Mutagenicity studies on FD&C red No.3.

abstract：:Monitoring oxidative stress in vivo is made easier by the ability to use samples obtained non-invasively, such as urine. The analysis of DNA oxidation, by measurement of oxidized 2'-deoxyribonucleosides in urine, particularly 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), has been reported extensively in the literatur...

journal_title：Mutagenesis

authors： Evans MD,Saparbaev M,Cooke MS

更新日期：2010-09-01 00:00:00

abstract：:1,8-Dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary data indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensi...

journal_title：Mutagenesis

authors： O'Donovan MR

更新日期：1990-05-01 00:00:00

abstract：:The adaptive response is a phenomenon by which cells exposed to low, non-cytotoxic doses of a genotoxicant become significantly resistant to a subsequent higher dose of the same or another genotoxic agent. Induction of the adaptive response has been mainly studied using ionizing radiation and alkylating agents as geno...

journal_title：Mutagenesis

authors： Oliveira NG,Rodrigues AS,Chaveca T,Rueff J

更新日期：1997-11-01 00:00:00

abstract：:Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise t...

journal_title：Mutagenesis

authors： Rieswijk L,Brauers KJ,Coonen ML,van Breda SG,Jennen DG,Kleinjans JC

更新日期：2015-11-01 00:00:00

abstract：:Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...

journal_title：Mutagenesis

authors： Oya E,Ovrevik J,Arlt VM,Nagy E,Phillips DH,Holme JA

更新日期：2011-11-01 00:00:00

abstract：:Each of the Escherichia coli tester strains in the WP3101P-WP3106P series contains an F' plasmid with a different base substitution mutation within the lacZ gene. Each of the six possible base substitution mutations, therefore, can be assayed with these strains by Lac(+) reversion. We used the strains to characterize ...

journal_title：Mutagenesis

authors： Ohta T,Watanabe-Akanuma M,Yamagata H

更新日期：2000-07-01 00:00:00

abstract：:Oxidative DNA lesions, constantly generated by both endogenous and environmentally induced reactive oxygen species, are removed via the base excision repair pathway. In bacteria, Fpg and Nei DNA glycosylases, belonging to the helix-two-turn-helix (H2TH) structural superfamily, remove oxidised purines and pyrimidines, ...

journal_title：Mutagenesis

authors： Makasheva KA,Endutkin AV,Zharkov DO

更新日期：2020-02-13 00:00:00

abstract：:Three short-term assays (the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test) were carried out to evaluate the genotoxicity of four trihalomethanes (chloroform, bromodichloromethane, chlorodibromomethane and bromoform). With the SOS chromotest, all the chemicals studied except chloroform were ...

journal_title：Mutagenesis

authors： Le Curieux F,Gauthier L,Erb F,Marzin D

更新日期：1995-07-01 00:00:00

abstract：:In the light of the CEC aneuploidy programme eight known or suspected aneugens were evaluated with the human lymphocyte 'in vitro' micronucleus test using the cytochalasin-B technique. Only colchicine, chloral hydrate and hydroquinone induced dose-dependent increases in micronucleus frequencies. The other five chemica...

journal_title：Mutagenesis

authors： Van Hummelen P,Kirsch-Volders M

更新日期：1992-11-01 00:00:00

abstract：:On April 6, 1993, near the town of Tomsk (Russia) there was an accident at the Siberian Chemical Plant (SCP) which resulted in extensive contamination of an area of 250 km(2) to the north of SCP with long-lived radionuclides such as (239)Pu, (137)Cs and (90)Sr. Cytogenetic methods and electron spin resonance (ESR) spe...

journal_title：Mutagenesis

authors： Ilyinskikh NN,Ilyinskikh IN,Porovskiy VA,Natarajan AT,Suskov II,Smirenniy LN,Ilyinskikh EN

更新日期：1999-09-01 00:00:00

abstract：:Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP) with ozone were investigated. Male and female B6C3F1 mice were exposed to ozone (0.5 p.p.m.), NNK (1.0 mg/kg), DBP (5000 p.p.m.) and different combinations of these toxicants 6 h/day for 16,...

journal_title：Mutagenesis

authors： Kim MY,Kim YC,Cho MH

更新日期：2002-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors. At least 15% of cases are inherited as an autosomal dominant mutation, but the majority are sporadic. We evaluated cytogenetic alterations, both spontaneous ...

journal_title：Mutagenesis

authors： Trippi F,Botto N,Scarpato R,Petrozzi L,Bonuccelli U,Latorraca S,Sorbi S,Migliore L

更新日期：2001-07-01 00:00:00

abstract：:Coal miners are exposed to coal dust, containing mineral particles, inorganic compounds and polycyclic aromatic hydrocarbons, and to ionizing radiation. These factors can induce oxidative stress and promote inflammation that leads to DNA damage. The aim of this investigation is to analyse the degree of DNA damage in m...

journal_title：Mutagenesis

authors： Sinitsky MY,Minina VI,Gafarov NI,Asanov MA,Larionov AV,Ponasenko AV,Volobaev VP,Druzhinin VG

更新日期：2016-11-01 00:00:00

abstract：:I suggest that there are several good reasons for retaining mammalian cell mutation assays in a basic test package for genotoxicity and that the possible existence of a non-clastogenic mammalian mutagen is not one of them. I put forward a number of propositions, not necessarily original, concerning in vitro assays, in...

journal_title：Mutagenesis

authors： Green MH

更新日期：1988-09-01 00:00:00

abstract：:In vivo genotoxicity studies-shortly followed by carcinogenicity-are posing high demand for test-related recourses in terms of animal lives and resources. Among those, the micronucleus test in rodents is the most widely used as a follow-up to positive in vitro mutagenicity results; therefore, the development and exten...

journal_title：Mutagenesis

authors： Benigni R,Bossa C,Worth A

更新日期：2010-07-01 00:00:00

abstract：:Studies in mono-culture of cells have shown that diesel exhaust particles (DEPs) increase the production of reactive oxygen species (ROS) and oxidative stress-related damage to DNA. However, the level of particle-generated genotoxicity may depend on interplay between different cell types, e.g. lung epithelium and immu...

journal_title：Mutagenesis

authors： Jantzen K,Roursgaard M,Desler C,Loft S,Rasmussen LJ,Møller P

更新日期：2012-11-01 00:00:00

abstract：:The coat and eye colour mutant beige (bg) leads to the production of distinctive retinal melanocytes with abnormally large pigment granules. Heterozygotes for bg were given 2 Gy acute X-irradiation at various times between day 11.5 of fetal life and 3 days after birth, at which age whole mounts were prepared of the re...

journal_title：Mutagenesis

authors： Stephenson DA,Searle AG

更新日期：1986-03-01 00:00:00

abstract：:Macrocyclic polyethers (crown ethers) are a family of compounds that possess the ability to complex with and transport metal ions across membranes. Because of their unique ionophoric characteristic, they have wide application in industry and research, chemistry and biology. In the current investigation the relationshi...

journal_title：Mutagenesis

authors： Cai MY,Arenaz P

更新日期：1998-01-01 00:00:00

abstract：:Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. First reported in 2006, further development occurred and a standard prot...

journal_title：Mutagenesis

authors： Kidd D,Phillips S,Chirom T,Mason N,Smith R,Saul J,Whitwell J,Clements J

更新日期：2019-12-03 00:00:00

abstract：:This is a review of the work on molecular dosimetry carried out by several laboratories within the third Environmental Programme of the Commission of the European Communities. The molecular dosimetry project is a coordinated research project in which several laboratories cooperated on various aspects of quantitative c...

journal_title：Mutagenesis

authors： van Zeeland AA

更新日期：1988-05-01 00:00:00

abstract：:Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and exogenous steroid hormones. The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones. Increased endogenous steroid hormone levels have been associated...

journal_title：Mutagenesis

authors： Ye Z,Parry JM

更新日期：2002-03-01 00:00:00

abstract：:Among the tests used to determine the mutagenic potential of chemicals, the chromosomal aberrations and micronucleus assays play an important role. These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. One of the hallmarks of apoptosis is DNA fragmentation into 50-300 k...

journal_title：Mutagenesis

authors： Meintières S,Biola A,Pallardy M,Marzin D

更新日期：2001-05-01 00:00:00

abstract：:The spectrum of mutations induced by cobalt(II) chloride (CoCl2) was examined using plasmid pUB3 DNA, which was propagated after transfection into Escherichia coli SY1032/pKY241 host cells. The vector plasmid carried an E.coli supF suppressor tRNA gene as a target for mutations. After CoCl2 treatment, 64 independent n...

journal_title：Mutagenesis

authors： Ogawa HI,Ohyama Y,Ohsumi Y,Kakimoto K,Kato Y,Shirai Y,Nunoshiba T,Yamamoto K

更新日期：1999-03-01 00:00:00

abstract：:The Mre11 complex (Mre11-Rad50-Nbs1) is involved in a diverse array of DNA metabolic processes including the response to DNA double-strand breaks (DSBs). The structure of Rad50 plays a key role in the DNA-binding and end-bridging activity of the complex. An interesting feature within the central portion of the Rad50 p...

journal_title：Mutagenesis

authors： Cahill D,Carney JP

更新日期：2007-07-01 00:00:00

abstract：:Extracts from lean pork heated at 200 degrees C have a strong mutagenic activity in the Ames Salmonella assay (strain TA98 +S9). The formation of mutagenicity is highly temperature dependent, thus an extract heated at 100 degrees C is not mutagenic in this system. This paper shows that the 200 degrees C extract also c...

journal_title：Mutagenesis

authors： Kolman A,Kleman M,Bohusová T,Gustafsson JA,Overvik E

更新日期：1992-03-01 00:00:00

abstract：:Alterations of DNA repair enzymes and consequential triggering of aberrant DNA damage response (DDR) pathways are thought to play a pivotal role in genomic instabilities associated with cancer development, and are further thought to be important predictive biomarkers for therapy using the synthetic lethality paradigm....

journal_title：Mutagenesis

authors： Malfatti MC,Antoniali G,Codrich M,Burra S,Mangiapane G,Dalla E,Tell G

更新日期：2020-02-13 00:00:00

abstract：:The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic aci...

journal_title：Mutagenesis

authors： Arlt VM,Stiborova M,Schmeiser HH

更新日期：2002-07-01 00:00:00

abstract：:Comparative investigations of sister-chromatid exchange (SCE) and micronucleus induction in the bone marrow of rats, mice and Chinese hamsters with the cytostatic alkylating mutagen cyclophosphamide (CP) revealed remarkable species differences in their mutagenic responses. With both test systems the sensitivities of t...

journal_title：Mutagenesis

authors： Madle E,Korte A,Beek B

更新日期：1986-11-01 00:00:00

abstract：:In the present study we evaluated campthotecin (CPT)-induced chromosomal damage in human lymphocytes in the G0 phase of the cell cycle as revealed by the premature chromosome condensation technique. The results obtained here indicate that CPT was able to induce chromosome fragments in the G0 phase of the cell cycle of...

journal_title：Mutagenesis

authors： Mosesso P,Fonti E,Bassi L,Lorenti Garcia C,Palitti F

更新日期：1999-01-01 00:00:00

abstract：:The widespread production and use of nanoparticles calls for faster and more reliable methods to assess their safety. The main aim of this study was to investigate the genotoxicity of three reference TiO2 nanomaterials (NM) within the frame of the FP7-NANoREG project, with a particular focus on testing the applicabili...

journal_title：Mutagenesis

authors： Di Bucchianico S,Cappellini F,Le Bihanic F,Zhang Y,Dreij K,Karlsson HL

更新日期：2017-01-01 00:00:00