ABO incompatible renal transplantation following lung transplantation.


:We present management strategies utilised for the first case of an urgent live-donor ABO incompatible B blood group renal transplant, in a patient with a prior A blood group lung transplant for cystic fibrosis. Three years on, renal function is excellent and stable, whilst lung function has improved.


Transpl Immunol


Transplant immunology


Snell GI,Davis AK,Menahem S,Kotecha S,Whitford HM,Levvey BJ,Paraskeva M,Webb A,Westall GW,Walker RG




Has Abstract


2016-11-01 00:00:00












  • The role of alemtuzumab in facilitating maintenance immunosuppression minimization following solid organ transplantation.

    abstract::National registry data indicate a trend towards the incorporation of lymphocyte depletion antibody induction therapy into immunosuppressive regimens for solid organ transplantation. Depletional induction has been shown to reduce the risk of early acute rejection, but increase the risk of immune incompetence. As such, ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Agarwal A,Shen LY,Kirk AD

    更新日期:2008-11-01 00:00:00

  • Helper T-cell type 1 or type 2 function of xeno-MHC-restricted T-cell clones in a direct xenoantigen recognition.

    abstract::There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Iida Y,Iwata H,Mori Y,Takagi H,Nitta T,Kanetake K,Umeda Y,Hirose H

    更新日期:2003-04-01 00:00:00

  • Concordance and discordance in anti-HLA antibody testing.

    abstract:BACKGROUND:Correct identification of the specificity of antibodies directed against HLA using single antigen Luminex beads (SALB) is essential in current HLA laboratory practice for transplantation. The aim of this study was to investigate the magnitude of concordance and discordance among laboratories in testing for a...

    journal_title:Transplant immunology

    pub_type: 杂志文章,多中心研究


    authors: Israeli M,Pollack MS,Shaut CA,Halpin A,DiPaola NR,Youngs D,Saidman SL,ASHI Proficiency Testing Program.

    更新日期:2015-01-01 00:00:00

  • Activation of PPARgamma enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes.

    abstract:BACKGROUND:Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a nuclear receptor that regulates the transcription of genes associated with lipid and glucose metabolism. Recently, it has been shown that PPARgamma modulates the activity of T cells, resulting in inhibition of T cell proliferation and IL-2 rel...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Rampino T,Ranghino A,Guidetti C,Gregorini M,Soccio G,Marasà M,Libetta C,Guida G,De Amici M,Dal Canton A

    更新日期:2007-07-01 00:00:00

  • Impact of pretransplant exposure to allosensitization factors generating HLA antibodies in the Luminex era.

    abstract:AIM:To identify the frequency of exposure to sensitizing factors and evaluate the risk ascribable to each sensitizing factor generating HLAabs measured by Luminex. METHODS:This is a retrospective cohort study that included 502 transplanted patients and 51 patients on the waiting list for a deceased donor graft. Patien...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Guichard-Romero A,Marino-Vazquez LA,Castelán N,López M,González-Tableros N,Arvizu A,De Santiago A,Alberú J,Morales-Buenrostro LE

    更新日期:2016-09-01 00:00:00

  • Distribution of intrahepatic T, NK and CD3(+)CD56(+)NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?

    abstract:BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

    journal_title:Transplant immunology

    pub_type: 临床试验,杂志文章


    authors: Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

    更新日期:2011-07-01 00:00:00

  • Dissociation of mouse cardiac transplant rejection and donor alloantigen-specific T cell responsiveness.

    abstract::Mouse hearts transplanted into MHC disparate donors are usually rejected 1 week after placement. It is widely accepted that alloantigen-reactive helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) are the key mediators of acute allograft rejection. This report demonstrates that the presence or absence of 'tra...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Bishop DK,DeBruyne LA,Chan S,Xu S,Eichwald EJ

    更新日期:1995-09-01 00:00:00

  • Circulating adhesion molecules during kidney allograft reperfusion.

    abstract::Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

    更新日期:2006-11-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract::Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Peck AB,Ramiya V

    更新日期:2004-04-01 00:00:00

  • Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients.

    abstract::Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Gibbs PJ,Tan LC,Sadek SA,Howell WM

    更新日期:2005-06-01 00:00:00

  • Immune regulation by regulatory T cells: implications for transplantation.

    abstract::The induction of antigen-specific T cell tolerance and its maintenance in the periphery are critical for the immune system to prevent autoaggressive immune responses. Our current state of knowledge about the immunoregulatory mechanisms responsible for T cell tolerance in the periphery offers new possibilities for immu...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Jonuleit H,Adema G,Schmitt E

    更新日期:2003-07-01 00:00:00

  • FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.

    abstract::FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...

    journal_title:Transplant immunology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vaessen LM,van Besouw NM,Mol WM,Ijzermans JN,Weimar W

    更新日期:2006-04-01 00:00:00

  • Clinical significance of selective decline of donor-reactive IL-2-producing T lymphocytes after renal transplantation.

    abstract::Limiting dilution analysis technique was used to enumerate the circulating precursor frequency of donor and third-party-reactive helper T lymphocytes (HTLpf) in 28 renal allograft recipients before (pre-tx) and at three intervals (T1: 60-90 days, T2: 120-180 days, T3: 360-1620 days) after transplantation (post-tx). Tw...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Beik AI,Higgins RM,Lam FT,Morris AG

    更新日期:1997-06-01 00:00:00

  • Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.

    abstract:BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

    更新日期:2014-08-01 00:00:00

  • Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts.

    abstract:BACKGROUND:Donor leucocytes (DL) play an important role in rat liver transplant tolerance and their postoperative administration can convert rejection to tolerance. They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drug...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: den Dulk M,Wang C,Li J,Clark DA,Hibberd AD,Terpstra OT,McCaughan GW,Bishop GA

    更新日期:2004-11-01 00:00:00

  • The number of regulatory T cells in transbronchial lung allograft biopsies is related to FoxP3 mRNA levels in bronchoalveolar lavage fluid and to the degree of acute cellular rejection.

    abstract:BACKGROUND:The transcription factor Forkhead Box P3 (FoxP3) is a marker of regulatory T cells (Tregs) - a subset of T cells known to suppress a wide range of immune responses. These cells are considered to be pivotal for the induction of tolerance to donor antigens in human allografts. We aimed to correlate the number ...

    journal_title:Transplant immunology

    pub_type: 临床试验,杂志文章


    authors: Krustrup D,Madsen CB,Iversen M,Engelholm L,Ryder LP,Andersen CB

    更新日期:2013-12-01 00:00:00

  • A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation.

    abstract::The expression of CD30 is restricted to cells of the immune system and strictly regulated under physiological conditions. However, active immune cells express CD30 and soluble CD30 (sCD30) is released. Several investigators reported the relevance for sCD30 as a predictive marker for allograft rejection following organ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Hübel K,Cremer B,Heuser E,von Strandmann EP,Hallek M,Hansen HP

    更新日期:2010-08-01 00:00:00

  • TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats.

    abstract::TIRC7 delivers essential signals during immune activation as antibodies targeting TIRC7 inhibit lymphocyte proliferation and Th1 cytokine expression in vitro and prolonged kidney and heart allograft survival in vivo. Immunohistochemical analysis of biopsy specimens from human renal allografts undergoing rejection desp...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Kumamoto Y,Tamura A,Volk HD,Reinke P,Löhler J,Tullius SG,Utku N

    更新日期:2006-11-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract:BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期:2014-08-01 00:00:00

  • Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

    abstract::Human anti-pig antibodies were obtained by perfusing pig hearts (n = 4) and kidneys (n = 8) with human AB or O plasma followed by elution with 3 M NaSCN. The antibodies were screened against a panel of 132 synthetic carbohydrates conjugated to bovine serum albumin using an enzyme-linked immunoassay. An anti-immunoglob...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cooper DK,Good AH,Koren E,Oriol R,Malcolm AJ,Ippolito RM,Neethling FA,Ye Y,Romano E,Zuhdi N

    更新日期:1993-01-01 00:00:00

  • Strategies in analysis of the genetic component of multifactorial diseases; biostatistical aspects.

    abstract::Complex polygenic and multifactorial diseases remain a challenge for human geneticists. Here we aim to remind basic definitions of multifactorial diseases and the genetic related concepts underlying classical methods. Knowledge on pathophysiological process and the genetic information available conditions the design o...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Barnetche T,Gourraud PA,Cambon-Thomsen A

    更新日期:2005-08-01 00:00:00

  • A modified splint tubing technique for heterotopic heart transplantation in mouse.

    abstract:BACKGROUND:The complexity of surgical procedure in mouse heterotopic heart transplantation (HHT) has prevented its widespread use. The present study reported a modified technique - splint tubing technique (STT) based on cuff technique (CT). MATERIALS AND METHODS:C57BL/10 and BALB/c mice were performed in syngeneic and...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Li C,Luo L,Lu J,Feng L,Shan J,Long D,Guo Y,Wu W,Li S,Li Y

    更新日期:2011-07-01 00:00:00

  • CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

    abstract:BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

    更新日期:2018-08-01 00:00:00

  • Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.

    abstract::Regulatory T cells, especially CD4(+)CD25(+) regulatory T cells are critical regulators of immune tolerance in humans and mice. Mice with humanized immunity have been developed by various transplantation strategies of human tissues or cells related to immunity, which are being extensively applied in biomedical researc...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Duan K,Zhang B,Zhang W,Zhao Y,Qu Y,Sun C,Zhao Y

    更新日期:2011-12-01 00:00:00

  • Immediate impact of COVID-19 on transplant activity in the Netherlands.

    abstract::The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: de Vries APJ,Alwayn IPJ,Hoek RAS,van den Berg AP,Ultee FCW,Vogelaar SM,Haase-Kromwijk BJJM,Heemskerk MBA,Hemke AC,Nijboer WN,Schaefer BS,Kuiper MA,de Jonge J,van der Kaaij NP,Reinders MEJ

    更新日期:2020-08-01 00:00:00

  • Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment.

    abstract::Diphtheria toxin (DT)-based anti-CD3 immunotoxins have clinical relevance in numerous applications including autoimmune disease therapies and organ transplantation tolerance protocols. Pre-existing anti-DT antibodies acquired either by vaccination against diphtheria toxin or infections with C. diphtheriae may interfer...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Matar AJ,Pathiraja V,Wang Z,Duran-Struuck R,Gusha A,Crepeau R,Tasaki M,Sachs DH,Huang CA

    更新日期:2012-08-01 00:00:00

  • Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation.

    abstract:BACKGROUND:Endothelial microparticles (EMPs) are membrane vesicles shed from endothelial cell in response to injury, activation or apoptosis. Kidney transplantation (KTx) is the treatment of choice for patients with end stage kidney disease (ESKD). The aim of this study was to analyze changes in EMP and serum creatinin...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Qamri Z,Pelletier R,Foster J,Kumar S,Momani H,Ware K,Von Visger J,Satoskar A,Nadasdy T,Brodsky SV

    更新日期:2014-08-01 00:00:00

  • Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes.

    abstract::Clinical ophthalmologists are highly successful in grafting allogeneic corneas onto healthy eye graft beds--only a small percentage are rejected. By contrast, a high percentage of allografts are rejected when grafted into vascularized or '"high-risk' recipient eyes. The following experiments test the hypothesis that d...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ksander BR,Sano Y,Streilein JW

    更新日期:1996-03-01 00:00:00

  • Limiting dilution analysis: quantification of IL-2 producing allospecific lymphocytes after renal and cardiac transplantation.

    abstract::A rapid and robust limiting dilution assay was developed to measure the frequency of donor-reactive, IL-2 (interleukin 2) producing, helper T lymphocytes in the peripheral T cell population of organ allograft recipients. The IL-2 bioassay was performed using two methodologies to assess the response of CTLL-2 indicator...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cattell EL,Cunningham AC,Bal W,Taylor RM,Dark JH,Kirby JA

    更新日期:1994-12-01 00:00:00

  • A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

    abstract:BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

    更新日期:2016-09-01 00:00:00