The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis.

abstract：:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant disorder characterized by blepharophimosis, ptosis and epicanthus inversus. Based on the presence and absence of premature ovarian failure, two clinical types have been distinguished. Both types of BPES have been mapped to chromosome ...

journal_title：Mutagenesis

authors： Tang S,Wang X,Lin L,Sun Y,Wang Y,Yu H

更新日期：2006-01-01 00:00:00

abstract：:Alcohol drinking-derived acetaldehyde is believed to cross-link DNA and induce sister chromatid exchanges in peripheral blood lymphocytes. However, little population data are available to illustrate effects of alcohol-derived acetaldehyde on DNA migration as assayed by the comet assay in peripheral lymphocytes. In the...

journal_title：Mutagenesis

authors： Lu Y,Morimoto K

更新日期：2009-07-01 00:00:00

abstract：:A pronase digestion procedure for the isolation of gastric mucosal cells was evaluated for its usefulness in measuring unscheduled DNA synthesis (UDS). The method has been claimed to be suited for assessing the genotoxicity potential of compounds. Compounds were given orally to rats. After 13 h [3H]thymidine was injec...

journal_title：Mutagenesis

authors： Larsson H,Fryklund J,Helander HF,Wallmark B

更新日期：1991-01-01 00:00:00

abstract：:In this study, we determined the induction and time-dependent accumulation of micronuclei in the peripheral blood of transgenic C57BL/6 p53+/- mice (p53+/- mice), FVB/N Tg.AC v-Ha-ras mice (Tg.AC mice) and their isogenic parental strains, FVB/N and C57BL/6 following inhalation exposure to benzene. Our objective was to...

journal_title：Mutagenesis

authors： Healy LN,Pluta LJ,James RA,Janszen DB,Torous D,French JE,Recio L

更新日期：2001-03-01 00:00:00

abstract：:We have investigated the relative importance of DNA methylation-directed repair of replication errors to the production of mutation/gene rearrangements in mammalian cells with hypomethylated genomes. Using a series of sibling (Chinese hamster derived) cell clones with stably altered DNA methylation levels, we found th...

journal_title：Mutagenesis

authors： Diver WP,Woodcock DM

更新日期：1989-11-01 00:00:00

abstract：:Five independently isolated glutathione-deficient (gsh-) mutants of Saccharomyces cerevisae with maximally 6% residual glutathione content have been analysed genetically. Complementation as well as tetrad analysis of the homo- and heterozygous diploids constructed by suitable crosses of the five mutants indicated that...

journal_title：Mutagenesis

authors： Kistler M,Maier K,Eckardt-Schupp F

更新日期：1990-01-01 00:00:00

abstract：:The human metabolome-the complement of small molecule metabolites present in biofluids and tissues-represents a significant part of the internal chemical milieu and is therefore an important aspect of the human exposome. Metabolic profiling approaches, commonly referred to as metabonomics or metabolomics, permit detai...

journal_title：Mutagenesis

authors： Athersuch TJ,Keun HC

更新日期：2015-11-01 00:00:00

abstract：:Nature is an attractive source of therapeutic compounds. In comparison to the artificial drugs, natural compounds cause less adverse side effects and are suitable for current molecularly oriented approaches to drug development and their mutual combining. Medicinal plants represent one of the most available remedy agai...

journal_title：Mutagenesis

authors： Horváthová E,Srančíková A,Regendová-Sedláčková E,Melušová M,Meluš V,Netriová J,Krajčovičová Z,Slameňová D,Pastorek M,Kozics K

更新日期：2016-01-01 00:00:00

abstract：:Detailed dose-response data for two reference aneugens, vincristine and nocodazole, have been derived for the mouse bone marrow micronucleus assay. Positive data have also been described for six other micronucleus-inducing agents: cyclophosphamide; aniline; urethane; 1,2-dimethylhydrazine; 7,12-dimethylbenzanthracene ...

journal_title：Mutagenesis

authors： Tinwell H,Ashby J

更新日期：1991-05-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:This is an investigation of the long-term effects of a shift from a mixed diet to a lacto-vegetarian diet and of a return to a mixed diet on the mutagenic activity in urine and faeces. The participants were 20 normal weight, non-smoking subjects. Dietary surveys and urinary and faecal samples were collected before and...

journal_title：Mutagenesis

authors： Johansson G,Holmén A,Persson L,Högstedt B,Wassén C,Ottova L,Gustafsson JA

更新日期：1998-03-01 00:00:00

abstract：:In the past decade, a number of case-control studies have been carried out to investigate the relationship between the HHEX polymorphism and type 2 diabetes (T2D). However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the rela...

journal_title：Mutagenesis

authors： Cai Y,Yi J,Ma Y,Fu D

更新日期：2011-03-01 00:00:00

abstract：:Chinese hamster ovary cells were exposed to N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene, and the resulting DNA adducts, sister-chromatid exchanges (SCEs) and mutations at the hypoxanthine-guanine phosphoribosyl transferase locus were quantified. Each agent produced a major DNA adduct su...

journal_title：Mutagenesis

authors： Heflich RH,Morris SM,Beranek DT,McGarrity LJ,Chen JJ,Beland FA

更新日期：1986-05-01 00:00:00

abstract：:Adducts of 1,2-epoxy-3-butene (EB) with haemoglobin were monitored in 17 workers from the 1,3-butadiene (BD) production unit of a petrochemical plant and in nine referents employed at the same factory but not exposed to BD. The air concentrations of BD were determined using stationary and personal monitoring. The ambi...

journal_title：Mutagenesis

authors： Osterman-Golkar S,Peltonen K,Anttinen-Klemetti T,Landin HH,Zorcec V,Sorsa M

更新日期：1996-03-01 00:00:00

abstract：:Cyclophosphamide (CP)-induced micronuclei were evaluated in females of two strains of mice (C57BL and CD1), in F1 hybrid females and in fetuses (day 13 of gestation) obtained from different crosses. F1 adult hybrids from a cross between the strain with a high level of induced micronuclei (C57BL) and the strain with a ...

journal_title：Mutagenesis

authors： Barale R,Migliore L,Zucconi D,Ciranni R,Casini D,Carducci A,Loprieno N

更新日期：1987-05-01 00:00:00

abstract：:The Mre11 complex (Mre11-Rad50-Nbs1) is involved in a diverse array of DNA metabolic processes including the response to DNA double-strand breaks (DSBs). The structure of Rad50 plays a key role in the DNA-binding and end-bridging activity of the complex. An interesting feature within the central portion of the Rad50 p...

journal_title：Mutagenesis

authors： Cahill D,Carney JP

更新日期：2007-07-01 00:00:00

abstract：:Among the tests used to determine the mutagenic potential of chemicals, the chromosomal aberrations and micronucleus assays play an important role. These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. One of the hallmarks of apoptosis is DNA fragmentation into 50-300 k...

journal_title：Mutagenesis

authors： Meintières S,Biola A,Pallardy M,Marzin D

更新日期：2001-05-01 00:00:00

abstract：:The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range of manufacturing industries and consumer products. Nanomaterial safety is therefore becoming an increasingly contentious issue that has intensified over the pas...

journal_title：Mutagenesis

authors： Doak SH,Griffiths SM,Manshian B,Singh N,Williams PM,Brown AP,Jenkins GJ

更新日期：2009-07-01 00:00:00

abstract：:Due to the very limited transduction capacity of hitherto available vectors, the success of gene therapy of tumours by means of suicide genes has so far essentially depended on the transfer of toxic drug metabolites from transduced (metabolizing) cells to adjacent non-transduced cells via gap junctions (bystander effe...

journal_title：Mutagenesis

authors： Thust R,Tomicic MT,Gräbner R,Friedrichs C,Wutzler P,Kaina B

更新日期：2004-01-01 00:00:00

abstract：:Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, the comet assay, the hprt gene mutation assay and the TCR gene mutation assay. The subjects were divided into two groups: (i) 21 workers from a plant producing methotrexate (MTX); (ii) 21 controls w...

journal_title：Mutagenesis

authors： Deng H,Zhang M,He J,Wu W,Jin L,Zheng W,Lou J,Wang B

更新日期：2005-09-01 00:00:00

abstract：:4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguanosin-N (2)-yl)-4AQO...

journal_title：Mutagenesis

authors： Brüsehafer K,Manshian BB,Doherty AT,Zaïr ZM,Johnson GE,Doak SH,Jenkins GJ

更新日期：2016-03-01 00:00:00

abstract：:Folic acid (FA), the most oxidized and stable form of folate, is commonly used as a dietary supplement and in culture media. FA must be reduced and methylated to become the metabolically active form found in blood and utilized by tissues, i.e. 5-methyltetrahydrofolate (5-MeTHF). 5-MeTHF is the methyl group donor requi...

journal_title：Mutagenesis

authors： Wang X,Fenech M

更新日期：2003-01-01 00:00:00

abstract：:With the aim of optimizing the efficiency of S9 fractions used in in vitro mutagenicity assays, different schemes for the induction of liver enzymes in rats were tried and the amount of S9 fraction required was assessed. The activity of 2-anthramine (2AA), 2-acetylaminofluorene (2AAF), 3-methylcholanthrene (3MTCL) and...

journal_title：Mutagenesis

authors： García Franco S,Domínguez G,Pico JC

更新日期：1999-05-01 00:00:00

abstract：:The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4...

journal_title：Mutagenesis

authors： Ennever FK,Rosenkranz HS

更新日期：1986-03-01 00:00:00

abstract：:The tetrahydrofuran-type abasic site analog (THF) induces large deletion mutations in human cells. To compare the large deletions induced by THF on leading and lagging strand templates, plasmid DNAs bearing the analog at a specific position outside the supF gene were introduced into human U2OS cells. The replicated DN...

journal_title：Mutagenesis

authors： Suzuki T,Katayama Y,Komatsu Y,Kamiya H

更新日期：2019-12-19 00:00:00

abstract：:Well-established in vitro methods for testing the genotoxic potency of chemicals--such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test--show a high false-positive rate for predicting in vivo genotoxicity and carcinogenicity. Thus, there is a need for mor...

journal_title：Mutagenesis

authors： Mathijs K,Brauers KJ,Jennen DG,Lizarraga D,Kleinjans JC,van Delft JH

更新日期：2010-11-01 00:00:00

abstract：:The cytokinesis-block micronucleus cytome (CBMNCyt) assay is a widely used technique for measuring DNA damage in human populations. The formation of micronuclei (MN) in dividing cells can result from chromosome breakage due to unrepaired or mis-repaired DNA lesions or chromosome malsegregation due to mitotic malfuncti...

journal_title：Mutagenesis

authors： Dhillon VS,Thomas P,Iarmarcovai G,Kirsch-Volders M,Bonassi S,Fenech M

更新日期：2011-01-01 00:00:00

abstract：:Autosomal recessive woolly hair/hypotrichosis (ARWH/HT: OMIM #278150/604379) is a rare hereditary hair disease characterized by tightly curled hair at birth which can lead to sparse hair later in life. The mutations in both LIPH and LPAR6/P2RY5 are responsible for autosomal recessive woolly hair with or without hypotr...

journal_title：Mutagenesis

authors： Chang XD,Gu YJ,Dai S,Chen XR,Zhang CL,Zhao HS,Song QH

更新日期：2017-12-31 00:00:00

abstract：:The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...

journal_title：Mutagenesis

authors： Lamerdin JE,Yamada NA,George JW,Souza B,Christian AT,Jones NJ,Thompson LH

更新日期：2004-05-01 00:00:00

abstract：:The restriction site mutation method described by Parry et al. (1990) for isolating mutant sequences directly from DNA is discussed and an additional enrichment step proposed using magnetic beads. ...

journal_title：Mutagenesis

authors： Bridges BA,Carr AM,Lehmann AR

更新日期：1990-11-01 00:00:00