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Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model.

Abstract：

:Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n=5) no BD, 2h ventilation; BD (n=5) BD and 2h ventilation; BD and rATG: BD, 2h ventilation, rATG (10mg/kg) after BD diagnosis. Histopathological damage scores were based on neutrophil infiltration, airway epithelial cell damage, interstitial edema, hyaline membrane formation, and pulmonary hemorrhage (lungs); neutrophil infiltration and interstitial edema (heart); Park score (bowel). Lung damage was significantly lower in BD+rATG group: V 5 ± 1.6; BD 11.25 ± 0.5, BD+rATG 6.5 ± 1.9 (p<0.01). Heart: V 2.0 ± 0.81; BD 4.75 ± 1.25 and BD+rATG 3.5 ± 1.7 (p>0.05). Small bowel: BD 2.25 ± 0.96 vs. BD+rATG 1.00 ± 1.15 (n.s.). Histological damage amelioration in lung and attenuation tendency in heart and small bowel encourages research of cytoprotective strategies to improve organ viability.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Cicora F,Stringa P,Guerrieri D,Vásquez D,Toniolo F,Roberti J,Raimondi C

doi

10.1016/j.trim.2013.04.002

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

203-5

issue

4

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(13)00021-X

journal_volume

28

pub_type

杂志文章

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