Impact of molecular alterations of BRAF in the pathogenesis of thyroid cancer.

abstract：:The ability of topoisomerase II inhibitor, teniposide, to induce aneuploidy and meiotic delay in somatic and germinal cells of male mice was investigated by fluorescence in situ hybridisation (FISH) assay using labelled DNA probes and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, respectively. Colchicine and mit...

journal_title：Mutagenesis

authors： Attia SM

更新日期：2012-01-01 00:00:00

abstract：:An immunohistochemical method for the determination of 6-thioguanine resistant (TGr) lymphocytes in human blood samples has been developed. The new technique is a modification of the autoradiographic assay and uses labelling of DNA synthesizing cells by bromodeoxyuridine (BrdU) instead of tritiated thymidine. The labe...

journal_title：Mutagenesis

authors： Montero R,Norppa H,Autio K,Lindholm C,Ostrosky-Wegman P,Sorsa M

更新日期：1991-03-01 00:00:00

abstract：:The effect of cerium oxide nanoparticle (CeNP) in plants has elicited substantial controversy. While some investigators have reported that CeNP possesses antioxidant properties, others observed CeNP to induce reactive oxygen species (ROS). In spite of considerable research carried out on the effects of CeNP in metazoa...

journal_title：Mutagenesis

authors： Sadhu A,Ghosh I,Moriyasu Y,Mukherjee A,Bandyopadhyay M

更新日期：2018-04-13 00:00:00

abstract：:Exposure to ambient air particles is associated with elevated levels of DNA strand breaks (SBs) and endonuclease III, formamidopyrimidine DNA glycosylase (FPG) and oxoguanine DNA glycosylase-sensitive sites in cell cultures, animals and humans. In both animals and cell cultures, increases in SB and in oxidatively dama...

journal_title：Mutagenesis

authors： Møller P,Hemmingsen JG,Jensen DM,Danielsen PH,Karottki DG,Jantzen K,Roursgaard M,Cao Y,Kermanizadeh A,Klingberg H,Christophersen DV,Hersoug LG,Loft S

更新日期：2015-01-01 00:00:00

abstract：:The aneuploidy inducing capacity of 2-chlorobenzylidene malonitrile (CS), a chemical used as a riot control agent, and its hydrolysis products o-chlorobenzaldehyde and malonitrile was studied at various exposure conditions in V79 Chinese hamster cells. Chromosomes were counted in metaphase preparations with preserved ...

journal_title：Mutagenesis

authors： Schmid E,Bauchinger M

更新日期：1991-07-01 00:00:00

abstract：:Alterations of DNA repair enzymes and consequential triggering of aberrant DNA damage response (DDR) pathways are thought to play a pivotal role in genomic instabilities associated with cancer development, and are further thought to be important predictive biomarkers for therapy using the synthetic lethality paradigm....

journal_title：Mutagenesis

authors： Malfatti MC,Antoniali G,Codrich M,Burra S,Mangiapane G,Dalla E,Tell G

更新日期：2020-02-13 00:00:00

abstract：:The induction of aneuploidy in cultured mammalian cells has been studied using two chemical agents, diethylstilboestrol dipropionate and Colcemid, which act on the mitotic spindle, in order to investigate different methods of scoring and statistical analysis. Two cell lines, one human and the other Chinese hamster, we...

journal_title：Mutagenesis

authors： Danford N,Balfe P

更新日期：1987-09-01 00:00:00

abstract：:Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involved. We used liver mi...

journal_title：Mutagenesis

authors： Beristain-Castillo E,Martínez-Vázquez M,Camacho-Carranza R,Espinosa-Aguirre JJ

更新日期：2013-11-01 00:00:00

abstract：:o-Phenylphenol (OPP), a widely used fungicide and antibacterial agent, has been considered to be among the top 10 home and garden pesticides used in the USA. Earlier studies have consistently shown that the sodium salt of OPP (SOPP) causes bladder cancer in male Fischer 344 (F344) rats, whereas OPP has produced variab...

journal_title：Mutagenesis

authors： Balakrishnan S,Uppala PT,Rupa DS,Hasegawa L,Eastmond DA

更新日期：2002-01-01 00:00:00

abstract：:The antineoplastic drug etoposide (ET) inhibits topoisomerase II (topo II) activity by forming a ternary complex (DNA-ET-topo II). This complex prevents the DNA-strand-rejoining activity of topo II and may result in structural chromosome aberrations. Inhibition of topo II activity may also predispose cells to aneuploi...

journal_title：Mutagenesis

authors： Mailhes JB,Marchetti F,Young D,London SN

更新日期：1996-07-01 00:00:00

abstract：:The development and use of chromosome-specific DNA probes to label entire human chromosomes has been an important advance in molecular cytogenetics. Fluorescence in situ hybridization using whole chromosome-specific DNA probes has been used to study both numerical and structural chromosomal aberrations in many human c...

journal_title：Mutagenesis

authors： Blakey DH,Bayley JM,Huang KC

更新日期：1993-05-01 00:00:00

abstract：:In response to DNA damage, cell cycle arrest, apoptosis, and DNA repair are mediated by a TP53 pathway that induces p21(WAF1/Cip1). The chemotherapeutic drug cis-diamminedichloroplatinum-II (cisplatin) damages cellular DNA by forming cis-diammineplatinum-N(7)-d[GpG] and cis-diammine-platinum-N(7)-d[ApG] adducts. To in...

journal_title：Mutagenesis

authors： van Gijssel HE,Leil TA,Weinberg WC,Divi RL,Olivero OA,Poirier MC

更新日期：2007-01-01 00:00:00

abstract：:We report on a new method for the study of radiation-induced chromatid breaks in stimulated human peripheral blood T lymphocytes, involving a combination of a 1-h colcemid block and a short (15 min) calyculin A treatment. We find that this procedure eliminates the problem of centromere splitting when calyculin A is us...

journal_title：Mutagenesis

authors： Shovman O,Riches AC,Adamson D,Bryant PE

更新日期：2008-07-01 00:00:00

abstract：:FD&C Red No.3 (erythrosine) has been used as a dye in foods, drugs and cosmetics since its approval by the US Department of Agriculture in 1907. In 1977 the Certified Color Manufacturers' Association (CCMA) initiated studies on FD&C Red No.3 including chronic toxicity and carcinogenicity studies in rats and mice. Data...

journal_title：Mutagenesis

authors： Lin GH,Brusick DJ

更新日期：1986-07-01 00:00:00

abstract：:The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the ageing process and mutations have been associated with cancer in many tissues, including human skin. This involvement is linked to the key roles of mitochondrial function and mtDNA in oxidative stress production and...

journal_title：Mutagenesis

authors： Birch-Machin MA,Swalwell H

更新日期：2010-03-01 00:00:00

abstract：:Ionising radiation induces several isolated and clustered DNA lesions in human cells. Depending on the type of lesions, DNA repair pathways get activated to maintain the integrity of the genome. Base excision repair (BER) pathway is known to repair single-strand breaks and base damages through short- and long-patch ge...

journal_title：Mutagenesis

authors： Toprani SM,Das B

更新日期：2015-03-01 00:00:00

abstract：:I suggest that there are several good reasons for retaining mammalian cell mutation assays in a basic test package for genotoxicity and that the possible existence of a non-clastogenic mammalian mutagen is not one of them. I put forward a number of propositions, not necessarily original, concerning in vitro assays, in...

journal_title：Mutagenesis

authors： Green MH

更新日期：1988-09-01 00:00:00

abstract：:Among the tests used to determine the mutagenic potential of chemicals, the chromosomal aberrations and micronucleus assays play an important role. These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. One of the hallmarks of apoptosis is DNA fragmentation into 50-300 k...

journal_title：Mutagenesis

authors： Meintières S,Biola A,Pallardy M,Marzin D

更新日期：2001-05-01 00:00:00

abstract：:The genotoxic effects of benzene in lung cells of mice exposed to single acute doses by inhalation have been estimated by cytogenetic analysis of micronuclei in primary cultures of lung fibroblasts. Mice were nose-only exposed to 1000 p.p.m. for 30 or 60 min or to 3500 p.p.m. for 30 min and sacrificed 24 h after the e...

journal_title：Mutagenesis

authors： Ranaldi R,Bassani B,Villani P,Lombardi CC,Tanzarella C,Pacchierotti F

更新日期：1998-09-01 00:00:00

abstract：:Autosomal recessive woolly hair/hypotrichosis (ARWH/HT: OMIM #278150/604379) is a rare hereditary hair disease characterized by tightly curled hair at birth which can lead to sparse hair later in life. The mutations in both LIPH and LPAR6/P2RY5 are responsible for autosomal recessive woolly hair with or without hypotr...

journal_title：Mutagenesis

authors： Chang XD,Gu YJ,Dai S,Chen XR,Zhang CL,Zhao HS,Song QH

更新日期：2017-12-31 00:00:00

abstract：:A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party conclud...

journal_title：Mutagenesis

authors： Elliott BM,Combes RD,Elcombe CR,Gatehouse DG,Gibson GG,Mackay JM,Wolf RC

更新日期：1992-05-01 00:00:00

abstract：:Gaulden reported a novel and unexpected mitomycin C (MMC) effect, namely a pronounced retardation of very late prophase and loss of chromosome orientation in neuroblasts of the grasshopper Chortophaga viridifasciate. Because this effect may be due to interactions of MMC with non-DNA targets, MMC was tested for its int...

journal_title：Mutagenesis

authors： Albertini S,Friederich U,Würgler FE

更新日期：1989-01-01 00:00:00

abstract：:The importance of diet in DNA damage prevention is well established; however, the comparison of weight loss diets with different micronutrient and macronutrient profiles on genome stability in peripheral blood lymphocytes (PBLs) has not been studied. This study tested the hypothesis that genome stability in PBLs of ov...

journal_title：Mutagenesis

authors： Benassi-Evans B,Clifton PM,Noakes M,Keogh JB,Fenech M

更新日期：2009-05-01 00:00:00

abstract：:Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise t...

journal_title：Mutagenesis

authors： Rieswijk L,Brauers KJ,Coonen ML,van Breda SG,Jennen DG,Kleinjans JC

更新日期：2015-11-01 00:00:00

abstract：:The clastogenic potential of sodium fluoride was determined both in vitro (using cultured human lymphocytes) and in vivo (using the rat bone-marrow micronucleus test). The incidence of chromosome aberrations in human lymphocyte cultures exposed to 20 or 40 micrograms/ml sodium fluoride (3 and 9% respectively) was sign...

journal_title：Mutagenesis

authors： Albanese R

更新日期：1987-11-01 00:00:00

abstract：:Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a s...

journal_title：Mutagenesis

authors： Tomlinson IP,Houlston RS,Montgomery GW,Sieber OM,Dunlop MG

更新日期：2012-03-01 00:00:00

abstract：:Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and exogenous steroid hormones. The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones. Increased endogenous steroid hormone levels have been associated...

journal_title：Mutagenesis

authors： Ye Z,Parry JM

更新日期：2002-03-01 00:00:00

abstract：:Basic extracts isolated from lamb meat treated at various temperatures were tested for mutagenicity in Salmonella typhimurium strain TA98 in the presence of S9 mix. Samples of ground lamb patties were cooked for 10 min per side at 100, 150, 200, 250 and 300 degrees C. Low cooking temperatures resulted in products with...

journal_title：Mutagenesis

authors： Sflomos C,Papadopoulou R,Athanasiou K

更新日期：1989-05-01 00:00:00

abstract：:We carried out statistical analysis of the frequency of loss of heterozygosity (LOH) at 10 microsatellite markers on chromosome 9. In 44 microdissected sporadic primary melanomas a comparison of LOH frequency data with other patient data, like age at diagnosis and tumour thickness, showed an interesting correlation be...

journal_title：Mutagenesis

authors： Smeds J,Kumar R,Rozell BL,Hemminki K

更新日期：2000-05-01 00:00:00

abstract：:The lines irs1, irs2 and irs3, derived from V79-4 hamster cells, are sensitive to DNA-damaging agents including ionizing radiations. However, unlike some other radiosensitive lines, the irs lines show no apparent defect in the repair of DNA strand breaks. We have now assessed the mis-repair of DNA damage in the irs li...

journal_title：Mutagenesis

authors： Thacker J,Ganesh AN,Stretch A,Benjamin DM,Zahalsky AJ,Hendrickson EA

更新日期：1994-03-01 00:00:00