The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies.

abstract：:Prostate cancer is a major health burden, being the second most commonly diagnosed malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer therapy, leading to significant long-term quality-of-life effects for patients and a broad socio-ecological burden. Biomarkers that could facilitat...

journal_title：Mutagenesis

authors： Brezina S,Feigl M,Gumpenberger T,Staudinger R,Baierl A,Gsur A

更新日期：2020-07-11 00:00:00

abstract：:A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at C...

journal_title：Mutagenesis

authors： Valentine CR,Rainey HF,Farrell JM,Shaddock JG,Dobrovolsky VN,Delongchamp RR

更新日期：2008-09-01 00:00:00

abstract：:Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, the comet assay, the hprt gene mutation assay and the TCR gene mutation assay. The subjects were divided into two groups: (i) 21 workers from a plant producing methotrexate (MTX); (ii) 21 controls w...

journal_title：Mutagenesis

authors： Deng H,Zhang M,He J,Wu W,Jin L,Zheng W,Lou J,Wang B

更新日期：2005-09-01 00:00:00

abstract：:Deregulation of control of the apoptotic process in Fanconi anaemia (FA) appears to be one of the main features of this disease at the cellular level. We show here that FA cells are resistant to treatments with rhodamine-1,2,3 and doxycycline, which both interfere with mitochondrial functionality by different mechanis...

journal_title：Mutagenesis

authors： Bogliolo M,Borghini S,Abbondandolo A,Degan P

更新日期：2002-01-01 00:00:00

abstract：:I suggest that there are several good reasons for retaining mammalian cell mutation assays in a basic test package for genotoxicity and that the possible existence of a non-clastogenic mammalian mutagen is not one of them. I put forward a number of propositions, not necessarily original, concerning in vitro assays, in...

journal_title：Mutagenesis

authors： Green MH

更新日期：1988-09-01 00:00:00

abstract：:In this study, we determined the induction and time-dependent accumulation of micronuclei in the peripheral blood of transgenic C57BL/6 p53+/- mice (p53+/- mice), FVB/N Tg.AC v-Ha-ras mice (Tg.AC mice) and their isogenic parental strains, FVB/N and C57BL/6 following inhalation exposure to benzene. Our objective was to...

journal_title：Mutagenesis

authors： Healy LN,Pluta LJ,James RA,Janszen DB,Torous D,French JE,Recio L

更新日期：2001-03-01 00:00:00

abstract：:Urine and serum samples of rats bearing three different experimental tumours (hepatocellular carcinoma, myelomonocytic leukemia and mesoblastic nephroma) were investigated for mutagenicity with the Ames Salmonella test. Enhancement of mutagenic activity in TA98 and TA100 was observed only in the case of urine samples ...

journal_title：Mutagenesis

authors： Varga C,Pocsai Z,Kertai P

更新日期：1995-01-01 00:00:00

abstract：:The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic aci...

journal_title：Mutagenesis

authors： Arlt VM,Stiborova M,Schmeiser HH

更新日期：2002-07-01 00:00:00

abstract：:ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test i...

journal_title：Mutagenesis

authors： Henry SP,Monteith DK,Matson JE,Mathison BH,Loveday KS,Winegar RA,Matson JE,Lee PS,Riccio ES,Bakke JP,Levin AA

更新日期：2002-05-01 00:00:00

abstract：:A systematic review of the literature has been conducted and studies reporting investigations of genotoxicity biomarkers in pesticide workers have been assessed with view to establishing whether there was evidence for any risk to those using pesticides approved in the United Kingdom. Each of the studies was evaluated ...

journal_title：Mutagenesis

authors： Bull S,Fletcher K,Boobis AR,Battershill JM

更新日期：2006-03-01 00:00:00

abstract：:Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. We established human SK-OV-3 cells that stably express the Zeocin resistance gene (Sh ble) using an ecdysone-inducible mammalian expression system. Surprisingly, our results demonstrated that Zeocin, added in the cultur...

journal_title：Mutagenesis

authors： Oliva-Trastoy M,Defais M,Larminat F

更新日期：2005-03-01 00:00:00

abstract：:The complementation group (CG) assignment is presented for 74 moderately sensitive (approximately 2-4x sensitivity of parental line based on ratio of D10s) UV-sensitive mutants of Chinese hamster ovary (CHO) cells from the Facility for Automated Experiments in Cell Biology (FAECB) collection. The distribution of mutan...

journal_title：Mutagenesis

authors： Busch D,Greiner C,Rosenfeld KL,Ford R,de Wit J,Hoeijmakers JH,Thompson LH

更新日期：1994-07-01 00:00:00

abstract：:This paper presents the results obtained within the framework of an EU research project aimed at investigating the relationship between occupational exposure to pesticides and the induction of cytogenetic damage. Populations from Greece, Spain, Poland and Hungary, all of them characterised by intensive agricultural ac...

journal_title：Mutagenesis

authors： Pastor S,Creus A,Parrón T,Cebulska-Wasilewska A,Siffel C,Piperakis S,Marcos R

更新日期：2003-05-01 00:00:00

abstract：:Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and exogenous steroid hormones. The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones. Increased endogenous steroid hormone levels have been associated...

journal_title：Mutagenesis

authors： Ye Z,Parry JM

更新日期：2002-03-01 00:00:00

abstract：:The widespread production and use of nanoparticles calls for faster and more reliable methods to assess their safety. The main aim of this study was to investigate the genotoxicity of three reference TiO2 nanomaterials (NM) within the frame of the FP7-NANoREG project, with a particular focus on testing the applicabili...

journal_title：Mutagenesis

authors： Di Bucchianico S,Cappellini F,Le Bihanic F,Zhang Y,Dreij K,Karlsson HL

更新日期：2017-01-01 00:00:00

abstract：:The coat and eye colour mutant beige (bg) leads to the production of distinctive retinal melanocytes with abnormally large pigment granules. Heterozygotes for bg were given 2 Gy acute X-irradiation at various times between day 11.5 of fetal life and 3 days after birth, at which age whole mounts were prepared of the re...

journal_title：Mutagenesis

authors： Stephenson DA,Searle AG

更新日期：1986-03-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) treatment as used therapeutically has been shown to induce DNA damage in the alkaline comet assay with leukocytes from test subjects. Using formamidopyrimidine-DNA glycosylase, a DNA repair enzyme which specifically nicks DNA at sites of 8-oxoguanines and formamidopyrimidines, we have detected ...

journal_title：Mutagenesis

authors： Speit G,Dennog C,Lampl L

更新日期：1998-01-01 00:00:00

abstract：:Famotidine, a histamine H2-receptor antagonist, was devoid of mutagenic activity in seven his- Salmonella typhimurium strains (TA1535, TA1537, TA1538, TA97, TA98, TA100 and TA102) and was equitoxic in repair-proficient (WP2) and repair-deficient (WP2uvrA, WP67, CM561, CM571, WP100 and CM871) Escherichia coli strains, ...

journal_title：Mutagenesis

authors： De Flora S,Camoirano A,Basso C,Astengo M,Zanacchi P,Bennicelli C

更新日期：1986-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors. At least 15% of cases are inherited as an autosomal dominant mutation, but the majority are sporadic. We evaluated cytogenetic alterations, both spontaneous ...

journal_title：Mutagenesis

authors： Trippi F,Botto N,Scarpato R,Petrozzi L,Bonuccelli U,Latorraca S,Sorbi S,Migliore L

更新日期：2001-07-01 00:00:00

abstract：:Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP) with ozone were investigated. Male and female B6C3F1 mice were exposed to ozone (0.5 p.p.m.), NNK (1.0 mg/kg), DBP (5000 p.p.m.) and different combinations of these toxicants 6 h/day for 16,...

journal_title：Mutagenesis

authors： Kim MY,Kim YC,Cho MH

更新日期：2002-07-01 00:00:00

abstract：:The genotoxic effects of benzene in lung cells of mice exposed to single acute doses by inhalation have been estimated by cytogenetic analysis of micronuclei in primary cultures of lung fibroblasts. Mice were nose-only exposed to 1000 p.p.m. for 30 or 60 min or to 3500 p.p.m. for 30 min and sacrificed 24 h after the e...

journal_title：Mutagenesis

authors： Ranaldi R,Bassani B,Villani P,Lombardi CC,Tanzarella C,Pacchierotti F

更新日期：1998-09-01 00:00:00

abstract：:Coleus aromaticus (Benth, Family: Laminaceae), Indian Oregano native to India and Mediterranean, is well known for its medicinal properties. A preliminary study was undertaken to elucidate in vitro free radical scavenging potential and inhibition of lipid peroxidation by C.aromaticus hydroalcoholic extract (CAE). Anti...

journal_title：Mutagenesis

authors： Rao BS,Shanbhoge R,Upadhya D,Jagetia GC,Adiga SK,Kumar P,Guruprasad K,Gayathri P

更新日期：2006-07-01 00:00:00

abstract：:Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...

journal_title：Mutagenesis

authors： Creton S,Aardema MJ,Carmichael PL,Harvey JS,Martin FL,Newbold RF,O'Donovan MR,Pant K,Poth A,Sakai A,Sasaki K,Scott AD,Schechtman LM,Shen RR,Tanaka N,Yasaei H

更新日期：2012-01-01 00:00:00

abstract：:This study investigated the effect of glucose and fructose, and advanced glycation end-products (AGEs) on genome damage in WIL2-NS cells, measured using the cytokinesis-block micronucleus cytome (CBMN-Cyt) assay. The effect of AGEs was investigated using the bovine serum albumin (AGE-BSA) model system induced either w...

journal_title：Mutagenesis

authors： Deo P,McCullough CL,Almond T,Jaunay EL,Donnellan L,Dhillon VS,Fenech M

更新日期：2020-03-27 00:00:00

abstract：:A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party conclud...

journal_title：Mutagenesis

authors： Elliott BM,Combes RD,Elcombe CR,Gatehouse DG,Gibson GG,Mackay JM,Wolf RC

更新日期：1992-05-01 00:00:00

abstract：:The induction of aneuploidy in cultured mammalian cells has been studied using two chemical agents, diethylstilboestrol dipropionate and Colcemid, which act on the mitotic spindle, in order to investigate different methods of scoring and statistical analysis. Two cell lines, one human and the other Chinese hamster, we...

journal_title：Mutagenesis

authors： Danford N,Balfe P

更新日期：1987-09-01 00:00:00

abstract：:We report on a new method for the study of radiation-induced chromatid breaks in stimulated human peripheral blood T lymphocytes, involving a combination of a 1-h colcemid block and a short (15 min) calyculin A treatment. We find that this procedure eliminates the problem of centromere splitting when calyculin A is us...

journal_title：Mutagenesis

authors： Shovman O,Riches AC,Adamson D,Bryant PE

更新日期：2008-07-01 00:00:00

abstract：:Carbon nanotubes (CNTs) are fibrous carbon-based nanomaterials with a potential to cause carcinogenesis in humans. Alterations in DNA methylation on cytosine-phosphate-guanidine (CpG) sites are potential markers of exposure-induced carcinogenesis. This study examined cytotoxicity, genotoxicity and DNA methylation alte...

journal_title：Mutagenesis

authors： Öner D,Moisse M,Ghosh M,Duca RC,Poels K,Luyts K,Putzeys E,Cokic SM,Van Landuyt K,Vanoirbeek J,Lambrechts D,Godderis L,Hoet PH

更新日期：2017-01-01 00:00:00

abstract：:The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4...

journal_title：Mutagenesis

authors： Ennever FK,Rosenkranz HS

更新日期：1986-03-01 00:00:00

abstract：:A modified method for the 32P-postlabeling assay that permits standardized quantitation for specific polycyclic aromatic hydrocarbon (PAH)-DNA adducts is described. This method has been designed to test the components of the 32P-postlabeling assay for use in the chemically specific detection of individual adducts with...

journal_title：Mutagenesis

authors： Shields PG,Harris CC,Petruzzelli S,Bowman ED,Weston A

更新日期：1993-03-01 00:00:00