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Embryonic stem cell transplantation for the treatment of myocardial infarction: immune privilege or rejection.

Abstract：

:Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique advantages. However, the controversy about the host immune attack and the transplanted ESCs or their derivatives transplanted into ischemic heart still existed. In this review, the immune properties of ESCs and ESC-derived cardiomyocytes and possible mechanisms were discussed; furthermore, the prevention strategies against potential immune responses were also identified.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Yuan X,Zhang H,Wei YJ,Hu SS

doi

10.1016/j.trim.2007.05.003

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

88-93

issue

2

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(07)00110-4

journal_volume

18

pub_type

杂志文章,评审

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