Abstract:
:The aneuploidy inducing capacity of 2-chlorobenzylidene malonitrile (CS), a chemical used as a riot control agent, and its hydrolysis products o-chlorobenzaldehyde and malonitrile was studied at various exposure conditions in V79 Chinese hamster cells. Chromosomes were counted in metaphase preparations with preserved cytoplasm. A significant increase in the number of aneuploid cells was found after CS and o-chlorobenzaldehyde exposure but not after malonitrile exposure. o-chlorobenzaldehyde, which also introduced high levels of polyploid cells, seems to be an important metabolite for the aneuploidogenic effectiveness of CS.
journal_name
Mutagenesisjournal_title
Mutagenesisauthors
Schmid E,Bauchinger Mdoi
10.1093/mutage/6.4.303subject
Has Abstractpub_date
1991-07-01 00:00:00pages
303-5issue
4eissn
0267-8357issn
1464-3804journal_volume
6pub_type
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