Abstract:
:A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party concluded that there was sufficient support in the literature to justify the use of an appropriate phenobarbital/beta-naphthoflavone regime as an acceptable alternative to Aroclor.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Elliott BM,Combes RD,Elcombe CR,Gatehouse DG,Gibson GG,Mackay JM,Wolf RCdoi
10.1093/mutage/7.3.175subject
Has Abstractpub_date
1992-05-01 00:00:00pages
175-7issue
3eissn
0267-8357issn
1464-3804journal_volume
7pub_type
相关文献
MUTAGENESIS文献大全abstract::Ionising radiation induces several isolated and clustered DNA lesions in human cells. Depending on the type of lesions, DNA repair pathways get activated to maintain the integrity of the genome. Base excision repair (BER) pathway is known to repair single-strand breaks and base damages through short- and long-patch ge...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geu065
更新日期:2015-03-01 00:00:00
abstract::Tobacco farming is an important economic income in Brazil, although it has been challenged as regard the occupational exposure to both pesticides and nicotine endured by farmers. Chronic occupational exposure to complex mixtures can lead to health hazardous. We examined genomic instability and epigenetic changes in to...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gex045
更新日期:2018-04-13 00:00:00
abstract::O6-Methylguanine-DNA methyltransferase (MT) specific activity (fmol/mg protein) was measured in human T lymphocytes which were maintained as exponentially growing cultures from 6 to 17 days. The T lymphocytes were not transformed and were grown under the same conditions used previously for determination of spontaneous...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/5.2.169
更新日期:1990-03-01 00:00:00
abstract::There are several reports demonstrating that aneugens may preferentially affect segregation of particular chromosomes in somatic cells. Much less is known on specific susceptibility of individual chromosomes to non-disjunction in mammalian meiosis in response to chemical exposures. To explore possible chromosome-speci...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/16.5.407
更新日期:2001-09-01 00:00:00
abstract::The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh019
更新日期:2004-05-01 00:00:00
abstract::Escherichia coli K12ND-160 possesses characteristics which make it highly suitable for studies on mutagenic/antimutagenic specificity and has been used to investigate such effects for several agents. Nitrofurazone (NFZ) was used as a mutagen at non-lethal concentrations; it causes mutation from fucose sensitivity to r...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/4.1.31
更新日期:1989-01-01 00:00:00
abstract::A transgenic mouse strain with a high copy number of rescuable lacZ sequences was evaluated for its effectiveness in detecting lacZ- mutations in selected tissues. Procarbazine, cyclophosphamide, ethylnitrosourea, 7,12-dimethylbenz[a]anthracene (DMBA), acrylamide and chlorambucil were tested following either single or...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/8.1.7
更新日期:1993-01-01 00:00:00
abstract::All of the published mutagenicity data generated using the Muta Mouse (lacZ) and the Big Blue (lacI) transgenic mouse mutation assays have been re-presented in a standard format. To date, 26 chemicals have been evaluated in one or other of the assays, and eight tissues have been sampled. The present analysis should ex...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/9.4.367
更新日期:1994-07-01 00:00:00
abstract::Five independently isolated glutathione-deficient (gsh-) mutants of Saccharomyces cerevisae with maximally 6% residual glutathione content have been analysed genetically. Complementation as well as tetrad analysis of the homo- and heterozygous diploids constructed by suitable crosses of the five mutants indicated that...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/5.1.39
更新日期:1990-01-01 00:00:00
abstract::The circulating human transcriptome, which includes both coding and non-coding RNA (ncRNA) molecules, represents a rich source of potential biomarkers for colorectal cancer (CRC) that has only recently been explored. In particular, the release of RNA-containing extracellular vesicles (EVs), in a multitude of different...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez038
更新日期:2020-07-11 00:00:00
abstract::Chinese hamster ovary cells were exposed to N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene, and the resulting DNA adducts, sister-chromatid exchanges (SCEs) and mutations at the hypoxanthine-guanine phosphoribosyl transferase locus were quantified. Each agent produced a major DNA adduct su...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/1.3.201
更新日期:1986-05-01 00:00:00
abstract::Photomutagenicity assays are required for regulatory submissions of some chemicals. As yet there are no well-validated protocols available for these assays. Critical factors which may contribute to the ability of a bacterial assay to detect photomutagens (e.g. dose of UV and test chemical, exposure conditions, light s...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/9.5.459
更新日期:1994-09-01 00:00:00
abstract::CI Solvent Yellow 14 has been reported to be carcinogenic in the rat, inducing neoplastic liver nodules, but non-carcinogenic in the mouse. The present experiments have extended previously reported investigations on the activity of CI Solvent Yellow 14 in in vivo genotoxicity assays. CI Solvent Yellow 14 has been exam...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/12.4.255
更新日期:1997-07-01 00:00:00
abstract::Mutation induction by UV irradiation was studied in a retroviral vector integrated in one copy per cell at various chromosomal positions. As a mutational target, hamster hprt cDNA was present on the retroviral vector. To minimize the influence of repair we used repair-deficient hamster cells, V-H1 and UV5, as a recipi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/8.5.399
更新日期:1993-09-01 00:00:00
abstract::Comparative investigations of sister-chromatid exchange (SCE) and micronucleus induction in the bone marrow of rats, mice and Chinese hamsters with the cytostatic alkylating mutagen cyclophosphamide (CP) revealed remarkable species differences in their mutagenic responses. With both test systems the sensitivities of t...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/1.6.419
更新日期:1986-11-01 00:00:00
abstract::Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. We established human SK-OV-3 cells that stably express the Zeocin resistance gene (Sh ble) using an ecdysone-inducible mammalian expression system. Surprisingly, our results demonstrated that Zeocin, added in the cultur...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei016
更新日期:2005-03-01 00:00:00
abstract::The non-syndromic cleft lip and/or palate (NSCL/P) is a common birth defect caused by a combination of genetic and environmental factors. The possible role of genome instability on NSCL/P patient needs more investigation, since DNA metabolism is an essential cellular function to keep cells with normal genotypes and ge...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gew068
更新日期:2017-03-01 00:00:00
abstract::The mechanism responsible for the modification of mutagenicity by chlorophyllin has been investigated using mutagenic compounds with different mechanisms of action, including the monofunctional alkylating agents, N-methyl-N'-nitrosourea (MNU) and ethylmethanesulphonate (EMS); nitrosamines related to tobacco products, ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/7.5.349
更新日期:1992-09-01 00:00:00
abstract::The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the ageing process and mutations have been associated with cancer in many tissues, including human skin. This involvement is linked to the key roles of mitochondrial function and mtDNA in oxidative stress production and...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/gep061
更新日期:2010-03-01 00:00:00
abstract::A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors w...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/10.5.449
更新日期:1995-09-01 00:00:00
abstract::Well-established in vitro methods for testing the genotoxic potency of chemicals--such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test--show a high false-positive rate for predicting in vivo genotoxicity and carcinogenicity. Thus, there is a need for mor...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq040
更新日期:2010-11-01 00:00:00
abstract::This is an investigation of the long-term effects of a shift from a mixed diet to a lacto-vegetarian diet and of a return to a mixed diet on the mutagenic activity in urine and faeces. The participants were 20 normal weight, non-smoking subjects. Dietary surveys and urinary and faecal samples were collected before and...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/13.2.167
更新日期:1998-03-01 00:00:00
abstract::The use of a white-ivory (wi) strain of Drosophila melanogaster carrying four copies of this allele, (wi)4, has proved to be useful in detecting somatic mutation in genotoxicity testing. Nevertheless, until now very little information exists about the nature of the genetic effects detected in such a strain. This work ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/14.2.187
更新日期:1999-03-01 00:00:00
abstract::The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic aci...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/17.4.265
更新日期:2002-07-01 00:00:00
abstract::The nucleoside analog zidovudine (3'-azido-3'-deoxythymidine, AZT), by itself or in combination with other anti- retroviral drugs, is used perinatally to prevent mother to child transmission of human immunodeficiency virus type 1. AZT is mutagenic in vitro and mutagenic and carcinogenic when administered to neonatal m...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh033
更新日期:2004-07-01 00:00:00
abstract::Coleus aromaticus (Benth, Family: Laminaceae), Indian Oregano native to India and Mediterranean, is well known for its medicinal properties. A preliminary study was undertaken to elucidate in vitro free radical scavenging potential and inhibition of lipid peroxidation by C.aromaticus hydroalcoholic extract (CAE). Anti...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gel023
更新日期:2006-07-01 00:00:00
abstract::Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. First reported in 2006, further development occurred and a standard prot...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez037
更新日期:2019-12-03 00:00:00
abstract::Aneuploidy has important consequences for human health. There is a requirement to detect aneugens that may not be fully satisfied by the current test batter. New cytogenetic techniques look promising. ...
journal_title:Mutagenesis
pub_type:
doi:10.1093/mutage/13.4.417
更新日期:1998-07-01 00:00:00
abstract::Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant disorder characterized by blepharophimosis, ptosis and epicanthus inversus. Based on the presence and absence of premature ovarian failure, two clinical types have been distinguished. Both types of BPES have been mapped to chromosome ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei067
更新日期:2006-01-01 00:00:00
abstract::The human metabolome-the complement of small molecule metabolites present in biofluids and tissues-represents a significant part of the internal chemical milieu and is therefore an important aspect of the human exposome. Metabolic profiling approaches, commonly referred to as metabonomics or metabolomics, permit detai...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/gev060
更新日期:2015-11-01 00:00:00