当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > Anti-HLA antibody analysis and crossmatching in heart and lung transplantation.

Anti-HLA antibody analysis and crossmatching in heart and lung transplantation.

Abstract：

:Although the clinical significance of anti-HLA antibodies in heart and lung transplantation is less well studied than in renal transplantation, several studies have shown that heart and lung recipients transplanted in the presence of donor-specific antibodies are at increased risk for early acute rejection and have a lower graft survival. In an effort to avoid any increase in organ ischemia time, heart and lung candidates with anti-HLA antibodies have to be identified prior to transplantation and crossmatches performed with donor materials obtained prior to organ recovery. Both class I and II antibodies have been found to be associated with chronic rejection, defined in heart transplantation as transplant-related coronary artery disease (TRCAV) and in lung transplantation as obliterative bronchiolitis (OB) or bronchiolitis obliterative syndrome (BOS). Post-transplant de novo development of donor antigen-specific class II antibodies has been found to be especially deleterious, significantly increasing the risk of chronic rejection and poor graft outcome. Based on the review of studies regarding the development of anti-HLA antibodies and thoracic organ allograft rejection several conclusions can be drawn. The presence of class I and II-directed anti-HLA antibodies, detected by any method, are associated with acute and chronic rejection in heart and lung transplantation. Different therapeutic strategies have been used pre-transplantation to decrease the level of anti-HLA antibodies and post-transplantation to maintain low antibody levels or treat rejection, thereby improving graft outcome. Thus, monitoring the presence and the level of anti-HLA antibodies is prognostic of graft outcome and allows for measurement of therapeutic efficacy.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Reinsmoen NL,Nelson K,Zeevi A

doi

10.1016/j.trim.2004.01.005

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

63-71

issue

1

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(04)00020-6

journal_volume

13

pub_type

杂志文章,评审

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Signal transduction and co-stimulatory pathways.

    abstract：:Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from im...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00009-6

    authors： Kiefer F,Vogel WF,Arnold R

    更新日期：2002-05-01 00:00:00

  • Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism.

    abstract：:Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.03.002

    authors： Lobashevsky AL,Manwaring JE,Travis MM,Nord BL,Higgins NG,Serov YA,Arnoff TS,Hommel-Berrey GA,Goggins WC,Taber TE,Carter CB Sr,Smith DS,Wozniak TC,O'Donnell JA,Turrentine MW

    更新日期：2009-07-01 00:00:00

  • The number of regulatory T cells in transbronchial lung allograft biopsies is related to FoxP3 mRNA levels in bronchoalveolar lavage fluid and to the degree of acute cellular rejection.

    abstract：BACKGROUND:The transcription factor Forkhead Box P3 (FoxP3) is a marker of regulatory T cells (Tregs) - a subset of T cells known to suppress a wide range of immune responses. These cells are considered to be pivotal for the induction of tolerance to donor antigens in human allografts. We aimed to correlate the number ...

    journal_title：Transplant immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.trim.2013.08.002

    authors： Krustrup D,Madsen CB,Iversen M,Engelholm L,Ryder LP,Andersen CB

    更新日期：2013-12-01 00:00:00

  • Do NK-cell receptors and alloreactivity affect solid organ transplantation?

    abstract：:Although natural killer cells lyse targets without pre-sensitization, and in an MHC-unrestricted manner, they can also respond to healthy allogeneic cells of different MHC type. Such alloreactivity is a consequence of NK cells using clonally distributed, inhibitory MHC class I receptors to achieve tolerance to healthy...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2006.09.022

    authors： Vilches C,Parham P

    更新日期：2006-12-01 00:00:00

  • Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice.

    abstract：BACKGROUND:Our laboratory has demonstrated that xenogeneic porcine thymus tissue grafted in thymectomized (ATX) and T cell-depleted mice induces donor-specific tolerance. Recipient thymectomy is essential for the success of tolerance induction. In contrast, studies in pigs grafted with non-vascularized allogeneic class...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2005.04.004

    authors： Rodríguez-Barbosa JI,Haller GW,Zhao G,Sachs DH,Sykes M

    更新日期：2005-10-01 00:00:00

  • Anti-cell surface endothelial antibodies in sera from cardiac and kidney transplant recipients: association with chronic rejection.

    abstract：:The aetiologies of accelerated or transplant-associated coronary artery disease (TxCAD) following cardiac transplantation and chronic rejection following renal transplantation remain ill-defined. Previous studies have used Western blotting to demonstrate an association between the formation of anti-endothelial (anti-E...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(97)80021-4

    authors： Ferry BL,Welsh KI,Dunn MJ,Law D,Proctor J,Chapel H,Yacoub MH,Rose ML

    更新日期：1997-03-01 00:00:00

  • Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population.

    abstract：:Recently, the signal transducer and activator of transcription 4 (STAT4) gene have been associated with multiple autoimmune diseases. Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 po...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.01.001

    authors： Yang H,Zhou Q,Chen ZM,Chen WQ,Wang MM,Chen JH

    更新日期：2011-05-01 00:00:00

  • Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.

    abstract：BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.06.005

    authors： Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

    更新日期：2014-08-01 00:00:00

  • Distribution of intrahepatic T, NK and CD3(+)CD56(+)NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?

    abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

    journal_title：Transplant immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.trim.2011.05.006

    authors： Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

    更新日期：2011-07-01 00:00:00

  • Prevention of calcineurin inhibitor nephrotoxicity in renal transplantation.

    abstract：:Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal gra...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.09.002

    authors： Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

    更新日期：2008-11-01 00:00:00

  • Helper T-cell type 1 or type 2 function of xeno-MHC-restricted T-cell clones in a direct xenoantigen recognition.

    abstract：:There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(02)00158-2

    authors： Iida Y,Iwata H,Mori Y,Takagi H,Nitta T,Kanetake K,Umeda Y,Hirose H

    更新日期：2003-04-01 00:00:00

  • Suppression of human macrophage-mediated cytotoxicity by transgenic swine endothelial cell expression of HLA-G.

    abstract：BACKGROUND:Xenotransplantation is an appealing alternative to human allotransplantation because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular rejection by the innate immune system, comprised of NK cells, monocytes, and macrophages. In this study the inhibitory function of HLA-G1, a ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.12.004

    authors： Esquivel EL,Maeda A,Eguchi H,Asada M,Sugiyama M,Manabe C,Sakai R,Matsuura R,Nakahata K,Okuyama H,Miyagawa S

    更新日期：2015-03-01 00:00:00

  • Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction.

    abstract：OBJECTIVE:To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS:CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twe...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.02.006

    authors： Xia Y,Deng J,Zhou Q,Shao X,Yang X,Sha M,Zou H

    更新日期：2018-06-01 00:00:00

  • Antibody-mediated activation of the classical complement pathway in xenograft rejection.

    abstract：:Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00042-4

    authors： Roos A,Daha MR

    更新日期：2002-05-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract：:Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2003.12.011

    authors： Peck AB,Ramiya V

    更新日期：2004-04-01 00:00:00

  • Eosinophils in acute renal allograft rejection.

    abstract：:Tissue eosinophils have been previously implicated in allograft rejection and graft loss. The aim of this study was to evaluate the role of eosinophils in acute renal allograft rejection. Data from 71 patients with 114 renal biopsies with acute allograft rejection were compared with those from 26 controls. The median ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90076-0

    authors： Hongwei W,Nanra RS,Stein A,Avis L,Price A,Hibberd AD

    更新日期：1994-01-01 00:00:00

  • Engraftment of human T, B and NK cells in CB.17 SCID/beige mice by transfer of human spleen cells.

    abstract：:Models of severe combined immuno-deficient (SCID) mice reconstituted with a competent human immune system represent a valuable tool for the study of human immune responses in vivo. Reconstitution with human cells can be achieved using large numbers of peripheral blood lymphocytes, but levels of engraftment are poor an...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2005.07.002

    authors： Yacoub-Youssef H,Marcheix B,Calise D,Thiers JC,Therville N,Benoist H,Blaes N,Ségui B,Dambrin C,Thomsen M

    更新日期：2005-12-01 00:00:00

  • Impact of pretransplant exposure to allosensitization factors generating HLA antibodies in the Luminex era.

    abstract：AIM:To identify the frequency of exposure to sensitizing factors and evaluate the risk ascribable to each sensitizing factor generating HLAabs measured by Luminex. METHODS:This is a retrospective cohort study that included 502 transplanted patients and 51 patients on the waiting list for a deceased donor graft. Patien...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.08.003

    authors： Guichard-Romero A,Marino-Vazquez LA,Castelán N,López M,González-Tableros N,Arvizu A,De Santiago A,Alberú J,Morales-Buenrostro LE

    更新日期：2016-09-01 00:00:00

  • Circulating adhesion molecules during kidney allograft reperfusion.

    abstract：:Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.08.002

    authors： Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

    更新日期：2006-11-01 00:00:00

  • Human herpesvirus-8 infection and Kaposi's sarcoma after liver and kidney transplantation in different geographical areas of Spain.

    abstract：:Since data on human herpesvirus 8 (HHV-8) infection in Spain is not available, our purpose was to determine the prevalence of HHV-8 infection and the risk of developing Kaposi's sarcoma (KS) among organ transplant recipients in different geographical areas of Spain. The study population consisted of 1019 liver and kid...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.09.008

    authors： García-Astudillo LA,Leyva-Cobián F

    更新日期：2006-12-01 00:00:00

  • Effect of blocking the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a rat small intestinal transplantation model.

    abstract：:The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.01.011

    authors： Ihara Y,Miyagawa S,Hasegawa T,Kimura T,Xu H,Fukuzawa M

    更新日期：2007-06-01 00:00:00

  • Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction.

    abstract：INTRODUCTION:Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.06.002

    authors： Tambyraja AL,Mitchell R,Driscoll PJ,Deans C,Parks RW,Rahman I,Megson IL

    更新日期：2007-11-01 00:00:00

  • Monitoring efficiency of humoral rejection episode therapy in liver transplantation: any role for complement binding Luminex Single Antigen assays?

    abstract：:Humoral rejection and its relationship with anti HLA antibodies have been extensively studied in organ transplantation with the exception of liver transplantation (LT). Recently, association between donor specific anti HLA antibodies (DSA) and increased risk of rejection and graft loss has been suggested in LT. When s...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.01.007

    authors： Ducreux S,Guillaud O,Bosch A,Thaunat O,Morelon E,Hervieu V,Mekki Y,Boillot O,Scoazec JY,Dubois V,Dumortier J

    更新日期：2016-03-01 00:00:00

  • Statins as immunomodulators.

    abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00030-8

    authors： Mach F

    更新日期：2002-05-01 00:00:00

  • Toll-like 4 receptor (TLR4) expression on peripheral blood mononuclear cells in renal transplant recipients with pre-transplant chronic interstitial nephritis indicates patients at risk of graft deterioration.

    abstract：:Data binding the expression of Toll-like 4 receptor (TLR4ex), transplanted kidney function, and the cause of pre-transplant end-stage renal disease are scarcely available. OBJECTIVE:To investigate the relationship between pre-transplant chronic interstitial nephritis (CIN), TLR4ex and transplanted kidney function. M...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101319

    authors： Zmonarski SC,Banasik M,Golebiowski T,Madziarska K,Mazanowska O,Myszka M,Zmonarska J,Letachowicz K,Dawiskiba T,Krajewska M

    更新日期：2020-10-01 00:00:00

  • Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients.

    abstract：BACKGROUND:Peripheral blood CD4+ T cell adenosine triphosphate (ATP) release has been reported to be an adjunct tool to evaluate global cellular immune response in solid-organ transplant recipients. However, the correlation between the ATP level and rejection was controversial. The aim of this prospective clinical stud...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.10.008

    authors： Wang XZ,Jin ZK,Tian XH,Xue WJ,Tian PX,Ding XM,Zheng J,Li Y,Jing X,Luo ZZ

    更新日期：2014-01-01 00:00:00

  • Free Airway C4d after Lung Transplantation - A Quantitative Analysis of Bronchoalveolar Lavage Fluid.

    abstract：:In recent years, the utility of vascular complement factor 4d (C4d) deposition as diagnostic tool for antibody mediated rejection (AMR) after lung transplantation, has become a controversial issue. We aimed to pinpoint the problematic nature of C4d as biomarker with a simple experiment. We quantified C4d in broncho-al...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101352

    authors： Heigl T,Saez-Gimenez B,Van Herck A,Kaes J,Sacreas A,Beeckmans H,Ambrocio GPL,Kwakkel-Van Erp H,Ordies S,Vanstapel A,Verleden SE,Neyrinck AP,Ceulemans LJ,Van Raemdonck DE,Verbeken E,Verleden GM,Vos R,Vanaudenaerde B

    更新日期：2021-02-01 00:00:00

  • T cell receptor (beta chain) transgenic mice have selective deficits in gamma delta T cell subpopulations.

    abstract：:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90063-9

    authors： Rimm IJ,Fruman DA,Abhyankar S,Sakamoto H,Orme IM,Milstone D,Seidman JG,Ferrara JL

    更新日期：1994-09-01 00:00:00

  • The detection and relevance of pretransplant antibodies.

    abstract：:Over the last 25 years the importance of the humoral presensitization status of transplant recipients has increasingly been recognized. With greater understanding of the precise specificity of the pretransplant antibody status of recipients it is clear that the graft survival figures will improve. The development of n...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0966-3274(94)90045-0

    authors： Shenton BK

    更新日期：1994-06-01 00:00:00

  • Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

    abstract：:Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(00)00020-4

    authors： Brogan IJ,Pravica V,Hutchinson IV

    更新日期：2000-06-01 00:00:00