claas FHJ

    更新日期:2021-02-01 00:00:00

  • New aspect of immunosuppressive treatment in liver transplantation. How could you induce tolerance in liver transplantation?

    abstract::New immunosuppressive strategies have improved short- and long-term graft survival. The current aim is to decrease the intensity of the immunosuppressive regimen, in an attempt to limit side effects and the direct toxicity of calcineurin inhibitor (CNI) for kidney function. We describe here current experience in liver...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Beaudreuil S,Samuel D,Rouas-Freiss N,Durrbach A

    更新日期:2007-02-01 00:00:00

  • Circulating adhesion molecules during kidney allograft reperfusion.

    abstract::Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

    更新日期:2006-11-01 00:00:00

  • Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients.

    abstract::The neomacrolide antibiotic azithromycin is known to have an anti-inflammatory effect and is increasingly being used in the treatment of chronic inflammatory pulmonary diseases. We investigated whether azithromycin influenced matrix remodeling. Matrix metalloproteinase (MMP)-9 protein levels were measured by ELISA in ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Verleden SE,Vandooren J,Vos R,Willems S,Dupont LJ,Verleden GM,Van Raemdonck DE,Opdenakker G,Vanaudenaerde BM

    更新日期:2011-09-01 00:00:00

  • Short-term anti-CD25 monoclonal antibody treatment and neogenetic CD4(+)CD25(high) regulatory T cells in kidney transplantation.

    abstract::CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...

    journal_title:Transplant immunology

    pub_type: 杂志文章,随机对照试验


    authors: Wang Z,Xiao L,Shi BY,Qian YY,Bai HW,Chang JY,Cai M

    更新日期:2008-04-01 00:00:00

  • Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

    abstract::This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

    更新日期:2020-10-01 00:00:00

  • Inflammatory immune responses in a reproducible mouse brain death model.

    abstract:BACKGROUND:Brain death impairs donor organ quality and accelerates immune responses after transplantation. Detailed aspects of immune activation following brain death remain unclear. We have established a mouse model and investigated the immediate consequences of brain death and anesthesia on immune responses. METHODS...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Floerchinger B,Yuan X,Jurisch A,Timsit MO,Ge X,Lee YL,Schmid C,Tullius SG

    更新日期:2012-08-01 00:00:00

  • Manipulation of skin graft rejection in alloimmune mice by anti-VCAM-1:VLA-4 but not anti-ICAM-1:LFA-1 monoclonal antibodies.

    abstract::C3H mice were immunized by repeated skin grafting with B10.BR tail skin. Ten days after the last immunization mice received 100 micrograms (intravenously) of a variety of different monoclonal antibodies (mAbs: anti-ICAM-1, -LFA-1, -VCAM-1, -VLA-4), alone or in combination, followed by further B10.BR skin grafts. Contr...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Gorcyznski RM,Chung S,Fu XM,Levy G,Sullivan B,Chen Z

    更新日期:1995-03-01 00:00:00

  • Effect of blocking the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a rat small intestinal transplantation model.

    abstract::The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ihara Y,Miyagawa S,Hasegawa T,Kimura T,Xu H,Fukuzawa M

    更新日期:2007-06-01 00:00:00

  • Anti-HLA antibody analysis and crossmatching in heart and lung transplantation.

    abstract::Although the clinical significance of anti-HLA antibodies in heart and lung transplantation is less well studied than in renal transplantation, several studies have shown that heart and lung recipients transplanted in the presence of donor-specific antibodies are at increased risk for early acute rejection and have a ...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Reinsmoen NL,Nelson K,Zeevi A

    更新日期:2004-06-01 00:00:00

  • Early onset of rejection in concordant hamster xeno hearts display signs of necrosis, but not apoptosis, correlating to the phosphocreatine concentration.

    abstract:BACKGROUND:The importance of apoptosis contra necrosis for ischemia/reperfusion (RP) and acute rejection in concordant rodent xenotransplantation is largely unknown. We explored this question by comparing rodent allo and concordant xenotransplants with different morphological methods to detect apoptosis and biochemical...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Lukes DJ,Tivesten A,Wilton J,Lundgren A,Rakotonirainy O,Kjellström C,Isgaard J,Karlsson-Parra A,Soussi B,Olausson M

    更新日期:2003-10-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract:BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期:2014-08-01 00:00:00