当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > Improved transplantation outcome by epigenetic changes.

Improved transplantation outcome by epigenetic changes.

Abstract：

:Epigenetics and transplantation seem an odd couple. The influence of epigenetic changes on the immune response of the host following an organ graft is not one of the more obvious connections. However, modifying host immunity to a graft via epigenetic changes of immune related genes could have unexpected ramifications for therapy post transplantation. This review discusses various studies concerning the effects of epigenetic alterations on transplantation-associated pathologies. We present tools for improving transplantation outcome, such as histone deacetylase inhibition, DNA methyltransferase inhibition or venous systemic oxygen persufflation. This will allow a reduction of immunosuppressive medication, leading to fewer side effects. We also show, however, that much effort needs to be put into the elucidation of the molecular mechanisms underlying these advantageous effects. Taken together, altering epigenetics in transplanted organs will ultimately lead to a higher quality of life for transplant patients.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Schildberg FA,Hagmann CA,Böhnert V,Tolba RH

doi

10.1016/j.trim.2010.05.001

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

104-10

issue

3

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(10)00051-1

journal_volume

23

pub_type

杂志文章,评审

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Effects of desferrioxamine on human cytomegalovirus replication and expression of HLA antigens and adhesion molecules in human vascular endothelial cells.

    abstract：:Desferrioxamine (DFO), commonly used in therapy as a chelator of ferric ion in disorders of iron overload, is a potent inhibitor of human cytomegalovirus (HCMV) replication in cultured fibroblast cells. Moreover, DFO has immunomodulatory activity both in vitro and in vivo. We studied DFO effects on HCMV replication in...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(95)80017-4

    authors： Cinatl J,Scholz M,Weber B,Cinatl J,Rabenau H,Markus BH,Encke A,Doerr HW

    更新日期：1995-12-01 00:00:00

  • Why statin therapy may increase the risk for posttransplantation squamous cell carcinoma.

    abstract：:We suggest that surveillance for squamous cell cancer might be particularly useful for transplant patients receiving statin therapy. We recommend that development of non melanoma skin cancer should be specified as a secondary endpoint in future large endpoint statin trials, and suggest that in transplant patients the ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.06.001

    authors： Mascitelli L,Pezzetta F,Goldstein MR

    更新日期：2010-08-01 00:00:00

  • Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population.

    abstract：:Recently, the signal transducer and activator of transcription 4 (STAT4) gene have been associated with multiple autoimmune diseases. Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 po...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.01.001

    authors： Yang H,Zhou Q,Chen ZM,Chen WQ,Wang MM,Chen JH

    更新日期：2011-05-01 00:00:00

  • Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

    abstract：:Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(00)00020-4

    authors： Brogan IJ,Pravica V,Hutchinson IV

    更新日期：2000-06-01 00:00:00

  • Activation of PPARgamma enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes.

    abstract：BACKGROUND:Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a nuclear receptor that regulates the transcription of genes associated with lipid and glucose metabolism. Recently, it has been shown that PPARgamma modulates the activity of T cells, resulting in inhibition of T cell proliferation and IL-2 rel...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.03.003

    authors： Rampino T,Ranghino A,Guidetti C,Gregorini M,Soccio G,Marasà M,Libetta C,Guida G,De Amici M,Dal Canton A

    更新日期：2007-07-01 00:00:00

  • Limiting dilution analysis: quantification of IL-2 producing allospecific lymphocytes after renal and cardiac transplantation.

    abstract：:A rapid and robust limiting dilution assay was developed to measure the frequency of donor-reactive, IL-2 (interleukin 2) producing, helper T lymphocytes in the peripheral T cell population of organ allograft recipients. The IL-2 bioassay was performed using two methodologies to assess the response of CTLL-2 indicator...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90006-x

    authors： Cattell EL,Cunningham AC,Bal W,Taylor RM,Dark JH,Kirby JA

    更新日期：1994-12-01 00:00:00

  • Anti-CD20 antibody suppresses anti-HLA antibody formation in a HLA-A2 transgenic mouse model of sensitization.

    abstract：BACKGROUND:B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. METHODS:A mouse model of HLA sensitization was used to study the effectiveness of anti-CD20 treatmen...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.05.004

    authors： Wu GD,He Y,Chai NN,Toyoda M,Dunn R,Kehry MR,Klein AS,Jordan SC

    更新日期：2008-07-01 00:00:00

  • The detection and relevance of pretransplant antibodies.

    abstract：:Over the last 25 years the importance of the humoral presensitization status of transplant recipients has increasingly been recognized. With greater understanding of the precise specificity of the pretransplant antibody status of recipients it is clear that the graft survival figures will improve. The development of n...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0966-3274(94)90045-0

    authors： Shenton BK

    更新日期：1994-06-01 00:00:00

  • Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction.

    abstract：OBJECTIVE:To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS:CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twe...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.02.006

    authors： Xia Y,Deng J,Zhou Q,Shao X,Yang X,Sha M,Zou H

    更新日期：2018-06-01 00:00:00

  • Antibody response to HBV vaccination on dialysis does not correlate with the development of deNovo anti-HLA antibodies after renal transplantation.

    abstract：BACKGROUND:Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2017.04.003

    authors： Kauke T,Link M,Rentsch M,Stangl M,Guba M,Andrassy J,Werner J,Meiser B,Fischereder M,Habicht A

    更新日期：2017-06-01 00:00:00

  • Added effects of dexamethasone and mesenchymal stem cells on early Natural Killer cell activation.

    abstract：:Graft rejection and graft-versus-host disease are leading causes of transplant related mortality despite advancements in immunosuppressive therapy. Mesenchymal stem cells (MSCs) offer a promising addition to immunosuppressive drugs (ISD), while NK-cells are increasingly used as effector cells in graft-versus-leukemia....

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.04.008

    authors： Michelo CM,Fasse E,van Cranenbroek B,Linda K,van der Meer A,Abdelrazik H,Joosten I

    更新日期：2016-07-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract：:Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2003.12.011

    authors： Peck AB,Ramiya V

    更新日期：2004-04-01 00:00:00

  • A modified splint tubing technique for heterotopic heart transplantation in mouse.

    abstract：BACKGROUND:The complexity of surgical procedure in mouse heterotopic heart transplantation (HHT) has prevented its widespread use. The present study reported a modified technique - splint tubing technique (STT) based on cuff technique (CT). MATERIALS AND METHODS:C57BL/10 and BALB/c mice were performed in syngeneic and...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.03.005

    authors： Li C,Luo L,Lu J,Feng L,Shan J,Long D,Guo Y,Wu W,Li S,Li Y

    更新日期：2011-07-01 00:00:00

  • Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts.

    abstract：BACKGROUND:Donor leucocytes (DL) play an important role in rat liver transplant tolerance and their postoperative administration can convert rejection to tolerance. They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drug...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2004.05.003

    authors： den Dulk M,Wang C,Li J,Clark DA,Hibberd AD,Terpstra OT,McCaughan GW,Bishop GA

    更新日期：2004-11-01 00:00:00

  • Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.

    abstract：:The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1mg/kg/day, day 0-5) and TAK-779 (10mg/kg/day, day 0-10). Graft surviv...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.04.003

    authors： Takama Y,Miyagawa S,Yamamoto A,Firdawes S,Ueno T,Ihara Y,Kondo A,Matsunami K,Otsuka H,Fukuzawa M

    更新日期：2011-07-01 00:00:00

  • Ex vivo and systemic transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of FK506 therapy prolongs islet graft survival.

    abstract：:Adenovirus-mediated CTLA4Ig gene transfer has been reported to enhance graft survival in several rodent transplantation models. In this study, we investigated the efficacy of ex vivo and systemic transfer of the CTLA4Ig gene by adenoviral vectors in pancreatic islet allo-transplantation. Islet grafts from BN rats were...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(02)00153-3

    authors： Akamaru Y,Ito T,Uchikoshi F,Maeda A,Tori M,Kiyomoto T,Komoda H,Miao G,Matsuda H

    更新日期：2003-01-01 00:00:00

  • Binding of lymphocytes to acutely rejecting rat kidney allografts in vitro is guided by events in the graft itself rather than by sensitization of host lymphocytes.

    abstract：:Circulating host lymphocytes recognize, bind to, become activated by, and infiltrate engrafted allogeneic tissues. The mechanisms responsible for these early events which lead to acute immunological rejection have not been precisely defined. We have examined sequentially in vitro lymphocyte binding patterns in a kidne...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(95)80035-2

    authors： Tullius SG,Heemann UW,Zeilinger K,Azuma H,Tamatami T,Miyasaka M,Tilney NL

    更新日期：1995-06-01 00:00:00

  • Isogeneic MSC application in a rat model of acute renal allograft rejection modulates immune response but does not prolong allograft survival.

    abstract：:Application of mesenchymal stromal cells (MSCs) has been proposed for solid organ transplantation based on their potent immuno-modulatory effects in vitro and in vivo. We investigated the potential of MSCs to improve acceptance of kidney transplants in an MHC-incompatible rat model including isogeneic kidney transplan...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.08.004

    authors： Koch M,Lehnhardt A,Hu X,Brunswig-Spickenheier B,Stolk M,Bröcker V,Noriega M,Seifert M,Lange C

    更新日期：2013-12-01 00:00:00

  • Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.

    abstract：BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.06.005

    authors： Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

    更新日期：2014-08-01 00:00:00

  • Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.

    abstract：:Induction and maintenance immunosuppression protocols with or without long-term steroid therapy in kidney transplant recipients are variable and are transplant center-specific. The aim of this prospective randomized pilot study was to compare 5-year outcomes in kidney recipients maintained on 4 different calcineurin i...

    journal_title：Transplant immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.trim.2008.08.005

    authors： Anil Kumar MS,Irfan Saeed M,Ranganna K,Malat G,Sustento-Reodica N,Kumar AM,Meyers WC

    更新日期：2008-11-01 00:00:00

  • The impact of pharmacogenomic factors on acute persistent rejection in adult lung transplant patients.

    abstract：:Persistent rejection in the face of treatment and multiple episodes of rejection are associated with the development of chronic rejection and graft loss in solid organ transplantation. The factors that create an environment for rejection that persists in the face of treatment are as yet not understood. The objective o...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2004.11.001

    authors： Zheng HX,Zeevi A,McCurry K,Schuetz E,Webber S,Ristich J,Zhang J,Iacono A,Dauber J,McDade K,Zaldonis D,Lamba J,Burckart GJ

    更新日期：2005-03-01 00:00:00

  • Effects of FTY720 on peripheral blood lymphocytes and graft infiltrating cells in a rat model of chronic renal allograft rejection.

    abstract：AIMS:Chronic renal allograft loss is still an unsolved problem in kidney transplantation. We evaluated the impact of FTY720, a S1P receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes and Peyer's patches, on blood lymphocytes and graft infiltrating cells in a ra...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.01.003

    authors： Koch M,Poehnert D,Nashan B

    更新日期：2016-03-01 00:00:00

  • Protective effect of immunosuppressive treatment before orthotopic kidney autotransplantation.

    abstract：BACKGROUND:Ischemia reperfusion injury (IRI) is one of the risk factors for delayed graft function, acute rejection and long term allograft survival after kidney transplantation. IRI is an independent antigen inflammatory process that produces tissue damage. Our objective was to study the impact of immunosuppressive tr...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.10.006

    authors： Cicora F,Lausada N,Vasquez DN,Cicora P,Guerrieri D,Gonzalez P,Zalazar G,Stringa P,Raimondi C

    更新日期：2011-01-15 00:00:00

  • Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation.

    abstract：BACKGROUND:We recently reported that autoreactive antibody (Ab) against nuclear histone H1 had been identified as an immunosuppressive factor in a rat tolerogenic orthotopic liver transplantation (OLT) model. The present study aimed to determine whether the up-regulation of antihistone H1 Ab by histone H1 vaccination l...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.01.003

    authors： Nakano T,Goto S,Lai CY,Hsu LW,Ono K,Kawamoto S,Lin YC,Kao YH,Chiang KC,Ohmori N,Goto T,Sato S,Tu CH,Jawan B,Cheng YF,Chen CL

    更新日期：2007-04-01 00:00:00

  • CMV increases tubular apoptosis through the TNF-alpha-TNF-R1 pathway in a rat model of chronic renal allograft rejection.

    abstract：INTRODUCTION:Destruction of transplanted kidneys through chronic allograft nephropathy [CAN], also known as chronic rejection, is the greatest obstacle in successful kidney transplantation. Causes behind CAN are many, from pre-transplant causes to infections. Viral infections, especially CMV, are a risk factor for chro...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.07.004

    authors： Krogerus L,Soots A,Loginov R,Bruggeman C,Lautenschlager I

    更新日期：2008-01-01 00:00:00

  • Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism.

    abstract：:Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.03.002

    authors： Lobashevsky AL,Manwaring JE,Travis MM,Nord BL,Higgins NG,Serov YA,Arnoff TS,Hommel-Berrey GA,Goggins WC,Taber TE,Carter CB Sr,Smith DS,Wozniak TC,O'Donnell JA,Turrentine MW

    更新日期：2009-07-01 00:00:00

  • TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats.

    abstract：:TIRC7 delivers essential signals during immune activation as antibodies targeting TIRC7 inhibit lymphocyte proliferation and Th1 cytokine expression in vitro and prolonged kidney and heart allograft survival in vivo. Immunohistochemical analysis of biopsy specimens from human renal allografts undergoing rejection desp...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.09.027

    authors： Kumamoto Y,Tamura A,Volk HD,Reinke P,Löhler J,Tullius SG,Utku N

    更新日期：2006-11-01 00:00:00

  • A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

    abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.08.002

    authors： Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

    更新日期：2016-09-01 00:00:00

  • Distribution of intrahepatic T, NK and CD3(+)CD56(+)NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?

    abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

    journal_title：Transplant immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.trim.2011.05.006

    authors： Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

    更新日期：2011-07-01 00:00:00

  • Intragraft mRNA cytotoxic molecule expression in renal allograft recipients.

    abstract：:The gene expression of the cytotoxic T-cell molecules perforin, granzyme B and Fas ligand are associated with acute rejection in renal allograft recipients. Several immune mechanisms are linked to severe systemic inflammation in brain-dead organ donors. We examined the mRNA expression of these T-cell activation biomar...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.12.002

    authors： Carstens J,Ozbay A,Tørring C,Hansen HE

    更新日期：2009-03-01 00:00:00