Abstract:
:Macrocyclic polyethers (crown ethers) are a family of compounds that possess the ability to complex with and transport metal ions across membranes. Because of their unique ionophoric characteristic, they have wide application in industry and research, chemistry and biology. In the current investigation the relationship between heavy metal mutagenesis and crown ether co-mutagenicity and/or antimutagenicity in mammalian cells has been examined using sister chromatid exchange (SCE) as the cytogenetic end point. Chinese hamster ovary cells were treated with lead or cadmium, with and without selected crown ethers. Several genotoxic end points, including SCEs were scored and statistically compared. We report here that most of the crown ethers studied had little or no influence on lead- or cadmium-induced SCEs or chromosome aberrations. On the other hand, the substituted crown ether dicyclohexyl 21-crown-7 significantly decreased both spontaneous and metal-induced SCE frequencies, suggesting that this crown ether may possess antimutagenic activity.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Cai MY,Arenaz Pdoi
10.1093/mutage/13.1.27subject
Has Abstractpub_date
1998-01-01 00:00:00pages
27-32issue
1eissn
0267-8357issn
1464-3804journal_volume
13pub_type
杂志文章相关文献
MUTAGENESIS文献大全abstract::The use of a white-ivory (wi) strain of Drosophila melanogaster carrying four copies of this allele, (wi)4, has proved to be useful in detecting somatic mutation in genotoxicity testing. Nevertheless, until now very little information exists about the nature of the genetic effects detected in such a strain. This work ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/14.2.187
更新日期:1999-03-01 00:00:00
abstract::The tetrahydrofuran-type abasic site analog (THF) induces large deletion mutations in human cells. To compare the large deletions induced by THF on leading and lagging strand templates, plasmid DNAs bearing the analog at a specific position outside the supF gene were introduced into human U2OS cells. The replicated DN...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez034
更新日期:2019-12-19 00:00:00
abstract::A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party conclud...
journal_title:Mutagenesis
pub_type:
doi:10.1093/mutage/7.3.175
更新日期:1992-05-01 00:00:00
abstract::Three short-term assays (the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test) were carried out to evaluate the genotoxicity of four trihalomethanes (chloroform, bromodichloromethane, chlorodibromomethane and bromoform). With the SOS chromotest, all the chemicals studied except chloroform were ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/10.4.333
更新日期:1995-07-01 00:00:00
abstract::Oligodontia, which is the congenital absence of six or more permanent teeth, excluding the third molars, may contribute to masticatory dysfunction, speech alteration, aesthetic problems and malocclusion. Msh homeobox 1 (MSX1) was the first gene identified as causing non-syndromic oligodontia. In this study, we identif...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geu019
更新日期:2014-09-01 00:00:00
abstract::Chinese hamster ovary cells were exposed to N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene, and the resulting DNA adducts, sister-chromatid exchanges (SCEs) and mutations at the hypoxanthine-guanine phosphoribosyl transferase locus were quantified. Each agent produced a major DNA adduct su...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/1.3.201
更新日期:1986-05-01 00:00:00
abstract::With the aim of optimizing the efficiency of S9 fractions used in in vitro mutagenicity assays, different schemes for the induction of liver enzymes in rats were tried and the amount of S9 fraction required was assessed. The activity of 2-anthramine (2AA), 2-acetylaminofluorene (2AAF), 3-methylcholanthrene (3MTCL) and...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/14.3.323
更新日期:1999-05-01 00:00:00
abstract::This is a review of the work on molecular dosimetry carried out by several laboratories within the third Environmental Programme of the Commission of the European Communities. The molecular dosimetry project is a coordinated research project in which several laboratories cooperated on various aspects of quantitative c...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/3.3.179
更新日期:1988-05-01 00:00:00
abstract::There are several reports demonstrating that aneugens may preferentially affect segregation of particular chromosomes in somatic cells. Much less is known on specific susceptibility of individual chromosomes to non-disjunction in mammalian meiosis in response to chemical exposures. To explore possible chromosome-speci...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/16.5.407
更新日期:2001-09-01 00:00:00
abstract::A relatively large, reproducible inter-individual variation was found in the ability of 17 human liver S9 samples to mediate the mutagenicity of 2-acetylaminofluorene (2AAF) in Salmonella typhimurium strain TA98. In an animal model, variation in metabolic activation of 2AAF did not appear to relate to the phenotype of...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/3.4.323
更新日期:1988-07-01 00:00:00
abstract::A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors w...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/10.5.449
更新日期:1995-09-01 00:00:00
abstract::CI Solvent Yellow 14 has been reported to be carcinogenic in the rat, inducing neoplastic liver nodules, but non-carcinogenic in the mouse. The present experiments have extended previously reported investigations on the activity of CI Solvent Yellow 14 in in vivo genotoxicity assays. CI Solvent Yellow 14 has been exam...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/12.4.255
更新日期:1997-07-01 00:00:00
abstract::Dibenz[a,h]anthracene (DB[a,h]A) is a polycyclic aromatic hydrocarbon that is a by-product of combustion and a potent carcinogen. Few studies have investigated the effects of DB[a,h]A on mRNA and microRNA expression to dissect the mechanisms involved in carcinogenesis. In this study, mature male mice (Muta(™)Mouse) we...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/get031
更新日期:2013-09-01 00:00:00
abstract::The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some epigenetic effects, which is simple to score, accurate, applicable in different cell types. In addition, it is predictive for cancer, ame...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/geq068
更新日期:2011-01-01 00:00:00
abstract::The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned to the same complementation group. The parental AA8 CHO cells are hemi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh019
更新日期:2004-05-01 00:00:00
abstract::Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vita...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez001
更新日期:2019-05-29 00:00:00
abstract::Aneuploidy of mouse chromosome 8 induced by a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH) was investigated by fluorescence in situ hybridization (FISH) in vivo. Male mice were treated with THH (single i.p. injection) at doses of 120, 240 and 480 mg/kg. Colchicine (COL, 1.5 mg/kg i.p.) was used...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geh044
更新日期:2004-09-01 00:00:00
abstract::Wood dust is recognised as a human carcinogen, based on the strong association of wood dust exposure and the elevated risk of malignant tumours of the nasal cavity and paranasal sinuses [sino-nasal cancer (SNC)]. The study aimed to assess genetic damage in workers exposed to wood dust using biomarkers in both buccal a...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geu003
更新日期:2014-05-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are stable pollutants, which can be found in almost every compartment of terrestrial and aquatic ecosystems. They are very lipophilic and therefore have the potency of accumulating in the fat stores of animals. The mechanisms by which PCBs exert their adverse effects are still unclear....
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/11.5.485
更新日期:1996-09-01 00:00:00
abstract::The induction of localized DNA damage within a discrete nuclear volume is an important tool in DNA repair studies. Both charged particle irradiation and laser microirradiation (LMI) systems allow for such a localized damage induction, but the results obtained are difficult to compare, as the delivered laser dose canno...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq005
更新日期:2010-05-01 00:00:00
abstract::The XPF and ERCC1 proteins form a tight complex and function as an endonuclease to incise on the 5'-side of pyrimidine dimers in DNA. Levels of both proteins are extremely low in group F xeroderma pigmentosum (XP-F) cells. We transfected XP-F cells with the plasmids expressing XPF or ERCC1 and examined levels of both ...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/13.6.595
更新日期:1998-11-01 00:00:00
abstract::The adaptive response is a phenomenon by which cells exposed to low, non-cytotoxic doses of a genotoxicant become significantly resistant to a subsequent higher dose of the same or another genotoxic agent. Induction of the adaptive response has been mainly studied using ionizing radiation and alkylating agents as geno...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/12.6.457
更新日期:1997-11-01 00:00:00
abstract::The micronucleus assay (MN assay) is a well-established assay in genetic toxicology, biomonitoring of mutagen-exposed populations and chromosomal radiosensitivity testing. To evaluate the effect of storage time on the chromosomal radiosensitivity assessment in lymphocytes, micronuclei (MN) yields in blood samples rece...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gev072
更新日期:2016-03-01 00:00:00
abstract::The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic aci...
journal_title:Mutagenesis
pub_type: 杂志文章,评审
doi:10.1093/mutage/17.4.265
更新日期:2002-07-01 00:00:00
abstract::Folic acid (FA), the most oxidized and stable form of folate, is commonly used as a dietary supplement and in culture media. FA must be reduced and methylated to become the metabolically active form found in blood and utilized by tissues, i.e. 5-methyltetrahydrofolate (5-MeTHF). 5-MeTHF is the methyl group donor requi...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/18.1.81
更新日期:2003-01-01 00:00:00
abstract::Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. First reported in 2006, further development occurred and a standard prot...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gez037
更新日期:2019-12-03 00:00:00
abstract::In vivo genotoxicity studies-shortly followed by carcinogenicity-are posing high demand for test-related recourses in terms of animal lives and resources. Among those, the micronucleus test in rodents is the most widely used as a follow-up to positive in vitro mutagenicity results; therefore, the development and exten...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/geq010
更新日期:2010-07-01 00:00:00
abstract::We have investigated the genotoxicity of lambda-cyhalothrin (LCT) (CAS registry No. 91465-08-06), a pyrethroid insecticide, in bone marrow cells and in colonic crypt epithelial cells of groups of four rats per dose treated in vivo by gavage at doses of 0.8, 3.06 and 6.12 mg/kg body weight (body wt). We measured genoto...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gei020
更新日期:2005-03-01 00:00:00
abstract::The use of DNA adduct analysis has previously focused on the use of marine organisms for biomonitoring, whereas similar investigations in freshwater organisms are sparse. In that context, we have investigated the relevance of DNA adducts as biomarkers of genotoxicity in the freshwater mussels Dreissena polymorpha. The...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/ges036
更新日期:2012-11-01 00:00:00
abstract::Protection from chronic exposure to cosmic radiation, which is primarily composed of protons, in future manned missions to Mars and beyond is considered to be a key unresolved issue. To model the effects of cosmic radiation on a living cell, we used Saccharomyces cerevisiae cells harboring various deletions of DNA rep...
journal_title:Mutagenesis
pub_type: 杂志文章
doi:10.1093/mutage/gem055
更新日期:2008-03-01 00:00:00