当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

Abstract：

BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duration of CMV reactivations and the incidence of CMV disease in R+D- and R+D+ patients after alemtuzumab-based T-cell depleted allogeneic stem cell transplantation (TCD alloSCT). To determine the presence of donor-derived primary CMV-specific T-cell responses we analyzed the origin of CMV-specific T-cells in R+D- patients. RESULTS:The duration of CMV reactivations (54 versus 38 days, respectively, p = 0.048) and the incidence of CMV disease (0.14 versus 0.02, p = 0.003 at 1 year after alloSCT) were higher in R+D- patients compared to R+D+ patients. In R+D- patients, CMV-specific CD4+ and CD8+ T-cells were mainly of recipient origin. However, in 53% of R+D- patients donor-derived CMV-specific T-cells were detected within the first year. CONCLUSIONS:In R+D- patients, immunity against CMV was predominantly mediated by recipient T-cells. Nevertheless, donor CMV serostatus significantly influenced the clinical severity of CMV reactivations indicating the role of CMV-specific memory T-cells transferred with the graft, despite the ultimate formation of primary donor-derived CMV-specific T-cell responses in R+D- patients.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

doi

10.1016/j.trim.2018.04.003

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

54-58

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(17)30167-3

journal_volume

49

pub_type

杂志文章

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Methotrexate regulates ICAM-1 expression in recipients of rat cardiac allografts.

    abstract：:The means by which methotrexate (MTX) mediates immunosuppression at low doses remains to be elucidated. MTX has been shown to inhibit the adherence of neutrophils and fibroblasts to endothelial cells in vitro. The hypothesis that MTX treatment may affect cellular adherence by downregulating cell adhesion molecule expr...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(98)80026-9

    authors： Ciesielski CJ,Pflug JJ,Mei J,Piccinini LA

    更新日期：1998-06-01 00:00:00

  • Screening of mortality in transplant patients using an assay for immune function.

    abstract：BACKGROUND:So far, the ImmuKnow Immune Cell Function Assay (Cylex, Inc., Columbia, MD, USA) has been used to assess risks of infection and rejection in transplant patients. We hypothesized that the ImmuKnow assay might be used for mortality screening in transplant patients overall. METHODS:In the period of February 20...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2010.12.005

    authors： Berglund D,Bengtsson M,Biglarnia A,Berglund E,Yamamoto S,von Zur-Mühlen B,Lorant T,Tufveson G

    更新日期：2011-05-01 00:00:00

  • The detection and relevance of pretransplant antibodies.

    abstract：:Over the last 25 years the importance of the humoral presensitization status of transplant recipients has increasingly been recognized. With greater understanding of the precise specificity of the pretransplant antibody status of recipients it is clear that the graft survival figures will improve. The development of n...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0966-3274(94)90045-0

    authors： Shenton BK

    更新日期：1994-06-01 00:00:00

  • The role of CD40L in T cell-dependent nitric oxide production by murine macrophages.

    abstract：:Upon activation, T cells express CD40L, a member of the TNF cytokine superfamily, which serves as a ligand for CD40 on antigen presenting cells, including dendritic cells, B cells, and macrophages. While initial studies on the function of CD40 focused its role in the regulation of B cell activation, more recent studie...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(00)00026-5

    authors： Bingaman AW,Pearson TC,Larsen CP

    更新日期：2000-11-01 00:00:00

  • Toll-like 4 receptor (TLR4) expression on peripheral blood mononuclear cells in renal transplant recipients with pre-transplant chronic interstitial nephritis indicates patients at risk of graft deterioration.

    abstract：:Data binding the expression of Toll-like 4 receptor (TLR4ex), transplanted kidney function, and the cause of pre-transplant end-stage renal disease are scarcely available. OBJECTIVE:To investigate the relationship between pre-transplant chronic interstitial nephritis (CIN), TLR4ex and transplanted kidney function. M...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101319

    authors： Zmonarski SC,Banasik M,Golebiowski T,Madziarska K,Mazanowska O,Myszka M,Zmonarska J,Letachowicz K,Dawiskiba T,Krajewska M

    更新日期：2020-10-01 00:00:00

  • 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes.

    abstract：:Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(96)80007-4

    authors： Borg AJ,Kumagai-Braesch M,Möller E

    更新日期：1996-06-01 00:00:00

  • Statins as immunomodulators.

    abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00030-8

    authors： Mach F

    更新日期：2002-05-01 00:00:00

  • Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

    abstract：:Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(00)00020-4

    authors： Brogan IJ,Pravica V,Hutchinson IV

    更新日期：2000-06-01 00:00:00

  • T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation.

    abstract：:The outcome of hyperacute grade 3-4 steroid-refractory graft-versus-host-disease (SR-GVHD) remains dismal despite a plethora of agents being tried alone or in combination. Following T replete haploidentical transplantation with post-transplantation cyclophosphamide on 75 patients, 10 patients (13%) aged 2-20years, dev...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.08.009

    authors： Jaiswal SR,Zaman S,Chakrabarti A,Sehrawat A,Bansal S,Gupta M,Chakrabarti S

    更新日期：2016-11-01 00:00:00

  • Combined analysis of cytokine gene polymorphism and the level of expression with allograft function in kidney transplant recipients.

    abstract：:Cytokines are important factors determining the outcome of transplantation since host ability in cytokine production may be affected by cytokine gene polymorphisms. The aim of the present study was to investigate the effect of IL-17, IL-23R and IL-21 gene polymorphisms in the outcome of kidney transplantation. A total...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2013.09.006

    authors： Karimi MH,Hejr S,Geramizadeh B,Yaghobi R,Sagheb MM,Kamali-Sarvestani E

    更新日期：2014-01-01 00:00:00

  • Intragraft mRNA cytotoxic molecule expression in renal allograft recipients.

    abstract：:The gene expression of the cytotoxic T-cell molecules perforin, granzyme B and Fas ligand are associated with acute rejection in renal allograft recipients. Several immune mechanisms are linked to severe systemic inflammation in brain-dead organ donors. We examined the mRNA expression of these T-cell activation biomar...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.12.002

    authors： Carstens J,Ozbay A,Tørring C,Hansen HE

    更新日期：2009-03-01 00:00:00

  • Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts.

    abstract：:The novel immunosuppressive agents malononitrilamides (MNA) 279 and 715 are derivatives of A77 1726, the primary metabolite of leflunomide. The effects of these agents have been previously demonstrated in rat skin and cardiac allo- and xenotransplant models. The aim of this study was to evaluate the combination of MNA...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(99)80036-7

    authors： Qi Z,Simanaitis M,Ekberg H

    更新日期：1999-09-01 00:00:00

  • MiR-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase.

    abstract：OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101320

    authors： Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

    更新日期：2020-10-01 00:00:00

  • Improved transplantation outcome by epigenetic changes.

    abstract：:Epigenetics and transplantation seem an odd couple. The influence of epigenetic changes on the immune response of the host following an organ graft is not one of the more obvious connections. However, modifying host immunity to a graft via epigenetic changes of immune related genes could have unexpected ramifications ...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2010.05.001

    authors： Schildberg FA,Hagmann CA,Böhnert V,Tolba RH

    更新日期：2010-07-01 00:00:00

  • Effects of recombinant thrombomodulin therapy and soluble human leukocyte antigen-G levels during hematopoietic stem cell transplantation.

    abstract：BACKGROUND:Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulat...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.12.001

    authors： Nomura S,Ito T,Katayama Y,Ota S,Hayashi K,Fujita S,Satake A,Ishii K

    更新日期：2019-04-01 00:00:00

  • A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

    abstract：BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.08.002

    authors： Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

    更新日期：2016-09-01 00:00:00

  • Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts.

    abstract：BACKGROUND:Donor leucocytes (DL) play an important role in rat liver transplant tolerance and their postoperative administration can convert rejection to tolerance. They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drug...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2004.05.003

    authors： den Dulk M,Wang C,Li J,Clark DA,Hibberd AD,Terpstra OT,McCaughan GW,Bishop GA

    更新日期：2004-11-01 00:00:00

  • Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.

    abstract：:Regulatory T cells, especially CD4(+)CD25(+) regulatory T cells are critical regulators of immune tolerance in humans and mice. Mice with humanized immunity have been developed by various transplantation strategies of human tissues or cells related to immunity, which are being extensively applied in biomedical researc...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.08.003

    authors： Duan K,Zhang B,Zhang W,Zhao Y,Qu Y,Sun C,Zhao Y

    更新日期：2011-12-01 00:00:00

  • Long-lasting donor passenger leukocytes after hepatic and intestinal transplantation in rats.

    abstract：BACKGROUND:Donor passenger leukocytes (DPLs) that migrate after organ transplantation stimulate the recipient immune system and normally cause rejection and graft vs. host reaction. However, DPLs also contribute to the unresponsiveness to the donor organ. The quantity and quality of these migrating cells are considered...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2003.10.001

    authors： Inoue S,Tahara K,Kaneko T,Ajiki T,Takeda S,Sato Y,Hakamata Y,Murakami T,Takahashi M,Kaneko M,Kobayashi E

    更新日期：2004-01-01 00:00:00

  • Rapid tolerance induction by hematopoietic progenitor cells in the absence of donor-matched lymphoid cells.

    abstract：BACKGROUND:Donor specific hematopoietic cell transplantation has long been recognized for its potential in tolerance induction for subsequently transplanted organs. We have recently published that co-administration of Myeloid Progenitor (MP) and third party Hematopoietic Stem Cells (HSC) can induce MP-specific toleranc...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.04.001

    authors： Domen J,Li Y,Sun L,Simpson P,Gandy K

    更新日期：2014-08-01 00:00:00

  • The selective biomarker IL-8 identifies IFTA after kidney transplantation in blood cells.

    abstract：:Cellular and antibody-mediated rejection processes and also interstitial fibrosis/tubular atrophy (IFTA) lead to allograft dysfunction and loss. The search for accurate, specific and non-invasive diagnostic tools is still ongoing and essential for successful treatment of renal transplanted patients. Molecular markers ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2016.09.003

    authors： Matz M,Lorkowski C,Fabritius K,Wu K,Rudolph B,Frischbutter S,Brakemeier S,Gaedeke J,Neumayer HH,Mashreghi MF,Budde K

    更新日期：2016-11-01 00:00:00

  • Effect of IL-18 and sIL2R on aGVHD occurrence after hematopoietic stem cell transplantation in some Iranian patients.

    abstract：BACKGROUND:Graft-versus-host disease is one of the major complications after allogeneic bone marrow transplantation, but it is not easy to anticipate the onset. Cytokines released by type 1 T helper cells are thought to play a pivotal role in acute graft-versus-host disease aGVHD. The ability to predict the likely occu...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2005.10.002

    authors： Shaiegan M,Iravani M,Babaee GR,Ghavamzadeh A

    更新日期：2006-01-01 00:00:00

  • Donor-specific tolerance in a murine model: the result of extra-thymic T cell deletion?

    abstract：:Previously, we established a murine model, that involves the engraftment of fully allogeneic T cell depleted donor bone marrow cells in sublethally irradiated and single dose anti-CD3 treated recipient mice. These mice developed permanent stable multilineage mixed chimerism and donor-specific tolerance without graft-v...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(02)00157-0

    authors： van Pel M,van Breugel DW,van Wijk M,Luypen S,Vingerhoed J,Roholl PJ,Boog CJ

    更新日期：2003-07-01 00:00:00

  • Impact of immunosuppressive therapy on brain derived cytokines after liver transplantation.

    abstract：BACKGROUND:While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the neuroimmune system, thereby, increasing the risk of neurodegeneration. Here, we measured the impact...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2019.101248

    authors： Dirks M,Pflugrad H,Tryc AB,Schrader AK,Ding X,Lanfermann H,Jäckel E,Schrem H,Beneke J,Barg-Hock H,Klempnauer J,Falk CS,Weissenborn K

    更新日期：2020-02-01 00:00:00

  • Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.

    abstract：BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.06.005

    authors： Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

    更新日期：2014-08-01 00:00:00

  • Concordance and discordance in anti-HLA antibody testing.

    abstract：BACKGROUND:Correct identification of the specificity of antibodies directed against HLA using single antigen Luminex beads (SALB) is essential in current HLA laboratory practice for transplantation. The aim of this study was to investigate the magnitude of concordance and discordance among laboratories in testing for a...

    journal_title：Transplant immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.trim.2014.10.003

    authors： Israeli M,Pollack MS,Shaut CA,Halpin A,DiPaola NR,Youngs D,Saidman SL,ASHI Proficiency Testing Program.

    更新日期：2015-01-01 00:00:00

  • T cells specific for viral antigens presented by HLA-Dw4 recognize DR13 on allogeneic cells: a possible mechanism for induction of rejection.

    abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(93)90005-s

    authors： Gjertsen HA,Lundin KE,Hansen T,Thorsby E

    更新日期：1993-01-01 00:00:00

  • Ex vivo and systemic transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of FK506 therapy prolongs islet graft survival.

    abstract：:Adenovirus-mediated CTLA4Ig gene transfer has been reported to enhance graft survival in several rodent transplantation models. In this study, we investigated the efficacy of ex vivo and systemic transfer of the CTLA4Ig gene by adenoviral vectors in pancreatic islet allo-transplantation. Islet grafts from BN rats were...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(02)00153-3

    authors： Akamaru Y,Ito T,Uchikoshi F,Maeda A,Tori M,Kiyomoto T,Komoda H,Miao G,Matsuda H

    更新日期：2003-01-01 00:00:00

  • Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model.

    abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.03.002

    authors： Watson D,Zhang GY,Hu M,Wang YM,Fletcher J,Sartor M,Alexander SI

    更新日期：2014-05-01 00:00:00

  • Alloreactivity from human viral specific memory T-cells.

    abstract：:The mechanisms by which alloreactive memory T-cells are generated in non-sensitized individuals have begun to be elucidated. It is generally accepted that a very high level of crossreactivity is an essential feature of the T-cell receptor. Indeed it has recently been shown that alloreactivity from viral specific memor...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2010.06.008

    authors： D'Orsogna LJ,Roelen DL,Doxiadis II,Claas FH

    更新日期：2010-08-01 00:00:00