Prevention of calcineurin inhibitor nephrotoxicity in renal transplantation.

Abstract:

:Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal graft function [Nankivell BJ, et al. The natural history of chronic allograft nephropathy. N Engl J Med. 2003 Dec 11;349(24):2326-33]. In view of these undesirable effects, several strategies have been developed to minimize or even avoid their use. These strategies are reviewed and discussed in this paper.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

doi

10.1016/j.trim.2008.09.002

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

29-31

issue

1-2

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(08)00081-6

journal_volume

20

pub_type

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