Abstract:
:The effects of salts of 27 elements on recombination and on the production of disomic and/or diploid spores during meiosis of Saccharomyces cerevisiae has been investigated. Be(NO3)2, MgSO4, FeSO4, CuSO4, AgNO3, Na2HAsO4 were inactive on the events studied during meiotic cell division. AuCl4, CdCl2, C4H6O4Pb, SnCl2, K2Cr2O7, RbCl induced both disomic and diploid spores. LiCl acted similarly and also affected recombination. Activity in the induction of disomic spores was shown by MnSO4, HgCl2 and SrCl2. CsCl, CaCl2, Na2MoO4, NiCl2, K2PtCl4 increased the frequency of diploid spores, while NaWO4, VOSO4, KCl, BaCl2 already increased recombination frequency. NaBiO3 showed an effect on meiotic recombination only. A decrease in the occurrence of both diploid and disomic spores was suggested by the data obtained with CoCl2.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Sora S,Agostoni Carbone ML,Pacciarini M,Magni GEdoi
10.1093/mutage/1.1.21subject
Has Abstractpub_date
1986-01-01 00:00:00pages
21-8issue
1eissn
0267-8357issn
1464-3804journal_volume
1pub_type
杂志文章相关文献
MUTAGENESIS文献大全abstract::We have investigated the relative importance of DNA methylation-directed repair of replication errors to the production of mutation/gene rearrangements in mammalian cells with hypomethylated genomes. Using a series of sibling (Chinese hamster derived) cell clones with stably altered DNA methylation levels, we found th...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/4.6.462
更新日期:1989-11-01 00:00:00
abstract::Folic acid (FA), the most oxidized and stable form of folate, is commonly used as a dietary supplement and in culture media. FA must be reduced and methylated to become the metabolically active form found in blood and utilized by tissues, i.e. 5-methyltetrahydrofolate (5-MeTHF). 5-MeTHF is the methyl group donor requi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/18.1.81
更新日期:2003-01-01 00:00:00
abstract::Many chronic inflammatory conditions are associated with an increased risk of cancer development. At the site of inflammation, cellular DNA is damaged by hypochlorous acid (HOCl), a potent oxidant generated by myeloperoxidase. 8-Chloro-2'-deoxyguanosine (8-Cl-dG) is a major DNA adduct formed by HOCl and has been detec...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges056
更新日期:2013-01-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO), a well-known differentiation inducer in several myeloid cells, also induces a reversible G(1) arrest in many cell lines. We recently showed that DMSO induces a G(1) phase arrest in Chinese hamster ovary (CHO) cells, by restoring contact inhibition and preventing high density-dependent apopto...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/17.5.419
更新日期:2002-09-01 00:00:00
abstract::Radiation-induced bystander effects have been evaluated extensively, including the involvement of the mitogen-activated protein kinase (MAPK) pathways. However, few studies have examined the ability of chemicals to induce bystander effects, and the molecular mechanisms involved in chemical bystander effects have not b...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq003
更新日期:2010-05-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors. At least 15% of cases are inherited as an autosomal dominant mutation, but the majority are sporadic. We evaluated cytogenetic alterations, both spontaneous ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/16.4.323
更新日期:2001-07-01 00:00:00
abstract::Autosomal recessive woolly hair/hypotrichosis (ARWH/HT: OMIM #278150/604379) is a rare hereditary hair disease characterized by tightly curled hair at birth which can lead to sparse hair later in life. The mutations in both LIPH and LPAR6/P2RY5 are responsible for autosomal recessive woolly hair with or without hypotr...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gex043
更新日期:2017-12-31 00:00:00
abstract::In the past decade, a number of case-control studies have been carried out to investigate the relationship between the HHEX polymorphism and type 2 diabetes (T2D). However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the rela...
journal_title:Mutagenesis
pub_type: 杂志文章,meta分析
doi:10.1093/mutage/geq095
更新日期:2011-03-01 00:00:00
abstract::The present study was undertaken to compare the antimutagenic activity of aqueous extracts, at the concentrations used for human consumption, from green, black and decaffeinated black tea. Antimutagenic potential was evaluated against three indirect-acting dietary carcinogens, Glu-P-1, benzo(a)pyrene and nitrosopyrrol...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.6.597
更新日期:1996-11-01 00:00:00
abstract::Quantitative and qualitative aspects of the in vivo micronucleus-inducing potential of five chemicals were studied using flow cytometric enumeration of micronucleated polychromatic peripheral blood erythrocytes in mice. The chemicals were hydroquinone, vinblastine sulphate, chloral hydrate (tested in two different mou...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/12.1.1
更新日期:1997-01-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are stable pollutants, which can be found in almost every compartment of terrestrial and aquatic ecosystems. They are very lipophilic and therefore have the potency of accumulating in the fat stores of animals. The mechanisms by which PCBs exert their adverse effects are still unclear....
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.5.485
更新日期:1996-09-01 00:00:00
abstract::Alcohol drinking-derived acetaldehyde is believed to cross-link DNA and induce sister chromatid exchanges in peripheral blood lymphocytes. However, little population data are available to illustrate effects of alcohol-derived acetaldehyde on DNA migration as assayed by the comet assay in peripheral lymphocytes. In the...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gep008
更新日期:2009-07-01 00:00:00
abstract::The antineoplastic drug etoposide (ET) inhibits topoisomerase II (topo II) activity by forming a ternary complex (DNA-ET-topo II). This complex prevents the DNA-strand-rejoining activity of topo II and may result in structural chromosome aberrations. Inhibition of topo II activity may also predispose cells to aneuploi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.4.357
更新日期:1996-07-01 00:00:00
abstract::The widespread production and use of nanoparticles calls for faster and more reliable methods to assess their safety. The main aim of this study was to investigate the genotoxicity of three reference TiO2 nanomaterials (NM) within the frame of the FP7-NANoREG project, with a particular focus on testing the applicabili...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gew030
更新日期:2017-01-01 00:00:00
abstract::Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, the comet assay, the hprt gene mutation assay and the TCR gene mutation assay. The subjects were divided into two groups: (i) 21 workers from a plant producing methotrexate (MTX); (ii) 21 controls w...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei048
更新日期:2005-09-01 00:00:00
abstract::In order to establish the capacity of Mytilus spp. to form genotoxin-DNA adducts, a series of in vitro and in vivo studies were conducted in which tissue samples and animals were exposed to five model genotoxins. Following the in vitro characterization of the major adducts induced by the compounds, a series of in vivo...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/12.3.153
更新日期:1997-05-01 00:00:00
abstract::Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. We established human SK-OV-3 cells that stably express the Zeocin resistance gene (Sh ble) using an ecdysone-inducible mammalian expression system. Surprisingly, our results demonstrated that Zeocin, added in the cultur...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei016
更新日期:2005-03-01 00:00:00
abstract::The human lymphocyte micronucleus (MN) test combined with fluorescence in situ hybridization (FISH) of a centromeric probe is considered a useful screening assay to distinguish between clastogenic and aneugenic agents. Four suspected aneuploidy-inducing chemicals, acetaldehyde (AA), diethylstilbestrol (DES), diethylst...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.3.285
更新日期:1996-05-01 00:00:00
abstract::A pronase digestion procedure for the isolation of gastric mucosal cells was evaluated for its usefulness in measuring unscheduled DNA synthesis (UDS). The method has been claimed to be suited for assessing the genotoxicity potential of compounds. Compounds were given orally to rats. After 13 h [3H]thymidine was injec...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/6.1.3
更新日期:1991-01-01 00:00:00
abstract::The restriction site mutation method described by Parry et al. (1990) for isolating mutant sequences directly from DNA is discussed and an additional enrichment step proposed using magnetic beads. ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/5.6.523
更新日期:1990-11-01 00:00:00
abstract::Recombinant lambda phage DNA containing segments of human O6-methylguanine-DNA transferase gene was employed to localize this gene among the human chromosomes using non-radioactive in situ hybridization technique. This gene was found to be present at the telomeric end, 26q, of the long arm of the chromosome 10. ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/7.1.83
更新日期:1992-01-01 00:00:00
abstract::Fanconi anaemia (FA) is a rare autosomal recessive disease characterized by increased spontaneous and DNA crosslinker-induced chromosome instability, progressive pancytopenia and cancer susceptibility. An increasing number of genes are involved in FA, including the breast cancer susceptibility gene BRCA2. Five of the ...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/17.6.529
更新日期:2002-11-01 00:00:00
abstract::There is a correlation between intestinal cancer and diets high in meat, so fried beef, chicken, lamb, pork and fish were tested for their ability to induce mutations in the small intestine of mice. The mice were bred to be heterozygous at the Dlb-1 locus so that loss of the dominant Dlb-1 b allele by mutation could b...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/16.2.103
更新日期:2001-03-01 00:00:00
abstract::Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger053
更新日期:2012-01-01 00:00:00
abstract::The genotoxicity of alpha-hexachlorocyclohexane (alpha-HCH) was evaluated in primary cultures of mouse, rat and human hepatocytes. DNA fragmentation was measured by the alkaline elution technique and DNA repair synthesis by quantitative autoradiography. A 20 h exposure to subtoxic concentrations ranging from 0.056 to ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.1.79
更新日期:1996-01-01 00:00:00
abstract::We have conducted a randomized trial which investigated the ability of dietary changes (in particular diets rich in cruciferous vegetables and flavonoids), to increase urinary antimutagenicity and inhibit DNA damage in smokers. Ninety heavy smokers were recruited and randomly assigned to three groups, and were given t...
journal_title:Mutagenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/mutage/gel021
更新日期:2006-05-01 00:00:00
abstract::Photomutagenicity assays are required for regulatory submissions of some chemicals. As yet there are no well-validated protocols available for these assays. Critical factors which may contribute to the ability of a bacterial assay to detect photomutagens (e.g. dose of UV and test chemical, exposure conditions, light s...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/9.5.459
更新日期:1994-09-01 00:00:00
abstract::The complementation group (CG) assignment is presented for 74 moderately sensitive (approximately 2-4x sensitivity of parental line based on ratio of D10s) UV-sensitive mutants of Chinese hamster ovary (CHO) cells from the Facility for Automated Experiments in Cell Biology (FAECB) collection. The distribution of mutan...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/9.4.301
更新日期:1994-07-01 00:00:00
abstract::The cytogenetic effects of mimosine, a naturally occurring plant amino acid known to arrest cell-cycle progression at the G1-S border in cultured cells, have been studied. It was found that mimosine inhibits the cell-cycle progression in a dose-dependent manner in primary and transformed Chinese hamster fibroblasts as...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/10.5.385
更新日期:1995-09-01 00:00:00
abstract::Hepatic microsomes from rats pretreated with PCB were found to metabolize the food mutagen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) to two major metabolites, one of which was identified as the N-hydroxy derivative, 2-hydroxy-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (N-OH-PhIP). This identification w...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/6.1.93
更新日期:1991-01-01 00:00:00