KIT and melanoma predisposition in pigs: sequence variants and association analysis.


:KIT mutations have been detected in different cancer subtypes, including melanoma. The gene also has been extensively studied in farm animals for its prominent role in coat color. The present work aimed at detecting KIT variants in a porcine model of cutaneous melanoma, the melanoblastoma-bearing Libechov Minipig (MeLiM). By sequencing exons and intron borders, 36 SNPs and one indel were identified. Of 10 coding SNPs, three were non-synonymous mutations, likely to affect the protein conformation. A promising variant, located in exon 19 (p.Val870Ala), was genotyped in a MeLiM × Duroc cross, and an association analysis was conducted on several melanoma-related traits. This variant showed a significant association with melanoma development, tumor ulceration and cutaneous invasion. In conclusion, although the KIT gene would not be a major causal gene for melanoma development in pig, its genetic variation could be influencing this trait.


Anim Genet


Animal genetics


Fernández-Rodríguez A,Estellé J,Blin A,Muñoz M,Créchet F,Demenais F,Vincent-Naulleau S,Bourneuf E




Has Abstract


2014-06-01 00:00:00












  • Sequence analysis of MHC class I alpha 2 domain exon variants in one diploid and two haploid Atlantic salmon pedigrees.

    abstract::Genetic diversity in the second domain exon of Atlantic salmon (Salmo salar) major histocompatibility complex (Mhc) class I was investigated in two dams and nine of their haploid offspring by means of polymerase chain reaction (PCR) and DNA sequence analysis. A similar study was also performed on nine diploid offsprin...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Grimholt U,Olsaker I,Lingaas F,Lie O

    更新日期:1997-12-01 00:00:00

  • Genetic analysis of erythrocyte superoxide dismutase polymorphism in the genus Cervus.

    abstract::A study of erythrocyte superoxide dismutase in Cervus dama, Cervus elaphus, Cervus nippon and Cervus elaphus x Cervus nippon hybrids has revealed a polymorphism of this enzyme system in Cervus elaphus as well as in the hybrid population. Genetic analysis suggests that this enzyme system is controlled by one gene locus...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Herzog S

    更新日期:1990-01-01 00:00:00

  • Association between ovocalyxin-32 gene haplotypes and eggshell quality traits in an F2 intercross between two chicken lines divergently selected for eggshell strength.

    abstract::Broken and cracked eggshells contribute significantly to economic losses in the egg production industry. We previously identified ovocalyxin-32 as a potential gene influencing eggshell traits, by analysing an intercross between two parent lines developed from the same founder population by a two-way selection for eggs...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Takahashi H,Sasaki O,Nirasawa K,Furukawa T

    更新日期:2010-10-01 00:00:00

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    abstract::We tested 174 bovine microsatellite primer pairs for use in a primitive breed of sheep and two species of deer. Of 173 markers, 127 (73.4%) gave a product in Soay sheep (Ovis aries) of which 54 (42.5%) were polymorphic. One hundred and twenty-nine of 174 (74.1%) markers gave a product in red deer (Cervus elaphus) of w...

    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1998-08-01 00:00:00

  • Transcriptome profile analysis of porcine adipose tissue by high-throughput sequencing.

    abstract::Novel high-throughput deep sequencing technology has dramatically changed the study of the functional complexity of transcriptomes. Here, we report the first use of this technology for analysing the wide range of transcriptional changes in porcine adipose tissue from different breeds and different growth phases in a m...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Li XJ,Yang H,Li GX,Zhang GH,Cheng J,Guan H,Yang GS

    更新日期:2012-04-01 00:00:00

  • Two new sheep haemoglobins, one of which is replaced by haemoglobin C in anaemia.

    abstract::Two new haemoglobin variants, provisionally named Hb G and Hb H, were found during a survey of 295 Welsh Mountain cross-bred sheep. Both haemoglobins appear to be beta chain variants controlled by genes allelic to those for the common forms Hb A and Hb B. Studies on an anaemic Hb AH and an Hb AG type sheep showed that...

    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1990-01-01 00:00:00

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    abstract::Polymerase chain reaction (PCR) primers specific to exon 2 of the bovine lymphocyte antigen (BoLA)-DRB3 gene were successfully used to amplify the equivalent region in 469 American bison (Bison bison). In domestic cattle, alleles of DRB3 are assigned through a restriction fragment length polymorphism (RFLP) analysis o...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Morris BG,Spencer MC,Stabile S,Dodd JN

    更新日期:1994-06-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1992-01-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Cao H,Robinson JA,Jiang Z,Melville JS,Golovan SP,Jones MW,Verrinder Gibbins AM

    更新日期:2004-10-01 00:00:00

  • Resistance to malignant catarrhal fever in American bison (Bison bison) is associated with MHC class IIa polymorphisms.

    abstract::The Rhadinovirus ovine herpesvirus-2 (OvHV-2) is the most common causative agent of malignant catarrhal fever (MCF) in clinically susceptible ruminants including cattle and bison. American bison (Bison bison) are highly susceptible to clinical MCF. Nevertheless, approximately 20% of bison on ranches or in feedlots bec...

    journal_title:Animal genetics

    pub_type: 杂志文章


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  • A non-coding regulatory variant in the 5'-region of the MITF gene is associated with white-spotted coat in Brown Swiss cattle.

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:2019-02-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:2008-12-01 00:00:00

  • Quantitative trait loci for body growth and sex determination in the hermaphrodite teleost fish Sparus aurata L.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Loukovitis D,Sarropoulou E,Batargias C,Apostolidis AP,Kotoulas G,Tsigenopoulos CS,Chatziplis D

    更新日期:2012-12-01 00:00:00

  • A search for associations between major histocompatibility complex restriction fragment length polymorphism bands and resistance to Haemonchus contortus infection in sheep.

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1993-08-01 00:00:00

  • Parentage testing of dogs using variants of blood proteins: description of five new plasma protein polymorphisms.

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1996-04-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Noce A,Amills M,Manunza A,Muwanika V,Muhangi D,Aliro T,Mayega J,Ademun R,Sànchez A,Egbhalsaied S,Mercadé A,Masembe C

    更新日期:2015-08-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章,评审


    authors: Peripolli E,Munari DP,Silva MVGB,Lima ALF,Irgang R,Baldi F

    更新日期:2017-06-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Herrero-Medrano JM,Megens HJ,Crooijmans RP,Abellaneda JM,Ramis G

    更新日期:2013-06-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:2006-08-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Takahashi H,Awata T,Yasue H

    更新日期:1992-01-01 00:00:00

  • Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA.

    abstract::One hundred and eighty-nine Thoroughbred horses that had won Graded Stakes races in North America were genotyped with the Illumina Equine SNP50 bead chip. Association tests using PLINK to determine whether any SNPs were associated with optimum racing distance (7 furlongs and under compared to 8-10 furlongs) identified...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Binns MM,Boehler DA,Lambert DH

    更新日期:2010-12-01 00:00:00

  • Associations of GH gene variants with performance traits in F2 generations of European wild boar, Piétrain and Meishan pigs.

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    journal_title:Animal genetics

    pub_type: 杂志文章


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    更新日期:1997-04-01 00:00:00

  • Anti-leucocyte antibodies and embryonic mortality in embryo transferred cows.

    abstract::Cows carrying unrelated transferred embryos (ET) produced anti-leucocyte serum antibodies (aLA) more often than cows carrying their own embryos. Cows carrying the ET showed a higher frequency of cytotoxic reactions against leucocytes from 40-60 randomly chosen cows than individuals carrying their own embryos. The perc...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Matousek J,Ríha J

    更新日期:1991-01-01 00:00:00