T cell receptor (beta chain) transgenic mice have selective deficits in gamma delta T cell subpopulations.


:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective function of in vivo alloantigen recognition, we analysed the gamma delta T cell development in TCR-beta mice. The presence of the TCR-V beta 8.2 chain transgene is associated with inhibition of gamma chain gene rearrangement. In order to determine how the presence of the TCR-beta transgene affects gamma delta T cell development, gamma delta T cells were studied in the skin, intestine and spleen. TCR-beta mice have dramatically reduced numbers of gamma delta T cells in the spleen and moderately reduced numbers of gamma delta T cells among intestinal intraepithelial lymphocytes. In contrast, these mice have normal numbers of gamma delta dendritic epidermal cells (DEC). These selective deficits could be due to the developmental regulation of transgene transcription during fetal life. We examined transcription of the TCR-beta transgene in the fetal thymus and found that the TCR-beta transgene is first transcribed at high levels on day 16 of fetal life, after DEC have already migrated from the thymus to the epidermis. Furthermore, mRNA from the transgene was detected in DEC, ruling out the formal possibility that DEC bear a gamma delta receptor only because they are incapable of expressing the transgene.(ABSTRACT TRUNCATED AT 250 WORDS)


Transpl Immunol


Transplant immunology


Rimm IJ,Fruman DA,Abhyankar S,Sakamoto H,Orme IM,Milstone D,Seidman JG,Ferrara JL




Has Abstract


1994-09-01 00:00:00














  • A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor.

    abstract::Immunisation against Human Leucocyte Antigens (HLA) can be caused by pregnancy, blood transfusion, or organ transplants. The HLA antibody status of a given patient significantly influences their access and waiting time to transplant. For some highly sensitised patients (HSP) there is hardly any suitable donor availabl...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: Mumford L,Fuggle SV,Martorell J,Slavcev A,Iniotaki A,Haasnoot GW,Heidt S,Claas FHJ

    更新日期:2021-02-01 00:00:00

  • Activation of PPARgamma enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes.

    abstract:BACKGROUND:Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a nuclear receptor that regulates the transcription of genes associated with lipid and glucose metabolism. Recently, it has been shown that PPARgamma modulates the activity of T cells, resulting in inhibition of T cell proliferation and IL-2 rel...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Rampino T,Ranghino A,Guidetti C,Gregorini M,Soccio G,Marasà M,Libetta C,Guida G,De Amici M,Dal Canton A

    更新日期:2007-07-01 00:00:00

  • Embryonic stem cell transplantation for the treatment of myocardial infarction: immune privilege or rejection.

    abstract::Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique ...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Yuan X,Zhang H,Wei YJ,Hu SS

    更新日期:2007-11-01 00:00:00

  • Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients.

    abstract::The myeloid-related proteins 8 and 14 exist as a dimeric complex (MRP 8/14) and serve as early and highly specific markers for inflammatory processes, such as allograft rejection and non-viral (bacterial or fungal) infections. An elevated procalcitonin (PCT) concentration in serum also serves as a diagnostic indicator...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Jung DY,Park JB,Lee EN,Lee HA,Joh JW,Kwon CH,Ki CS,Lee SY,Kim SJ

    更新日期:2008-02-01 00:00:00

  • Protective effect of immunosuppressive treatment before orthotopic kidney autotransplantation.

    abstract:BACKGROUND:Ischemia reperfusion injury (IRI) is one of the risk factors for delayed graft function, acute rejection and long term allograft survival after kidney transplantation. IRI is an independent antigen inflammatory process that produces tissue damage. Our objective was to study the impact of immunosuppressive tr...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cicora F,Lausada N,Vasquez DN,Cicora P,Guerrieri D,Gonzalez P,Zalazar G,Stringa P,Raimondi C

    更新日期:2011-01-15 00:00:00

  • Biomarkers for acute and chronic graft-versus-host disease in regulatory T cells.

    abstract::Despite improvements in the prevention and treatment of graft-versus-host disease (GvHD) this allogeneic immune response is still one of major complications following allogeneic stem cell transplantation (SCT). Identification of patients at risk for the development of acute and chronic GvHD would facilitate early inte...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ukena SN,Geffers R,Buchholz S,Stadler M,Franzke A

    更新日期:2012-12-01 00:00:00

  • Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.

    abstract::The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1mg/kg/day, day 0-5) and TAK-779 (10mg/kg/day, day 0-10). Graft surviv...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Takama Y,Miyagawa S,Yamamoto A,Firdawes S,Ueno T,Ihara Y,Kondo A,Matsunami K,Otsuka H,Fukuzawa M

    更新日期:2011-07-01 00:00:00

  • Prevention of calcineurin inhibitor nephrotoxicity in renal transplantation.

    abstract::Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal gra...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

    更新日期:2008-11-01 00:00:00

  • Immunity to islet grafts transduced with adenovirus vectors does not inhibit long-term islet function.

    abstract::Adenoviral gene transfer is a potential ex vivo gene therapy for islet transplantation. However, the immunogenicity of adenoviral vectors can potentially impair vector efficacy in transplants where long-term gene expression is required. We investigated the effect of this antiviral immunity on vector expression and isl...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cheng J,Sun J,Sung RS

    更新日期:2009-05-01 00:00:00

  • Anti-cell surface endothelial antibodies in sera from cardiac and kidney transplant recipients: association with chronic rejection.

    abstract::The aetiologies of accelerated or transplant-associated coronary artery disease (TxCAD) following cardiac transplantation and chronic rejection following renal transplantation remain ill-defined. Previous studies have used Western blotting to demonstrate an association between the formation of anti-endothelial (anti-E...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ferry BL,Welsh KI,Dunn MJ,Law D,Proctor J,Chapel H,Yacoub MH,Rose ML

    更新日期:1997-03-01 00:00:00

  • Long-lasting donor passenger leukocytes after hepatic and intestinal transplantation in rats.

    abstract:BACKGROUND:Donor passenger leukocytes (DPLs) that migrate after organ transplantation stimulate the recipient immune system and normally cause rejection and graft vs. host reaction. However, DPLs also contribute to the unresponsiveness to the donor organ. The quantity and quality of these migrating cells are considered...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Inoue S,Tahara K,Kaneko T,Ajiki T,Takeda S,Sato Y,Hakamata Y,Murakami T,Takahashi M,Kaneko M,Kobayashi E

    更新日期:2004-01-01 00:00:00

  • High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination.

    abstract::Pancreas grafts do not survive for lengthy periods, especially in a high-responder rat combination. Recent data indicated that a combined spleen/pancreas graft protects against acute graft rejection and induces donor-specific tolerance. In this study, we performed a combination spleen/pancreas transplantation using hi...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Sakuma Y,Uchida H,Nagai H,Kobayashi E

    更新日期:2001-10-01 00:00:00

  • Circulating adhesion molecules during kidney allograft reperfusion.

    abstract::Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

    更新日期:2006-11-01 00:00:00

  • TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats.

    abstract::TIRC7 delivers essential signals during immune activation as antibodies targeting TIRC7 inhibit lymphocyte proliferation and Th1 cytokine expression in vitro and prolonged kidney and heart allograft survival in vivo. Immunohistochemical analysis of biopsy specimens from human renal allografts undergoing rejection desp...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Kumamoto Y,Tamura A,Volk HD,Reinke P,Löhler J,Tullius SG,Utku N

    更新日期:2006-11-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract:BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期:2014-08-01 00:00:00

  • Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction.

    abstract:INTRODUCTION:Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Tambyraja AL,Mitchell R,Driscoll PJ,Deans C,Parks RW,Rahman I,Megson IL

    更新日期:2007-11-01 00:00:00

  • Free light chain and intact immunoglobulin abnormalities in heart transplant recipients: Two year follow-up timelines and clinical correlations.

    abstract:OBJECTIVES:To assess the timelines of serum free light chain (sFLC) concentrations and the kappa/lambda light chain (K/L) ratio in heart transplant (HTX) recipients. To analyze the performance of serum protein electrophoresis (SPE), serum immunofixation (sIFE) and sFLC measurements for gammopathy detection following a ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Sečník P Jr,Lavríková P,Hošková L,Malíková P,Jabor A,Franeková J

    更新日期:2017-03-01 00:00:00

  • Strategies to achieve immune tolerance in allogeneic solid organ transplantation.

    abstract::Organ transplantation is an effective way to treat many end-stage diseases. In order to overcome post-transplant rejection, immunosuppressive agents have been widely used, but the long-term survival of transplanted organs still has not been achieved in the clinic. For decades, tolerance is the "holy grail" that transp...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Zeng S,Xiao Z,Wang Q,Guo Y,He Y,Zhu Q,Zou Y

    更新日期:2020-02-01 00:00:00

  • Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model.

    abstract:BACKGROUND:Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Angin M,Poirier N,Dilek N,Le Guiner C,Toromanoff A,Blancher A,Cherel Y,Deschamps JY,Tillou X,Renaudin K,Minault D,Hervouet J,Blancho G,Vanhove B,Anegon I,Le Mauff B

    更新日期:2012-12-01 00:00:00

  • Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

    abstract::This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

    更新日期:2020-10-01 00:00:00

  • Limiting dilution analysis: quantification of IL-2 producing allospecific lymphocytes after renal and cardiac transplantation.

    abstract::A rapid and robust limiting dilution assay was developed to measure the frequency of donor-reactive, IL-2 (interleukin 2) producing, helper T lymphocytes in the peripheral T cell population of organ allograft recipients. The IL-2 bioassay was performed using two methodologies to assess the response of CTLL-2 indicator...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Cattell EL,Cunningham AC,Bal W,Taylor RM,Dark JH,Kirby JA

    更新日期:1994-12-01 00:00:00

  • A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation.

    abstract::The expression of CD30 is restricted to cells of the immune system and strictly regulated under physiological conditions. However, active immune cells express CD30 and soluble CD30 (sCD30) is released. Several investigators reported the relevance for sCD30 as a predictive marker for allograft rejection following organ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Hübel K,Cremer B,Heuser E,von Strandmann EP,Hallek M,Hansen HP

    更新日期:2010-08-01 00:00:00

  • HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

    abstract:BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

    更新日期:2019-04-01 00:00:00

  • Distribution of intrahepatic T, NK and CD3(+)CD56(+)NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?

    abstract:BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

    journal_title:Transplant immunology

    pub_type: 临床试验,杂志文章


    authors: Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

    更新日期:2011-07-01 00:00:00

  • The concept of "partial" clinical tolerance.

    abstract::The status of "partial" tolerance to organ allografts versus the status of complete tolerance is the main topic of this paper. Progress made in immunosuppression, particularly by use of various lymphocyte depleting agents for "induction therapy", seems to favor the subsequent development of T cells with suppressor/reg...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Cortesini R,Suciu-Foca N

    更新日期:2004-09-01 00:00:00

  • Early onset of rejection in concordant hamster xeno hearts display signs of necrosis, but not apoptosis, correlating to the phosphocreatine concentration.

    abstract:BACKGROUND:The importance of apoptosis contra necrosis for ischemia/reperfusion (RP) and acute rejection in concordant rodent xenotransplantation is largely unknown. We explored this question by comparing rodent allo and concordant xenotransplants with different morphological methods to detect apoptosis and biochemical...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Lukes DJ,Tivesten A,Wilton J,Lundgren A,Rakotonirainy O,Kjellström C,Isgaard J,Karlsson-Parra A,Soussi B,Olausson M

    更新日期:2003-10-01 00:00:00

  • Immediate impact of COVID-19 on transplant activity in the Netherlands.

    abstract::The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: de Vries APJ,Alwayn IPJ,Hoek RAS,van den Berg AP,Ultee FCW,Vogelaar SM,Haase-Kromwijk BJJM,Heemskerk MBA,Hemke AC,Nijboer WN,Schaefer BS,Kuiper MA,de Jonge J,van der Kaaij NP,Reinders MEJ

    更新日期:2020-08-01 00:00:00

  • MiR-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase.

    abstract:OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

    更新日期:2020-10-01 00:00:00

  • T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation.

    abstract::The outcome of hyperacute grade 3-4 steroid-refractory graft-versus-host-disease (SR-GVHD) remains dismal despite a plethora of agents being tried alone or in combination. Following T replete haploidentical transplantation with post-transplantation cyclophosphamide on 75 patients, 10 patients (13%) aged 2-20years, dev...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Jaiswal SR,Zaman S,Chakrabarti A,Sehrawat A,Bansal S,Gupta M,Chakrabarti S

    更新日期:2016-11-01 00:00:00

  • HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms.

    abstract::Autoimmune diseases are the result of an interplay between predisposing genes and triggering environmental factors, leading to loss of self-tolerance and an immune-mediated destruction of autologous cells and/or tissues. Genes in the HLA complex are among the strongest predisposing genetic factors. The HLA complex gen...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Thorsby E,Lie BA

    更新日期:2005-08-01 00:00:00