当前位置： SCI文献检索 > TRANSPLANT IMMUNOLOGY期刊下所有文献 > A novel MyD88 inhibitor attenuates allograft rejection after heterotopic tracheal transplantation in mice.

A novel MyD88 inhibitor attenuates allograft rejection after heterotopic tracheal transplantation in mice.

Abstract：

BACKGROUND:After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse model to examine the effects of a newtype of innate immune inhibitor, TJ-M2010-5. METHODS:Syngeneic tracheal grafts were transplanted heterotopically from C57BL/6 mice to C57BL/6 mice. Allografts from BALB/c mice were transplanted to C57BL/6 mice. The allograft recipients were treated with TJ-M2010-5, and anti-mouse CD154 (MR-1). The grafts were harvested at 7, 14, and 28 days and evaluated by histological and real-time RT-PCR analyses. RESULTS:In untreated allografts, almost all epithelial cells fell off at 7 days and tracheal occlusion reached a peak at 28 days. However, the loss of the epithelium and airway obstruction were significantly improved in mice treated with TJ-M2010-5 combined with MR-1. The relative mRNA expression levels of pro-inflammatory cytokines were upregulated in allogeneic tracheal grafts, and treatment with the two drugs reduced the production of pro-inflammatory cytokines and infiltration of inflammatory cells. CONCLUSIONS:In heterotopic tracheal transplantation models, TJ-M2010-5 combined with MR-1 could ameliorate the development of OB.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Yang M,Chen G,Zhang X,Ding Z,Miao Y,Yang Y,Chen ZK,Jiang F,Chang S,Zhou P

doi

10.1016/j.trim.2018.11.006

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

1-6

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(18)30049-2

journal_volume

53

pub_type

杂志文章

相关文献

TRANSPLANT IMMUNOLOGY文献大全
  • Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model.

    abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2014.03.002

    authors： Watson D,Zhang GY,Hu M,Wang YM,Fletcher J,Sartor M,Alexander SI

    更新日期：2014-05-01 00:00:00

  • The concept of "partial" clinical tolerance.

    abstract：:The status of "partial" tolerance to organ allografts versus the status of complete tolerance is the main topic of this paper. Progress made in immunosuppression, particularly by use of various lymphocyte depleting agents for "induction therapy", seems to favor the subsequent development of T cells with suppressor/reg...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.trim.2004.05.002

    authors： Cortesini R,Suciu-Foca N

    更新日期：2004-09-01 00:00:00

  • T and B cell crossmatching using three-colour flow cytometry.

    abstract：:We have developed a highly sensitive method for the simultaneous crossmatching of T and B cells using three-colour flow cytometry. This method identifies T and B cell populations in a lymphocyte sample and analyses each for the presence of bound patient IgG alloantibodies. A fluorescein isothiocyanate conjugated rabbi...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(96)80018-9

    authors： Robson A,Martin S

    更新日期：1996-09-01 00:00:00

  • Downregulation of Janus kinase 3 expression by small interfering RNA in rat composite tissue allotransplantation.

    abstract：:RNA interference (RNAi) has recently emerged as an efficient method to silence gene expression in mammalian cells by transfection of small interfering RNAs (siRNAs). The Janus kinase 3 (JAK3) is also pertinent to the development of a new immuno-suppressant. This study aimed to inhibit JAK3 expression using RNAi to det...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2009.02.004

    authors： Chang KP,Lai CH,Huang SH,Tai HT,Chang LL,Lin SD,Hwang SL,Lai CS

    更新日期：2009-05-01 00:00:00

  • Clinical significance of selective decline of donor-reactive IL-2-producing T lymphocytes after renal transplantation.

    abstract：:Limiting dilution analysis technique was used to enumerate the circulating precursor frequency of donor and third-party-reactive helper T lymphocytes (HTLpf) in 28 renal allograft recipients before (pre-tx) and at three intervals (T1: 60-90 days, T2: 120-180 days, T3: 360-1620 days) after transplantation (post-tx). Tw...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(97)80048-2

    authors： Beik AI,Higgins RM,Lam FT,Morris AG

    更新日期：1997-06-01 00:00:00

  • Murine dendritic cells that are resistant to maturation are unable to induce tolerance to allogeneic stem cells.

    abstract：:Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2006.03.001

    authors： Vanclée A,Schouten HC,Bos GM

    更新日期：2006-06-01 00:00:00

  • Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction.

    abstract：OBJECTIVE:To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS:CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twe...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2018.02.006

    authors： Xia Y,Deng J,Zhou Q,Shao X,Yang X,Sha M,Zou H

    更新日期：2018-06-01 00:00:00

  • Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients.

    abstract：:Gene polymorphisms of cytotoxic T lymphocyte associated antigen 4 (CTLA4) play an influential role in the graft rejection and long-term clinical outcome of organ transplantation. We investigated the associations of five CTLA4 single nucleotide polymorphisms (SNPs) (rs733618T/C, rs4553808A/G, rs5742909C/T, rs231775G/A,...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2012.02.005

    authors： Gao JW,Guo YF,Fan Y,Qiu JX,Bao ED,Liu Y,Qin Y,Zhang F

    更新日期：2012-06-01 00:00:00

  • Anti-CD20 antibody suppresses anti-HLA antibody formation in a HLA-A2 transgenic mouse model of sensitization.

    abstract：BACKGROUND:B cell depletion by anti-CD20 antibody is used in desensitization protocols and for treatment of antibody-mediated rejection (AMR). However, little is known about the efficacy and the mechanism(s) of action. METHODS:A mouse model of HLA sensitization was used to study the effectiveness of anti-CD20 treatmen...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.05.004

    authors： Wu GD,He Y,Chai NN,Toyoda M,Dunn R,Kehry MR,Klein AS,Jordan SC

    更新日期：2008-07-01 00:00:00

  • Antibody-mediated activation of the classical complement pathway in xenograft rejection.

    abstract：:Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...

    journal_title：Transplant immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0966-3274(02)00042-4

    authors： Roos A,Daha MR

    更新日期：2002-05-01 00:00:00

  • Fas Ligand gene transfer enhances the survival of tissue-engineered chondrocyte allografts in mini-pigs.

    abstract：BACKGROUND AND PURPOSE:Since the Fas/Fas Ligand (FasL) interaction has been recognized as an apoptotic pathway, it eliminates the activated T cells and promotes the survival of grafts. In this study, the effect of FasL transfection of pig chondrocytes on allogeneic transplantation was examined in vitro and in vivo. ME...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.02.001

    authors： Xie GH,Wang SJ,Wang Y,Zhang Y,Zhang HZ,Jin S,Wang QF,Liu ZC,Ge HL

    更新日期：2008-05-01 00:00:00

  • Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4.

    abstract：:Administration of anti-intercellular adhesion molecule (ICAM)-1 monoclonal antibody (mAb) plus anti-lymphocyte function associated antigen (LFA)-1 mAb induces tolerance in murine cardiac transplantation, while anti-vascular cell adhesion molecule (VCAM)-1 mAb plus anti-very late antigen (VLA)-4 mAb administration prol...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(99)80021-5

    authors： Suzuki J,Isobe M,Izawa A,Takahashi W,Yamazaki S,Okubo Y,Amano J,Sekiguchi M

    更新日期：1999-03-01 00:00:00

  • Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.

    abstract：:Induction and maintenance immunosuppression protocols with or without long-term steroid therapy in kidney transplant recipients are variable and are transplant center-specific. The aim of this prospective randomized pilot study was to compare 5-year outcomes in kidney recipients maintained on 4 different calcineurin i...

    journal_title：Transplant immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.trim.2008.08.005

    authors： Anil Kumar MS,Irfan Saeed M,Ranganna K,Malat G,Sustento-Reodica N,Kumar AM,Meyers WC

    更新日期：2008-11-01 00:00:00

  • MiR-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase.

    abstract：OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101320

    authors： Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

    更新日期：2020-10-01 00:00:00

  • Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.

    abstract：:Introduction of MHC class I Kb cDNA via recombinant retrovirus into B10.AKM (Kk) bone marrow cells (BMC) has been shown to confer specific hyporesponsiveness to B10.MBR (Kb) allogeneic skin grafts in lethally irradiated B10.AKM recipients of the transduced syngeneic BMC. We have recently developed a nonmyeloablative c...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(96)80044-x

    authors： Hayashi H,LeGuern C,Sachs DH,Sykes M

    更新日期：1996-03-01 00:00:00

  • T cells specific for viral antigens presented by HLA-Dw4 recognize DR13 on allogeneic cells: a possible mechanism for induction of rejection.

    abstract：:Alloreactivity probably involves T cell recognition of peptides bound to allogeneic HLA molecules. In order to study whether T cells recognizing common viral antigens presented by self HLA molecules also recognize some allogeneic HLA molecules we generated T lymphocyte clones (TLC) specific for herpes simplex virus (H...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(93)90005-s

    authors： Gjertsen HA,Lundin KE,Hansen T,Thorsby E

    更新日期：1993-01-01 00:00:00

  • Unresponsiveness to human leukocytes in immunosuppressed mice by combined donor-derived human transferrin and antigens.

    abstract：:Previous work on the facilitation of xenogeneic and allogeneic bone marrow engraftment in irradiated mice and dogs with transferrins allowed the development of a model for induction of an apparently durable state of immunological unresponsiveness or 'tolerance' in chemically immunosuppressed mice. The system is based ...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/s0966-3274(96)80051-7

    authors： Pierpaoli W,Lesnikov VA,Lesnikova MP,Arrighi S,Bardotti A

    更新日期：1996-12-01 00:00:00

  • Short-term anti-CD25 monoclonal antibody treatment and neogenetic CD4(+)CD25(high) regulatory T cells in kidney transplantation.

    abstract：:CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...

    journal_title：Transplant immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.trim.2008.01.005

    authors： Wang Z,Xiao L,Shi BY,Qian YY,Bai HW,Chang JY,Cai M

    更新日期：2008-04-01 00:00:00

  • Genetic modification of cold-preserved renal grafts using HSP70 or bcl-2 HVJ-liposome method.

    abstract：BACKGROUND:We tested the hypothesis that the best time for genetic modification is while the cell viability of the graft is reduced for long-term preservation. The hemagglutinating virus of Japan (HVJ)-liposome method, a nonviral gene transfer technique, was used with a luciferase gene to test the efficacy of protein i...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(03)00002-9

    authors： Kita J,Kobayashi E,Hishinuma A,Kaneda Y

    更新日期：2003-01-01 00:00:00

  • Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.

    abstract：:The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1mg/kg/day, day 0-5) and TAK-779 (10mg/kg/day, day 0-10). Graft surviv...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.04.003

    authors： Takama Y,Miyagawa S,Yamamoto A,Firdawes S,Ueno T,Ihara Y,Kondo A,Matsunami K,Otsuka H,Fukuzawa M

    更新日期：2011-07-01 00:00:00

  • Impact of rituximab on the T-cell flow cytometric crossmatch.

    abstract：:Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101360

    authors： Doss SA,Mittal S,Daniel D

    更新日期：2021-02-01 00:00:00

  • Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice.

    abstract：BACKGROUND:Our laboratory has demonstrated that xenogeneic porcine thymus tissue grafted in thymectomized (ATX) and T cell-depleted mice induces donor-specific tolerance. Recipient thymectomy is essential for the success of tolerance induction. In contrast, studies in pigs grafted with non-vascularized allogeneic class...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2005.04.004

    authors： Rodríguez-Barbosa JI,Haller GW,Zhao G,Sachs DH,Sykes M

    更新日期：2005-10-01 00:00:00

  • Effect of blocking the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a rat small intestinal transplantation model.

    abstract：:The effect of blocking the expression of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in a graft by an antibody, and immunohistochemical changes in the graft were monitored, using a rat small intestinal transplantation model. Dark Agouti (DA) rat small intestines were heterotopically transplanted into Lew...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2007.01.011

    authors： Ihara Y,Miyagawa S,Hasegawa T,Kimura T,Xu H,Fukuzawa M

    更新日期：2007-06-01 00:00:00

  • Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation.

    abstract：:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2012.06.003

    authors： Remberger M,Persson M,Mattsson J,Gustafsson B,Uhlin M

    更新日期：2012-08-01 00:00:00

  • Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.

    abstract：:Regulatory T cells, especially CD4(+)CD25(+) regulatory T cells are critical regulators of immune tolerance in humans and mice. Mice with humanized immunity have been developed by various transplantation strategies of human tissues or cells related to immunity, which are being extensively applied in biomedical researc...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2011.08.003

    authors： Duan K,Zhang B,Zhang W,Zhao Y,Qu Y,Sun C,Zhao Y

    更新日期：2011-12-01 00:00:00

  • Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

    abstract：:This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2020.101318

    authors： Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

    更新日期：2020-10-01 00:00:00

  • Early onset of rejection in concordant hamster xeno hearts display signs of necrosis, but not apoptosis, correlating to the phosphocreatine concentration.

    abstract：BACKGROUND:The importance of apoptosis contra necrosis for ischemia/reperfusion (RP) and acute rejection in concordant rodent xenotransplantation is largely unknown. We explored this question by comparing rodent allo and concordant xenotransplants with different morphological methods to detect apoptosis and biochemical...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/S0966-3274(03)00018-2

    authors： Lukes DJ,Tivesten A,Wilton J,Lundgren A,Rakotonirainy O,Kjellström C,Isgaard J,Karlsson-Parra A,Soussi B,Olausson M

    更新日期：2003-10-01 00:00:00

  • T cell receptor (beta chain) transgenic mice have selective deficits in gamma delta T cell subpopulations.

    abstract：:TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta cells and the defective...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/0966-3274(94)90063-9

    authors： Rimm IJ,Fruman DA,Abhyankar S,Sakamoto H,Orme IM,Milstone D,Seidman JG,Ferrara JL

    更新日期：1994-09-01 00:00:00

  • Long-lasting donor passenger leukocytes after hepatic and intestinal transplantation in rats.

    abstract：BACKGROUND:Donor passenger leukocytes (DPLs) that migrate after organ transplantation stimulate the recipient immune system and normally cause rejection and graft vs. host reaction. However, DPLs also contribute to the unresponsiveness to the donor organ. The quantity and quality of these migrating cells are considered...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2003.10.001

    authors： Inoue S,Tahara K,Kaneko T,Ajiki T,Takeda S,Sato Y,Hakamata Y,Murakami T,Takahashi M,Kaneko M,Kobayashi E

    更新日期：2004-01-01 00:00:00

  • Prevention of calcineurin inhibitor nephrotoxicity in renal transplantation.

    abstract：:Calcineurin inhibitors (CNI) cyclosporine (Csa) and tacrolimus (Tac) are now first intention immunosuppressive drugs in renal transplantation. However, although these treatments are effective for preventing allograft rejection, they are nephrotoxic: they can cause chronic renal dysfunction and degradation of renal gra...

    journal_title：Transplant immunology

    pub_type： 杂志文章

    doi：10.1016/j.trim.2008.09.002

    authors： Jacquet A,Francois H,Frangie C,Ahmad L,Charpentier B,Durrbach A

    更新日期：2008-11-01 00:00:00