Current cellular immunological hurdles in pig-to-primate xenotransplantation.


:In this review, we summarize the work published over the last few years relative to cellular immunological hurdles encountered specifically in pig-to-primate xenotransplantation models. The works summarized here cover both the innate and adaptative cellular immune response as well as strategies to overcome them and consequently prevent xenograft rejection.


Transpl Immunol


Transplant immunology


Le Bas-Bernardet S,Blancho G




Has Abstract


2009-06-01 00:00:00














  • Impact of rituximab on the T-cell flow cytometric crossmatch.

    abstract::Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Doss SA,Mittal S,Daniel D

    更新日期:2021-02-01 00:00:00

  • Activation of PPARgamma enhances in vitro the immunosuppressive effect of cyclosporine on T lymphocytes.

    abstract:BACKGROUND:Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) is a nuclear receptor that regulates the transcription of genes associated with lipid and glucose metabolism. Recently, it has been shown that PPARgamma modulates the activity of T cells, resulting in inhibition of T cell proliferation and IL-2 rel...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Rampino T,Ranghino A,Guidetti C,Gregorini M,Soccio G,Marasà M,Libetta C,Guida G,De Amici M,Dal Canton A

    更新日期:2007-07-01 00:00:00

  • Preventive effects of syngeneic bone marrow transplantation on diabetic nephropathy in mice.

    abstract::Treatment with autologous bone marrow transplantation (ABMT) can change the natural history of diabetes in patients with new-onset Type 1 diabetes (T1D). Effects of syngeneic bone marrow transplantation (syn-BMT) on diabetic nephropathy were studied in streptozotocin-induced diabetic mice. Diabetic mice received sibli...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Ouyang J,Hu G,Wen Y,Zhang X

    更新日期:2010-02-01 00:00:00

  • FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.

    abstract::FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK...

    journal_title:Transplant immunology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vaessen LM,van Besouw NM,Mol WM,Ijzermans JN,Weimar W

    更新日期:2006-04-01 00:00:00

  • Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets, CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection.

    abstract::We investigated the dynamics of the CD4+ and CD8+ lymphocyte subsets, and the expression of activation markers in cardiac transplant recipients. We tested 132 peripheral blood samples from 62 cardiac transplant recipients using fluorescent staining and flow cytometry analysis. The results were correlated with histolog...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Creemers P,Brink J,Wainwright H,Moore K,Shephard E,Kahn D

    更新日期:2002-11-01 00:00:00

  • A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor.

    abstract::Immunisation against Human Leucocyte Antigens (HLA) can be caused by pregnancy, blood transfusion, or organ transplants. The HLA antibody status of a given patient significantly influences their access and waiting time to transplant. For some highly sensitised patients (HSP) there is hardly any suitable donor availabl...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: Mumford L,Fuggle SV,Martorell J,Slavcev A,Iniotaki A,Haasnoot GW,Heidt S,Claas FHJ

    更新日期:2021-02-01 00:00:00

  • Levels of peripheral T cell tolerance.

    abstract::The immune system is an adaptive defense system capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. This highly specific response is provided by T and B lymphocytes. The enormous diversity of the antigen-specific receptors on these cells is generated by random rearr...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Arnold B

    更新日期:2002-08-01 00:00:00

  • An alternative conditioning regimen for induction of specific skin graft tolerance across full major histocompatibility complex barriers.

    abstract::Previously, we developed a well-tolerated single-day protocol for induction of stable multilineage chimerism and permanent donor-specific tolerance across major histocompatibility complex (MHC) barriers, with preservation of the host's normal immune responses. In our murine model, recipient mice were treated with a si...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: de Vries-van der Zwan A,van der Pol MA,de Waal LP,Boog CJ

    更新日期:1998-09-01 00:00:00

  • Statins as immunomodulators.

    abstract::HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Mach F

    更新日期:2002-05-01 00:00:00

  • Human keratinocytes activate primed major and minor histocompatibility antigen specific Th cells in vitro.

    abstract::Keratinocytes are activated to express MHC class II and ICAM-1 molecules during cutaneous inflammatory reactions. It is controversial how the interaction between these 'nonprofessional' antigen presenting cells (APC) and infiltrating T cells affects the local inflammatory response. To address this issue we analyzed wh...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: de Bueger M,Bakker A,Goulmy E

    更新日期:1993-01-01 00:00:00

  • Immunosuppressant-induced cutaneous drug reactions in solid organ transplant recipients.

    abstract::Solid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifesta...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Miotto IZ,Souza BCE,Tyring SK,de Oliveira WRP

    更新日期:2021-02-01 00:00:00

  • Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction.

    abstract:OBJECTIVE:To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS:CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twe...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Xia Y,Deng J,Zhou Q,Shao X,Yang X,Sha M,Zou H

    更新日期:2018-06-01 00:00:00

  • Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients.

    abstract::Immunological monitoring of transplant recipients is an attractive concept. Cytokines provide an obvious focus for research, as they are central to the human immune response. This study aimed to identify cytokines whose sequential gene expression differentiated rejectors from non-rejectors immediately following renal ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Gibbs PJ,Tan LC,Sadek SA,Howell WM

    更新日期:2005-06-01 00:00:00

  • Immediate impact of COVID-19 on transplant activity in the Netherlands.

    abstract::The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, sc...

    journal_title:Transplant immunology

    pub_type: 社论


    authors: de Vries APJ,Alwayn IPJ,Hoek RAS,van den Berg AP,Ultee FCW,Vogelaar SM,Haase-Kromwijk BJJM,Heemskerk MBA,Hemke AC,Nijboer WN,Schaefer BS,Kuiper MA,de Jonge J,van der Kaaij NP,Reinders MEJ

    更新日期:2020-08-01 00:00:00

  • The role of alemtuzumab in facilitating maintenance immunosuppression minimization following solid organ transplantation.

    abstract::National registry data indicate a trend towards the incorporation of lymphocyte depletion antibody induction therapy into immunosuppressive regimens for solid organ transplantation. Depletional induction has been shown to reduce the risk of early acute rejection, but increase the risk of immune incompetence. As such, ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Agarwal A,Shen LY,Kirk AD

    更新日期:2008-11-01 00:00:00

  • 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes.

    abstract::Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Borg AJ,Kumagai-Braesch M,Möller E

    更新日期:1996-06-01 00:00:00

  • High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination.

    abstract::Pancreas grafts do not survive for lengthy periods, especially in a high-responder rat combination. Recent data indicated that a combined spleen/pancreas graft protects against acute graft rejection and induces donor-specific tolerance. In this study, we performed a combination spleen/pancreas transplantation using hi...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Sakuma Y,Uchida H,Nagai H,Kobayashi E

    更新日期:2001-10-01 00:00:00

  • Clinical significance of selective decline of donor-reactive IL-2-producing T lymphocytes after renal transplantation.

    abstract::Limiting dilution analysis technique was used to enumerate the circulating precursor frequency of donor and third-party-reactive helper T lymphocytes (HTLpf) in 28 renal allograft recipients before (pre-tx) and at three intervals (T1: 60-90 days, T2: 120-180 days, T3: 360-1620 days) after transplantation (post-tx). Tw...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Beik AI,Higgins RM,Lam FT,Morris AG

    更新日期:1997-06-01 00:00:00

  • Helper T-cell type 1 or type 2 function of xeno-MHC-restricted T-cell clones in a direct xenoantigen recognition.

    abstract::There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Iida Y,Iwata H,Mori Y,Takagi H,Nitta T,Kanetake K,Umeda Y,Hirose H

    更新日期:2003-04-01 00:00:00

  • Ex vivo and systemic transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of FK506 therapy prolongs islet graft survival.

    abstract::Adenovirus-mediated CTLA4Ig gene transfer has been reported to enhance graft survival in several rodent transplantation models. In this study, we investigated the efficacy of ex vivo and systemic transfer of the CTLA4Ig gene by adenoviral vectors in pancreatic islet allo-transplantation. Islet grafts from BN rats were...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Akamaru Y,Ito T,Uchikoshi F,Maeda A,Tori M,Kiyomoto T,Komoda H,Miao G,Matsuda H

    更新日期:2003-01-01 00:00:00

  • HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

    abstract:BACKGROUND:Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown. METHODS:A murine heterotopic tracheal transplantation model was used. Protein concentrations...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Takamori S,Shoji F,Okamoto T,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Takada K,Toyokawa G,Tagawa T,Maehara Y

    更新日期:2019-04-01 00:00:00

  • Association between transforming growth factor beta-1 +869T/C polymorphism and acute rejection of solid organ allograft: A meta-analysis and systematic review.

    abstract:BACKGROUND:Transforming growth factor beta-1(TGFB1) is involved in the acute rejection (AR) episodes of solid organ transplant recipients. However, results from published studies on the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk are conflicting and inconclusive. METHODS:PUBMED, EMBASE, ...

    journal_title:Transplant immunology

    pub_type: 杂志文章,meta分析,评审


    authors: Ge YZ,Yu P,Jia RP,Wu R,Ding AX,Li LP,Zhao Y,Feng YM,Gui ZL,Liao S

    更新日期:2014-03-01 00:00:00

  • Clinical utility of CD4+ function assessment (ViraCor-IBT ImmuKnow test) in lung recipients.

    abstract::The ImmuKnow assay measures cell-mediated immunity, quantifying ATP production from peripheral blood CD4+T-cells in solid-organ transplant patients who undergo immunosuppressive therapy. We aimed to measure functional immunity in lung transplant recipients and correlate Immuknow values with immunosuppression levels, p...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Piloni D,Magni S,Oggionni T,Benazzo A,Stella G,Scudeller L,Morosini M,Cova E,Meloni F

    更新日期:2016-07-01 00:00:00

  • Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.

    abstract::Induction and maintenance immunosuppression protocols with or without long-term steroid therapy in kidney transplant recipients are variable and are transplant center-specific. The aim of this prospective randomized pilot study was to compare 5-year outcomes in kidney recipients maintained on 4 different calcineurin i...

    journal_title:Transplant immunology

    pub_type: 杂志文章,随机对照试验


    authors: Anil Kumar MS,Irfan Saeed M,Ranganna K,Malat G,Sustento-Reodica N,Kumar AM,Meyers WC

    更新日期:2008-11-01 00:00:00

  • Immunomodulatory effects of mesenchymal stem cells involved in favoring type 2 T cell subsets.

    abstract::Graft-vs.-host disease (GVHD) caused by immunologic activated cells remains a real problem in human allogeneic hematopoetic stem cell transplantation. Mesenchymal stem cells (MSCs) play some important roles on immunomodulatory. We developed a parent-into-F1 model of acute GVHD to evaluate the mechanisms involved in im...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Lu X,Liu T,Gu L,Huang C,Zhu H,Meng W,Xi Y,Li S,Liu Y

    更新日期:2009-12-01 00:00:00

  • Effects of recombinant thrombomodulin therapy and soluble human leukocyte antigen-G levels during hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulat...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Nomura S,Ito T,Katayama Y,Ota S,Hayashi K,Fujita S,Satake A,Ishii K

    更新日期:2019-04-01 00:00:00

  • Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model.

    abstract:BACKGROUND:Blockade of costimulation signaling required for immune response, such as CD40/CD40L and CD28/B7, is a reasonable strategy to prevent rejection and in defined combinations may allow donor specific tolerance. Indeed, in rodents, costimulation blockade with CD28/B7 antagonists or with CD40Ig was able to induce...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Angin M,Poirier N,Dilek N,Le Guiner C,Toromanoff A,Blancher A,Cherel Y,Deschamps JY,Tillou X,Renaudin K,Minault D,Hervouet J,Blancho G,Vanhove B,Anegon I,Le Mauff B

    更新日期:2012-12-01 00:00:00

  • Why statin therapy may increase the risk for posttransplantation squamous cell carcinoma.

    abstract::We suggest that surveillance for squamous cell cancer might be particularly useful for transplant patients receiving statin therapy. We recommend that development of non melanoma skin cancer should be specified as a secondary endpoint in future large endpoint statin trials, and suggest that in transplant patients the ...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Mascitelli L,Pezzetta F,Goldstein MR

    更新日期:2010-08-01 00:00:00

  • An N-(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model.

    abstract::We investigated the immunosuppressive effects of the dihydroortate dehydrogenase (DHODH) inhibitor compounds ABR-222417 and ABR-224050 from Active Biotech (Sweden). We verified the inhibitory effects of these compounds on the proliferation of CD4(+) and CD8(+) T-cells in vivo by using superantigen staphylococcus enter...

    journal_title:Transplant immunology

    pub_type: 杂志文章


    authors: Chen J,Xia J,Axelsson B,Fritzson I,Ekberg H,Törngren M,Qi Z

    更新日期:2010-08-01 00:00:00

  • Embryonic stem cell transplantation for the treatment of myocardial infarction: immune privilege or rejection.

    abstract::Stem cell transplantation (SCT) has emerged to be an appealing tool for repair medicine. In the treatment of ischemic heart diseases, SCT will be of great help because it is capable of replacing scar with new myocardial tissue. Among the many candidate cell lines for SCT, embryonic stem cells (ESCs) have their unique ...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审


    authors: Yuan X,Zhang H,Wei YJ,Hu SS

    更新日期:2007-11-01 00:00:00