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Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation.

Abstract：

:We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte globulin (ATG) at a total dose of 6 or 8mg/kg as part of the conditioning. No correlation between the dose of ATG and serum r-ATG levels post UCBT was found. The cumulative incidence of acute GVHD grades III-IV in patients given the 6 and 8mg/kg ATG dose was 15% and 13% (ns), respectively. Patients with r-ATG≤40μg/mL 11days after UCBT (n=19) had a higher incidence of grades III-IV acute GVHD (32% vs. 0%, p<0.01), higher TRM (69% vs. 7%, p=0.005), less relapse (17% vs. 82%, p<0.01) but similar relapse-free survival (RFS) (10% vs. 18%, p=0.4) compared to those with r-ATG>40μg/mL (n=17). Low serum-levels of r-ATG early after transplantation seem to be a strong predictor for acute GVHD grades III-IV, TRM and a low incidence of relapse in patients treated with thymoglobulin before unrelated donor UCBT.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Remberger M,Persson M,Mattsson J,Gustafsson B,Uhlin M

doi

10.1016/j.trim.2012.06.003

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

59-62

issue

1

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(12)00043-3

journal_volume

27

pub_type

杂志文章

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