Hypodermin C improves the survival of kidney allografts.

abstract：BACKGROUND:The importance of apoptosis contra necrosis for ischemia/reperfusion (RP) and acute rejection in concordant rodent xenotransplantation is largely unknown. We explored this question by comparing rodent allo and concordant xenotransplants with different morphological methods to detect apoptosis and biochemical...

journal_title：Transplant immunology

authors： Lukes DJ,Tivesten A,Wilton J,Lundgren A,Rakotonirainy O,Kjellström C,Isgaard J,Karlsson-Parra A,Soussi B,Olausson M

更新日期：2003-10-01 00:00:00

abstract：:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective...

journal_title：Transplant immunology

authors： Rimm IJ,Fruman DA,Abhyankar S,Sakamoto H,Orme IM,Milstone D,Seidman JG,Ferrara JL

更新日期：1994-09-01 00:00:00

abstract：:There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...

journal_title：Transplant immunology

authors： Iida Y,Iwata H,Mori Y,Takagi H,Nitta T,Kanetake K,Umeda Y,Hirose H

更新日期：2003-04-01 00:00:00

abstract：:In recent years, the utility of vascular complement factor 4d (C4d) deposition as diagnostic tool for antibody mediated rejection (AMR) after lung transplantation, has become a controversial issue. We aimed to pinpoint the problematic nature of C4d as biomarker with a simple experiment. We quantified C4d in broncho-al...

journal_title：Transplant immunology

authors： Heigl T,Saez-Gimenez B,Van Herck A,Kaes J,Sacreas A,Beeckmans H,Ambrocio GPL,Kwakkel-Van Erp H,Ordies S,Vanstapel A,Verleden SE,Neyrinck AP,Ceulemans LJ,Van Raemdonck DE,Verbeken E,Verleden GM,Vos R,Vanaudenaerde B

更新日期：2021-02-01 00:00:00

abstract：:The mechanisms by which alloreactive memory T-cells are generated in non-sensitized individuals have begun to be elucidated. It is generally accepted that a very high level of crossreactivity is an essential feature of the T-cell receptor. Indeed it has recently been shown that alloreactivity from viral specific memor...

journal_title：Transplant immunology

authors： D'Orsogna LJ,Roelen DL,Doxiadis II,Claas FH

更新日期：2010-08-01 00:00:00

abstract：:Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

journal_title：Transplant immunology

authors： Borg AJ,Kumagai-Braesch M,Möller E

更新日期：1996-06-01 00:00:00

abstract：:Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique ...

journal_title：Transplant immunology

authors： Yuan X,Zhang H,Wei YJ,Hu SS

更新日期：2007-11-01 00:00:00

abstract：:Humoral rejection and its relationship with anti HLA antibodies have been extensively studied in organ transplantation with the exception of liver transplantation (LT). Recently, association between donor specific anti HLA antibodies (DSA) and increased risk of rejection and graft loss has been suggested in LT. When s...

journal_title：Transplant immunology

authors： Ducreux S,Guillaud O,Bosch A,Thaunat O,Morelon E,Hervieu V,Mekki Y,Boillot O,Scoazec JY,Dubois V,Dumortier J

更新日期：2016-03-01 00:00:00

abstract：:National registry data indicate a trend towards the incorporation of lymphocyte depletion antibody induction therapy into immunosuppressive regimens for solid organ transplantation. Depletional induction has been shown to reduce the risk of early acute rejection, but increase the risk of immune incompetence. As such, ...

journal_title：Transplant immunology

authors： Agarwal A,Shen LY,Kirk AD

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...

journal_title：Transplant immunology

authors： van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Donor leucocytes (DL) play an important role in rat liver transplant tolerance and their postoperative administration can convert rejection to tolerance. They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drug...

journal_title：Transplant immunology

authors： den Dulk M,Wang C,Li J,Clark DA,Hibberd AD,Terpstra OT,McCaughan GW,Bishop GA

更新日期：2004-11-01 00:00:00

abstract：:Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal gra...

journal_title：Transplant immunology

authors： Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

更新日期：2008-11-01 00:00:00

abstract：AIM:To identify the frequency of exposure to sensitizing factors and evaluate the risk ascribable to each sensitizing factor generating HLAabs measured by Luminex. METHODS:This is a retrospective cohort study that included 502 transplanted patients and 51 patients on the waiting list for a deceased donor graft. Patien...

journal_title：Transplant immunology

authors： Guichard-Romero A,Marino-Vazquez LA,Castelán N,López M,González-Tableros N,Arvizu A,De Santiago A,Alberú J,Morales-Buenrostro LE

更新日期：2016-09-01 00:00:00

abstract：:Adhesion molecule expression is an important event during early transplant failure. The aim of the present study was to examine the release of adhesion molecules during the first minutes of kidney allograft reperfusion in relation to delayed graft function and acute graft rejection. We enrolled 49 renal transplant rec...

journal_title：Transplant immunology

authors： Domański L,Gryczman M,Pawlik A,Sulikowski M,Romanowski M,Ostrowski M,Myślak M,Rózański J,Safranow K,Dutkiewicz G,Ciechanowski K

更新日期：2006-11-01 00:00:00

abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

journal_title：Transplant immunology

authors： Mach F

更新日期：2002-05-01 00:00:00

abstract：:Complex polygenic and multifactorial diseases remain a challenge for human geneticists. Here we aim to remind basic definitions of multifactorial diseases and the genetic related concepts underlying classical methods. Knowledge on pathophysiological process and the genetic information available conditions the design o...

journal_title：Transplant immunology

authors： Barnetche T,Gourraud PA,Cambon-Thomsen A

更新日期：2005-08-01 00:00:00

abstract：:Administration of anti-D immunoglobulin to D- women after delivery of a D+ infant has dramatically reduced the number of immunised women and cases of haemolytic disease of the fetus and newborn. The use of monoclonal anti-D might alleviate some of the pressures on maintaining adequate supplies of plasma sourced anti-D...

journal_title：Transplant immunology

authors： Kumpel BM

更新日期：2002-08-01 00:00:00

abstract：:Diphtheria toxin (DT)-based anti-CD3 immunotoxins have clinical relevance in numerous applications including autoimmune disease therapies and organ transplantation tolerance protocols. Pre-existing anti-DT antibodies acquired either by vaccination against diphtheria toxin or infections with C. diphtheriae may interfer...

journal_title：Transplant immunology

authors： Matar AJ,Pathiraja V,Wang Z,Duran-Struuck R,Gusha A,Crepeau R,Tasaki M,Sachs DH,Huang CA

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Acute rejection is a major obstacle in patients with prolonged ischemia in deceased-donor renal transplantation. Chemokines and their receptors play a critical role in leukocyte trafficking, resulting in allograft rejection; therefore, the role of chemokine receptor CXCR3 in acute rejection induced by prolon...

journal_title：Transplant immunology

authors： Zou XF,Song B,Duan JH,Hu ZD,Cui ZL,Gu C

更新日期：2015-10-01 00:00:00

abstract：:In this review, we summarize the work published over the last few years relative to cellular immunological hurdles encountered specifically in pig-to-primate xenotransplantation models. The works summarized here cover both the innate and adaptative cellular immune response as well as strategies to overcome them and co...

journal_title：Transplant immunology

authors： Le Bas-Bernardet S,Blancho G

更新日期：2009-06-01 00:00:00

abstract：:The novel immunosuppressive agents malononitrilamides (MNA) 279 and 715 are derivatives of A77 1726, the primary metabolite of leflunomide. The effects of these agents have been previously demonstrated in rat skin and cardiac allo- and xenotransplant models. The aim of this study was to evaluate the combination of MNA...

journal_title：Transplant immunology

authors： Qi Z,Simanaitis M,Ekberg H

更新日期：1999-09-01 00:00:00

abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...

journal_title：Transplant immunology

authors： Watson D,Zhang GY,Hu M,Wang YM,Fletcher J,Sartor M,Alexander SI

更新日期：2014-05-01 00:00:00

abstract：:C3H mice were immunized by repeated skin grafting with B10.BR tail skin. Ten days after the last immunization mice received 100 micrograms (intravenously) of a variety of different monoclonal antibodies (mAbs: anti-ICAM-1, -LFA-1, -VCAM-1, -VLA-4), alone or in combination, followed by further B10.BR skin grafts. Contr...

journal_title：Transplant immunology

authors： Gorcyznski RM,Chung S,Fu XM,Levy G,Sullivan B,Chen Z

更新日期：1995-03-01 00:00:00

abstract：:Administration of anti-intercellular adhesion molecule (ICAM)-1 monoclonal antibody (mAb) plus anti-lymphocyte function associated antigen (LFA)-1 mAb induces tolerance in murine cardiac transplantation, while anti-vascular cell adhesion molecule (VCAM)-1 mAb plus anti-very late antigen (VLA)-4 mAb administration prol...

journal_title：Transplant immunology

authors： Suzuki J,Isobe M,Izawa A,Takahashi W,Yamazaki S,Okubo Y,Amano J,Sekiguchi M

更新日期：1999-03-01 00:00:00

abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

journal_title：Transplant immunology

authors： Gjertsen HA,Lundin KE,Hansen T,Thorsby E

更新日期：1993-01-01 00:00:00

abstract：:Today, most clinically used methods for analysis of alloreactivity in organ transplantation are based on humoral immunity. In order to study the cellular alloresponse, a rat kidney transplantation model with culturing of graft infiltrating lymphocytes was developed. Kidney transplantations between inbred rat strains w...

journal_title：Transplant immunology

authors： Engstrand M,Johnsson C,Korsgren O,Tufveson G

更新日期：1999-12-01 00:00:00

abstract：:CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...

journal_title：Transplant immunology

authors： Wang Z,Xiao L,Shi BY,Qian YY,Bai HW,Chang JY,Cai M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The liver is an immunological organ containing a large number of T, NK and NKT cells, but little is known about intrahepatic immunity after LTx. Here, we investigated whether the distribution of T, NK and CD3(+)CD56(+)NKT cells is altered in transplanted livers under different circumstances. METHODS:Core bi...

journal_title：Transplant immunology

authors： Werner JM,Lang C,Scherer MN,Farkas SA,Geissler EK,Schlitt HJ,Hornung M

更新日期：2011-07-01 00:00:00

abstract：:Previously, we established a murine model, that involves the engraftment of fully allogeneic T cell depleted donor bone marrow cells in sublethally irradiated and single dose anti-CD3 treated recipient mice. These mice developed permanent stable multilineage mixed chimerism and donor-specific tolerance without graft-v...

journal_title：Transplant immunology

authors： van Pel M,van Breugel DW,van Wijk M,Luypen S,Vingerhoed J,Roholl PJ,Boog CJ

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Transforming growth factor beta-1(TGFB1) is involved in the acute rejection (AR) episodes of solid organ transplant recipients. However, results from published studies on the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk are conflicting and inconclusive. METHODS:PUBMED, EMBASE, ...

journal_title：Transplant immunology

authors： Ge YZ,Yu P,Jia RP,Wu R,Ding AX,Li LP,Zhao Y,Feng YM,Gui ZL,Liao S

更新日期：2014-03-01 00:00:00