Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients.

abstract：:Ground chicken breast and ground beef with either endogenous or a 10-fold increase in the concentration of creatine were fried at 220 degrees C for 10 min per side. One patty (100 g) of chicken meat yielded 120,000 Salmonella (TA1538) revertants following metabolic activation. The pan residues had 39% of the total act...

journal_title：Mutagenesis

authors： Knize MG,Shen NH,Felton JS

更新日期：1988-11-01 00:00:00

abstract：:The aim of the present study was to develop and standardize a cytogenetic approach for evaluation of the mutagenic potential of chemicals that induce cell cycle arrest in the G2 phase. Even though cytogenetic end-points such as sister chromatid exchange (SCE) have been extensively used to indirectly assess the DNA-dam...

journal_title：Mutagenesis

authors： Terzoudi GI,Malik SI,Pantelias GE,Margaritis K,Manola K,Makropoulos W

更新日期：2003-11-01 00:00:00

abstract：:Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involved. We used liver mi...

journal_title：Mutagenesis

authors： Beristain-Castillo E,Martínez-Vázquez M,Camacho-Carranza R,Espinosa-Aguirre JJ

更新日期：2013-11-01 00:00:00

abstract：:Famotidine, a histamine H2-receptor antagonist, was devoid of mutagenic activity in seven his- Salmonella typhimurium strains (TA1535, TA1537, TA1538, TA97, TA98, TA100 and TA102) and was equitoxic in repair-proficient (WP2) and repair-deficient (WP2uvrA, WP67, CM561, CM571, WP100 and CM871) Escherichia coli strains, ...

journal_title：Mutagenesis

authors： De Flora S,Camoirano A,Basso C,Astengo M,Zanacchi P,Bennicelli C

更新日期：1986-03-01 00:00:00

abstract：:A relatively large, reproducible inter-individual variation was found in the ability of 17 human liver S9 samples to mediate the mutagenicity of 2-acetylaminofluorene (2AAF) in Salmonella typhimurium strain TA98. In an animal model, variation in metabolic activation of 2AAF did not appear to relate to the phenotype of...

journal_title：Mutagenesis

authors： Smith AJ,Chipman JK

更新日期：1988-07-01 00:00:00

abstract：:The human JC virus (JCV) is potentially carcinogenic to humans as a Group 2B carcinogen, and it is ubiquitous in human populations. To investigate whether the small tumour (ST) antigen of the JCV contributes to genomic instability, we established cell lines stably expressing the JCV ST and examined its role in DNA rep...

journal_title：Mutagenesis

authors： Huang JL,Lin CS,Chang CC,Lu YN,Hsu YL,Wong TY,Wang YF

更新日期：2015-07-01 00:00:00

abstract：:The International Agency for Research on Cancer has classified several antineoplastic drugs in Group 1 (human carcinogens), among which chlorambucil, cyclophosphamide (CP) and tamoxifen, Group 2A (probable human carcinogens), among which cisplatin, etoposide, N-ethyl- and N-methyl-N-nitrosourea, and Group 2B (possible...

journal_title：Mutagenesis

authors： Villarini M,Dominici L,Piccinini R,Fatigoni C,Ambrogi M,Curti G,Morucci P,Muzi G,Monarca S,Moretti M

更新日期：2011-05-01 00:00:00

abstract：:Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated the effects of DB[a,h]A on mRNA and microRNA expression to dissect the mechanisms involved in carcinogenesis. In this study, mature male mice (Muta(™)Mouse) we...

journal_title：Mutagenesis

authors： Malik AI,Rowan-Carroll A,Williams A,Lemieux CL,Long AS,Arlt VM,Phillips DH,White PA,Yauk CL

更新日期：2013-09-01 00:00:00

abstract：:In response to DNA damage, cell cycle arrest, apoptosis, and DNA repair are mediated by a TP53 pathway that induces p21(WAF1/Cip1). The chemotherapeutic drug cis-diamminedichloroplatinum-II (cisplatin) damages cellular DNA by forming cis-diammineplatinum-N(7)-d[GpG] and cis-diammine-platinum-N(7)-d[ApG] adducts. To in...

journal_title：Mutagenesis

authors： van Gijssel HE,Leil TA,Weinberg WC,Divi RL,Olivero OA,Poirier MC

更新日期：2007-01-01 00:00:00

abstract：:Carbaryl causes depolymerization of spindle microtubules and apparent uncoupling of karyokinesis and cytokinesis in mitotic V79 cells. The metabolite 1-naphthol has virtually identical effects at equimolar concentrations. The closely related 2-naphthol causes similar configurations, but at a much lower frequency than ...

journal_title：Mutagenesis

authors： Renglin A,Olsson A,Wachtmeister CA,Onfelt A

更新日期：1998-07-01 00:00:00

abstract：:This study was a part of an international project sponsored by the Commission of the European Communities to evaluate the utility of certain bioassays including hexaploid wheat assay to identify potential aneugens. Ten suspect spindle poisons, i.e. colchicine (COL), cadmium chloride (CdCl2), chloral hydrate (CH), diaz...

journal_title：Mutagenesis

authors： Sandhu SS,Dhesi JS,Gill BS,Svendsgaard D

更新日期：1991-09-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) treatment as used therapeutically has been shown to induce DNA damage in the alkaline comet assay with leukocytes from test subjects. Using formamidopyrimidine-DNA glycosylase, a DNA repair enzyme which specifically nicks DNA at sites of 8-oxoguanines and formamidopyrimidines, we have detected ...

journal_title：Mutagenesis

authors： Speit G,Dennog C,Lampl L

更新日期：1998-01-01 00:00:00

abstract：:Many chronic inflammatory conditions are associated with an increased risk of cancer development. At the site of inflammation, cellular DNA is damaged by hypochlorous acid (HOCl), a potent oxidant generated by myeloperoxidase. 8-Chloro-2'-deoxyguanosine (8-Cl-dG) is a major DNA adduct formed by HOCl and has been detec...

journal_title：Mutagenesis

authors： Sassa A,Kamoshita N,Matsuda T,Ishii Y,Kuraoka I,Nohmi T,Ohta T,Honma M,Yasui M

更新日期：2013-01-01 00:00:00

abstract：:The major risk factor for skin cancer is exposure to UV radiation from sunlight, but other environmental exposures may also play a role in combination with UV. We have studied the effects of combined exposure of primary human skin cells in vitro to UVA, UVB or UVC with benzo[a] pyrene (BaP), an environmental carcinoge...

journal_title：Mutagenesis

authors： Crallan RA,Ingham E,Routledge MN

更新日期：2005-07-01 00:00:00

abstract：:FD&C Red No.3 (erythrosine) has been used as a dye in foods, drugs and cosmetics since its approval by the US Department of Agriculture in 1907. In 1977 the Certified Color Manufacturers' Association (CCMA) initiated studies on FD&C Red No.3 including chronic toxicity and carcinogenicity studies in rats and mice. Data...

journal_title：Mutagenesis

authors： Lin GH,Brusick DJ

更新日期：1986-07-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are stable pollutants, which can be found in almost every compartment of terrestrial and aquatic ecosystems. They are very lipophilic and therefore have the potency of accumulating in the fat stores of animals. The mechanisms by which PCBs exert their adverse effects are still unclear....

journal_title：Mutagenesis

authors： Belpaeme K,Delbeke K,Zhu L,Kirsch-Volders M

更新日期：1996-09-01 00:00:00

abstract：:A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at C...

journal_title：Mutagenesis

authors： Valentine CR,Rainey HF,Farrell JM,Shaddock JG,Dobrovolsky VN,Delongchamp RR

更新日期：2008-09-01 00:00:00

abstract：:Gaulden reported a novel and unexpected mitomycin C (MMC) effect, namely a pronounced retardation of very late prophase and loss of chromosome orientation in neuroblasts of the grasshopper Chortophaga viridifasciate. Because this effect may be due to interactions of MMC with non-DNA targets, MMC was tested for its int...

journal_title：Mutagenesis

authors： Albertini S,Friederich U,Würgler FE

更新日期：1989-01-01 00:00:00

abstract：:A modified protocol is described for the in vitro analysis of micronuclei in whole blood or separated lymphocyte cultures. The induction of binucleate cells by various concentrations of cytochalasin B (3, 4.5 or 6 micrograms/ml) was examined at two harvest times (68 or 72 h). An optimal yield was obtained by adding cy...

journal_title：Mutagenesis

authors： Ellard S,Parry EM

更新日期：1993-07-01 00:00:00

abstract：:An immunohistochemical method for the determination of 6-thioguanine resistant (TGr) lymphocytes in human blood samples has been developed. The new technique is a modification of the autoradiographic assay and uses labelling of DNA synthesizing cells by bromodeoxyuridine (BrdU) instead of tritiated thymidine. The labe...

journal_title：Mutagenesis

authors： Montero R,Norppa H,Autio K,Lindholm C,Ostrosky-Wegman P,Sorsa M

更新日期：1991-03-01 00:00:00

abstract：:The mechanism responsible for the modification of mutagenicity by chlorophyllin has been investigated using mutagenic compounds with different mechanisms of action, including the monofunctional alkylating agents, N-methyl-N'-nitrosourea (MNU) and ethylmethanesulphonate (EMS); nitrosamines related to tobacco products, ...

journal_title：Mutagenesis

authors： Romert L,Curvall M,Jenssen D

更新日期：1992-09-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:Escherichia coli K12ND-160 possesses characteristics which make it highly suitable for studies on mutagenic/antimutagenic specificity and has been used to investigate such effects for several agents. Nitrofurazone (NFZ) was used as a mutagen at non-lethal concentrations; it causes mutation from fucose sensitivity to r...

journal_title：Mutagenesis

authors： Clarke CH,Shankel DM

更新日期：1989-01-01 00:00:00

abstract：:In this study, we determined the induction and time-dependent accumulation of micronuclei in the peripheral blood of transgenic C57BL/6 p53+/- mice (p53+/- mice), FVB/N Tg.AC v-Ha-ras mice (Tg.AC mice) and their isogenic parental strains, FVB/N and C57BL/6 following inhalation exposure to benzene. Our objective was to...

journal_title：Mutagenesis

authors： Healy LN,Pluta LJ,James RA,Janszen DB,Torous D,French JE,Recio L

更新日期：2001-03-01 00:00:00

abstract：:The aim of the present work was to investigate the processes involved in the origin of trisomic karyotypes, i.e. co-migration of sister chromatids (mitotic non-disjunction, MND) and recovery of micronuclei (MN) originating from lagging chromosomes/chromatids at anaphase (mitotic indirect non-disjunction, MIND), and to...

journal_title：Mutagenesis

authors： Minissi S,Degrassi F,Tanzarella C,Gustavino B

更新日期：1999-11-01 00:00:00

abstract：:The adduct that would arise from cis opening of (+)-(1S,2R,3R, 4S)-3,4-dihydroxy-1,2-epoxy-benzo[c]phenan-threne (benzo[c]phenanthrene diol epoxide-2, where the benzylic hydroxyl group and the epoxide oxygen are trans) by the exocyclic N6-amino group of deoxyadenosine was incorporated at the marked site into four olig...

journal_title：Mutagenesis

authors： Pontén I,Waters LS,Sayer JM,Pilcher AS,Dipple A,Jerina DM

更新日期：2001-01-01 00:00:00

abstract：:Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) T1349G (Asp148Glu) polymorphism and cancer risk show inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 27 published studies that included 12 432 cancer cases and...

journal_title：Mutagenesis

authors： Gu D,Wang M,Wang M,Zhang Z,Chen J

更新日期：2009-11-01 00:00:00

abstract：:The effect of cerium oxide nanoparticle (CeNP) in plants has elicited substantial controversy. While some investigators have reported that CeNP possesses antioxidant properties, others observed CeNP to induce reactive oxygen species (ROS). In spite of considerable research carried out on the effects of CeNP in metazoa...

journal_title：Mutagenesis

authors： Sadhu A,Ghosh I,Moriyasu Y,Mukherjee A,Bandyopadhyay M

更新日期：2018-04-13 00:00:00

abstract：:The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...

journal_title：Mutagenesis

authors： Lamerdin JE,Yamada NA,George JW,Souza B,Christian AT,Jones NJ,Thompson LH

更新日期：2004-05-01 00:00:00

abstract：:The antineoplastic drug etoposide (ET) inhibits topoisomerase II (topo II) activity by forming a ternary complex (DNA-ET-topo II). This complex prevents the DNA-strand-rejoining activity of topo II and may result in structural chromosome aberrations. Inhibition of topo II activity may also predispose cells to aneuploi...

journal_title：Mutagenesis

authors： Mailhes JB,Marchetti F,Young D,London SN

更新日期：1996-07-01 00:00:00