The influence of blood storage time and general anaesthesia on chromosomal radiosensitivity assessment.

abstract：:There are several reports demonstrating that aneugens may preferentially affect segregation of particular chromosomes in somatic cells. Much less is known on specific susceptibility of individual chromosomes to non-disjunction in mammalian meiosis in response to chemical exposures. To explore possible chromosome-speci...

journal_title：Mutagenesis

authors： Sun F,Yin H,Eichenlaub-Ritter U

更新日期：2001-09-01 00:00:00

abstract：:The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic aci...

journal_title：Mutagenesis

authors： Arlt VM,Stiborova M,Schmeiser HH

更新日期：2002-07-01 00:00:00

abstract：:Five selectively methylated analogs of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) and of the nematocide 1,2-dibromo-3-chloropropane (DBCP) were synthesized and their relative mutagenicities determined in Salmonella typhimurium TA100 in the presence of rat liver microsomes. In all cases, methylation...

journal_title：Mutagenesis

authors： Omichinski JG,Søderlund EJ,Bausano JA,Dybing E,Nelson SD

更新日期：1987-07-01 00:00:00

abstract：:The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...

journal_title：Mutagenesis

authors： Lamerdin JE,Yamada NA,George JW,Souza B,Christian AT,Jones NJ,Thompson LH

更新日期：2004-05-01 00:00:00

abstract：:The non-syndromic cleft lip and/or palate (NSCL/P) is a common birth defect caused by a combination of genetic and environmental factors. The possible role of genome instability on NSCL/P patient needs more investigation, since DNA metabolism is an essential cellular function to keep cells with normal genotypes and ge...

journal_title：Mutagenesis

authors： Xavier LA,Bezerra JF,de Rezende AA,Oliveira RA,Dalmolin RJ,do Amaral VS

更新日期：2017-03-01 00:00:00

abstract：:To evaluate the genetic damage induced by tuberculosis infection and also by a combination of therapeutic exposure to anti-tuberculosis (anti-TB) drugs (isoniazid + rifampicin + pyrazinamide + ethambutol or streptomycin) we have considered chromosome aberrations (CA) and micronuclei (MN) in binucleate peripheral blood...

journal_title：Mutagenesis

authors： Masjedi MR,Heidary A,Mohammadi F,Velayati AA,Dokouhaki P

更新日期：2000-11-01 00:00:00

abstract：:Prostate cancer is a major health burden, being the second most commonly diagnosed malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer therapy, leading to significant long-term quality-of-life effects for patients and a broad socio-ecological burden. Biomarkers that could facilitat...

journal_title：Mutagenesis

authors： Brezina S,Feigl M,Gumpenberger T,Staudinger R,Baierl A,Gsur A

更新日期：2020-07-11 00:00:00

abstract：:Neurocysticercosis (NCC) has been associated with a high frequency of DNA damage in human circulating lymphocytes and more recently with the development of hematological malignancies. Chronic inflammation, a common feature of helminthic infections, has been proposed to play a key role in carcinogenesis induced by para...

journal_title：Mutagenesis

authors： Herrera LA,Rodríguez U,Gebhart E,Ostrosky-Wegman P

更新日期：2001-11-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) treatment as used therapeutically has been shown to induce DNA damage in the alkaline comet assay with leukocytes from test subjects. Using formamidopyrimidine-DNA glycosylase, a DNA repair enzyme which specifically nicks DNA at sites of 8-oxoguanines and formamidopyrimidines, we have detected ...

journal_title：Mutagenesis

authors： Speit G,Dennog C,Lampl L

更新日期：1998-01-01 00:00:00

abstract：:The cytogenetic effects of mimosine, a naturally occurring plant amino acid known to arrest cell-cycle progression at the G1-S border in cultured cells, have been studied. It was found that mimosine inhibits the cell-cycle progression in a dose-dependent manner in primary and transformed Chinese hamster fibroblasts as...

journal_title：Mutagenesis

authors： Jha AN,Hande PM,Mullenders LH,Natarajan AT

更新日期：1995-09-01 00:00:00

abstract：:The presence of centromeric DNA was studied in micronuclei isolated from the blood of male ddY mice after five weekly intraperitoneal injections of mitomycin C (MMC), 1-beta-D-arabinofuranosylcytosine (Ara-C), colchicine (COL) or vinblastine sulfate (VBL). In agreement with our earlier findings, about half of the micr...

journal_title：Mutagenesis

authors： Mäki-Paakkanen J,Hayashi M,Suzuki T,Tanabe H,Honma M,Sofuni T

更新日期：1995-11-01 00:00:00

abstract：:The adduct that would arise from cis opening of (+)-(1S,2R,3R, 4S)-3,4-dihydroxy-1,2-epoxy-benzo[c]phenan-threne (benzo[c]phenanthrene diol epoxide-2, where the benzylic hydroxyl group and the epoxide oxygen are trans) by the exocyclic N6-amino group of deoxyadenosine was incorporated at the marked site into four olig...

journal_title：Mutagenesis

authors： Pontén I,Waters LS,Sayer JM,Pilcher AS,Dipple A,Jerina DM

更新日期：2001-01-01 00:00:00

abstract：:The repairability during G(1) of DNA lesions eliciting sister chromatid exchanges (SCE) induced by methylmethanesulfonate (MMS) and ethylmethanesulfonate (EMS) in BrdU-substituted and unsubstituted DNA strands was determined in murine salivary gland cells in vivo. The SCE frequency was determined after exposure to MMS...

journal_title：Mutagenesis

authors： González-Beltrán F,Morales-Ramírez P

更新日期：2003-01-01 00:00:00

abstract：:Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise t...

journal_title：Mutagenesis

authors： Rieswijk L,Brauers KJ,Coonen ML,van Breda SG,Jennen DG,Kleinjans JC

更新日期：2015-11-01 00:00:00

abstract：:We employed the three-way differential staining technique (TWD), which allows SCEs to be distinguished on a per generation basis by scoring third metaphases (M3), in order to study the spontaneous levels of SCEs in normal and high frequency cells (HFCs) that occurred in the first (S1), second (S2) and third (S3) S pha...

journal_title：Mutagenesis

authors： Ponzanelli I,Landi S,Bernacchi F,Barale R

更新日期：1997-09-01 00:00:00

abstract：:Protection from chronic exposure to cosmic radiation, which is primarily composed of protons, in future manned missions to Mars and beyond is considered to be a key unresolved issue. To model the effects of cosmic radiation on a living cell, we used Saccharomyces cerevisiae cells harboring various deletions of DNA rep...

journal_title：Mutagenesis

authors： Rostek C,Turner EL,Robbins M,Rightnar S,Xiao W,Obenaus A,Harkness TA

更新日期：2008-03-01 00:00:00

abstract：:The importance of diet in DNA damage prevention is well established; however, the comparison of weight loss diets with different micronutrient and macronutrient profiles on genome stability in peripheral blood lymphocytes (PBLs) has not been studied. This study tested the hypothesis that genome stability in PBLs of ov...

journal_title：Mutagenesis

authors： Benassi-Evans B,Clifton PM,Noakes M,Keogh JB,Fenech M

更新日期：2009-05-01 00:00:00

abstract：:The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2(-/-)Tk(+/-), Pms2(+/+)Tk(+/-), Pms2(+/-)Tk(+/-) and Pms2(-/-)Tk(-/-) mice were bred from Pms2(+/-)Tk(+/-) mic...

journal_title：Mutagenesis

authors： Dobrovolsky VN,McKinzie PB,Shaddock JG,Mittelstaedt RA,Heflich RH,Parsons BL

更新日期：2003-07-01 00:00:00

abstract：:The effects of salts of 27 elements on recombination and on the production of disomic and/or diploid spores during meiosis of Saccharomyces cerevisiae has been investigated. Be(NO3)2, MgSO4, FeSO4, CuSO4, AgNO3, Na2HAsO4 were inactive on the events studied during meiotic cell division. AuCl4, CdCl2, C4H6O4Pb, SnCl2, K...

journal_title：Mutagenesis

authors： Sora S,Agostoni Carbone ML,Pacciarini M,Magni GE

更新日期：1986-01-01 00:00:00

abstract：:Five independently isolated glutathione-deficient (gsh-) mutants of Saccharomyces cerevisae with maximally 6% residual glutathione content have been analysed genetically. Complementation as well as tetrad analysis of the homo- and heterozygous diploids constructed by suitable crosses of the five mutants indicated that...

journal_title：Mutagenesis

authors： Kistler M,Maier K,Eckardt-Schupp F

更新日期：1990-01-01 00:00:00

abstract：:Among the tests used to determine the mutagenic potential of chemicals, the chromosomal aberrations and micronucleus assays play an important role. These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. One of the hallmarks of apoptosis is DNA fragmentation into 50-300 k...

journal_title：Mutagenesis

authors： Meintières S,Biola A,Pallardy M,Marzin D

更新日期：2001-05-01 00:00:00

abstract：:Wood dust is recognised as a human carcinogen, based on the strong association of wood dust exposure and the elevated risk of malignant tumours of the nasal cavity and paranasal sinuses [sino-nasal cancer (SNC)]. The study aimed to assess genetic damage in workers exposed to wood dust using biomarkers in both buccal a...

journal_title：Mutagenesis

authors： Bruschweiler ED,Hopf NB,Wild P,Huynh CK,Fenech M,Thomas P,Hor M,Charriere N,Savova-Bianchi D,Danuser B

更新日期：2014-05-01 00:00:00

abstract：:A collaborative study of interlaboratory variability in bacterial mutagenicity induced by mitomycin C (MMC) and bleomycin (BLM) was performed using the four strains Salmonella typhimurium TA102 and TA2638 and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101. Thirteen laboratories participated in this study. The four st...

journal_title：Mutagenesis

authors： Watanabe K,Sakamoto K,Sasaki T

更新日期：1995-05-01 00:00:00

abstract：:Fanconi anaemia (FA) patients show cellular sensitivity to a variety of clastogens and prominently to cross-linking agents. Although there is a long-standing clinical impression of radiosensitivity, in vitro studies have yielded conflicting results. In this study, initial radiation-induced DNA damage and kinetics of D...

journal_title：Mutagenesis

authors： Mohseni-Meybodi A,Mozdarani H,Mozdarani S

更新日期：2009-01-01 00:00:00

abstract：:The induction of aneuploidy in cultured mammalian cells has been studied using two chemical agents, diethylstilboestrol dipropionate and Colcemid, which act on the mitotic spindle, in order to investigate different methods of scoring and statistical analysis. Two cell lines, one human and the other Chinese hamster, we...

journal_title：Mutagenesis

authors： Danford N,Balfe P

更新日期：1987-09-01 00:00:00

abstract：:We carried out statistical analysis of the frequency of loss of heterozygosity (LOH) at 10 microsatellite markers on chromosome 9. In 44 microdissected sporadic primary melanomas a comparison of LOH frequency data with other patient data, like age at diagnosis and tumour thickness, showed an interesting correlation be...

journal_title：Mutagenesis

authors： Smeds J,Kumar R,Rozell BL,Hemminki K

更新日期：2000-05-01 00:00:00

abstract：:The tetrahydrofuran-type abasic site analog (THF) induces large deletion mutations in human cells. To compare the large deletions induced by THF on leading and lagging strand templates, plasmid DNAs bearing the analog at a specific position outside the supF gene were introduced into human U2OS cells. The replicated DN...

journal_title：Mutagenesis

authors： Suzuki T,Katayama Y,Komatsu Y,Kamiya H

更新日期：2019-12-19 00:00:00

abstract：:The use of DNA adduct analysis has previously focused on the use of marine organisms for biomonitoring, whereas similar investigations in freshwater organisms are sparse. In that context, we have investigated the relevance of DNA adducts as biomarkers of genotoxicity in the freshwater mussels Dreissena polymorpha. The...

journal_title：Mutagenesis

authors： Châtel A,Faucet-Marquis V,Perret M,Gourlay-Francé C,Uher E,Pfohl-Leszkowicz A,Vincent-Hubert F

更新日期：2012-11-01 00:00:00

abstract：:Photomutagenicity assays are required for regulatory submissions of some chemicals. As yet there are no well-validated protocols available for these assays. Critical factors which may contribute to the ability of a bacterial assay to detect photomutagens (e.g. dose of UV and test chemical, exposure conditions, light s...

journal_title：Mutagenesis

authors： Henderson L,Fedyk J,Bourner C,Windebank S,Fletcher S,Lovell W

更新日期：1994-09-01 00:00:00

abstract：:Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors. Using a cell-free NHEJ assay, we...

journal_title：Mutagenesis

authors： Kuhfittig-Kulle S,Feldmann E,Odersky A,Kuliczkowska A,Goedecke W,Eggert A,Pfeiffer P

更新日期：2007-05-01 00:00:00