Functional analysis of the new barley gene HvKu80 indicates that it plays a key role in double-strand DNA break repair and telomere length regulation.

abstract：:The induction of aneuploidy in cultured mammalian cells has been studied using two chemical agents, diethylstilboestrol dipropionate and Colcemid, which act on the mitotic spindle, in order to investigate different methods of scoring and statistical analysis. Two cell lines, one human and the other Chinese hamster, we...

journal_title：Mutagenesis

authors： Danford N,Balfe P

更新日期：1987-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors. At least 15% of cases are inherited as an autosomal dominant mutation, but the majority are sporadic. We evaluated cytogenetic alterations, both spontaneous ...

journal_title：Mutagenesis

authors： Trippi F,Botto N,Scarpato R,Petrozzi L,Bonuccelli U,Latorraca S,Sorbi S,Migliore L

更新日期：2001-07-01 00:00:00

abstract：:Radiation-induced exchange aberrations are thought to arise as a consequence of misrejoining of free ends of DNA double strand breaks (dsbs). In quiescent mammalian cells this process of misrejoining is prevalently taken up by the non-homologous end joining (NHEJ) process. In order to investigate the role of glutathio...

journal_title：Mutagenesis

authors： Dutta A,Chakraborty A,Saha A,Ray S,Chatterjee A

更新日期：2005-09-01 00:00:00

abstract：:This is an investigation of the long-term effects of a shift from a mixed diet to a lacto-vegetarian diet and of a return to a mixed diet on the mutagenic activity in urine and faeces. The participants were 20 normal weight, non-smoking subjects. Dietary surveys and urinary and faecal samples were collected before and...

journal_title：Mutagenesis

authors： Johansson G,Holmén A,Persson L,Högstedt B,Wassén C,Ottova L,Gustafsson JA

更新日期：1998-03-01 00:00:00

abstract：:o-Phenylphenol (OPP), a widely used fungicide and antibacterial agent, has been considered to be among the top 10 home and garden pesticides used in the USA. Earlier studies have consistently shown that the sodium salt of OPP (SOPP) causes bladder cancer in male Fischer 344 (F344) rats, whereas OPP has produced variab...

journal_title：Mutagenesis

authors： Balakrishnan S,Uppala PT,Rupa DS,Hasegawa L,Eastmond DA

更新日期：2002-01-01 00:00:00

abstract：:Eight widely used halogenated benzenes, including bromobenzene (BB), chlorobenzene (CB), three isomers of dichlorobenzene (DCB) and three isomers of trichlorobenzene (TCB) were tested for acute toxicity (LD50) and clastogenicity in 8-week-old NMRI mice by intraperitoneal administration. Four doses of each chemical (up...

journal_title：Mutagenesis

authors： Mohtashamipur E,Triebel R,Straeter H,Norpoth K

更新日期：1987-03-01 00:00:00

abstract：:Recombinant lambda phage DNA containing segments of human O6-methylguanine-DNA transferase gene was employed to localize this gene among the human chromosomes using non-radioactive in situ hybridization technique. This gene was found to be present at the telomeric end, 26q, of the long arm of the chromosome 10. ...

journal_title：Mutagenesis

authors： Natarajan AT,Vermeulen S,Darroudi F,Valentine MB,Brent TP,Mitra S,Tano K

更新日期：1992-01-01 00:00:00

abstract：:ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test i...

journal_title：Mutagenesis

authors： Henry SP,Monteith DK,Matson JE,Mathison BH,Loveday KS,Winegar RA,Matson JE,Lee PS,Riccio ES,Bakke JP,Levin AA

更新日期：2002-05-01 00:00:00

abstract：:The mechanistic/mammalian target of rapamycin (mTOR) is a conserved protein kinase that controls several anabolic processes required for cell growth and proliferation. As such, mTOR has been implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes and neurodegeneration....

journal_title：Mutagenesis

authors： Cargnello M,Tcherkezian J,Roux PP

更新日期：2015-03-01 00:00:00

abstract：:Down syndrome (DS) is the most common chromosomal abnormality. Many studies have assessed the association between maternal gene polymorphisms involved in folate metabolism and the risk of having a DS offspring, but data are conflicting. Our study aimed to arrive at a more accurate estimation. Therefore, we carried out...

journal_title：Mutagenesis

authors： Yang M,Gong T,Lin X,Qi L,Guo Y,Cao Z,Shen M,Du Y

更新日期：2013-11-01 00:00:00

abstract：:Over the past several years, we have been evaluating the mutagenicity and clastogenicity of compounds capable of Michael-type reactions. These compounds, including acrylamide, several acrylate and methacrylate esters, vinyl sulfones, and phorone, have been evaluated using TK+/- -3.7.2C mouse lymphoma cells. Mutagenic ...

journal_title：Mutagenesis

authors： Dearfield KL,Harrington-Brock K,Doerr CL,Rabinowitz JR,Moore MM

更新日期：1991-11-01 00:00:00

abstract：:Prostate cancer is a major health burden, being the second most commonly diagnosed malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer therapy, leading to significant long-term quality-of-life effects for patients and a broad socio-ecological burden. Biomarkers that could facilitat...

journal_title：Mutagenesis

authors： Brezina S,Feigl M,Gumpenberger T,Staudinger R,Baierl A,Gsur A

更新日期：2020-07-11 00:00:00

abstract：:The effects of salts of 27 elements on recombination and on the production of disomic and/or diploid spores during meiosis of Saccharomyces cerevisiae has been investigated. Be(NO3)2, MgSO4, FeSO4, CuSO4, AgNO3, Na2HAsO4 were inactive on the events studied during meiotic cell division. AuCl4, CdCl2, C4H6O4Pb, SnCl2, K...

journal_title：Mutagenesis

authors： Sora S,Agostoni Carbone ML,Pacciarini M,Magni GE

更新日期：1986-01-01 00:00:00

abstract：:Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. We established human SK-OV-3 cells that stably express the Zeocin resistance gene (Sh ble) using an ecdysone-inducible mammalian expression system. Surprisingly, our results demonstrated that Zeocin, added in the cultur...

journal_title：Mutagenesis

authors： Oliva-Trastoy M,Defais M,Larminat F

更新日期：2005-03-01 00:00:00

abstract：:Barrett's oesophagus (BO) carries an increased risk of progression to oesophageal adenocarcinoma. Chromoendoscopy with methylene blue (MB) can be used to facilitate identification of BO and target areas for biopsy. If photoexcited, MB can generate reactive oxygen species and genotoxic photodegradation products leading...

journal_title：Mutagenesis

authors： Sturmey RG,Wild CP,Hardie LJ

更新日期：2009-05-01 00:00:00

abstract：:In order to validate the in vivo micronucleus test in mouse splenocytes using the cytokinesis block method, 14 compounds with various mechanisms of action were tested: three direct alkylating agents (mitomycin C, ethylnitrosourea, beta-propiolactone), seven indirect alkylating agents (cyclophosphamide, benzo[a]pyrene,...

journal_title：Mutagenesis

authors： Benning V,Brault D,Duvinage C,Thybaud V,Melcion C

更新日期：1994-05-01 00:00:00

abstract：:Famotidine, a histamine H2-receptor antagonist, was devoid of mutagenic activity in seven his- Salmonella typhimurium strains (TA1535, TA1537, TA1538, TA97, TA98, TA100 and TA102) and was equitoxic in repair-proficient (WP2) and repair-deficient (WP2uvrA, WP67, CM561, CM571, WP100 and CM871) Escherichia coli strains, ...

journal_title：Mutagenesis

authors： De Flora S,Camoirano A,Basso C,Astengo M,Zanacchi P,Bennicelli C

更新日期：1986-03-01 00:00:00

abstract：:Each of the Escherichia coli tester strains in the WP3101P-WP3106P series contains an F' plasmid with a different base substitution mutation within the lacZ gene. Each of the six possible base substitution mutations, therefore, can be assayed with these strains by Lac(+) reversion. We used the strains to characterize ...

journal_title：Mutagenesis

authors： Ohta T,Watanabe-Akanuma M,Yamagata H

更新日期：2000-07-01 00:00:00

abstract：:The aim of the present work was to investigate the processes involved in the origin of trisomic karyotypes, i.e. co-migration of sister chromatids (mitotic non-disjunction, MND) and recovery of micronuclei (MN) originating from lagging chromosomes/chromatids at anaphase (mitotic indirect non-disjunction, MIND), and to...

journal_title：Mutagenesis

authors： Minissi S,Degrassi F,Tanzarella C,Gustavino B

更新日期：1999-11-01 00:00:00

abstract：:We have characterized six SV40-transformed xeroderma pigmentosum cell lines (XP20S and XP12BE derived from female donors, XP12RO-SV, XP3BR/12SV, XP4PA-SV and XP8CAC-SV from male donors) for their usability in HPRT mutation studies. All cell lines exhibit hypersensitivity, compared with MRC5CV1 cells, towards the cytot...

journal_title：Mutagenesis

authors： Merk O,Speit G

更新日期：1997-09-01 00:00:00

abstract：:Escherichia coli K12ND-160 possesses characteristics which make it highly suitable for studies on mutagenic/antimutagenic specificity and has been used to investigate such effects for several agents. Nitrofurazone (NFZ) was used as a mutagen at non-lethal concentrations; it causes mutation from fucose sensitivity to r...

journal_title：Mutagenesis

authors： Clarke CH,Shankel DM

更新日期：1989-01-01 00:00:00

abstract：:We have investigated the relative importance of DNA methylation-directed repair of replication errors to the production of mutation/gene rearrangements in mammalian cells with hypomethylated genomes. Using a series of sibling (Chinese hamster derived) cell clones with stably altered DNA methylation levels, we found th...

journal_title：Mutagenesis

authors： Diver WP,Woodcock DM

更新日期：1989-11-01 00:00:00

abstract：:A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors w...

journal_title：Mutagenesis

authors： Cole J,Green MH

更新日期：1995-09-01 00:00:00

abstract：:The importance of diet in DNA damage prevention is well established; however, the comparison of weight loss diets with different micronutrient and macronutrient profiles on genome stability in peripheral blood lymphocytes (PBLs) has not been studied. This study tested the hypothesis that genome stability in PBLs of ov...

journal_title：Mutagenesis

authors： Benassi-Evans B,Clifton PM,Noakes M,Keogh JB,Fenech M

更新日期：2009-05-01 00:00:00

abstract：:Carbon nanotubes (CNTs) are fibrous carbon-based nanomaterials with a potential to cause carcinogenesis in humans. Alterations in DNA methylation on cytosine-phosphate-guanidine (CpG) sites are potential markers of exposure-induced carcinogenesis. This study examined cytotoxicity, genotoxicity and DNA methylation alte...

journal_title：Mutagenesis

authors： Öner D,Moisse M,Ghosh M,Duca RC,Poels K,Luyts K,Putzeys E,Cokic SM,Van Landuyt K,Vanoirbeek J,Lambrechts D,Godderis L,Hoet PH

更新日期：2017-01-01 00:00:00

abstract：:In a sample of healthy subjects (23-59 years old), comprising 49 non-smokers and 23 smokers, we studied the effects of smoking on DNA repair synthesis (UDS) in peripheral lymphocytes. DNA repair after UV-irradiation was measured by [3H]TdR incorporation into DNA (semi-conservative synthesis was inhibited by hydroxyure...

journal_title：Mutagenesis

authors： Celotti L,Furlan D,Ferraro P,Levis AG

更新日期：1989-03-01 00:00:00

abstract：:Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...

journal_title：Mutagenesis

authors： Oya E,Ovrevik J,Arlt VM,Nagy E,Phillips DH,Holme JA

更新日期：2011-11-01 00:00:00

abstract：:Macrocyclic polyethers (crown ethers) are a family of compounds which possess the ability to transport ionic species across natural and artificial membranes. Because of this characteristic, they have wide applications in industry and are being investigated for their potential as pharmacologic agents. However, these co...

journal_title：Mutagenesis

authors： Arenaz P,Bitticks L,Pannell K,Garcia S

更新日期：1989-11-01 00:00:00

abstract：UNLABELLED:Gastric cancer is the second leading cause of cancer-related death worldwide with a low 5-year survival (S5y) after initial diagnosis. Although aberrant Wnt/β-catenin (CTNNB1) signaling has been observed in multiple human cancers, there is no information on the role of CTNNB1 polymorphisms in gastric cancer ...

journal_title：Mutagenesis

authors： Wang S,Tian Y,Wu D,Zhu H,Luo D,Gong W,Zhou Y,Zhou J,Zhang Z

更新日期：2012-11-01 00:00:00

abstract：:We have shown previously that UVC irradiation of benzo[a]pyrene diol epoxide (BPDE)-adducted DNA (BPDE/UVC) induces an increase in mutation frequency in the supF gene greater than the calculated additive value derived from either treatment alone, with a greater absolute increase in the level of BPDE signature transver...

journal_title：Mutagenesis

authors： McLuckie KI,Gaskell M,Farmer PB,Martin EA,Jones GD,Routledge MN

更新日期：2004-03-01 00:00:00