Lymphocyte DNA damage precedes DNA repair or cell death after orthopaedic surgery under general anaesthesia.

abstract：:Macrocyclic polyethers (crown ethers) are a family of compounds that possess the ability to complex with and transport metal ions across membranes. Because of their unique ionophoric characteristic, they have wide application in industry and research, chemistry and biology. In the current investigation the relationshi...

journal_title：Mutagenesis

authors： Cai MY,Arenaz P

更新日期：1998-01-01 00:00:00

abstract：:Previous reports showed the protective effect of the synthetic antioxidant butylated hydroxytoluene (BHT) against the chromosomal damage induced by bleomycin (BLM), cadmium chloride and potassium dichromate. To test the hypothesis that this effect was exerted by inhibition and/or scavenging of reactive oxygen species ...

journal_title：Mutagenesis

authors： Grillo CA,Dulout FN

更新日期：2006-11-01 00:00:00

abstract：:A pronase digestion procedure for the isolation of gastric mucosal cells was evaluated for its usefulness in measuring unscheduled DNA synthesis (UDS). The method has been claimed to be suited for assessing the genotoxicity potential of compounds. Compounds were given orally to rats. After 13 h [3H]thymidine was injec...

journal_title：Mutagenesis

authors： Larsson H,Fryklund J,Helander HF,Wallmark B

更新日期：1991-01-01 00:00:00

abstract：:The human metabolome-the complement of small molecule metabolites present in biofluids and tissues-represents a significant part of the internal chemical milieu and is therefore an important aspect of the human exposome. Metabolic profiling approaches, commonly referred to as metabonomics or metabolomics, permit detai...

journal_title：Mutagenesis

authors： Athersuch TJ,Keun HC

更新日期：2015-11-01 00:00:00

abstract：:Comparative investigations of sister-chromatid exchange (SCE) and micronucleus induction in the bone marrow of rats, mice and Chinese hamsters with the cytostatic alkylating mutagen cyclophosphamide (CP) revealed remarkable species differences in their mutagenic responses. With both test systems the sensitivities of t...

journal_title：Mutagenesis

authors： Madle E,Korte A,Beek B

更新日期：1986-11-01 00:00:00

abstract：:Sanfetrinem cilexetil, a hexetil ester of a Trinem antibiotic, does not induce micronuclei in rat bone marrow cells or induce DNA repair synthesis in rat hepatocytes following oral dosing. However, in vitro chromosome damage and mutations are induced in mammalian cells lacking carboxylesterase activity (human lymphocy...

journal_title：Mutagenesis

authors： Oliver J,Naidoo A,Vandin L,Pugnaghi F,Gatehouse D,Comelli R

更新日期：2000-01-01 00:00:00

abstract：:An established human hepatoma cell strain (Hep G2) was used in micronuclei (MN) and sister chromatid exchange (SCE) assays to evaluate the clastogenic potential of several indirectly-acting mutagenic carcinogens. Benzo[a]pyrene, cyclophosphamide, dimethyl nitrosamine, hexamethylphosphoramide, pyrene and safrole were s...

journal_title：Mutagenesis

authors： Natarajan AT,Darroudi F

更新日期：1991-09-01 00:00:00

abstract：:In vivo genotoxicity studies-shortly followed by carcinogenicity-are posing high demand for test-related recourses in terms of animal lives and resources. Among those, the micronucleus test in rodents is the most widely used as a follow-up to positive in vitro mutagenicity results; therefore, the development and exten...

journal_title：Mutagenesis

authors： Benigni R,Bossa C,Worth A

更新日期：2010-07-01 00:00:00

abstract：:The induction of aneuploidy in cultured mammalian cells has been studied using two chemical agents, diethylstilboestrol dipropionate and Colcemid, which act on the mitotic spindle, in order to investigate different methods of scoring and statistical analysis. Two cell lines, one human and the other Chinese hamster, we...

journal_title：Mutagenesis

authors： Danford N,Balfe P

更新日期：1987-09-01 00:00:00

abstract：:The cytokinesis-block micronucleus cytome (CBMNCyt) assay is a widely used technique for measuring DNA damage in human populations. The formation of micronuclei (MN) in dividing cells can result from chromosome breakage due to unrepaired or mis-repaired DNA lesions or chromosome malsegregation due to mitotic malfuncti...

journal_title：Mutagenesis

authors： Dhillon VS,Thomas P,Iarmarcovai G,Kirsch-Volders M,Bonassi S,Fenech M

更新日期：2011-01-01 00:00:00

abstract：:Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors. Using a cell-free NHEJ assay, we...

journal_title：Mutagenesis

authors： Kuhfittig-Kulle S,Feldmann E,Odersky A,Kuliczkowska A,Goedecke W,Eggert A,Pfeiffer P

更新日期：2007-05-01 00:00:00

abstract：:Ionising radiation induces several isolated and clustered DNA lesions in human cells. Depending on the type of lesions, DNA repair pathways get activated to maintain the integrity of the genome. Base excision repair (BER) pathway is known to repair single-strand breaks and base damages through short- and long-patch ge...

journal_title：Mutagenesis

authors： Toprani SM,Das B

更新日期：2015-03-01 00:00:00

abstract：:A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors w...

journal_title：Mutagenesis

authors： Cole J,Green MH

更新日期：1995-09-01 00:00:00

abstract：:Studies in mono-culture of cells have shown that diesel exhaust particles (DEPs) increase the production of reactive oxygen species (ROS) and oxidative stress-related damage to DNA. However, the level of particle-generated genotoxicity may depend on interplay between different cell types, e.g. lung epithelium and immu...

journal_title：Mutagenesis

authors： Jantzen K,Roursgaard M,Desler C,Loft S,Rasmussen LJ,Møller P

更新日期：2012-11-01 00:00:00

abstract：:Recent studies suggest increased cancer risk in patients with type 2 diabetes mellitus (T2DM) compared with healthy individuals. The present study aims to assess whether T2DM is associated with increased genome instability and whether a healthy diet with natural foods can improve genome stability in peripheral blood l...

journal_title：Mutagenesis

authors： Müllner E,Brath H,Toferer D,Adrigan S,Bulla MT,Stieglmayer R,Wallner M,Marek R,Wagner KH

更新日期：2013-03-01 00:00:00

abstract：:Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP) with ozone were investigated. Male and female B6C3F1 mice were exposed to ozone (0.5 p.p.m.), NNK (1.0 mg/kg), DBP (5000 p.p.m.) and different combinations of these toxicants 6 h/day for 16,...

journal_title：Mutagenesis

authors： Kim MY,Kim YC,Cho MH

更新日期：2002-07-01 00:00:00

abstract：:The human lymphocyte micronucleus (MN) test combined with fluorescence in situ hybridization (FISH) of a centromeric probe is considered a useful screening assay to distinguish between clastogenic and aneugenic agents. Four suspected aneuploidy-inducing chemicals, acetaldehyde (AA), diethylstilbestrol (DES), diethylst...

journal_title：Mutagenesis

authors： Migliore L,Cocchi L,Scarpato R

更新日期：1996-05-01 00:00:00

abstract：:Genotoxic stress causes a reduced stability of the plant genome and has a detrimental effect on plant growth and productivity. Double-strand breaks (DSBs) are the most harmful of all DNA lesions because they cause the loss of genetic information on both strands of the DNA helix. In the presented study the coding and g...

journal_title：Mutagenesis

authors： Stolarek M,Gruszka D,Braszewska-Zalewska A,Maluszynski M

更新日期：2015-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:Autosomal recessive woolly hair/hypotrichosis (ARWH/HT: OMIM #278150/604379) is a rare hereditary hair disease characterized by tightly curled hair at birth which can lead to sparse hair later in life. The mutations in both LIPH and LPAR6/P2RY5 are responsible for autosomal recessive woolly hair with or without hypotr...

journal_title：Mutagenesis

authors： Chang XD,Gu YJ,Dai S,Chen XR,Zhang CL,Zhao HS,Song QH

更新日期：2017-12-31 00:00:00

abstract：:CASE, an artificial intelligence structure-activity relational system, was used to predict the carcinogenicity of a group of chemicals currently being tested in rodent bioassays by the US National Toxicology Program. The 'learning set' for the CASE predictions consisted of the results of previous 252 rodent carcinogen...

journal_title：Mutagenesis

authors： Rosenkranz HS,Klopman G

更新日期：1990-09-01 00:00:00

abstract：:This study investigated the effect of glucose and fructose, and advanced glycation end-products (AGEs) on genome damage in WIL2-NS cells, measured using the cytokinesis-block micronucleus cytome (CBMN-Cyt) assay. The effect of AGEs was investigated using the bovine serum albumin (AGE-BSA) model system induced either w...

journal_title：Mutagenesis

authors： Deo P,McCullough CL,Almond T,Jaunay EL,Donnellan L,Dhillon VS,Fenech M

更新日期：2020-03-27 00:00:00

abstract：:Black tea theafulvins, a fraction of thearubigins isolated from black tea aqueous infusions, potentiated the mutagenic activity of the mycotoxin aflatoxin B(1) in the Ames test, in the presence of a hepatic S9 activation system derived from Aroclor 1254-treated rats. In contrast, when the S9 activation system was repl...

journal_title：Mutagenesis

authors： Catterall F,Copeland E,Clifford MN,Ioannides C

更新日期：2003-03-01 00:00:00

abstract：:The lines irs1, irs2 and irs3, derived from V79-4 hamster cells, are sensitive to DNA-damaging agents including ionizing radiations. However, unlike some other radiosensitive lines, the irs lines show no apparent defect in the repair of DNA strand breaks. We have now assessed the mis-repair of DNA damage in the irs li...

journal_title：Mutagenesis

authors： Thacker J,Ganesh AN,Stretch A,Benjamin DM,Zahalsky AJ,Hendrickson EA

更新日期：1994-03-01 00:00:00

abstract：:Aneuploidy of mouse chromosome 8 induced by a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH) was investigated by fluorescence in situ hybridization (FISH) in vivo. Male mice were treated with THH (single i.p. injection) at doses of 120, 240 and 480 mg/kg. Colchicine (COL, 1.5 mg/kg i.p.) was used...

journal_title：Mutagenesis

authors： Xu W,Ziqing L,Yinrun D,Xiaoyan W,Jinglun X

更新日期：2004-09-01 00:00:00

abstract：:The effects of salts of 27 elements on recombination and on the production of disomic and/or diploid spores during meiosis of Saccharomyces cerevisiae has been investigated. Be(NO3)2, MgSO4, FeSO4, CuSO4, AgNO3, Na2HAsO4 were inactive on the events studied during meiotic cell division. AuCl4, CdCl2, C4H6O4Pb, SnCl2, K...

journal_title：Mutagenesis

authors： Sora S,Agostoni Carbone ML,Pacciarini M,Magni GE

更新日期：1986-01-01 00:00:00

abstract：:Many chemical carcinogens require metabolic activation to form genotoxic compounds in human. Standard in vitro genotoxicity assays performed with activation systems, such as rat liver S9, are recognised to lead to a high number of false positives. The aim of this study was to evaluate the suitability of differentiated...

journal_title：Mutagenesis

authors： Le Hegarat L,Dumont J,Josse R,Huet S,Lanceleur R,Mourot A,Poul JM,Guguen-Guillouzo C,Guillouzo A,Fessard V

更新日期：2010-11-01 00:00:00

abstract：:Nanoremediation of soil, ground and surface water using nanoscale zerovalent iron particles (nZVI) has facilitated their direct environmental exposure posing ecotoxicological concerns. Numerous studies elucidate their phytotoxicity in terms of growth and their fate within the plant system. However, their potential gen...

journal_title：Mutagenesis

authors： Ghosh I,Mukherjee A,Mukherjee A

更新日期：2017-05-01 00:00:00

abstract：:ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test i...

journal_title：Mutagenesis

authors： Henry SP,Monteith DK,Matson JE,Mathison BH,Loveday KS,Winegar RA,Matson JE,Lee PS,Riccio ES,Bakke JP,Levin AA

更新日期：2002-05-01 00:00:00

abstract：:The repairability during G(1) of DNA lesions eliciting sister chromatid exchanges (SCE) induced by methylmethanesulfonate (MMS) and ethylmethanesulfonate (EMS) in BrdU-substituted and unsubstituted DNA strands was determined in murine salivary gland cells in vivo. The SCE frequency was determined after exposure to MMS...

journal_title：Mutagenesis

authors： González-Beltrán F,Morales-Ramírez P

更新日期：2003-01-01 00:00:00