abstract：:Immunisation against Human Leucocyte Antigens (HLA) can be caused by pregnancy, blood transfusion, or organ transplants. The HLA antibody status of a given patient significantly influences their access and waiting time to transplant. For some highly sensitised patients (HSP) there is hardly any suitable donor availabl...

journal_title：Transplant immunology

authors： Mumford L,Fuggle SV,Martorell J,Slavcev A,Iniotaki A,Haasnoot GW,Heidt S,Claas FHJ

更新日期：2021-02-01 00:00:00

abstract：:Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...

journal_title：Transplant immunology

authors： Doss SA,Mittal S,Daniel D

更新日期：2021-02-01 00:00:00

abstract：:Solid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifesta...

journal_title：Transplant immunology

authors： Miotto IZ,Souza BCE,Tyring SK,de Oliveira WRP

更新日期：2021-02-01 00:00:00

abstract：:In recent years, the utility of vascular complement factor 4d (C4d) deposition as diagnostic tool for antibody mediated rejection (AMR) after lung transplantation, has become a controversial issue. We aimed to pinpoint the problematic nature of C4d as biomarker with a simple experiment. We quantified C4d in broncho-al...

journal_title：Transplant immunology

authors： Heigl T,Saez-Gimenez B,Van Herck A,Kaes J,Sacreas A,Beeckmans H,Ambrocio GPL,Kwakkel-Van Erp H,Ordies S,Vanstapel A,Verleden SE,Neyrinck AP,Ceulemans LJ,Van Raemdonck DE,Verbeken E,Verleden GM,Vos R,Vanaudenaerde B

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

journal_title：Transplant immunology

authors： Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

更新日期：2020-10-01 00:00:00

abstract：:Data binding the expression of Toll-like 4 receptor (TLR4ex), transplanted kidney function, and the cause of pre-transplant end-stage renal disease are scarcely available. OBJECTIVE:To investigate the relationship between pre-transplant chronic interstitial nephritis (CIN), TLR4ex and transplanted kidney function. M...

journal_title：Transplant immunology

authors： Zmonarski SC,Banasik M,Golebiowski T,Madziarska K,Mazanowska O,Myszka M,Zmonarska J,Letachowicz K,Dawiskiba T,Krajewska M

更新日期：2020-10-01 00:00:00

abstract：:This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

journal_title：Transplant immunology

authors： Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

更新日期：2020-10-01 00:00:00

abstract：:The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...

journal_title：Transplant immunology

authors： de Vries APJ,Alwayn IPJ,Hoek RAS,van den Berg AP,Ultee FCW,Vogelaar SM,Haase-Kromwijk BJJM,Heemskerk MBA,Hemke AC,Nijboer WN,Schaefer BS,Kuiper MA,de Jonge J,van der Kaaij NP,Reinders MEJ

更新日期：2020-08-01 00:00:00

abstract：:Organ transplantation is an effective way to treat many end-stage diseases. In order to overcome post-transplant rejection, immunosuppressive agents have been widely used, but the long-term survival of transplanted organs still has not been achieved in the clinic. For decades, tolerance is the "holy grail" that transp...

journal_title：Transplant immunology

authors： Zeng S,Xiao Z,Wang Q,Guo Y,He Y,Zhu Q,Zou Y

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the neuroimmune system, thereby, increasing the risk of neurodegeneration. Here, we measured the impact...

journal_title：Transplant immunology

authors： Dirks M,Pflugrad H,Tryc AB,Schrader AK,Ding X,Lanfermann H,Jäckel E,Schrem H,Beneke J,Barg-Hock H,Klempnauer J,Falk CS,Weissenborn K

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulat...

journal_title：Transplant immunology

authors： Nomura S,Ito T,Katayama Y,Ota S,Hayashi K,Fujita S,Satake A,Ishii K

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

journal_title：Transplant immunology

authors： Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse mode...

journal_title：Transplant immunology

authors： Yang M,Chen G,Zhang X,Ding Z,Miao Y,Yang Y,Chen ZK,Jiang F,Chang S,Zhou P

更新日期：2019-04-01 00:00:00

abstract：:Although immunosuppressive therapies have made organ transplantation a common medical procedure worldwide, chronic toxicity is a major issue of long-term treatment. One method to improve such therapies is the application of immunomodulatory agents from parasites, such as Hypoderma lineatum (Diptera: Oestridae). Hypode...

journal_title：Transplant immunology

authors： Hu A,Wang Y,Yuan H,Wu L,Zheng K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Antibody-mediated rejection (ABMR) is the leading cause of kidney graft loss worldwide. Criteria for acute humoral rejection (currently labeled active humoral rejection) established by the 2007 Banff classification are highly specific but lack sensitivity. Modifications to the Banff classification were intro...

journal_title：Transplant immunology

authors： Solar-Cafaggi D,Marino L,Uribe-Uribe N,Morales-Buenrostro LE

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...

journal_title：Transplant immunology

authors： van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Molecules of the innate immune response are increasingly recognized as important mediators in allograft injury during and after kidney transplantation. We therefore aimed to establish the relationship between the expression of these genes at implantation, during an acute rejection (AR) and on graft outcome. ...

journal_title：Transplant immunology

authors： Yang J,Snijders MLH,Haasnoot GW,van Kooten C,Mallat M,de Fijter JW,Clahsen-van Groningen MC,Claas FHJ,Eikmans M

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS:CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twe...

journal_title：Transplant immunology

authors： Xia Y,Deng J,Zhou Q,Shao X,Yang X,Sha M,Zou H

更新日期：2018-06-01 00:00:00

abstract：:The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1...

journal_title：Transplant immunology

authors： Salek Farrokhi A,Zarnani AH,Moazzeni SM

更新日期：2018-04-01 00:00:00

abstract：:MicroRNAs are small, noncoding RNAs that control expression of target genes through inhibiting protein translation or inducing degradation of mRNA transcripts of target genes. According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of mult...

journal_title：Transplant immunology

authors： Bergallo M,Gambarino S,Montanari P,Daprà V,Rassu M,Galliano I,Ravanini P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to ...

journal_title：Transplant immunology

authors： Kauke T,Link M,Rentsch M,Stangl M,Guba M,Andrassy J,Werner J,Meiser B,Fischereder M,Habicht A

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:To assess the timelines of serum free light chain (sFLC) concentrations and the kappa/lambda light chain (K/L) ratio in heart transplant (HTX) recipients. To analyze the performance of serum protein electrophoresis (SPE), serum immunofixation (sIFE) and sFLC measurements for gammopathy detection following a ...

journal_title：Transplant immunology

authors： Sečník P Jr,Lavríková P,Hošková L,Malíková P,Jabor A,Franeková J

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Pigs are frequently used as animal models for experiments in the surgical field, including allo- and xeno-transplantation. Regeneration studies, including studies dealing with human- and monkey-induced pluripotent stem cells (iPSC), have gradually progressed, with pigs sometimes being used as the scaffold. H...

journal_title：Transplant immunology

authors： Sakai R,Kitano E,Maeda A,Lo PC,Eguchi H,Watanabe M,Nagashima H,Okuyama H,Miyagawa S

更新日期：2017-02-01 00:00:00

abstract：:Cellular and antibody-mediated rejection processes and also interstitial fibrosis/tubular atrophy (IFTA) lead to allograft dysfunction and loss. The search for accurate, specific and non-invasive diagnostic tools is still ongoing and essential for successful treatment of renal transplanted patients. Molecular markers ...

journal_title：Transplant immunology

authors： Matz M,Lorkowski C,Fabritius K,Wu K,Rudolph B,Frischbutter S,Brakemeier S,Gaedeke J,Neumayer HH,Mashreghi MF,Budde K

更新日期：2016-11-01 00:00:00

abstract：:The outcome of hyperacute grade 3-4 steroid-refractory graft-versus-host-disease (SR-GVHD) remains dismal despite a plethora of agents being tried alone or in combination. Following T replete haploidentical transplantation with post-transplantation cyclophosphamide on 75 patients, 10 patients (13%) aged 2-20years, dev...

journal_title：Transplant immunology

authors： Jaiswal SR,Zaman S,Chakrabarti A,Sehrawat A,Bansal S,Gupta M,Chakrabarti S

更新日期：2016-11-01 00:00:00

abstract：:We present management strategies utilised for the first case of an urgent live-donor ABO incompatible B blood group renal transplant, in a patient with a prior A blood group lung transplant for cystic fibrosis. Three years on, renal function is excellent and stable, whilst lung function has improved. ...

journal_title：Transplant immunology

authors： Snell GI,Davis AK,Menahem S,Kotecha S,Whitford HM,Levvey BJ,Paraskeva M,Webb A,Westall GW,Walker RG

更新日期：2016-11-01 00:00:00

abstract：AIM:To identify the frequency of exposure to sensitizing factors and evaluate the risk ascribable to each sensitizing factor generating HLAabs measured by Luminex. METHODS:This is a retrospective cohort study that included 502 transplanted patients and 51 patients on the waiting list for a deceased donor graft. Patien...

journal_title：Transplant immunology

authors： Guichard-Romero A,Marino-Vazquez LA,Castelán N,López M,González-Tableros N,Arvizu A,De Santiago A,Alberú J,Morales-Buenrostro LE

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

journal_title：Transplant immunology

authors： Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

更新日期：2016-09-01 00:00:00

abstract：:Graft rejection and graft-versus-host disease are leading causes of transplant related mortality despite advancements in immunosuppressive therapy. Mesenchymal stem cells (MSCs) offer a promising addition to immunosuppressive drugs (ISD), while NK-cells are increasingly used as effector cells in graft-versus-leukemia....

journal_title：Transplant immunology

authors： Michelo CM,Fasse E,van Cranenbroek B,Linda K,van der Meer A,Abdelrazik H,Joosten I

更新日期：2016-07-01 00:00:00

abstract：:The ImmuKnow assay measures cell-mediated immunity, quantifying ATP production from peripheral blood CD4+T-cells in solid-organ transplant patients who undergo immunosuppressive therapy. We aimed to measure functional immunity in lung transplant recipients and correlate Immuknow values with immunosuppression levels, p...

journal_title：Transplant immunology

authors： Piloni D,Magni S,Oggionni T,Benazzo A,Stella G,Scudeller L,Morosini M,Cova E,Meloni F

更新日期：2016-07-01 00:00:00

abstract：AIMS:Chronic renal allograft loss is still an unsolved problem in kidney transplantation. We evaluated the impact of FTY720, a S1P receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes and Peyer's patches, on blood lymphocytes and graft infiltrating cells in a ra...

journal_title：Transplant immunology

authors： Koch M,Poehnert D,Nashan B

更新日期：2016-03-01 00:00:00

abstract：:Humoral rejection and its relationship with anti HLA antibodies have been extensively studied in organ transplantation with the exception of liver transplantation (LT). Recently, association between donor specific anti HLA antibodies (DSA) and increased risk of rejection and graft loss has been suggested in LT. When s...

journal_title：Transplant immunology

authors： Ducreux S,Guillaud O,Bosch A,Thaunat O,Morelon E,Hervieu V,Mekki Y,Boillot O,Scoazec JY,Dubois V,Dumortier J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Every transplanted organ relies on a reliable and sound vascular system. Therefore, our study focused on the investigation if platelet inhibition alone or combined with mTOR-inhibition has a beneficial effect on the microvascular integrity in allogeneic murine skin grafts. METHODS:Skin transplantation was p...

journal_title：Transplant immunology

authors： Motsch B,Heim C,Koch N,Ramsperger-Gleixner M,Weyand M,Ensminger SM

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Acute rejection is a major obstacle in patients with prolonged ischemia in deceased-donor renal transplantation. Chemokines and their receptors play a critical role in leukocyte trafficking, resulting in allograft rejection; therefore, the role of chemokine receptor CXCR3 in acute rejection induced by prolon...

journal_title：Transplant immunology

authors： Zou XF,Song B,Duan JH,Hu ZD,Cui ZL,Gu C

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Xenotransplantation is an appealing alternative to human allotransplantation because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular rejection by the innate immune system, comprised of NK cells, monocytes, and macrophages. In this study the inhibitory function of HLA-G1, a ...

journal_title：Transplant immunology

authors： Esquivel EL,Maeda A,Eguchi H,Asada M,Sugiyama M,Manabe C,Sakai R,Matsuura R,Nakahata K,Okuyama H,Miyagawa S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Correct identification of the specificity of antibodies directed against HLA using single antigen Luminex beads (SALB) is essential in current HLA laboratory practice for transplantation. The aim of this study was to investigate the magnitude of concordance and discordance among laboratories in testing for a...

journal_title：Transplant immunology

authors： Israeli M,Pollack MS,Shaut CA,Halpin A,DiPaola NR,Youngs D,Saidman SL,ASHI Proficiency Testing Program.

更新日期：2015-01-01 00:00:00

abstract：:Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transpl...

journal_title：Transplant immunology

authors： Hart-Matyas M,Gareau AJ,Hirsch GM,Lee TD

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Endothelial microparticles (EMPs) are membrane vesicles shed from endothelial cell in response to injury, activation or apoptosis. Kidney transplantation (KTx) is the treatment of choice for patients with end stage kidney disease (ESKD). The aim of this study was to analyze changes in EMP and serum creatinin...

journal_title：Transplant immunology

authors： Qamri Z,Pelletier R,Foster J,Kumar S,Momani H,Ware K,Von Visger J,Satoskar A,Nadasdy T,Brodsky SV

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

journal_title：Transplant immunology

authors： Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

journal_title：Transplant immunology

authors： Domen J,Li Y,Sun L,Simpson P,Gandy K

更新日期：2014-08-01 00:00:00