当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > Monitoring efficiency of humoral rejection episode therapy in liver transplantation: any role for complement binding Luminex Single Antigen assays?

Monitoring efficiency of humoral rejection episode therapy in liver transplantation: any role for complement binding Luminex Single Antigen assays?

Abstract：

:Humoral rejection and its relationship with anti HLA antibodies have been extensively studied in organ transplantation with the exception of liver transplantation (LT). Recently, association between donor specific anti HLA antibodies (DSA) and increased risk of rejection and graft loss has been suggested in LT. When such antibodies appear, adequate treatment and monitoring are needed to avoid or delay allograft loss. We report here three cases of probable antibody-mediated rejection developed after pregnancy in liver transplanted women. Sera at the time of rejection and during follow-up have been retrospectively tested for the ability of DSA to bind complement components. These cases display different outcomes depending on the complement binding DSA capacity and titers after treatment of the rejection episodes. Thus, they highlight the potential interest of complement binding Luminex Single Antigen assays to monitor the efficiency of anti-rejection therapy.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Ducreux S,Guillaud O,Bosch A,Thaunat O,Morelon E,Hervieu V,Mekki Y,Boillot O,Scoazec JY,Dubois V,Dumortier J

doi

10.1016/j.trim.2016.01.007

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

23-8

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(16)30005-3

journal_volume

35

pub_type

杂志文章

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Protective effect of immunosuppressive treatment before orthotopic kidney autotransplantation.

    abstract：BACKGROUND:Ischemia reperfusion injury (IRI) is one of the risk factors for delayed graft function, acute rejection and long term allograft survival after kidney transplantation. IRI is an independent antigen inflammatory process that produces tissue damage. Our objective was to study the impact of immunosuppressive tr...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.10.006

    authors： Cicora F,Lausada N,Vasquez DN,Cicora P,Guerrieri D,Gonzalez P,Zalazar G,Stringa P,Raimondi C

    更新日期：2011-01-15 00:00:00

  • Monoclonal anti-D development programme.

    abstract：:Administration of anti-D immunoglobulin to D- women after delivery of a D+ infant has dramatically reduced the number of immunised women and cases of haemolytic disease of the fetus and newborn. The use of monoclonal anti-D might alleviate some of the pressures on maintaining adequate supplies of plasma sourced anti-D...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00066-7

    authors： Kumpel BM

    更新日期：2002-08-01 00:00:00

  • Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients.

    abstract：:Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2005.02.003

    authors： Gibbs PJ,Tan LC,Sadek SA,Howell WM

    更新日期：2005-06-01 00:00:00

  • Embryonic stem cell transplantation for the treatment of myocardial infarction: immune privilege or rejection.

    abstract：:Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique ...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2007.05.003

    authors： Yuan X,Zhang H,Wei YJ,Hu SS

    更新日期：2007-11-01 00:00:00

  • Why statin therapy may increase the risk for posttransplantation squamous cell carcinoma.

    abstract：:We suggest that surveillance for squamous cell cancer might be particularly useful for transplant patients receiving statin therapy. We recommend that development of non melanoma skin cancer should be specified as a secondary endpoint in future large endpoint statin trials, and suggest that in transplant patients the ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.06.001

    authors： Mascitelli L,Pezzetta F,Goldstein MR

    更新日期：2010-08-01 00:00:00

  • Strategies to achieve immune tolerance in allogeneic solid organ transplantation.

    abstract：:Organ transplantation is an effective way to treat many end-stage diseases. In order to overcome post-transplant rejection, immunosuppressive agents have been widely used, but the long-term survival of transplanted organs still has not been achieved in the clinic. For decades, tolerance is the "holy grail" that transp...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2019.101250

    authors： Zeng S,Xiao Z,Wang Q,Guo Y,He Y,Zhu Q,Zou Y

    更新日期：2020-02-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract：BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.04.001

    authors： Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期：2014-08-01 00:00:00

  • Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model.

    abstract：BACKGROUND:Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2012.10.004

    authors： Angin M,Poirier N,Dilek N,Le Guiner C,Toromanoff A,Blancher A,Cherel Y,Deschamps JY,Tillou X,Renaudin K,Minault D,Hervouet J,Blancho G,Vanhove B,Anegon I,Le Mauff B

    更新日期：2012-12-01 00:00:00

  • HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

    abstract：BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.11.007

    authors： Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

    更新日期：2019-04-01 00:00:00

  • Antibody-mediated activation of the classical complement pathway in xenograft rejection.

    abstract：:Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00042-4

    authors： Roos A,Daha MR

    更新日期：2002-05-01 00:00:00

  • Screening of mortality in transplant patients using an assay for immune function.

    abstract：BACKGROUND:So far, the ImmuKnow Immune Cell Function Assay (Cylex, Inc., Columbia, MD, USA) has been used to assess risks of infection and rejection in transplant patients. We hypothesized that the ImmuKnow assay might be used for mortality screening in transplant patients overall. METHODS:In the period of February 20...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.12.005

    authors： Berglund D,Bengtsson M,Biglarnia A,Berglund E,Yamamoto S,von Zur-Mühlen B,Lorant T,Tufveson G

    更新日期：2011-05-01 00:00:00

  • Downregulation of Janus kinase 3 expression by small interfering RNA in rat composite tissue allotransplantation.

    abstract：:RNA interference (RNAi) has recently emerged as an efficient method to silence gene expression in mammalian cells by transfection of small interfering RNAs (siRNAs). The Janus kinase 3 (JAK3) is also pertinent to the development of a new immuno-suppressant. This study aimed to inhibit JAK3 expression using RNAi to det...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.02.004

    authors： Chang KP,Lai CH,Huang SH,Tai HT,Chang LL,Lin SD,Hwang SL,Lai CS

    更新日期：2009-05-01 00:00:00

  • Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model.

    abstract：:Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n=5) no BD, 2h ventilation...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.04.002

    authors： Cicora F,Stringa P,Guerrieri D,Vásquez D,Toniolo F,Roberti J,Raimondi C

    更新日期：2013-06-01 00:00:00

  • Combined analysis of cytokine gene polymorphism and the level of expression with allograft function in kidney transplant recipients.

    abstract：:Cytokines are important factors determining the outcome of transplantation since host ability in cytokine production may be affected by cytokine gene polymorphisms. The aim of the present study was to investigate the effect of IL-17, IL-23R and IL-21 gene polymorphisms in the outcome of kidney transplantation. A total...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.09.006

    authors： Karimi MH,Hejr S,Geramizadeh B,Yaghobi R,Sagheb MM,Kamali-Sarvestani E

    更新日期：2014-01-01 00:00:00

  • CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

    abstract：BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.04.003

    authors： van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

    更新日期：2018-08-01 00:00:00

  • Inflammatory immune responses in a reproducible mouse brain death model.

    abstract：BACKGROUND:Brain death impairs donor organ quality and accelerates immune responses after transplantation. Detailed aspects of immune activation following brain death remain unclear. We have established a mouse model and investigated the immediate consequences of brain death and anesthesia on immune responses. METHODS...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2012.04.002

    authors： Floerchinger B,Yuan X,Jurisch A,Timsit MO,Ge X,Lee YL,Schmid C,Tullius SG

    更新日期：2012-08-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract：:Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2003.12.011

    authors： Peck AB,Ramiya V

    更新日期：2004-04-01 00:00:00

  • Circulating adhesion molecules during kidney allograft reperfusion.

    abstract：:Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.08.002

    authors： Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

    更新日期：2006-11-01 00:00:00

  • HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms.

    abstract：:Autoimmune diseases are the result of an interplay between predisposing genes and triggering environmental factors, leading to loss of self-tolerance and an immune-mediated destruction of autologous cells and/or tissues. Genes in the HLA complex are among the strongest predisposing genetic factors. The HLA complex gen...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2005.03.021

    authors： Thorsby E,Lie BA

    更新日期：2005-08-01 00:00:00

  • Anti-CD20 antibody suppresses anti-HLA antibody formation in a HLA-A2 transgenic mouse model of sensitization.

    abstract：BACKGROUND:B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. METHODS:A mouse model of HLA sensitization was used to study the effectiveness of anti-CD20 treatmen...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.05.004

    authors： Wu GD,He Y,Chai NN,Toyoda M,Dunn R,Kehry MR,Klein AS,Jordan SC

    更新日期：2008-07-01 00:00:00

  • Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model.

    abstract：BACKGROUND:Mesenchymal stem cells (MSCs) can be used for immunomodulation therapy after solid organ transplantation. Here, we focus on the immunoregulatory potential of combination therapies of MSCs and classic pharmacotherapy to mediate acceptance of solid organ grafts. METHODS:To determine which drugs influence the ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.06.002

    authors： Eggenhofer E,Renner P,Soeder Y,Popp FC,Hoogduijn MJ,Geissler EK,Schlitt HJ,Dahlke MH

    更新日期：2011-09-01 00:00:00

  • Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients.

    abstract：BACKGROUND:Peripheral blood CD4+ T cell adenosine triphosphate (ATP) release has been reported to be an adjunct tool to evaluate global cellular immune response in solid-organ transplant recipients. However, the correlation between the ATP level and rejection was controversial. The aim of this prospective clinical stud...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.10.008

    authors： Wang XZ,Jin ZK,Tian XH,Xue WJ,Tian PX,Ding XM,Zheng J,Li Y,Jing X,Luo ZZ

    更新日期：2014-01-01 00:00:00

  • Immunomodulatory effects of mesenchymal stem cells involved in favoring type 2 T cell subsets.

    abstract：:Graft-vs.-host disease (GVHD) caused by immunologic activated cells remains a real problem in human allogeneic hematopoetic stem cell transplantation. Mesenchymal stem cells (MSCs) play some important roles on immunomodulatory. We developed a parent-into-F1 model of acute GVHD to evaluate the mechanisms involved in im...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.08.002

    authors： Lu X,Liu T,Gu L,Huang C,Zhu H,Meng W,Xi Y,Li S,Liu Y

    更新日期：2009-12-01 00:00:00

  • Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation.

    abstract：BACKGROUND:Endothelial microparticles (EMPs) are membrane vesicles shed from endothelial cell in response to injury, activation or apoptosis. Kidney transplantation (KTx) is the treatment of choice for patients with end stage kidney disease (ESKD). The aim of this study was to analyze changes in EMP and serum creatinin...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.06.006

    authors： Qamri Z,Pelletier R,Foster J,Kumar S,Momani H,Ware K,Von Visger J,Satoskar A,Nadasdy T,Brodsky SV

    更新日期：2014-08-01 00:00:00

  • A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor.

    abstract：:Immunisation against Human Leucocyte Antigens (HLA) can be caused by pregnancy, blood transfusion, or organ transplants. The HLA antibody status of a given patient significantly influences their access and waiting time to transplant. For some highly sensitised patients (HSP) there is hardly any suitable donor availabl...

    journal_title：Transplant immunology

    pub_type： 社论

    doi：10.1016/j.trim.2020.101354

    authors： Mumford L,Fuggle SV,Martorell J,Slavcev A,Iniotaki A,Haasnoot GW,Heidt S,Claas FHJ

    更新日期：2021-02-01 00:00:00

  • Anti-cell surface endothelial antibodies in sera from cardiac and kidney transplant recipients: association with chronic rejection.

    abstract：:The aetiologies of accelerated or transplant-associated coronary artery disease (TxCAD) following cardiac transplantation and chronic rejection following renal transplantation remain ill-defined. Previous studies have used Western blotting to demonstrate an association between the formation of anti-endothelial (anti-E...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(97)80021-4

    authors： Ferry BL,Welsh KI,Dunn MJ,Law D,Proctor J,Chapel H,Yacoub MH,Rose ML

    更新日期：1997-03-01 00:00:00

  • Eosinophils in acute renal allograft rejection.

    abstract：:Tissue eosinophils have been previously implicated in allograft rejection and graft loss. The aim of this study was to evaluate the role of eosinophils in acute renal allograft rejection. Data from 71 patients with 114 renal biopsies with acute allograft rejection were compared with those from 26 controls. The median ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90076-0

    authors： Hongwei W,Nanra RS,Stein A,Avis L,Price A,Hibberd AD

    更新日期：1994-01-01 00:00:00

  • Impact of rituximab on the T-cell flow cytometric crossmatch.

    abstract：:Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101360

    authors： Doss SA,Mittal S,Daniel D

    更新日期：2021-02-01 00:00:00

  • Ex vivo propagation and characterization of lymphocytes from rejecting rat-kidney allografts.

    abstract：:Today, most clinically used methods for analysis of alloreactivity in organ transplantation are based on humoral immunity. In order to study the cellular alloresponse, a rat kidney transplantation model with culturing of graft infiltrating lymphocytes was developed. Kidney transplantations between inbred rat strains w...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(99)80001-x

    authors： Engstrand M,Johnsson C,Korsgren O,Tufveson G

    更新日期：1999-12-01 00:00:00

  • Immunosuppressant-induced cutaneous drug reactions in solid organ transplant recipients.

    abstract：:Solid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifesta...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101355

    authors： Miotto IZ,Souza BCE,Tyring SK,de Oliveira WRP

    更新日期：2021-02-01 00:00:00