Rebound effect of the allogenic T-cell response to donor and third-party lymphocytes after cyclosporine withdrawal in renal transplant recipients.

abstract：:In recent years, the utility of vascular complement factor 4d (C4d) deposition as diagnostic tool for antibody mediated rejection (AMR) after lung transplantation, has become a controversial issue. We aimed to pinpoint the problematic nature of C4d as biomarker with a simple experiment. We quantified C4d in broncho-al...

journal_title：Transplant immunology

authors： Heigl T,Saez-Gimenez B,Van Herck A,Kaes J,Sacreas A,Beeckmans H,Ambrocio GPL,Kwakkel-Van Erp H,Ordies S,Vanstapel A,Verleden SE,Neyrinck AP,Ceulemans LJ,Van Raemdonck DE,Verbeken E,Verleden GM,Vos R,Vanaudenaerde B

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. METHODS:A mouse model of HLA sensitization was used to study the effectiveness of anti-CD20 treatmen...

journal_title：Transplant immunology

authors： Wu GD,He Y,Chai NN,Toyoda M,Dunn R,Kehry MR,Klein AS,Jordan SC

更新日期：2008-07-01 00:00:00

abstract：:Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

journal_title：Transplant immunology

authors： Borg AJ,Kumagai-Braesch M,Möller E

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

journal_title：Transplant immunology

authors： Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to ...

journal_title：Transplant immunology

authors： Kauke T,Link M,Rentsch M,Stangl M,Guba M,Andrassy J,Werner J,Meiser B,Fischereder M,Habicht A

更新日期：2017-06-01 00:00:00

abstract：:Mouse hearts transplanted into MHC disparate donors are usually rejected 1 week after placement. It is widely accepted that alloantigen-reactive helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) are the key mediators of acute allograft rejection. This report demonstrates that the presence or absence of 'tra...

journal_title：Transplant immunology

authors： Bishop DK,DeBruyne LA,Chan S,Xu S,Eichwald EJ

更新日期：1995-09-01 00:00:00

abstract：:Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...

journal_title：Transplant immunology

authors： Vanclée A,Schouten HC,Bos GM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The complexity of surgical procedure in mouse heterotopic heart transplantation (HHT) has prevented its widespread use. The present study reported a modified technique - splint tubing technique (STT) based on cuff technique (CT). MATERIALS AND METHODS:C57BL/10 and BALB/c mice were performed in syngeneic and...

journal_title：Transplant immunology

authors： Li C,Luo L,Lu J,Feng L,Shan J,Long D,Guo Y,Wu W,Li S,Li Y

更新日期：2011-07-01 00:00:00

abstract：:Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...

journal_title：Transplant immunology

authors： Lobashevsky AL,Manwaring JE,Travis MM,Nord BL,Higgins NG,Serov YA,Arnoff TS,Hommel-Berrey GA,Goggins WC,Taber TE,Carter CB Sr,Smith DS,Wozniak TC,O'Donnell JA,Turrentine MW

更新日期：2009-07-01 00:00:00

abstract：:This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

journal_title：Transplant immunology

authors： Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

更新日期：2020-10-01 00:00:00

abstract：:Epigenetics and transplantation seem an odd couple. The influence of epigenetic changes on the immune response of the host following an organ graft is not one of the more obvious connections. However, modifying host immunity to a graft via epigenetic changes of immune related genes could have unexpected ramifications ...

journal_title：Transplant immunology

authors： Schildberg FA,Hagmann CA,Böhnert V,Tolba RH

更新日期：2010-07-01 00:00:00

abstract：:Tissue eosinophils have been previously implicated in allograft rejection and graft loss. The aim of this study was to evaluate the role of eosinophils in acute renal allograft rejection. Data from 71 patients with 114 renal biopsies with acute allograft rejection were compared with those from 26 controls. The median ...

journal_title：Transplant immunology

authors： Hongwei W,Nanra RS,Stein A,Avis L,Price A,Hibberd AD

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Transforming growth factor beta-1(TGFB1) is involved in the acute rejection (AR) episodes of solid organ transplant recipients. However, results from published studies on the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk are conflicting and inconclusive. METHODS:PUBMED, EMBASE, ...

journal_title：Transplant immunology

authors： Ge YZ,Yu P,Jia RP,Wu R,Ding AX,Li LP,Zhao Y,Feng YM,Gui ZL,Liao S

更新日期：2014-03-01 00:00:00

abstract：:Despite improvements in the prevention and treatment of graft-versus-host disease (GvHD) this allogeneic immune response is still one of major complications following allogeneic stem cell transplantation (SCT). Identification of patients at risk for the development of acute and chronic GvHD would facilitate early inte...

journal_title：Transplant immunology

authors： Ukena SN,Geffers R,Buchholz S,Stadler M,Franzke A

更新日期：2012-12-01 00:00:00

abstract：:We investigated the dynamics of the CD4+ and CD8+ lymphocyte subsets, and the expression of activation markers in cardiac transplant recipients. We tested 132 peripheral blood samples from 62 cardiac transplant recipients using fluorescent staining and flow cytometry analysis. The results were correlated with histolog...

journal_title：Transplant immunology

authors： Creemers P,Brink J,Wainwright H,Moore K,Shephard E,Kahn D

更新日期：2002-11-01 00:00:00

abstract：:B(io) B(reedding)/O(ttawa) K(alsburg) rats spontaneously develop insulin-dependent type 1 diabetes. Days before BB/OK rats become diabetic, their body seems to be flabby which may be attributed to loss of subcutaneous fat. However, the rats are normoglycemic and manifest 3-4 days later. This observation prompted us to...

journal_title：Transplant immunology

authors： Bahr J,Klöting N,Klöting I,Follak N

更新日期：2011-05-01 00:00:00

abstract：:It is known that the expression level of the heat shock protein (HSP) is elevated in allograft tissues, but the specific role of the HSP in the acute rejection has not been elucidated. This study aims to determine how and when the HSP72 molecule works immunologically in the process of acute allograft rejection from a ...

journal_title：Transplant immunology

authors： Oh KH,Kim JY,Kim D,Lee EM,Oh HY,Seo JS,Han JS,Kim S,Lee JS,Ahn C

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

journal_title：Transplant immunology

authors： Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

更新日期：2016-09-01 00:00:00

abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

journal_title：Transplant immunology

authors： Mach F

更新日期：2002-05-01 00:00:00

abstract：:Dendritic cells (DC) are considered to be the major cell type responsible for induction of primary immune responses. While they have been shown to play a critical role in eliciting allosensitization via the direct pathway, there is evidence that maturational and/or activational heterogeneity between DC in different do...

journal_title：Transplant immunology

authors： Steptoe RJ,Patel RK,Subbotin VM,Thomson AW

更新日期：2000-03-01 00:00:00

abstract：AIM:To investigate the influence of immunosuppressants on the fertility of males who undergo renal transplantation as well as on the immune function of their offspring. METHODS:A survey was performed on the fertility of 164 male renal transplant recipients who underwent a long-term treatment with cyclosporine A (CsA),...

journal_title：Transplant immunology

authors： Xu L,Han S,Liu Y,Wang H,Yang Y,Qiu F,Peng W,Tang L,Fu J,Zhu XF,Ding X,Zhu Y

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The transcription factor Forkhead Box P3 (FoxP3) is a marker of regulatory T cells (Tregs) - a subset of T cells known to suppress a wide range of immune responses. These cells are considered to be pivotal for the induction of tolerance to donor antigens in human allografts. We aimed to correlate the number ...

journal_title：Transplant immunology

authors： Krustrup D,Madsen CB,Iversen M,Engelholm L,Ryder LP,Andersen CB

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Acute rejection is a major obstacle in patients with prolonged ischemia in deceased-donor renal transplantation. Chemokines and their receptors play a critical role in leukocyte trafficking, resulting in allograft rejection; therefore, the role of chemokine receptor CXCR3 in acute rejection induced by prolon...

journal_title：Transplant immunology

authors： Zou XF,Song B,Duan JH,Hu ZD,Cui ZL,Gu C

更新日期：2015-10-01 00:00:00

abstract：:Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal gra...

journal_title：Transplant immunology

authors： Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Tim-3 was recently described as a Th1-specific molecule, participating in the regulation of immune responses and in the induction of allograft tolerance. Here, we studied Tim-3 mRNA expression together with molecular markers of T-cell activation and cytotoxicity, in rejected human kidney grafts. METHODS:Twe...

journal_title：Transplant immunology

authors： Ponciano VC,Renesto PG,Nogueira E,Rangel EB,Cenedeze MA,Franco MF,Câmara NO,Pacheco-Silva A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Since the Fas/Fas Ligand (FasL) interaction has been recognized as an apoptotic pathway, it eliminates the activated T cells and promotes the survival of grafts. In this study, the effect of FasL transfection of pig chondrocytes on allogeneic transplantation was examined in vitro and in vivo. ME...

journal_title：Transplant immunology

authors： Xie GH,Wang SJ,Wang Y,Zhang Y,Zhang HZ,Jin S,Wang QF,Liu ZC,Ge HL

更新日期：2008-05-01 00:00:00

abstract：:RNA interference (RNAi) has recently emerged as an efficient method to silence gene expression in mammalian cells by transfection of small interfering RNAs (siRNAs). The Janus kinase 3 (JAK3) is also pertinent to the development of a new immuno-suppressant. This study aimed to inhibit JAK3 expression using RNAi to det...

journal_title：Transplant immunology

authors： Chang KP,Lai CH,Huang SH,Tai HT,Chang LL,Lin SD,Hwang SL,Lai CS

更新日期：2009-05-01 00:00:00

abstract：:Pancreas grafts do not survive for lengthy periods, especially in a high-responder rat combination. Recent data indicated that a combined spleen/pancreas graft protects against acute graft rejection and induces donor-specific tolerance. In this study, we performed a combination spleen/pancreas transplantation using hi...

journal_title：Transplant immunology

authors： Sakuma Y,Uchida H,Nagai H,Kobayashi E

更新日期：2001-10-01 00:00:00

abstract：:Circulating host lymphocytes recognize, bind to, become activated by, and infiltrate engrafted allogeneic tissues. The mechanisms responsible for these early events which lead to acute immunological rejection have not been precisely defined. We have examined sequentially in vitro lymphocyte binding patterns in a kidne...

journal_title：Transplant immunology

authors： Tullius SG,Heemann UW,Zeilinger K,Azuma H,Tamatami T,Miyasaka M,Tilney NL

更新日期：1995-06-01 00:00:00

abstract：:Since data on human herpesvirus 8 (HHV-8) infection in Spain is not available, our purpose was to determine the prevalence of HHV-8 infection and the risk of developing Kaposi's sarcoma (KS) among organ transplant recipients in different geographical areas of Spain. The study population consisted of 1019 liver and kid...

journal_title：Transplant immunology

authors： García-Astudillo LA,Leyva-Cobián F

更新日期：2006-12-01 00:00:00