当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.

Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.

Abstract：

:Regulatory T cells, especially CD4(+)CD25(+) regulatory T cells are critical regulators of immune tolerance in humans and mice. Mice with humanized immunity have been developed by various transplantation strategies of human tissues or cells related to immunity, which are being extensively applied in biomedical research. However, it is unclear whether human CD4(+)CD25(+) regulatory T cells can normally develop in human thymic grafts and efficiently populate in the periphery in NOD/SCID mouse recipients. In human thymic grafts, high percentage of mature human CD4(+)CD25(high) regulatory T cells was detected. Human CD4(+)CD25(+) regulatory T cells maturing in fetal human thymus grafts could subsequently output to the periphery of NOD/SCID mouse recipients. Importantly, these cells exhibited Foxp3(+)CD45RO(+)CTLA4(+)CD127(-) phenotype, similarly to those in healthy individuals. In addition, human CD4(+)CD25(+) regulatory T cells maturing in human thymic grafts suppressed proliferative response of CD4(+)CD25(-) T cells to allogeneic antigens, though the peripheral CD4(+)CD25(+) regulatory T cells in fetal human thymus-grafted NOD/SCID mice showed somewhat decreased immunosuppressive ability compared with normal CD4(+)CD25(+) regulatory T cells. Thus, this humanized animal model is suitable for examining development and function of human CD4(+)CD25(+) regulatory T cells in vivo.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Duan K,Zhang B,Zhang W,Zhao Y,Qu Y,Sun C,Zhao Y

doi

10.1016/j.trim.2011.08.003

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

173-9

issue

4

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(11)00080-3

journal_volume

25

pub_type

杂志文章

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation.

    abstract：:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2012.06.003

    authors： Remberger M,Persson M,Mattsson J,Gustafsson B,Uhlin M

    更新日期：2012-08-01 00:00:00

  • Immediate impact of COVID-19 on transplant activity in the Netherlands.

    abstract：:The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...

    journal_title：Transplant immunology

    pub_type： 社论

    doi：10.1016/j.trim.2020.101304

    authors： de Vries APJ,Alwayn IPJ,Hoek RAS,van den Berg AP,Ultee FCW,Vogelaar SM,Haase-Kromwijk BJJM,Heemskerk MBA,Hemke AC,Nijboer WN,Schaefer BS,Kuiper MA,de Jonge J,van der Kaaij NP,Reinders MEJ

    更新日期：2020-08-01 00:00:00

  • Distribution of intrahepatic T, NK and CD3(+)CD56(+)NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?

    abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

    journal_title：Transplant immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.trim.2011.05.006

    authors： Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

    更新日期：2011-07-01 00:00:00

  • FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.

    abstract：:FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...

    journal_title：Transplant immunology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.trim.2006.02.002

    authors： Vaessen LM,van Besouw NM,Mol WM,Ijzermans JN,Weimar W

    更新日期：2006-04-01 00:00:00

  • Elevated intragraft expression of innate immunity and cell death-related markers is a risk factor for adverse graft outcome.

    abstract：BACKGROUND:Molecules of the innate immune response are increasingly recognized as important mediators in allograft injury during and after kidney transplantation. We therefore aimed to establish the relationship between the expression of these genes at implantation, during an acute rejection (AR) and on graft outcome. ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.02.009

    authors： Yang J,Snijders MLH,Haasnoot GW,van Kooten C,Mallat M,de Fijter JW,Clahsen-van Groningen MC,Claas FHJ,Eikmans M

    更新日期：2018-06-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract：:Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2003.12.011

    authors： Peck AB,Ramiya V

    更新日期：2004-04-01 00:00:00

  • ABO incompatible renal transplantation following lung transplantation.

    abstract：:We present management strategies utilised for the first case of an urgent live-donor ABO incompatible B blood group renal transplant, in a patient with a prior A blood group lung transplant for cystic fibrosis. Three years on, renal function is excellent and stable, whilst lung function has improved. ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.09.002

    authors： Snell GI,Davis AK,Menahem S,Kotecha S,Whitford HM,Levvey BJ,Paraskeva M,Webb A,Westall GW,Walker RG

    更新日期：2016-11-01 00:00:00

  • Eosinophils in acute renal allograft rejection.

    abstract：:Tissue eosinophils have been previously implicated in allograft rejection and graft loss. The aim of this study was to evaluate the role of eosinophils in acute renal allograft rejection. Data from 71 patients with 114 renal biopsies with acute allograft rejection were compared with those from 26 controls. The median ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90076-0

    authors： Hongwei W,Nanra RS,Stein A,Avis L,Price A,Hibberd AD

    更新日期：1994-01-01 00:00:00

  • Intragraft mRNA cytotoxic molecule expression in renal allograft recipients.

    abstract：:The gene expression of the cytotoxic T-cell molecules perforin, granzyme B and Fas ligand are associated with acute rejection in renal allograft recipients. Several immune mechanisms are linked to severe systemic inflammation in brain-dead organ donors. We examined the mRNA expression of these T-cell activation biomar...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.12.002

    authors： Carstens J,Ozbay A,Tørring C,Hansen HE

    更新日期：2009-03-01 00:00:00

  • T cells specific for viral antigens presented by HLA-Dw4 recognize DR13 on allogeneic cells: a possible mechanism for induction of rejection.

    abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(93)90005-s

    authors： Gjertsen HA,Lundin KE,Hansen T,Thorsby E

    更新日期：1993-01-01 00:00:00

  • Ex vivo propagation and characterization of lymphocytes from rejecting rat-kidney allografts.

    abstract：:Today, most clinically used methods for analysis of alloreactivity in organ transplantation are based on humoral immunity. In order to study the cellular alloresponse, a rat kidney transplantation model with culturing of graft infiltrating lymphocytes was developed. Kidney transplantations between inbred rat strains w...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(99)80001-x

    authors： Engstrand M,Johnsson C,Korsgren O,Tufveson G

    更新日期：1999-12-01 00:00:00

  • Gene therapy using adenoviral vector encoding 4-1BBIg gene significantly prolonged murine cardiac allograft survival.

    abstract：:4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, interacts with 4-1BBL expressed on APC and delivers a costimulatory signal for T cell activation and growth. In this study, we investigated the efficacy of an adenoviral vector encoding murine 4-1BB extracellular domain and human IgG1 Fc (Ad4-1BB...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.03.010

    authors： Huang BJ,Yin H,Huang YF,Xu JF,Xiong P,Feng W,Zheng F,Xu Y,Fang M,Gong FL

    更新日期：2006-08-01 00:00:00

  • CMV increases tubular apoptosis through the TNF-alpha-TNF-R1 pathway in a rat model of chronic renal allograft rejection.

    abstract：INTRODUCTION:Destruction of transplanted kidneys through chronic allograft nephropathy [CAN], also known as chronic rejection, is the greatest obstacle in successful kidney transplantation. Causes behind CAN are many, from pre-transplant causes to infections. Viral infections, especially CMV, are a risk factor for chro...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.07.004

    authors： Krogerus L,Soots A,Loginov R,Bruggeman C,Lautenschlager I

    更新日期：2008-01-01 00:00:00

  • Preventive effects of syngeneic bone marrow transplantation on diabetic nephropathy in mice.

    abstract：:Treatment with autologous bone marrow transplantation (ABMT) can change the natural history of diabetes in patients with new-onset Type 1 diabetes (T1D). Effects of syngeneic bone marrow transplantation (syn-BMT) on diabetic nephropathy were studied in streptozotocin-induced diabetic mice. Diabetic mice received sibli...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.12.003

    authors： Ouyang J,Hu G,Wen Y,Zhang X

    更新日期：2010-02-01 00:00:00

  • Dissociation of mouse cardiac transplant rejection and donor alloantigen-specific T cell responsiveness.

    abstract：:Mouse hearts transplanted into MHC disparate donors are usually rejected 1 week after placement. It is widely accepted that alloantigen-reactive helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) are the key mediators of acute allograft rejection. This report demonstrates that the presence or absence of 'tra...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(95)80028-x

    authors： Bishop DK,DeBruyne LA,Chan S,Xu S,Eichwald EJ

    更新日期：1995-09-01 00:00:00

  • Studies of innate immune systems against human cells.

    abstract：BACKGROUND:Pigs are frequently used as animal models for experiments in the surgical field, including allo- and xeno-transplantation. Regeneration studies, including studies dealing with human- and monkey-induced pluripotent stem cells (iPSC), have gradually progressed, with pigs sometimes being used as the scaffold. H...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.12.002

    authors： Sakai R,Kitano E,Maeda A,Lo PC,Eguchi H,Watanabe M,Nagashima H,Okuyama H,Miyagawa S

    更新日期：2017-02-01 00:00:00

  • Antibody-mediated activation of the classical complement pathway in xenograft rejection.

    abstract：:Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00042-4

    authors： Roos A,Daha MR

    更新日期：2002-05-01 00:00:00

  • Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance.

    abstract：:Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts. Because clinically significant responses appear to be directed at only a few antigen...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.10.005

    authors： Hess SM,Young EF,Miller KR,Vincent BG,Buntzman AS,Collins EJ,Frelinger JA,Hess PR

    更新日期：2013-12-01 00:00:00

  • Effects of recombinant thrombomodulin therapy and soluble human leukocyte antigen-G levels during hematopoietic stem cell transplantation.

    abstract：BACKGROUND:Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulat...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.12.001

    authors： Nomura S,Ito T,Katayama Y,Ota S,Hayashi K,Fujita S,Satake A,Ishii K

    更新日期：2019-04-01 00:00:00

  • Immunity to islet grafts transduced with adenovirus vectors does not inhibit long-term islet function.

    abstract：:Adenoviral gene transfer is a potential ex vivo gene therapy for islet transplantation. However, the immunogenicity of adenoviral vectors can potentially impair vector efficacy in transplants where long-term gene expression is required. We investigated the effect of this antiviral immunity on vector expression and isl...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.02.001

    authors： Cheng J,Sun J,Sung RS

    更新日期：2009-05-01 00:00:00

  • Mesenchymal stem cells therapy protects fetuses from resorption and induces Th2 type cytokines profile in abortion prone mouse model.

    abstract：:The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.01.002

    authors： Salek Farrokhi A,Zarnani AH,Moazzeni SM

    更新日期：2018-04-01 00:00:00

  • The role of CD40L in T cell-dependent nitric oxide production by murine macrophages.

    abstract：:Upon activation, T cells express CD40L, a member of the TNF cytokine superfamily, which serves as a ligand for CD40 on antigen presenting cells, including dendritic cells, B cells, and macrophages. While initial studies on the function of CD40 focused its role in the regulation of B cell activation, more recent studie...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(00)00026-5

    authors： Bingaman AW,Pearson TC,Larsen CP

    更新日期：2000-11-01 00:00:00

  • T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation.

    abstract：:The outcome of hyperacute grade 3-4 steroid-refractory graft-versus-host-disease (SR-GVHD) remains dismal despite a plethora of agents being tried alone or in combination. Following T replete haploidentical transplantation with post-transplantation cyclophosphamide on 75 patients, 10 patients (13%) aged 2-20years, dev...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.08.009

    authors： Jaiswal SR,Zaman S,Chakrabarti A,Sehrawat A,Bansal S,Gupta M,Chakrabarti S

    更新日期：2016-11-01 00:00:00

  • Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings.

    abstract：:Mycophenolate mofetil (MMF) a potent immunosuppressive agent, has recently been approved for clinical use (CellCept) in renal transplant patients in combination with cyclosporine (CsA). With the expanded use of tacrolimus (Prograf) as well in renal transplant patients, there is a lack of pharmacokinetic studies clarif...

    journal_title：Transplant immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0966-3274(97)80042-1

    authors： Zucker K,Rosen A,Tsaroucha A,de Faria L,Roth D,Ciancio G,Esquenazi V,Burke G,Tzakis A,Miller J

    更新日期：1997-09-01 00:00:00

  • De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed.

    abstract：:Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transpl...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.10.001

    authors： Hart-Matyas M,Gareau AJ,Hirsch GM,Lee TD

    更新日期：2015-01-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract：BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.04.001

    authors： Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期：2014-08-01 00:00:00

  • A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation.

    abstract：:The expression of CD30 is restricted to cells of the immune system and strictly regulated under physiological conditions. However, active immune cells express CD30 and soluble CD30 (sCD30) is released. Several investigators reported the relevance for sCD30 as a predictive marker for allograft rejection following organ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.07.001

    authors： Hübel K,Cremer B,Heuser E,von Strandmann EP,Hallek M,Hansen HP

    更新日期：2010-08-01 00:00:00

  • Added effects of dexamethasone and mesenchymal stem cells on early Natural Killer cell activation.

    abstract：:Graft rejection and graft-versus-host disease are leading causes of transplant related mortality despite advancements in immunosuppressive therapy. Mesenchymal stem cells (MSCs) offer a promising addition to immunosuppressive drugs (ISD), while NK-cells are increasingly used as effector cells in graft-versus-leukemia....

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.04.008

    authors： Michelo CM,Fasse E,van Cranenbroek B,Linda K,van der Meer A,Abdelrazik H,Joosten I

    更新日期：2016-07-01 00:00:00

  • Toll-like 4 receptor (TLR4) expression on peripheral blood mononuclear cells in renal transplant recipients with pre-transplant chronic interstitial nephritis indicates patients at risk of graft deterioration.

    abstract：:Data binding the expression of Toll-like 4 receptor (TLR4ex), transplanted kidney function, and the cause of pre-transplant end-stage renal disease are scarcely available. OBJECTIVE:To investigate the relationship between pre-transplant chronic interstitial nephritis (CIN), TLR4ex and transplanted kidney function. M...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101319

    authors： Zmonarski SC,Banasik M,Golebiowski T,Madziarska K,Mazanowska O,Myszka M,Zmonarska J,Letachowicz K,Dawiskiba T,Krajewska M

    更新日期：2020-10-01 00:00:00

  • Early onset of rejection in concordant hamster xeno hearts display signs of necrosis, but not apoptosis, correlating to the phosphocreatine concentration.

    abstract：BACKGROUND:The importance of apoptosis contra necrosis for ischemia/reperfusion (RP) and acute rejection in concordant rodent xenotransplantation is largely unknown. We explored this question by comparing rodent allo and concordant xenotransplants with different morphological methods to detect apoptosis and biochemical...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(03)00018-2

    authors： Lukes DJ,Tivesten A,Wilton J,Lundgren A,Rakotonirainy O,Kjellström C,Isgaard J,Karlsson-Parra A,Soussi B,Olausson M

    更新日期：2003-10-01 00:00:00