Abstract:
:The present study was undertaken to compare the antimutagenic activity of aqueous extracts, at the concentrations used for human consumption, from green, black and decaffeinated black tea. Antimutagenic potential was evaluated against three indirect-acting dietary carcinogens, Glu-P-1, benzo(a)pyrene and nitrosopyrrolidine. All three types of tea gave rise to strong and concentration-dependent suppression of the mutagenicity of the three premutagens in the presence of an activation system. No major difference in the antimutagenic potential of the three types of tea could be discerned. Black tea, decaffeinated black tea and, to a lesser extent, green tea also antagonized the mutagenicity of the direct-acting mutagen 9-aminoacridine. All three types of tea inhibited markedly the NADPH-dependent reduction of cytochrome c and the O-dealkylations of ethoxy-, methoxy- and, to a much lesser extent, pentoxy-resorufin. When the microsomal metabolism was terminated, after the metabolic activation of the premutagens, incorporation of the aqueous tea extracts into the activation system caused a concentration-dependent suppression of mutagenic response. No significant difference in the antimutagenic activity of the three types of tea in this system was evident. Bearing in mind the much higher concentration of flavanols in green tea compared with the black teas, it may be concluded either that these compounds are unlikely to be the major tea components responsible for the antimutagenic, and possibly anticarcinogenic, properties of tea or that their fermentation products are similarly active.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Bu-Abbas A,Nunez X,Clifford MN,Walker R,Ioannides Cdoi
10.1093/mutage/11.6.597subject
Has Abstractpub_date
1996-11-01 00:00:00pages
597-603issue
6eissn
0267-8357issn
1464-3804journal_volume
11pub_type
杂志文章相关文献
MUTAGENESIS文献大全abstract::Genotoxic stress causes a reduced stability of the plant genome and has a detrimental effect on plant growth and productivity. Double-strand breaks (DSBs) are the most harmful of all DNA lesions because they cause the loss of genetic information on both strands of the DNA helix. In the presented study the coding and g...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gev033
更新日期:2015-11-01 00:00:00
abstract::The mechanistic/mammalian target of rapamycin (mTOR) is a conserved protein kinase that controls several anabolic processes required for cell growth and proliferation. As such, mTOR has been implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes and neurodegeneration....
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/geu045
更新日期:2015-03-01 00:00:00
abstract::Coleus aromaticus (Benth, Family: Laminaceae), Indian Oregano native to India and Mediterranean, is well known for its medicinal properties. A preliminary study was undertaken to elucidate in vitro free radical scavenging potential and inhibition of lipid peroxidation by C.aromaticus hydroalcoholic extract (CAE). Anti...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gel023
更新日期:2006-07-01 00:00:00
abstract::O6-Methylguanine-DNA methyltransferase (MT) specific activity (fmol/mg protein) was measured in human T lymphocytes which were maintained as exponentially growing cultures from 6 to 17 days. The T lymphocytes were not transformed and were grown under the same conditions used previously for determination of spontaneous...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/5.2.169
更新日期:1990-03-01 00:00:00
abstract::4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguanosin-N (2)-yl)-4AQO...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gev069
更新日期:2016-03-01 00:00:00
abstract::Nature is an attractive source of therapeutic compounds. In comparison to the artificial drugs, natural compounds cause less adverse side effects and are suitable for current molecularly oriented approaches to drug development and their mutual combining. Medicinal plants represent one of the most available remedy agai...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gev056
更新日期:2016-01-01 00:00:00
abstract::The human metabolome-the complement of small molecule metabolites present in biofluids and tissues-represents a significant part of the internal chemical milieu and is therefore an important aspect of the human exposome. Metabolic profiling approaches, commonly referred to as metabonomics or metabolomics, permit detai...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/gev060
更新日期:2015-11-01 00:00:00
abstract::The micronucleus assay (MN assay) is a well-established assay in genetic toxicology, biomonitoring of mutagen-exposed populations and chromosomal radiosensitivity testing. To evaluate the effect of storage time on the chromosomal radiosensitivity assessment in lymphocytes, micronuclei (MN) yields in blood samples rece...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gev072
更新日期:2016-03-01 00:00:00
abstract::Eight widely used halogenated benzenes, including bromobenzene (BB), chlorobenzene (CB), three isomers of dichlorobenzene (DCB) and three isomers of trichlorobenzene (TCB) were tested for acute toxicity (LD50) and clastogenicity in 8-week-old NMRI mice by intraperitoneal administration. Four doses of each chemical (up...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/2.2.111
更新日期:1987-03-01 00:00:00
abstract:UNLABELLED:Gastric cancer is the second leading cause of cancer-related death worldwide with a low 5-year survival (S5y) after initial diagnosis. Although aberrant Wnt/β-catenin (CTNNB1) signaling has been observed in multiple human cancers, there is no information on the role of CTNNB1 polymorphisms in gastric cancer ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges027
更新日期:2012-11-01 00:00:00
abstract::Many chemical carcinogens require metabolic activation to form genotoxic compounds in human. Standard in vitro genotoxicity assays performed with activation systems, such as rat liver S9, are recognised to lead to a high number of false positives. The aim of this study was to evaluate the suitability of differentiated...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq039
更新日期:2010-11-01 00:00:00
abstract::Comparative investigations of sister-chromatid exchange (SCE) and micronucleus induction in the bone marrow of rats, mice and Chinese hamsters with the cytostatic alkylating mutagen cyclophosphamide (CP) revealed remarkable species differences in their mutagenic responses. With both test systems the sensitivities of t...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/1.6.419
更新日期:1986-11-01 00:00:00
abstract::Three short-term assays (the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test) were carried out to evaluate the genotoxicity of four trihalomethanes (chloroform, bromodichloromethane, chlorodibromomethane and bromoform). With the SOS chromotest, all the chemicals studied except chloroform were ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/10.4.333
更新日期:1995-07-01 00:00:00
abstract::Wood dust is recognised as a human carcinogen, based on the strong association of wood dust exposure and the elevated risk of malignant tumours of the nasal cavity and paranasal sinuses [sino-nasal cancer (SNC)]. The study aimed to assess genetic damage in workers exposed to wood dust using biomarkers in both buccal a...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geu003
更新日期:2014-05-01 00:00:00
abstract::The nucleoside analog zidovudine (3'-azido-3'-deoxythymidine, AZT), by itself or in combination with other anti- retroviral drugs, is used perinatally to prevent mother to child transmission of human immunodeficiency virus type 1. AZT is mutagenic in vitro and mutagenic and carcinogenic when administered to neonatal m...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh033
更新日期:2004-07-01 00:00:00
abstract::The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2(-/-)Tk(+/-), Pms2(+/+)Tk(+/-), Pms2(+/-)Tk(+/-) and Pms2(-/-)Tk(-/-) mice were bred from Pms2(+/-)Tk(+/-) mic...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geg007
更新日期:2003-07-01 00:00:00
abstract::Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. We established human SK-OV-3 cells that stably express the Zeocin resistance gene (Sh ble) using an ecdysone-inducible mammalian expression system. Surprisingly, our results demonstrated that Zeocin, added in the cultur...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei016
更新日期:2005-03-01 00:00:00
abstract::Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ger035
更新日期:2011-11-01 00:00:00
abstract::Escherichia coli K12ND-160 possesses characteristics which make it highly suitable for studies on mutagenic/antimutagenic specificity and has been used to investigate such effects for several agents. Nitrofurazone (NFZ) was used as a mutagen at non-lethal concentrations; it causes mutation from fucose sensitivity to r...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/4.1.31
更新日期:1989-01-01 00:00:00
abstract::The complementation group (CG) assignment is presented for 74 moderately sensitive (approximately 2-4x sensitivity of parental line based on ratio of D10s) UV-sensitive mutants of Chinese hamster ovary (CHO) cells from the Facility for Automated Experiments in Cell Biology (FAECB) collection. The distribution of mutan...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/9.4.301
更新日期:1994-07-01 00:00:00
abstract::The circulating human transcriptome, which includes both coding and non-coding RNA (ncRNA) molecules, represents a rich source of potential biomarkers for colorectal cancer (CRC) that has only recently been explored. In particular, the release of RNA-containing extracellular vesicles (EVs), in a multitude of different...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez038
更新日期:2020-07-11 00:00:00
abstract::The revertibility of three spontaneous hypoxanthine phosphoribosyl transferase (HPRT)-deficient V79 cell lines has been determined after exposure to a number of alkylating agents. TG11 and 19 reverted at frequencies ranging from 1 X 10(-5) to 1 X 10(-4) after exposure to doses of ethylmethane sulphonate (EMS) N-methyl...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/3.1.15
更新日期:1988-01-01 00:00:00
abstract::Adducts of 1,2-epoxy-3-butene (EB) with haemoglobin were monitored in 17 workers from the 1,3-butadiene (BD) production unit of a petrochemical plant and in nine referents employed at the same factory but not exposed to BD. The air concentrations of BD were determined using stationary and personal monitoring. The ambi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.2.145
更新日期:1996-03-01 00:00:00
abstract::Previous reports showed the protective effect of the synthetic antioxidant butylated hydroxytoluene (BHT) against the chromosomal damage induced by bleomycin (BLM), cadmium chloride and potassium dichromate. To test the hypothesis that this effect was exerted by inhibition and/or scavenging of reactive oxygen species ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gel046
更新日期:2006-11-01 00:00:00
abstract::A modified protocol is described for the in vitro analysis of micronuclei in whole blood or separated lymphocyte cultures. The induction of binucleate cells by various concentrations of cytochalasin B (3, 4.5 or 6 micrograms/ml) was examined at two harvest times (68 or 72 h). An optimal yield was obtained by adding cy...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/8.4.317
更新日期:1993-07-01 00:00:00
abstract::There is a correlation between intestinal cancer and diets high in meat, so fried beef, chicken, lamb, pork and fish were tested for their ability to induce mutations in the small intestine of mice. The mice were bred to be heterozygous at the Dlb-1 locus so that loss of the dominant Dlb-1 b allele by mutation could b...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/16.2.103
更新日期:2001-03-01 00:00:00
abstract::The repairability during G(1) of DNA lesions eliciting sister chromatid exchanges (SCE) induced by methylmethanesulfonate (MMS) and ethylmethanesulfonate (EMS) in BrdU-substituted and unsubstituted DNA strands was determined in murine salivary gland cells in vivo. The SCE frequency was determined after exposure to MMS...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/18.1.13
更新日期:2003-01-01 00:00:00
abstract::A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party conclud...
journal_title:Mutagenesis
pub_type:
doi:10.1093/mutage/7.3.175
更新日期:1992-05-01 00:00:00
abstract::AHH-1 TK+/- is a human B cell-derived lymphoblastoid cell line that constitutively expresses a high level of the cytochrome CYP1A1. The MCL-5 cell line was developed by transfection of AHH-1 with cDNAs encoding the human cytochrome P450s, CYP1A2, CYP2A6, CYP2E1, CYP3A4 and microsomal epoxide hydrolase carried in plasm...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/14.4.417
更新日期:1999-07-01 00:00:00
abstract::Aneuploidy of mouse chromosome 8 induced by a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH) was investigated by fluorescence in situ hybridization (FISH) in vivo. Male mice were treated with THH (single i.p. injection) at doses of 120, 240 and 480 mg/kg. Colchicine (COL, 1.5 mg/kg i.p.) was used...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh044
更新日期:2004-09-01 00:00:00