Abstract：
:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective function of in vivo alloantigen recognition, we analysed the gamma delta T cell development in TCR-beta mice. The presence of the TCR-V beta 8.2 chain transgene is associated with inhibition of gamma chain gene rearrangement. In order to determine how the presence of the TCR-beta transgene affects gamma delta T cell development, gamma delta T cells were studied in the skin, intestine and spleen. TCR-beta mice have dramatically reduced numbers of gamma delta T cells in the spleen and moderately reduced numbers of gamma delta T cells among intestinal intraepithelial lymphocytes. In contrast, these mice have normal numbers of gamma delta dendritic epidermal cells (DEC). These selective deficits could be due to the developmental regulation of transgene transcription during fetal life. We examined transcription of the TCR-beta transgene in the fetal thymus and found that the TCR-beta transgene is first transcribed at high levels on day 16 of fetal life, after DEC have already migrated from the thymus to the epidermis. Furthermore, mRNA from the transgene was detected in DEC, ruling out the formal possibility that DEC bear a gamma delta receptor only because they are incapable of expressing the transgene.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Transpl Immunoljournal_title
Transplant immunologyauthors
Rimm IJ,Fruman DA,Abhyankar S,Sakamoto H,Orme IM,Milstone D,Seidman JG,Ferrara JLdoi
10.1016/0966-3274(94)90063-9subject
Has Abstractpub_date
1994-09-01 00:00:00pages
218-24issue
3eissn
0966-3274issn
1878-5492pii
0966-3274(94)90063-9journal_volume
2pub_type
杂志文章abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.trim.2011.05.006
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:We tested the hypothesis that the best time for genetic modification is while the cell viability of the graft is reduced for long-term preservation. The hemagglutinating virus of Japan (HVJ)-liposome method, a nonviral gene transfer technique, was used with a luciferase gene to test the efficacy of protein i...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/S0966-3274(03)00002-9
更新日期：2003-01-01 00:00:00
abstract：:Keratinocytes are activated to express MHC class II and ICAM-1 molecules during cutaneous inflammatory reactions. It is controversial how the interaction between these 'nonprofessional' antigen presenting cells (APC) and infiltrating T cells affects the local inflammatory response. To address this issue we analyzed wh...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/0966-3274(93)90059-h
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse mode...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2018.11.006
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) can be used for immunomodulation therapy after solid organ transplantation. Here, we focus on the immunoregulatory potential of combination therapies of MSCs and classic pharmacotherapy to mediate acceptance of solid organ grafts. METHODS:To determine which drugs influence the ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2011.06.002
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.04.001
更新日期：2014-08-01 00:00:00
abstract：:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.06.003
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Brain death impairs donor organ quality and accelerates immune responses after transplantation. Detailed aspects of immune activation following brain death remain unclear. We have established a mouse model and investigated the immediate consequences of brain death and anesthesia on immune responses. METHODS...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2012.04.002
更新日期：2012-08-01 00:00:00
abstract：:Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2005.02.003
更新日期：2005-06-01 00:00:00
abstract：:The means by which methotrexate (MTX) mediates immunosuppression at low doses remains to be elucidated. MTX has been shown to inhibit the adherence of neutrophils and fibroblasts to endothelial cells in vitro. The hypothesis that MTX treatment may affect cellular adherence by downregulating cell adhesion molecule expr...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(98)80026-9
更新日期：1998-06-01 00:00:00
abstract：:4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, interacts with 4-1BBL expressed on APC and delivers a costimulatory signal for T cell activation and growth. In this study, we investigated the efficacy of an adenoviral vector encoding murine 4-1BB extracellular domain and human IgG1 Fc (Ad4-1BB...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2006.03.010
更新日期：2006-08-01 00:00:00
abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/s0966-3274(02)00030-8
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2020.101320
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. METHODS:A mouse model of HLA sensitization was used to study the effectiveness of anti-CD20 treatmen...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2008.05.004
更新日期：2008-07-01 00:00:00
abstract：:FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...
journal_title：Transplant immunology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.trim.2006.02.002
更新日期：2006-04-01 00:00:00
abstract：:Adenoviral gene transfer is a potential ex vivo gene therapy for islet transplantation. However, the immunogenicity of adenoviral vectors can potentially impair vector efficacy in transplants where long-term gene expression is required. We investigated the effect of this antiviral immunity on vector expression and isl...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.02.001
更新日期：2009-05-01 00:00:00
abstract：:Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transpl...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.10.001
更新日期：2015-01-01 00:00:00
abstract：:The immune system is an adaptive defense system capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. This highly specific response is provided by T and B lymphocytes. The enormous diversity of the antigen-specific receptors on these cells is generated by random rearr...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/s0966-3274(02)00056-4
更新日期：2002-08-01 00:00:00
abstract：:Circulating host lymphocytes recognize, bind to, become activated by, and infiltrate engrafted allogeneic tissues. The mechanisms responsible for these early events which lead to acute immunological rejection have not been precisely defined. We have examined sequentially in vitro lymphocyte binding patterns in a kidne...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/0966-3274(95)80035-2
更新日期：1995-06-01 00:00:00
abstract：:Limiting dilution analysis technique was used to enumerate the circulating precursor frequency of donor and third-party-reactive helper T lymphocytes (HTLpf) in 28 renal allograft recipients before (pre-tx) and at three intervals (T1: 60-90 days, T2: 120-180 days, T3: 360-1620 days) after transplantation (post-tx). Tw...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(97)80048-2
更新日期：1997-06-01 00:00:00
abstract：:Graft-vs.-host disease (GVHD) caused by immunologic activated cells remains a real problem in human allogeneic hematopoetic stem cell transplantation. Mesenchymal stem cells (MSCs) play some important roles on immunomodulatory. We developed a parent-into-F1 model of acute GVHD to evaluate the mechanisms involved in im...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:Pancreas grafts do not survive for lengthy periods, especially in a high-responder rat combination. Recent data indicated that a combined spleen/pancreas graft protects against acute graft rejection and induces donor-specific tolerance. In this study, we performed a combination spleen/pancreas transplantation using hi...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(01)00049-1
更新日期：2001-10-01 00:00:00
abstract：:The neomacrolide antibiotic azithromycin is known to have an anti-inflammatory effect and is increasingly being used in the treatment of chronic inflammatory pulmonary diseases. We investigated whether azithromycin influenced matrix remodeling. Matrix metalloproteinase (MMP)-9 protein levels were measured by ELISA in ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2011.06.006
更新日期：2011-09-01 00:00:00
abstract：:The mechanisms by which alloreactive memory T-cells are generated in non-sensitized individuals have begun to be elucidated. It is generally accepted that a very high level of crossreactivity is an essential feature of the T-cell receptor. Indeed it has recently been shown that alloreactivity from viral specific memor...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2010.06.008
更新日期：2010-08-01 00:00:00
abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.03.002
更新日期：2014-05-01 00:00:00
abstract：:Graft rejection and graft-versus-host disease are leading causes of transplant related mortality despite advancements in immunosuppressive therapy. Mesenchymal stem cells (MSCs) offer a promising addition to immunosuppressive drugs (ISD), while NK-cells are increasingly used as effector cells in graft-versus-leukemia....
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：:We suggest that surveillance for squamous cell cancer might be particularly useful for transplant patients receiving statin therapy. We recommend that development of non melanoma skin cancer should be specified as a secondary endpoint in future large endpoint statin trials, and suggest that in transplant patients the ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2010.06.001
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.08.002
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2018.11.007
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Xenotransplantation is an appealing alternative to human allotransplantation because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular rejection by the innate immune system, comprised of NK cells, monocytes, and macrophages. In this study the inhibitory function of HLA-G1, a ...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.12.004
更新日期：2015-03-01 00:00:00
