Current cellular immunological hurdles in pig-to-primate xenotransplantation.

Abstract:

:In this review, we summarize the work published over the last few years relative to cellular immunological hurdles encountered specifically in pig-to-primate xenotransplantation models. The works summarized here cover both the innate and adaptative cellular immune response as well as strategies to overcome them and consequently prevent xenograft rejection.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Le Bas-Bernardet S,Blancho G

doi

10.1016/j.trim.2008.10.006

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

60-4

issue

2

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(08)00101-9

journal_volume

21

pub_type

杂志文章,评审
  • Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets, CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection.

    abstract::We investigated the dynamics of the CD4+ and CD8+ lymphocyte subsets, and the expression of activation markers in cardiac transplant recipients. We tested 132 peripheral blood samples from 62 cardiac transplant recipients using fluorescent staining and flow cytometry analysis. The results were correlated with histolog...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(02)00072-2

    authors: Creemers P,Brink J,Wainwright H,Moore K,Shephard E,Kahn D

    更新日期:2002-11-01 00:00:00

  • 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes.

    abstract::Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(96)80007-4

    authors: Borg AJ,Kumagai-Braesch M,Möller E

    更新日期:1996-06-01 00:00:00

  • In vitro-generation of surrogate islets from adult stem cells.

    abstract::Type 1 diabetes is one of the more costly chronic diseases of children and adolescents throughout North America and Europe, exhibiting an average estimated prevalence rate of nearly 0.2%. It occurs in genetically predisposed individuals when the immune system attacks and destroys specifically the insulin-producing bet...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.trim.2003.12.011

    authors: Peck AB,Ramiya V

    更新日期:2004-04-01 00:00:00

  • Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment.

    abstract::Diphtheria toxin (DT)-based anti-CD3 immunotoxins have clinical relevance in numerous applications including autoimmune disease therapies and organ transplantation tolerance protocols. Pre-existing anti-DT antibodies acquired either by vaccination against diphtheria toxin or infections with C. diphtheriae may interfer...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2012.05.003

    authors: Matar AJ,Pathiraja V,Wang Z,Duran-Struuck R,Gusha A,Crepeau R,Tasaki M,Sachs DH,Huang CA

    更新日期:2012-08-01 00:00:00

  • Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

    abstract::Human anti-pig antibodies were obtained by perfusing pig hearts (n = 4) and kidneys (n = 8) with human AB or O plasma followed by elution with 3 M NaSCN. The antibodies were screened against a panel of 132 synthetic carbohydrates conjugated to bovine serum albumin using an enzyme-linked immunoassay. An anti-immunoglob...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(93)90047-c

    authors: Cooper DK,Good AH,Koren E,Oriol R,Malcolm AJ,Ippolito RM,Neethling FA,Ye Y,Romano E,Zuhdi N

    更新日期:1993-01-01 00:00:00

  • Manipulation of skin graft rejection in alloimmune mice by anti-VCAM-1:VLA-4 but not anti-ICAM-1:LFA-1 monoclonal antibodies.

    abstract::C3H mice were immunized by repeated skin grafting with B10.BR tail skin. Ten days after the last immunization mice received 100 micrograms (intravenously) of a variety of different monoclonal antibodies (mAbs: anti-ICAM-1, -LFA-1, -VCAM-1, -VLA-4), alone or in combination, followed by further B10.BR skin grafts. Contr...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(95)80007-7

    authors: Gorcyznski RM,Chung S,Fu XM,Levy G,Sullivan B,Chen Z

    更新日期:1995-03-01 00:00:00

  • Impact of rituximab on the T-cell flow cytometric crossmatch.

    abstract::Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2020.101360

    authors: Doss SA,Mittal S,Daniel D

    更新日期:2021-02-01 00:00:00

  • Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance.

    abstract::Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts. Because clinically significant responses appear to be directed at only a few antigen...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2013.10.005

    authors: Hess SM,Young EF,Miller KR,Vincent BG,Buntzman AS,Collins EJ,Frelinger JA,Hess PR

    更新日期:2013-12-01 00:00:00

  • Toll-like 4 receptor (TLR4) expression on peripheral blood mononuclear cells in renal transplant recipients with pre-transplant chronic interstitial nephritis indicates patients at risk of graft deterioration.

    abstract::Data binding the expression of Toll-like 4 receptor (TLR4ex), transplanted kidney function, and the cause of pre-transplant end-stage renal disease are scarcely available. OBJECTIVE:To investigate the relationship between pre-transplant chronic interstitial nephritis (CIN), TLR4ex and transplanted kidney function. M...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2020.101319

    authors: Zmonarski SC,Banasik M,Golebiowski T,Madziarska K,Mazanowska O,Myszka M,Zmonarska J,Letachowicz K,Dawiskiba T,Krajewska M

    更新日期:2020-10-01 00:00:00

  • Screening of mortality in transplant patients using an assay for immune function.

    abstract:BACKGROUND:So far, the ImmuKnow Immune Cell Function Assay (Cylex, Inc., Columbia, MD, USA) has been used to assess risks of infection and rejection in transplant patients. We hypothesized that the ImmuKnow assay might be used for mortality screening in transplant patients overall. METHODS:In the period of February 20...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2010.12.005

    authors: Berglund D,Bengtsson M,Biglarnia A,Berglund E,Yamamoto S,von Zur-Mühlen B,Lorant T,Tufveson G

    更新日期:2011-05-01 00:00:00

  • Tim-3 expression in human kidney allografts.

    abstract:BACKGROUND:Tim-3 was recently described as a Th1-specific molecule, participating in the regulation of immune responses and in the induction of allograft tolerance. Here, we studied Tim-3 mRNA expression together with molecular markers of T-cell activation and cytotoxicity, in rejected human kidney grafts. METHODS:Twe...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2006.11.003

    authors: Ponciano VC,Renesto PG,Nogueira E,Rangel EB,Cenedeze MA,Franco MF,Câmara NO,Pacheco-Silva A

    更新日期:2007-04-01 00:00:00

  • Murine dendritic cells that are resistant to maturation are unable to induce tolerance to allogeneic stem cells.

    abstract::Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2006.03.001

    authors: Vanclée A,Schouten HC,Bos GM

    更新日期:2006-06-01 00:00:00

  • A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy.

    abstract:BACKGROUND:The Fischer-to-Lewis (LEW) rat model of kidney transplantation is a widely accepted and well-characterized model of chronic rejection. In contrast to transplantation in a clinical setting, however, the absence of treatment with immunosuppressants and only minor mismatch of major histocompatibility complexes ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2016.08.002

    authors: Hanaoka K,Kawato Y,Kubo K,Nakanishi T,Maeda M,Nakamura K,Hirose J,Noto T,Fukahori H,Fujikawa A,Miyoshi S,Takakura S,Morokata T,Higashi Y

    更新日期:2016-09-01 00:00:00

  • Elevated intragraft expression of innate immunity and cell death-related markers is a risk factor for adverse graft outcome.

    abstract:BACKGROUND:Molecules of the innate immune response are increasingly recognized as important mediators in allograft injury during and after kidney transplantation. We therefore aimed to establish the relationship between the expression of these genes at implantation, during an acute rejection (AR) and on graft outcome. ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2018.02.009

    authors: Yang J,Snijders MLH,Haasnoot GW,van Kooten C,Mallat M,de Fijter JW,Clahsen-van Groningen MC,Claas FHJ,Eikmans M

    更新日期:2018-06-01 00:00:00

  • Association between IL-6 -174G/C polymorphism and acute rejection of renal allograft: evidence from a meta-analysis.

    abstract:BACKGROUND:Results from published studies on the association of donor or recipient IL-6 -174G/C (rs1800795) polymorphism with acute rejection (AR) of renal allograft are conflicting. We performed a meta-analysis to estimate the possible association. METHODS:Studies were identified by searching PUBMED and EMBASE until ...

    journal_title:Transplant immunology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.trim.2011.10.003

    authors: Lv R,Hu X,Bai Y,Long H,Xu L,Liu Z,Li X,Huang H,Wang L,Ying B

    更新日期:2012-01-01 00:00:00

  • Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.

    abstract:BACKGROUND:The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapa...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2014.06.005

    authors: Wang H,Qi F,Dai X,Tian W,Liu T,Han H,Zhang B,Li H,Zhang Z,Du C

    更新日期:2014-08-01 00:00:00

  • An alternative conditioning regimen for induction of specific skin graft tolerance across full major histocompatibility complex barriers.

    abstract::Previously, we developed a well-tolerated single-day protocol for induction of stable multilineage chimerism and permanent donor-specific tolerance across major histocompatibility complex (MHC) barriers, with preservation of the host's normal immune responses. In our murine model, recipient mice were treated with a si...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(98)80039-7

    authors: de Vries-van der Zwan A,van der Pol MA,de Waal LP,Boog CJ

    更新日期:1998-09-01 00:00:00

  • Binding of lymphocytes to acutely rejecting rat kidney allografts in vitro is guided by events in the graft itself rather than by sensitization of host lymphocytes.

    abstract::Circulating host lymphocytes recognize, bind to, become activated by, and infiltrate engrafted allogeneic tissues. The mechanisms responsible for these early events which lead to acute immunological rejection have not been precisely defined. We have examined sequentially in vitro lymphocyte binding patterns in a kidne...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(95)80035-2

    authors: Tullius SG,Heemann UW,Zeilinger K,Azuma H,Tamatami T,Miyasaka M,Tilney NL

    更新日期:1995-06-01 00:00:00

  • Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation.

    abstract::We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2012.06.003

    authors: Remberger M,Persson M,Mattsson J,Gustafsson B,Uhlin M

    更新日期:2012-08-01 00:00:00

  • Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

    abstract::This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2020.101318

    authors: Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

    更新日期:2020-10-01 00:00:00

  • T and B cell crossmatching using three-colour flow cytometry.

    abstract::We have developed a highly sensitive method for the simultaneous crossmatching of T and B cells using three-colour flow cytometry. This method identifies T and B cell populations in a lymphocyte sample and analyses each for the presence of bound patient IgG alloantibodies. A fluorescein isothiocyanate conjugated rabbi...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(96)80018-9

    authors: Robson A,Martin S

    更新日期:1996-09-01 00:00:00

  • Impact of immunosuppressive therapy on brain derived cytokines after liver transplantation.

    abstract:BACKGROUND:While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the neuroimmune system, thereby, increasing the risk of neurodegeneration. Here, we measured the impact...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2019.101248

    authors: Dirks M,Pflugrad H,Tryc AB,Schrader AK,Ding X,Lanfermann H,Jäckel E,Schrem H,Beneke J,Barg-Hock H,Klempnauer J,Falk CS,Weissenborn K

    更新日期:2020-02-01 00:00:00

  • Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation.

    abstract:BACKGROUND:We recently reported that autoreactive antibody (Ab) against nuclear histone H1 had been identified as an immunosuppressive factor in a rat tolerogenic orthotopic liver transplantation (OLT) model. The present study aimed to determine whether the up-regulation of antihistone H1 Ab by histone H1 vaccination l...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2007.01.003

    authors: Nakano T,Goto S,Lai CY,Hsu LW,Ono K,Kawamoto S,Lin YC,Kao YH,Chiang KC,Ohmori N,Goto T,Sato S,Tu CH,Jawan B,Cheng YF,Chen CL

    更新日期:2007-04-01 00:00:00

  • The concept of "partial" clinical tolerance.

    abstract::The status of "partial" tolerance to organ allografts versus the status of complete tolerance is the main topic of this paper. Progress made in immunosuppression, particularly by use of various lymphocyte depleting agents for "induction therapy", seems to favor the subsequent development of T cells with suppressor/reg...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.trim.2004.05.002

    authors: Cortesini R,Suciu-Foca N

    更新日期:2004-09-01 00:00:00

  • De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed.

    abstract::Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transpl...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2014.10.001

    authors: Hart-Matyas M,Gareau AJ,Hirsch GM,Lee TD

    更新日期:2015-01-01 00:00:00

  • HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

    abstract:BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2018.11.007

    authors: Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

    更新日期:2019-04-01 00:00:00

  • Genetic modification of cold-preserved renal grafts using HSP70 or bcl-2 HVJ-liposome method.

    abstract:BACKGROUND:We tested the hypothesis that the best time for genetic modification is while the cell viability of the graft is reduced for long-term preservation. The hemagglutinating virus of Japan (HVJ)-liposome method, a nonviral gene transfer technique, was used with a luciferase gene to test the efficacy of protein i...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/S0966-3274(03)00002-9

    authors: Kita J,Kobayashi E,Hishinuma A,Kaneda Y

    更新日期:2003-01-01 00:00:00

  • T cells specific for viral antigens presented by HLA-Dw4 recognize DR13 on allogeneic cells: a possible mechanism for induction of rejection.

    abstract::Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(93)90005-s

    authors: Gjertsen HA,Lundin KE,Hansen T,Thorsby E

    更新日期:1993-01-01 00:00:00

  • Activation of PPARgamma enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes.

    abstract:BACKGROUND:Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a nuclear receptor that regulates the transcription of genes associated with lipid and glucose metabolism. Recently, it has been shown that PPARgamma modulates the activity of T cells, resulting in inhibition of T cell proliferation and IL-2 rel...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2007.03.003

    authors: Rampino T,Ranghino A,Guidetti C,Gregorini M,Soccio G,Marasà M,Libetta C,Guida G,De Amici M,Dal Canton A

    更新日期:2007-07-01 00:00:00

  • Comparative analysis of dendritic cells and anti-CD3/CD28 expanded regulatory T cells for application in transplantation.

    abstract::The containment of direct and indirect recognition of donor alloantigens by enhancement of the number and activity of regulatory T cells (Tregs) has been one of the promising approaches to achieve transplant tolerance. Two major methods, dendritic cell (DC) and anti-CD3/CD28 antibodies (Abs) have been introduced for e...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2009.07.004

    authors: Zeng M,Guinet E,Nouri-Shirazi M

    更新日期:2009-12-01 00:00:00