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Do NK-cell receptors and alloreactivity affect solid organ transplantation?

Abstract：

:Although natural killer cells lyse targets without pre-sensitization, and in an MHC-unrestricted manner, they can also respond to healthy allogeneic cells of different MHC type. Such alloreactivity is a consequence of NK cells using clonally distributed, inhibitory MHC class I receptors to achieve tolerance to healthy autologous cells. Absence of an appropriate MHC class I ligand on an allogeneic cell erroneously informs the NK cell that the allogeneic cell has lost MHC class I expression and should be killed. Potential NK-cell allo-reactivities are common in non-HLA-identical hematopoietic cell transplants and can have both beneficial and detrimental effects. Less is known of NK-cell allo-reactivities in solid organ transplantation. In animal models NK cells are neither necessary nor sufficient for acute transplant rejection, but they can make a contribution by helping activate T cells. Genes encoding NK-cell receptors for polymorphic MHC class I molecules are also highly polymorphic, contributing to variability of the NK-cell repertoire and response in the human population. These receptors could represent intrinsic patient factors that influence the success of their transplanted solid organs.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Vilches C,Parham P

doi

10.1016/j.trim.2006.09.022

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

27-30

issue

1

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(06)00130-4

journal_volume

17

pub_type

杂志文章,评审

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