Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation.

Abstract:

BACKGROUND:Endothelial microparticles (EMPs) are membrane vesicles shed from endothelial cell in response to injury, activation or apoptosis. Kidney transplantation (KTx) is the treatment of choice for patients with end stage kidney disease (ESKD). The aim of this study was to analyze changes in EMP and serum creatinine (SCr) in patients following KTx. METHODS:Blood was periodically collected from patients before (pre-KTx) and after KTx for two months. EMPs were identified as CD31(+)/CD42b(-) microparticles and quantified by fluorescence-activated cell scanning. RESULTS:This study included 213 KTx, 14 kidney/pancreas (KPTx) recipients and 60 healthy donors prior to donation. The recipients were divided into 5 groups based on the cause of ESKD. No differences in the quantity of circulating EMP were seen in the pre-KPTx or KTx recipient sera and healthy donor sera. Patients with ESKD secondary to diabetes mellitus, obstructive/inherited kidney disease and autoimmune disease had a decrease in both circulating EMP and SCr by day 60 after KTx. CONCLUSION:Reduction in both circulating EMP and SCr was seen after kidney KTx in patients with selective ESKD.

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Qamri Z,Pelletier R,Foster J,Kumar S,Momani H,Ware K,Von Visger J,Satoskar A,Nadasdy T,Brodsky SV

doi

10.1016/j.trim.2014.06.006

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

60-4

issue

2

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(14)00049-5

journal_volume

31

pub_type

杂志文章
  • Alpha-galactosyl antibody redistributes alpha-galactosyl at the surface of pig blood and endothelial cells.

    abstract::The interaction of antibodies with cell surface antigens may induce redistribution of immune complexes, followed by antigen depletion, with increased resistance to injurious effect of antibody and complement (antigenic modulation). Human natural antibodies to Gal alpha 1,3Gal beta 1,4GlcNAc-R (alpha Gal) epitopes expr...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(99)80026-4

    authors: Maruyama S,Cantu E3rd,Pernis B,Galili U,Godman G,Stern DM,Andres G

    更新日期:1999-06-01 00:00:00

  • Eosinophils in acute renal allograft rejection.

    abstract::Tissue eosinophils have been previously implicated in allograft rejection and graft loss. The aim of this study was to evaluate the role of eosinophils in acute renal allograft rejection. Data from 71 patients with 114 renal biopsies with acute allograft rejection were compared with those from 26 controls. The median ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(94)90076-0

    authors: Hongwei W,Nanra RS,Stein A,Avis L,Price A,Hibberd AD

    更新日期:1994-01-01 00:00:00

  • Manipulation of skin graft rejection in alloimmune mice by anti-VCAM-1:VLA-4 but not anti-ICAM-1:LFA-1 monoclonal antibodies.

    abstract::C3H mice were immunized by repeated skin grafting with B10.BR tail skin. Ten days after the last immunization mice received 100 micrograms (intravenously) of a variety of different monoclonal antibodies (mAbs: anti-ICAM-1, -LFA-1, -VCAM-1, -VLA-4), alone or in combination, followed by further B10.BR skin grafts. Contr...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/0966-3274(95)80007-7

    authors: Gorcyznski RM,Chung S,Fu XM,Levy G,Sullivan B,Chen Z

    更新日期:1995-03-01 00:00:00

  • Levels of peripheral T cell tolerance.

    abstract::The immune system is an adaptive defense system capable of specifically recognizing and eliminating an apparently limitless variety of foreign invaders. This highly specific response is provided by T and B lymphocytes. The enormous diversity of the antigen-specific receptors on these cells is generated by random rearr...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-3274(02)00056-4

    authors: Arnold B

    更新日期:2002-08-01 00:00:00

  • Natural anti-galactose alpha1,3 galactose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts.

    abstract::Naturally occurring antibodies to the galactose alpha1,3 galactose (alpha gal) epitope expressed on xenogeneic grafts are a major barrier to organ transplantation in humans. Porcine small intestinal submucosa (SIS) expresses the alpha gal epitope and is currently being used as a bioscaffold for tissue remodeling. To e...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(01)00044-2

    authors: Raeder RH,Badylak SF,Sheehan C,Kallakury B,Metzger DW

    更新日期:2002-06-01 00:00:00

  • Signal transduction and co-stimulatory pathways.

    abstract::Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular cues that elicit complex intracellular biochemical signals. Essential molecules involved in signal transduction from im...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-3274(02)00009-6

    authors: Kiefer F,Vogel WF,Arnold R

    更新日期:2002-05-01 00:00:00

  • Monoclonal anti-D development programme.

    abstract::Administration of anti-D immunoglobulin to D- women after delivery of a D+ infant has dramatically reduced the number of immunised women and cases of haemolytic disease of the fetus and newborn. The use of monoclonal anti-D might alleviate some of the pressures on maintaining adequate supplies of plasma sourced anti-D...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-3274(02)00066-7

    authors: Kumpel BM

    更新日期:2002-08-01 00:00:00

  • Preventive effects of syngeneic bone marrow transplantation on diabetic nephropathy in mice.

    abstract::Treatment with autologous bone marrow transplantation (ABMT) can change the natural history of diabetes in patients with new-onset Type 1 diabetes (T1D). Effects of syngeneic bone marrow transplantation (syn-BMT) on diabetic nephropathy were studied in streptozotocin-induced diabetic mice. Diabetic mice received sibli...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2009.12.003

    authors: Ouyang J,Hu G,Wen Y,Zhang X

    更新日期:2010-02-01 00:00:00

  • Antibody-mediated activation of the classical complement pathway in xenograft rejection.

    abstract::Transplant rejection is a multifactorial process involving complex interactions between components of the innate and the acquired immune system. In view of the shortage of donor organs available for transplantation, xenotransplantation of pig organs into man has been considered as a potential solution. However, in com...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-3274(02)00042-4

    authors: Roos A,Daha MR

    更新日期:2002-05-01 00:00:00

  • Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients.

    abstract::The myeloid-related proteins 8 and 14 exist as a dimeric complex (MRP 8/14) and serve as early and highly specific markers for inflammatory processes, such as allograft rejection and non-viral (bacterial or fungal) infections. An elevated procalcitonin (PCT) concentration in serum also serves as a diagnostic indicator...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2007.10.004

    authors: Jung DY,Park JB,Lee EN,Lee HA,Joh JW,Kwon CH,Ki CS,Lee SY,Kim SJ

    更新日期:2008-02-01 00:00:00

  • Statins as immunomodulators.

    abstract::HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-3274(02)00030-8

    authors: Mach F

    更新日期:2002-05-01 00:00:00

  • Concordance and discordance in anti-HLA antibody testing.

    abstract:BACKGROUND:Correct identification of the specificity of antibodies directed against HLA using single antigen Luminex beads (SALB) is essential in current HLA laboratory practice for transplantation. The aim of this study was to investigate the magnitude of concordance and discordance among laboratories in testing for a...

    journal_title:Transplant immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.trim.2014.10.003

    authors: Israeli M,Pollack MS,Shaut CA,Halpin A,DiPaola NR,Youngs D,Saidman SL,ASHI Proficiency Testing Program.

    更新日期:2015-01-01 00:00:00

  • Studies of innate immune systems against human cells.

    abstract:BACKGROUND:Pigs are frequently used as animal models for experiments in the surgical field, including allo- and xeno-transplantation. Regeneration studies, including studies dealing with human- and monkey-induced pluripotent stem cells (iPSC), have gradually progressed, with pigs sometimes being used as the scaffold. H...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2016.12.002

    authors: Sakai R,Kitano E,Maeda A,Lo PC,Eguchi H,Watanabe M,Nagashima H,Okuyama H,Miyagawa S

    更新日期:2017-02-01 00:00:00

  • Murine dendritic cells that are resistant to maturation are unable to induce tolerance to allogeneic stem cells.

    abstract::Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2006.03.001

    authors: Vanclée A,Schouten HC,Bos GM

    更新日期:2006-06-01 00:00:00

  • Short-term anti-CD25 monoclonal antibody treatment and neogenetic CD4(+)CD25(high) regulatory T cells in kidney transplantation.

    abstract::CD4(+)CD25(high) T cells named regulatory T (Treg) cells are generated and play a key role in the induction and maintenance of transplant tolerance in organ recipients. Interleukin-2 (IL-2) enhance the development of effector cells and is essential for generation of Treg cells. The effect of the anti-CD25 monoclonal a...

    journal_title:Transplant immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.trim.2008.01.005

    authors: Wang Z,Xiao L,Shi BY,Qian YY,Bai HW,Chang JY,Cai M

    更新日期:2008-04-01 00:00:00

  • Do NK-cell receptors and alloreactivity affect solid organ transplantation?

    abstract::Although natural killer cells lyse targets without pre-sensitization, and in an MHC-unrestricted manner, they can also respond to healthy allogeneic cells of different MHC type. Such alloreactivity is a consequence of NK cells using clonally distributed, inhibitory MHC class I receptors to achieve tolerance to healthy...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.trim.2006.09.022

    authors: Vilches C,Parham P

    更新日期:2006-12-01 00:00:00

  • New aspect of immunosuppressive treatment in liver transplantation. How could you induce tolerance in liver transplantation?

    abstract::New immunosuppressive strategies have improved short- and long-term graft survival. The current aim is to decrease the intensity of the immunosuppressive regimen, in an attempt to limit side effects and the direct toxicity of calcineurin inhibitor (CNI) for kidney function. We describe here current experience in liver...

    journal_title:Transplant immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.trim.2006.11.007

    authors: Beaudreuil S,Samuel D,Rouas-Freiss N,Durrbach A

    更新日期:2007-02-01 00:00:00

  • mir-155 expression is downregulated in kidney transplant patients with human cytomegalovirus infection.

    abstract::MicroRNAs are small, noncoding RNAs that control expression of target genes through inhibiting protein translation or inducing degradation of mRNA transcripts of target genes. According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of mult...

    journal_title:Transplant immunology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.trim.2017.06.002

    authors: Bergallo M,Gambarino S,Montanari P,Daprà V,Rassu M,Galliano I,Ravanini P

    更新日期:2017-08-01 00:00:00

  • Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets, CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection.

    abstract::We investigated the dynamics of the CD4+ and CD8+ lymphocyte subsets, and the expression of activation markers in cardiac transplant recipients. We tested 132 peripheral blood samples from 62 cardiac transplant recipients using fluorescent staining and flow cytometry analysis. The results were correlated with histolog...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(02)00072-2

    authors: Creemers P,Brink J,Wainwright H,Moore K,Shephard E,Kahn D

    更新日期:2002-11-01 00:00:00

  • Elevated intragraft expression of innate immunity and cell death-related markers is a risk factor for adverse graft outcome.

    abstract:BACKGROUND:Molecules of the innate immune response are increasingly recognized as important mediators in allograft injury during and after kidney transplantation. We therefore aimed to establish the relationship between the expression of these genes at implantation, during an acute rejection (AR) and on graft outcome. ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2018.02.009

    authors: Yang J,Snijders MLH,Haasnoot GW,van Kooten C,Mallat M,de Fijter JW,Clahsen-van Groningen MC,Claas FHJ,Eikmans M

    更新日期:2018-06-01 00:00:00

  • Effects of different serum-levels of ATG after unrelated donor umbilical cord blood transplantation.

    abstract::We determined total rabbit-IgG (r-ATG) levels in serum samples before (day 0) and after (day 11 and day 25) unrelated donor umbilical cord blood transplantation (UCBT). Most patients (27/41) suffered from a haematological malignancy. There were 25 children and 16 adults. All patients received rabbit anti-thymocyte glo...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2012.06.003

    authors: Remberger M,Persson M,Mattsson J,Gustafsson B,Uhlin M

    更新日期:2012-08-01 00:00:00

  • CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

    abstract:BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2018.04.003

    authors: van der Heiden PLJ,van Egmond HM,Veld SAJ,van de Meent M,Eefting M,de Wreede LC,Halkes CJM,Falkenburg JHF,Marijt WAF,Jedema I

    更新日期:2018-08-01 00:00:00

  • Isogeneic MSC application in a rat model of acute renal allograft rejection modulates immune response but does not prolong allograft survival.

    abstract::Application of mesenchymal stromal cells (MSCs) has been proposed for solid organ transplantation based on their potent immuno-modulatory effects in vitro and in vivo. We investigated the potential of MSCs to improve acceptance of kidney transplants in an MHC-incompatible rat model including isogeneic kidney transplan...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2013.08.004

    authors: Koch M,Lehnhardt A,Hu X,Brunswig-Spickenheier B,Stolk M,Bröcker V,Noriega M,Seifert M,Lange C

    更新日期:2013-12-01 00:00:00

  • Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism.

    abstract::Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2009.03.002

    authors: Lobashevsky AL,Manwaring JE,Travis MM,Nord BL,Higgins NG,Serov YA,Arnoff TS,Hommel-Berrey GA,Goggins WC,Taber TE,Carter CB Sr,Smith DS,Wozniak TC,O'Donnell JA,Turrentine MW

    更新日期:2009-07-01 00:00:00

  • Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.

    abstract::This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2020.101318

    authors: Grubic Z,Burek Kamenaric M,Kljajic J,Stingl Jankovic K,Maskalan M,Zunec R

    更新日期:2020-10-01 00:00:00

  • Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.

    abstract::Introduction of MHC class I Kb cDNA via recombinant retrovirus into B10.AKM (Kk) bone marrow cells (BMC) has been shown to confer specific hyporesponsiveness to B10.MBR (Kb) allogeneic skin grafts in lethally irradiated B10.AKM recipients of the transduced syngeneic BMC. We have recently developed a nonmyeloablative c...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/s0966-3274(96)80044-x

    authors: Hayashi H,LeGuern C,Sachs DH,Sykes M

    更新日期:1996-03-01 00:00:00

  • MiR-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase.

    abstract:OBJECTIVE:Acute rejection is a major cause of morbidity and mortality after solid organ transplantation. Therefore, optimizing treatment strategies and improving curative effect is urgent and necessary. Reliable biomarkers for acute rejection and the underlying molecular mechanisms remain to be determined. METHODS:In ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2020.101320

    authors: Li C,Wang X,Yuan F,Zhao Z,Zhang B,Zhang J,Li W,Liu T

    更新日期:2020-10-01 00:00:00

  • Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model.

    abstract:BACKGROUND:Mesenchymal stem cells (MSCs) can be used for immunomodulation therapy after solid organ transplantation. Here, we focus on the immunoregulatory potential of combination therapies of MSCs and classic pharmacotherapy to mediate acceptance of solid organ grafts. METHODS:To determine which drugs influence the ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2011.06.002

    authors: Eggenhofer E,Renner P,Soeder Y,Popp FC,Hoogduijn MJ,Geissler EK,Schlitt HJ,Dahlke MH

    更新日期:2011-09-01 00:00:00

  • Suppression of human macrophage-mediated cytotoxicity by transgenic swine endothelial cell expression of HLA-G.

    abstract:BACKGROUND:Xenotransplantation is an appealing alternative to human allotransplantation because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular rejection by the innate immune system, comprised of NK cells, monocytes, and macrophages. In this study the inhibitory function of HLA-G1, a ...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2014.12.004

    authors: Esquivel EL,Maeda A,Eguchi H,Asada M,Sugiyama M,Manabe C,Sakai R,Matsuura R,Nakahata K,Okuyama H,Miyagawa S

    更新日期:2015-03-01 00:00:00

  • Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction.

    abstract:INTRODUCTION:Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE...

    journal_title:Transplant immunology

    pub_type: 杂志文章

    doi:10.1016/j.trim.2007.06.002

    authors: Tambyraja AL,Mitchell R,Driscoll PJ,Deans C,Parks RW,Rahman I,Megson IL

    更新日期:2007-11-01 00:00:00