Analysis of the aneuploidy inducing capacity of 2-chlorobenzylidene malonitrile (CS) and metabolites in V79 Chinese hamster cells.

Abstract:

:The aneuploidy inducing capacity of 2-chlorobenzylidene malonitrile (CS), a chemical used as a riot control agent, and its hydrolysis products o-chlorobenzaldehyde and malonitrile was studied at various exposure conditions in V79 Chinese hamster cells. Chromosomes were counted in metaphase preparations with preserved cytoplasm. A significant increase in the number of aneuploid cells was found after CS and o-chlorobenzaldehyde exposure but not after malonitrile exposure. o-chlorobenzaldehyde, which also introduced high levels of polyploid cells, seems to be an important metabolite for the aneuploidogenic effectiveness of CS.

journal_name

Mutagenesis

journal_title

Mutagenesis

authors

Schmid E,Bauchinger M

doi

10.1093/mutage/6.4.303

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

303-5

issue

4

eissn

0267-8357

issn

1464-3804

journal_volume

6

pub_type

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