1,8-Dinitropyrene: comparative mutagenicity in Chinese hamster V79 and CHO cells.

abstract：:The circulating human transcriptome, which includes both coding and non-coding RNA (ncRNA) molecules, represents a rich source of potential biomarkers for colorectal cancer (CRC) that has only recently been explored. In particular, the release of RNA-containing extracellular vesicles (EVs), in a multitude of different...

journal_title：Mutagenesis

authors： Francavilla A,Turoczi S,Tarallo S,Vodicka P,Pardini B,Naccarati A

更新日期：2020-07-11 00:00:00

abstract：:Recent problems with the supply of Difco bacto agar have forced some laboratories to evaluate alternative agars for use in the Salmonella/microsome assay. This led to the independent observation in two laboratories (Boots and Glaxo) that Salmonella typhimurium TA97a is sensitive to certain types of agar that may be us...

journal_title：Mutagenesis

authors： Wilcox P,Wedd DJ,Williams WR,Mee CD,O'Donovan MR

更新日期：1992-01-01 00:00:00

abstract：:A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at C...

journal_title：Mutagenesis

authors： Valentine CR,Rainey HF,Farrell JM,Shaddock JG,Dobrovolsky VN,Delongchamp RR

更新日期：2008-09-01 00:00:00

abstract：:It has been hypothesised that positive associations between age and levels of oxidative stress-generated damage to DNA may be related to an age-dependent decline in DNA repair activity. The objective of this study was to investigate the association between age and repair activity of oxidatively damaged DNA in peripher...

journal_title：Mutagenesis

authors： Løhr M,Jensen A,Eriksen L,Grønbæk M,Loft S,Møller P

更新日期：2015-09-01 00:00:00

abstract：:Extracts from lean pork heated at 200 degrees C have a strong mutagenic activity in the Ames Salmonella assay (strain TA98 +S9). The formation of mutagenicity is highly temperature dependent, thus an extract heated at 100 degrees C is not mutagenic in this system. This paper shows that the 200 degrees C extract also c...

journal_title：Mutagenesis

authors： Kolman A,Kleman M,Bohusová T,Gustafsson JA,Overvik E

更新日期：1992-03-01 00:00:00

abstract：:The use of DNA adduct analysis has previously focused on the use of marine organisms for biomonitoring, whereas similar investigations in freshwater organisms are sparse. In that context, we have investigated the relevance of DNA adducts as biomarkers of genotoxicity in the freshwater mussels Dreissena polymorpha. The...

journal_title：Mutagenesis

authors： Châtel A,Faucet-Marquis V,Perret M,Gourlay-Francé C,Uher E,Pfohl-Leszkowicz A,Vincent-Hubert F

更新日期：2012-11-01 00:00:00

abstract：:The presence of an adaptive response to low doses of alkylating chemicals in the phototrophic bacteria Rhodobacter sphaeroides and R.capsulatus has been studied. Results obtained show that both strains display this repair response against the challenge doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), when they ar...

journal_title：Mutagenesis

authors： Vericat JA,Barbé J

更新日期：1988-03-01 00:00:00

abstract：:We have shown previously that UVC irradiation of benzo[a]pyrene diol epoxide (BPDE)-adducted DNA (BPDE/UVC) induces an increase in mutation frequency in the supF gene greater than the calculated additive value derived from either treatment alone, with a greater absolute increase in the level of BPDE signature transver...

journal_title：Mutagenesis

authors： McLuckie KI,Gaskell M,Farmer PB,Martin EA,Jones GD,Routledge MN

更新日期：2004-03-01 00:00:00

abstract：:The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2(-/-)Tk(+/-), Pms2(+/+)Tk(+/-), Pms2(+/-)Tk(+/-) and Pms2(-/-)Tk(-/-) mice were bred from Pms2(+/-)Tk(+/-) mic...

journal_title：Mutagenesis

authors： Dobrovolsky VN,McKinzie PB,Shaddock JG,Mittelstaedt RA,Heflich RH,Parsons BL

更新日期：2003-07-01 00:00:00

abstract：:The use of a white-ivory (wi) strain of Drosophila melanogaster carrying four copies of this allele, (wi)4, has proved to be useful in detecting somatic mutation in genotoxicity testing. Nevertheless, until now very little information exists about the nature of the genetic effects detected in such a strain. This work ...

journal_title：Mutagenesis

authors： Suárez S,Cabré O,Velázquez A,Marcos R,Xamena N

更新日期：1999-03-01 00:00:00

abstract：:Nature is an attractive source of therapeutic compounds. In comparison to the artificial drugs, natural compounds cause less adverse side effects and are suitable for current molecularly oriented approaches to drug development and their mutual combining. Medicinal plants represent one of the most available remedy agai...

journal_title：Mutagenesis

authors： Horváthová E,Srančíková A,Regendová-Sedláčková E,Melušová M,Meluš V,Netriová J,Krajčovičová Z,Slameňová D,Pastorek M,Kozics K

更新日期：2016-01-01 00:00:00

abstract：:Sister chromatid exchanges (SCE) and chromosome aberrations (CA) were studied in the lymphocytes of 70 male agricultural workers occupationally exposed to several pesticides and 69 matched controls, without indication of exposure to pesticides, from 'El Maresme' (Barcelona, Spain), Comparison between both groups revea...

journal_title：Mutagenesis

authors： Carbonell E,Xamena N,Creus A,Marcos R

更新日期：1993-11-01 00:00:00

abstract：:Primary liver fibroblasts were applied in a cytokinesis-block micronucleus assay in combination with fluorescence in situ hybridization (FISH) using two protocols. In protocol A (Prot. A), cytochalasin B (Cyt B) was added at the end of the treatment time directly to the medium containing the standard compounds, wherea...

journal_title：Mutagenesis

authors： Nesti C,Trippi F,Scarpato R,Migliore L,Turchi G

更新日期：2000-03-01 00:00:00

abstract：:Antiretroviral therapy for the human immunodeficiency virus-1 (HIV-1) typically includes two nucleoside reverse transcriptase inhibitors (NRTIs). 3'-Azido-3'-deoxythymidine (AZT, Zidovudine) plus 2'-deoxy-3'-thiacytidine (3TC, Lamivudine) is a combination that is used frequently. The NRTIs are mutagenic nucleoside ana...

journal_title：Mutagenesis

authors： Olivero OA,Tejera AM,Fernandez JJ,Taylor BJ,Das S,Divi RL,Poirier MC

更新日期：2005-03-01 00:00:00

abstract：:The nucleoside analog zidovudine (3'-azido-3'-deoxythymidine, AZT), by itself or in combination with other anti- retroviral drugs, is used perinatally to prevent mother to child transmission of human immunodeficiency virus type 1. AZT is mutagenic in vitro and mutagenic and carcinogenic when administered to neonatal m...

journal_title：Mutagenesis

authors： Von Tungeln LS,Dobrovolsky VN,Bishop ME,Shaddock JG,Heflich RH,Beland FA

更新日期：2004-07-01 00:00:00

abstract：:A transgenic mouse strain with a high copy number of rescuable lacZ sequences was evaluated for its effectiveness in detecting lacZ- mutations in selected tissues. Procarbazine, cyclophosphamide, ethylnitrosourea, 7,12-dimethylbenz[a]anthracene (DMBA), acrylamide and chlorambucil were tested following either single or...

journal_title：Mutagenesis

authors： Hoorn AJ,Custer LL,Myhr BC,Brusick D,Gossen J,Vijg J

更新日期：1993-01-01 00:00:00

abstract：:We have characterized six SV40-transformed xeroderma pigmentosum cell lines (XP20S and XP12BE derived from female donors, XP12RO-SV, XP3BR/12SV, XP4PA-SV and XP8CAC-SV from male donors) for their usability in HPRT mutation studies. All cell lines exhibit hypersensitivity, compared with MRC5CV1 cells, towards the cytot...

journal_title：Mutagenesis

authors： Merk O,Speit G

更新日期：1997-09-01 00:00:00

abstract：:Oligodontia, which is the congenital absence of six or more permanent teeth, excluding the third molars, may contribute to masticatory dysfunction, speech alteration, aesthetic problems and malocclusion. Msh homeobox 1 (MSX1) was the first gene identified as causing non-syndromic oligodontia. In this study, we identif...

journal_title：Mutagenesis

authors： Wong SW,Liu HC,Han D,Chang HG,Zhao HS,Wang YX,Feng HL

更新日期：2014-09-01 00:00:00

abstract：:The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4...

journal_title：Mutagenesis

authors： Ennever FK,Rosenkranz HS

更新日期：1986-03-01 00:00:00

abstract：:This is an investigation of the long-term effects of a shift from a mixed diet to a lacto-vegetarian diet and of a return to a mixed diet on the mutagenic activity in urine and faeces. The participants were 20 normal weight, non-smoking subjects. Dietary surveys and urinary and faecal samples were collected before and...

journal_title：Mutagenesis

authors： Johansson G,Holmén A,Persson L,Högstedt B,Wassén C,Ottova L,Gustafsson JA

更新日期：1998-03-01 00:00:00

abstract：:The revertibility of three spontaneous hypoxanthine phosphoribosyl transferase (HPRT)-deficient V79 cell lines has been determined after exposure to a number of alkylating agents. TG11 and 19 reverted at frequencies ranging from 1 X 10(-5) to 1 X 10(-4) after exposure to doses of ethylmethane sulphonate (EMS) N-methyl...

journal_title：Mutagenesis

authors： Fox M,Rossiter BJ,Brennand J

更新日期：1988-01-01 00:00:00

abstract：:We have developed a two dose/single-sample protocol for the in vivo/in vitro rat hepatocyte unscheduled DNA synthesis (UDS) assay. In order to enhance the effectiveness of grain detection by image analysis we found minor technical modifications to be beneficial. These included the use of 3% acetic acid in ethanol (or ...

journal_title：Mutagenesis

authors： Amphlett NW,Mitchell ID,Rees RW,Haynes GA

更新日期：1996-01-01 00:00:00

abstract：:Urine and serum samples of rats bearing three different experimental tumours (hepatocellular carcinoma, myelomonocytic leukemia and mesoblastic nephroma) were investigated for mutagenicity with the Ames Salmonella test. Enhancement of mutagenic activity in TA98 and TA100 was observed only in the case of urine samples ...

journal_title：Mutagenesis

authors： Varga C,Pocsai Z,Kertai P

更新日期：1995-01-01 00:00:00

abstract：:To evaluate the genetic damage induced by tuberculosis infection and also by a combination of therapeutic exposure to anti-tuberculosis (anti-TB) drugs (isoniazid + rifampicin + pyrazinamide + ethambutol or streptomycin) we have considered chromosome aberrations (CA) and micronuclei (MN) in binucleate peripheral blood...

journal_title：Mutagenesis

authors： Masjedi MR,Heidary A,Mohammadi F,Velayati AA,Dokouhaki P

更新日期：2000-11-01 00:00:00

abstract：:The cytokinesis-block micronucleus cytome (CBMNCyt) assay is a widely used technique for measuring DNA damage in human populations. The formation of micronuclei (MN) in dividing cells can result from chromosome breakage due to unrepaired or mis-repaired DNA lesions or chromosome malsegregation due to mitotic malfuncti...

journal_title：Mutagenesis

authors： Dhillon VS,Thomas P,Iarmarcovai G,Kirsch-Volders M,Bonassi S,Fenech M

更新日期：2011-01-01 00:00:00

abstract：:Anaesthetics have gained a lot of attention for their potential mutagenic/carcinogenic effects. In the present study we have investigated the genotoxicity of the inhalation anaesthetic sevoflurane on DNA of lymphocytes isolated from 20 patients undergoing orthopaedic surgery. The genotoxicity of the anaesthetic was st...

journal_title：Mutagenesis

authors： Alleva R,Tomasetti M,Solenghi MD,Stagni F,Gamberini F,Bassi A,Fornasari PM,Fanelli G,Borghi B

更新日期：2003-09-01 00:00:00

abstract：:Folic acid (FA), the most oxidized and stable form of folate, is commonly used as a dietary supplement and in culture media. FA must be reduced and methylated to become the metabolically active form found in blood and utilized by tissues, i.e. 5-methyltetrahydrofolate (5-MeTHF). 5-MeTHF is the methyl group donor requi...

journal_title：Mutagenesis

authors： Wang X,Fenech M

更新日期：2003-01-01 00:00:00

abstract：:BRAF alterations represent a novel indicator of the progression and aggressiveness of thyroid carcinogenesis. So, the main aim of the study was to elucidate the involvement of BRAF gene mutations and its expression in Kashmiri (North India) patients and investigate their association with clinico-pathological character...

journal_title：Mutagenesis

authors： Khan MS,Pandith AA,Azad N,Hussain MU,Masoodi SR,Wani KA,Andrabi KI,Mudassar S

更新日期：2014-03-01 00:00:00

abstract：:Aneuploidy of mouse chromosome 8 induced by a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH) was investigated by fluorescence in situ hybridization (FISH) in vivo. Male mice were treated with THH (single i.p. injection) at doses of 120, 240 and 480 mg/kg. Colchicine (COL, 1.5 mg/kg i.p.) was used...

journal_title：Mutagenesis

authors： Xu W,Ziqing L,Yinrun D,Xiaoyan W,Jinglun X

更新日期：2004-09-01 00:00:00

abstract：:The induction of localized DNA damage within a discrete nuclear volume is an important tool in DNA repair studies. Both charged particle irradiation and laser microirradiation (LMI) systems allow for such a localized damage induction, but the results obtained are difficult to compare, as the delivered laser dose canno...

journal_title：Mutagenesis

authors： Splinter J,Jakob B,Lang M,Yano K,Engelhardt J,Hell SW,Chen DJ,Durante M,Taucher-Scholz G

更新日期：2010-05-01 00:00:00